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UniProtKB - O60721 (NCKX1_HUMAN)

Entry version 177 (25 May 2022)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
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Protein

Sodium/potassium/calcium exchanger 1

Gene

SLC24A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+ (PubMed:26631410).

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105).

Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Sensory transduction, Symport, Transport, Vision
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60721

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2485179, Activation of the phototransduction cascade
R-HSA-425561, Sodium/Calcium exchangers
R-HSA-5619077, Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O60721

SIGNOR Signaling Network Open Resource

More...SIGNORi		O60721

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.19.4.9, the ca(2+):cation antiporter (caca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 1
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 11 Publication
Retinal rod Na-Ca+K exchanger1 Publication
Solute carrier family 24 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC24A11 PublicationImported
Synonyms:KIAA07021 Publication, NCKX11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10975, SLC24A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603617, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60721

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000074621

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 452ExtracellularSequence analysisAdd BLAST452
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 497CytoplasmicSequence analysisAdd BLAST24
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Topological domaini519 – 522ExtracellularSequence analysis4
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 563CytoplasmicSequence analysisAdd BLAST20
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585ExtracellularSequence analysis1
Transmembranei586 – 606HelicalSequence analysisAdd BLAST21
Topological domaini607 – 907CytoplasmicSequence analysisAdd BLAST301
Transmembranei908 – 928HelicalSequence analysisAdd BLAST21
Topological domaini929 – 935ExtracellularSequence analysis7
Transmembranei936 – 956HelicalSequence analysisAdd BLAST21
Topological domaini957 – 971CytoplasmicSequence analysisAdd BLAST15
Transmembranei972 – 992HelicalSequence analysisAdd BLAST21
Topological domaini993 – 1010ExtracellularSequence analysisAdd BLAST18
Transmembranei1011 – 1031HelicalSequence analysisAdd BLAST21
Topological domaini1032 – 1039CytoplasmicSequence analysis8
Transmembranei1040 – 1060HelicalSequence analysisAdd BLAST21
Topological domaini1061 – 1068ExtracellularSequence analysis8
Transmembranei1069 – 1089HelicalSequence analysisAdd BLAST21
Topological domaini1090 – 1099CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Night blindness, congenital stationary, 1D (CSNB1D)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus.
Related information in OMIM

Keywords - Diseasei

Congenital stationary night blindness

Organism-specific databases

DisGeNET

More...DisGeNETi		9187

MalaCards human disease database

More...MalaCardsi		SLC24A1
MIMi613830, phenotype

Open Targets

More...OpenTargetsi		ENSG00000074621

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		215, Congenital stationary night blindness

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35851

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60721, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC24A1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002233031 – 1099Sodium/potassium/calcium exchanger 1Add BLAST1099
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Not cleaved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei658PhosphoserineSequence analysis1
Modified residuei724PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60721

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60721

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60721

PeptideAtlas

More...PeptideAtlasi		O60721

PRoteomics IDEntifications database

More...PRIDEi		O60721

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49569 [O60721-1]
49570 [O60721-2]
61158

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O60721, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60721

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60721

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000074621, Expressed in amniotic fluid and 171 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60721, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60721, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000074621, Tissue enriched (retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114624, 3 interactors

Protein interaction database and analysis system

More...IntActi		O60721, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261892

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60721, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O60721

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati494 – 534Alpha-1Add BLAST41
Repeati979 – 1010Alpha-2Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni123 – 150DisorderedSequence analysisAdd BLAST28
Regioni169 – 199DisorderedSequence analysisAdd BLAST31
Regioni284 – 304DisorderedSequence analysisAdd BLAST21
Regioni690 – 901DisorderedSequence analysisAdd BLAST212

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi752 – 766Acidic residuesSequence analysisAdd BLAST15
Compositional biasi767 – 788Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi789 – 814Acidic residuesSequence analysisAdd BLAST26
Compositional biasi815 – 853Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi854 – 894Acidic residuesSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1307, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234532

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60721

Identification of Orthologs from Complete Genome Data

More...OMAi		WPESRQK

Database of Orthologous Groups

More...OrthoDBi		1168500at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60721

TreeFam database of animal gene trees

More...TreeFami		TF318759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1420.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004481, K/Na/Ca-exchanger
IPR004837, NaCa_Exmemb
IPR044880, NCX_ion-bd_dom_sf
IPR004817, SLC24A1

The PANTHER Classification System

More...PANTHERi		PTHR10846, PTHR10846, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01699, Na_Ca_ex, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00927, 2A1904, 1 hit
TIGR00367, TIGR00367, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60721-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKLIRMGPQ ERWLLRTKRL HWSRLLFLLG MLIIGSTYQH LRRPRGLSSL 
        60         70         80         90        100
WAAVSSHQPI KLASRDLSSE EMMMMSSSPS KPSSEMGGKM LVPQASVGSD 
       110        120        130        140        150
EATLSMTVEN IPSMPKRTAK MIPTTTKNNY SPTAAGTERR KEDTPTSSRT 
       160        170        180        190        200
LTYYTSTSSR QIVKKYTPTP RGEMKSYSPT QVREKVKYTP SPRGRRVGTY 
       210        220        230        240        250
VPSTFMTMET SHAITPRTTV KDSDITATYK ILETNSLKRI MEETTPTTLK 
       260        270        280        290        300
GMFDSTPTFL THEVEANVLT SPRSVMEKNN LFPPRRVESN SSAHPWGLVG 
       310        320        330        340        350
KSNPKTPQGT VLLHTPATSE GQVTISTMTG SSPAETKAFT AAWSLRNPSP 
       360        370        380        390        400
RTSVSAIKTA PAIVWRLAKK PSTAPSTSTT PTVRAKLTMQ VHHCVVVKPT 
       410        420        430        440        450
PAMLTTPSPS LTTALLPEEL SPSPSVLPPS LPDLHPKGEY PPDLFSVEER 
       460        470        480        490        500
RQGWVVLHVF GMMYVFVALA IVCDEYFVPA LGVITDKLQI SEDVAGATFM 
       510        520        530        540        550
AAGGSAPELF TSLIGVFISH SNVGIGTIVG SAVFNILFVI GTCSLFSREI 
       560        570        580        590        600
LNLTWWPLFR DVSFYILDLI MLILFFLDSL IAWWESLLLL LAYAFYVFTM 
       610        620        630        640        650
KWNKHIEVWV KEQLSRRPVA KVMALEDLSK PGDGAIAVDE LQDNKKLKLP 
       660        670        680        690        700
SLLTRGSSST SLHNSTIRST IYQLMLHSLD PLREVRLAKE KEEESLNQGA 
       710        720        730        740        750
RAQPQAKAES KPEEEEPAKL PAVTVTPAPV PDIKGDQKEN PGGQEDVAEA 
       760        770        780        790        800
ESTGEMPGEE GETAGEGETE EKSGGETQPE GEGETETQGK GEECEDENEA 
       810        820        830        840        850
EGKGDNEGED EGEIHAEDGE MKGNEGETES QELSAENHGE AKNDEKGVED 
       860        870        880        890        900
GGGSDGGDSE EEEEEEEEQE EEEEEEEQEE EEEEEEEEEE KGNEEPLSLD 
       910        920        930        940        950
WPETRQKQAI YLFLLPIVFP LWLTVPDVRR QESRKFFVFT FLGSIMWIAM 
       960        970        980        990       1000
FSYLMVWWAH QVGETIGISE EIMGLTILAA GTSIPDLITS VIVARKGLGD 
      1010       1020       1030       1040       1050
MAVSSSVGSN IFDITVGLPV PWLLFSLING LQPVPVSSNG LFCAIVLLFL 
      1060       1070       1080       1090 
MLLFVISSIA SCKWRMNKIL GFTMFLLYFV FLIISVMLED RIISCPVSV
Length:1,099
Mass (Da):121,374
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3911856BB088B5FD
GO
Isoform 2 (identifier: O60721-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     631-648: Missing.

Show »
Length:1,081
Mass (Da):119,481
Checksum:iA72589F54E4C05B3
GO
Isoform 3 (identifier: O60721-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     932-961: Missing.

Show »
Length:1,069
Mass (Da):117,632
Checksum:iBC2036012DF4E930
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H483F5H483_HUMAN
Sodium/potassium/calcium exchanger ...
SLC24A1
985Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H127F5H127_HUMAN
Sodium/potassium/calcium exchanger ...
SLC24A1
1,012Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH06H0YH06_HUMAN
Sodium/potassium/calcium exchanger ...
SLC24A1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti516V → I in AAB97832 (PubMed:9478004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05022137T → S. Corresponds to variant dbSNP:rs3743171EnsemblClinVar.1
Natural variantiVAR_050222311V → L. Corresponds to variant dbSNP:rs34363823EnsemblClinVar.1
Natural variantiVAR_050223313L → V. Corresponds to variant dbSNP:rs35571449EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006160631 – 648Missing in isoform 2. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_054491932 – 961Missing in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF062921 mRNA Translation: AAC16732.1
AF062922 mRNA Translation: AAC77912.1
AF026132 mRNA Translation: AAB97832.1
AC011939 Genomic DNA No translation available.
AC027220 Genomic DNA No translation available.
BC117263 mRNA Translation: AAI17264.1
BC143375 mRNA Translation: AAI43376.1
AB014602 mRNA Translation: BAA31677.2 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45284.1 [O60721-1]
CCDS73742.1 [O60721-3]
CCDS73743.1 [O60721-2]

NCBI Reference Sequences

More...RefSeqi		NP_001287960.1, NM_001301031.1 [O60721-3]
NP_001287961.1, NM_001301032.1 [O60721-2]
NP_001287962.1, NM_001301033.1
NP_004718.1, NM_004727.2 [O60721-1]
XP_005254835.1, XM_005254778.3 [O60721-1]
XP_011520521.1, XM_011522219.1 [O60721-1]
XP_011520522.1, XM_011522220.2 [O60721-2]
XP_011520523.1, XM_011522221.2 [O60721-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261892.11; ENSP00000261892.6; ENSG00000074621.14
ENST00000339868.10; ENSP00000341837.7; ENSG00000074621.14 [O60721-3]
ENST00000399033.8; ENSP00000381991.4; ENSG00000074621.14 [O60721-3]
ENST00000546330.1; ENSP00000439190.1; ENSG00000074621.14 [O60721-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9187

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9187

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000261892.11; ENSP00000261892.6; NM_004727.3; NP_004718.1

UCSC genome browser

More...UCSCi		uc010ujf.2, human [O60721-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062921 mRNA Translation: AAC16732.1
AF062922 mRNA Translation: AAC77912.1
AF026132 mRNA Translation: AAB97832.1
AC011939 Genomic DNA No translation available.
AC027220 Genomic DNA No translation available.
BC117263 mRNA Translation: AAI17264.1
BC143375 mRNA Translation: AAI43376.1
AB014602 mRNA Translation: BAA31677.2 Sequence problems.
CCDSiCCDS45284.1 [O60721-1]
CCDS73742.1 [O60721-3]
CCDS73743.1 [O60721-2]
RefSeqiNP_001287960.1, NM_001301031.1 [O60721-3]
NP_001287961.1, NM_001301032.1 [O60721-2]
NP_001287962.1, NM_001301033.1
NP_004718.1, NM_004727.2 [O60721-1]
XP_005254835.1, XM_005254778.3 [O60721-1]
XP_011520521.1, XM_011522219.1 [O60721-1]
XP_011520522.1, XM_011522220.2 [O60721-2]
XP_011520523.1, XM_011522221.2 [O60721-3]

3D structure databases

AlphaFoldDBiO60721
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi114624, 3 interactors
IntActiO60721, 5 interactors
STRINGi9606.ENSP00000261892

Protein family/group databases

TCDBi2.A.19.4.9, the ca(2+):cation antiporter (caca) family

PTM databases

GlyGeniO60721, 1 site
iPTMnetiO60721
PhosphoSitePlusiO60721

Genetic variation databases

BioMutaiSLC24A1

Proteomic databases

MassIVEiO60721
MaxQBiO60721
PaxDbiO60721
PeptideAtlasiO60721
PRIDEiO60721
ProteomicsDBi49569 [O60721-1]
49570 [O60721-2]
61158

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26029, 133 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		9187

Genome annotation databases

EnsembliENST00000261892.11; ENSP00000261892.6; ENSG00000074621.14
ENST00000339868.10; ENSP00000341837.7; ENSG00000074621.14 [O60721-3]
ENST00000399033.8; ENSP00000381991.4; ENSG00000074621.14 [O60721-3]
ENST00000546330.1; ENSP00000439190.1; ENSG00000074621.14 [O60721-2]
GeneIDi9187
KEGGihsa:9187
MANE-SelectiENST00000261892.11; ENSP00000261892.6; NM_004727.3; NP_004718.1
UCSCiuc010ujf.2, human [O60721-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9187
DisGeNETi9187

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC24A1
HGNCiHGNC:10975, SLC24A1
HPAiENSG00000074621, Tissue enriched (retina)
MalaCardsiSLC24A1
MIMi603617, gene
613830, phenotype
neXtProtiNX_O60721
OpenTargetsiENSG00000074621
Orphaneti215, Congenital stationary night blindness
PharmGKBiPA35851
VEuPathDBiHostDB:ENSG00000074621

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1307, Eukaryota
GeneTreeiENSGT01030000234532
InParanoidiO60721
OMAiWPESRQK
OrthoDBi1168500at2759
PhylomeDBiO60721
TreeFamiTF318759

Enzyme and pathway databases

PathwayCommonsiO60721
ReactomeiR-HSA-2485179, Activation of the phototransduction cascade
R-HSA-425561, Sodium/Calcium exchangers
R-HSA-5619077, Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)
SignaLinkiO60721
SIGNORiO60721

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9187, 9 hits in 1072 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC24A1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9187
PharosiO60721, Tbio

Protein Ontology

More...PROi		PR:O60721
RNActiO60721, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000074621, Expressed in amniotic fluid and 171 other tissues
ExpressionAtlasiO60721, baseline and differential
GenevisibleiO60721, HS

Family and domain databases

Gene3Di1.20.1420.30, 2 hits
InterProiView protein in InterPro
IPR004481, K/Na/Ca-exchanger
IPR004837, NaCa_Exmemb
IPR044880, NCX_ion-bd_dom_sf
IPR004817, SLC24A1
PANTHERiPTHR10846, PTHR10846, 2 hits
PfamiView protein in Pfam
PF01699, Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00927, 2A1904, 1 hit
TIGR00367, TIGR00367, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCKX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60721
Secondary accession number(s): O43485, O75184, Q17RM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: August 1, 1998
Last modified: May 25, 2022
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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