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UniProtKB - O60716 (CTND1_HUMAN)

Entry version 197 (16 Oct 2019)
Sequence version 1 (01 Aug 1998)
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Protein

Catenin delta-1

Gene

CTNND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei401Essential for interaction with cadherins1
Sitei478Essential for interaction with cadherins1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418990 Adherens junctions interactions
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O60716

SIGNOR Signaling Network Open Resource

More...SIGNORi		O60716

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Catenin delta-1
Alternative name(s):
Cadherin-associated Src substrate
Short name:
CAS
p120 catenin
Short name:
p120(ctn)
p120(cas)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTNND1
Synonyms:KIAA0384
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2515 CTNND1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601045 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60716

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Blepharocheilodontic syndrome 2 (BCDS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of blepharocheilodontic syndrome, a rare autosomal dominant disorder. It is characterized by lower eyelid ectropion, upper eyelid distichiasis, euryblepharon, bilateral cleft lip and palate, and features of ectodermal dysplasia, including hair anomalies, conical teeth and tooth agenesis. An additional rare manifestation is imperforate anus. There is considerable phenotypic variability among affected individuals.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079395365 – 968Missing in BCDS2. 1 PublicationAdd BLAST604
Natural variantiVAR_079396700 – 968Missing in BCDS2. 1 PublicationAdd BLAST269

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi363W → A: Severely disrupts cadherin interaction. 1 Publication1
Mutagenesisi401K → M: Complete loss of cadherin interaction. 1 Publication1
Mutagenesisi444K → M: Severely disrupts cadherin interaction. 1 Publication1
Mutagenesisi477W → A: Severely disrupts cadherin interaction. 1 Publication1
Mutagenesisi478N → A: Complete loss of cadherin interaction. 1 Publication1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia

Organism-specific databases

DisGeNET

More...DisGeNETi		1500

MalaCards human disease database

More...MalaCardsi		CTNND1
MIMi617681 phenotype

Open Targets

More...OpenTargetsi		ENSG00000198561

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1997 Blepharo-cheilo-odontic syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27016

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60716

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CTNND1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642961 – 968Catenin delta-1Add BLAST968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei59PhosphothreonineCombined sources1
Modified residuei112Phosphotyrosine; by FYN1 Publication1
Modified residuei125PhosphoserineCombined sources1
Modified residuei217PhosphotyrosineBy similarity1
Modified residuei221PhosphotyrosineBy similarity1
Modified residuei225PhosphoserineCombined sources1
Modified residuei228PhosphotyrosineBy similarity1
Modified residuei230PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei257PhosphotyrosineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei280PhosphotyrosineBy similarity1
Modified residuei288Phosphoserine; by PAK5Combined sources1 Publication1
Modified residuei291PhosphotyrosineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei304PhosphothreonineBy similarity1
Modified residuei320PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki517Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei617PhosphoserineCombined sources1
Modified residuei713PhosphoserineBy similarity1
Modified residuei811PhosphoserineCombined sources1
Modified residuei847PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei859PhosphoserineCombined sources1
Modified residuei861PhosphoserineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei865PhosphotyrosineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei869PhosphothreonineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Cross-linki882Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei899PhosphoserineBy similarity1
Modified residuei904PhosphotyrosineBy similarity1
Modified residuei906PhosphothreonineCombined sources1
Modified residuei916PhosphothreonineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1
Isoform 4C (identifier: O60716-31)
Modified residuei572PhosphothreonineCombined sources1
Isoform 4A (identifier: O60716-29)
Modified residuei587PhosphothreonineCombined sourcesBy similarity1
Isoform 4AC (identifier: O60716-27)
Modified residuei593PhosphothreonineCombined sources1
Isoform 3C (identifier: O60716-23)
Modified residuei794PhosphothreonineCombined sources1
Isoform 3AC (identifier: O60716-19)
Modified residuei815PhosphothreonineCombined sources1
Isoform 2 (identifier: O60716-16)
Modified residuei835PhosphothreonineCombined sourcesBy similarity1
Isoform 2C (identifier: O60716-15)
Modified residuei841PhosphothreonineCombined sources1
Isoform 2AC (identifier: O60716-11)
Modified residuei862PhosphothreonineCombined sources1
Isoform 1 (identifier: O60716-8)
Modified residuei889PhosphothreonineCombined sourcesBy similarity1
Isoform 1C (identifier: O60716-7)
Modified residuei895PhosphothreonineCombined sources1
Isoform 1AC (identifier: O60716-3)
Modified residuei916PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.4 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60716

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60716

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60716

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60716

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60716

PeptideAtlas

More...PeptideAtlasi		O60716

PRoteomics IDEntifications database

More...PRIDEi		O60716

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49537 [O60716-1]
49538 [O60716-10]
49539 [O60716-11]
49540 [O60716-12]
49541 [O60716-13]
49542 [O60716-14]
49543 [O60716-15]
49544 [O60716-16]
49545 [O60716-17]
49546 [O60716-18]
49547 [O60716-19]
49548 [O60716-2]
49549 [O60716-20]
49550 [O60716-21]
49551 [O60716-22]
49552 [O60716-23]
49553 [O60716-24]
49554 [O60716-25]
49555 [O60716-26]
49556 [O60716-27]
49557 [O60716-28]
49558 [O60716-29]
49559 [O60716-3]
49560 [O60716-30]
49561 [O60716-31]
49562 [O60716-32]
49563 [O60716-4]
49564 [O60716-5]
49565 [O60716-6]
49566 [O60716-7]
49567 [O60716-8]
49568 [O60716-9]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		O60716

GlyConnect protein glycosylation platform

More...GlyConnecti		1078

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60716

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60716

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O60716

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198561 Expressed in 235 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60716 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60716 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB003837
HPA015954
HPA015955

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin/CDH1, alpha-catenin/CTNNA1, beta-catenin/CTNNB1, and gamma-catenin/JUP (PubMed:20371349, PubMed:15240885).

Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (PubMed:28051089). Binds to the C-terminal fragment of PSEN1 and mutually competes for CDH1.

Interacts with ZBTB33 (PubMed:10207085).

Interacts with GLIS2 (PubMed:17344476).

Interacts with FER (PubMed:7623846).

Interacts with NANOS1 (via N-terminal region) (PubMed:17047063).

Interacts (via N-terminus) with GNA12; the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885).

Interacts with GNA13 (PubMed:15240885).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107881, 83 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O60716

Database of interacting proteins

More...DIPi		DIP-33850N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O60716

Protein interaction database and analysis system

More...IntActi		O60716, 65 interactors

Molecular INTeraction database

More...MINTi		O60716

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382004

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1968
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60716

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O60716

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati358 – 395ARM 1Add BLAST38
Repeati398 – 437ARM 2Add BLAST40
Repeati441 – 475ARM 3Add BLAST35
Repeati476 – 516ARM 4Add BLAST41
Repeati534 – 573ARM 5Add BLAST40
Repeati583 – 624ARM 6Add BLAST42
Repeati653 – 693ARM 7Add BLAST41
Repeati700 – 739ARM 8Add BLAST40
Repeati740 – 780ARM 9Add BLAST41
Repeati781 – 826ARM 10Add BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili10 – 46Sequence analysisAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
ARM repeats 1 to 5 mediate interaction with cadherins.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1048 Eukaryota
ENOG410Y21Q LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156045

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60716

KEGG Orthology (KO)

More...KOi		K05690

Identification of Orthologs from Complete Genome Data

More...OMAi		TMDRNFR

Database of Orthologous Groups

More...OrthoDBi		233858at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60716

TreeFam database of animal gene trees

More...TreeFami		TF321877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028439 Catenin_d1
IPR028435 Plakophilin/d_Catenin

The PANTHER Classification System

More...PANTHERi		PTHR10372 PTHR10372, 1 hit
PTHR10372:SF6 PTHR10372:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00514 Arm, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00185 ARM, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (32+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 32 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
Note: Isoforms result of a combination of four transcription start sites and three alternatively spliced exons(A, B and C).

This entry has 32 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1ABC (identifier: O60716-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD 
        60         70         80         90        100
ANPLMANGTL TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP 
       110        120        130        140        150
RMQEPGQIVE TYTEEDPEGA MSVVSVETSD DGTTRRTETT VKKVVKTVTT 
       160        170        180        190        200
RTVQPVAMGP DGLPVDASSV SNNYIQTLGR DFRKNGNGGP GPYVGQAGTA 
       210        220        230        240        250
TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER YRPSMEGYRA 
       260        270        280        290        300
PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 
       310        320        330        340        350
DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL 
       360        370        380        390        400
DSLRKGGPPP PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV 
       410        420        430        440        450
KTDVRKLKGI PVLVGLLDHP KKEVHLGACG ALKNISFGRD QDNKIAIKNC 
       460        470        480        490        500
DGVPALVRLL RKARDMDLTE VITGTLWNLS SHDSIKMEIV DHALHALTDE 
       510        520        530        540        550
VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE RSEARRKLRE 
       560        570        580        590        600
CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 
       610        620        630        640        650
QEAAPNVANN TGPHAASCFG AKKGKDEWFS RGKKPIEDPA NDTVDFPKRT 
       660        670        680        690        700
SPARGYELLF QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR 
       710        720        730        740        750
YIRSALRQEK ALSAIADLLT NEHERVVKAA SGALRNLAVD ARNKELIGKH 
       760        770        780        790        800
AIPNLVKNLP GGQQNSSWNF SEDTVISILN TINEVIAENL EAAKKLRETQ 
       810        820        830        840        850
GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE KEGWKKSDFQ 
       860        870        880        890        900
VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIQM SNMGSNTKSL 
       910        920        930        940        950
DNNYSTPNER GDHNRTLDRS GDLGDMEPLK GTTPLMQDEG QESLEEELDV 
       960 
LVLDDEGGQV SYPSMQKI
Length:968
Mass (Da):108,170
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5C37489A891F292
GO
Isoform 1AB (identifier: O60716-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 622-629.By similarity
Show »
Length:962
Mass (Da):107,349
Checksum:i62C1AA58EC4ED712
GO
Isoform 1AC (identifier: O60716-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     937-965: Missing.

Show »
Length:939
Mass (Da):104,977
Checksum:iD436D996ECBEBDC7
GO
Isoform 1BC (identifier: O60716-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     880-900: Missing.

Show »
Length:947
Mass (Da):105,779
Checksum:i46867A61854BBEDF
GO
Isoform 1A (identifier: O60716-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     937-965: Missing.

Note: Contains a phosphothreonine at position 910 (PubMed:18669648). Contains a nuclear localization signal (NLS) domain at positions 622-629 (By similarity).Combined sourcesBy similarity
Show »
Length:933
Mass (Da):104,156
Checksum:iA4E1ABA2FE3D6B54
GO
Isoform 1B (identifier: O60716-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     880-900: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 622-629.By similarity
Show »
Length:941
Mass (Da):104,958
Checksum:iA82D282A5DF1C4BE
GO
Isoform 1C (identifier: O60716-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     880-900: Missing.
     937-965: Missing.

Show »
Length:918
Mass (Da):102,586
Checksum:i17D678061E042572
GO
Isoform 1 (identifier: O60716-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     880-900: Missing.
     937-965: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 622-629.Combined sourcesBy similarity
Show »
Length:912
Mass (Da):101,765
Checksum:i879022D64712C805
GO
Isoform 2ABC (identifier: O60716-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:914
Mass (Da):102,063
Checksum:i57A26859239AA55A
GO
Isoform 2AB (identifier: O60716-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 568-575.By similarity
Show »
Length:908
Mass (Da):101,242
Checksum:i95094A101A1B6DB4
GO
Isoform 2AC (identifier: O60716-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     937-965: Missing.

Show »
Length:885
Mass (Da):98,870
Checksum:iDF4D8956D2827CAA
GO
Isoform 2BC (identifier: O60716-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     880-900: Missing.

Show »
Length:893
Mass (Da):99,673
Checksum:iD0985DD5A04D4B3F
GO
Isoform 2A (identifier: O60716-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     937-965: Missing.

Note: Contains a phosphothreonine at position 856 (PubMed:18669648). Contains a nuclear localization signal (NLS) domain at positions 622-629.Combined sourcesBy similarity
Show »
Length:879
Mass (Da):98,049
Checksum:iF58CA78A7097EFEB
GO
Isoform 2B (identifier: O60716-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     880-900: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 622-629.By similarity
Show »
Length:887
Mass (Da):98,852
Checksum:i1DCDD3510D31FA82
GO
Isoform 2C (identifier: O60716-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:864
Mass (Da):96,479
Checksum:iE418647839C3B386
GO
Isoform 2 (identifier: O60716-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     880-900: Missing.
     937-965: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 622-629.Combined sourcesBy similarity
Show »
Length:858
Mass (Da):95,658
Checksum:iA16496DCF8B2F524
GO
Isoform 3ABC (identifier: O60716-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:867
Mass (Da):96,689
Checksum:i5F9E3A466CA81D74
GO
Isoform 3AB (identifier: O60716-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 521-528.By similarity
Show »
Length:861
Mass (Da):95,868
Checksum:i3D2744052161BD93
GO
Isoform 3AC (identifier: O60716-19) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     937-965: Missing.

Show »
Length:838
Mass (Da):93,496
Checksum:iF840912548316394
GO
Isoform 3BC (identifier: O60716-20) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     880-900: Missing.

Show »
Length:846
Mass (Da):94,299
Checksum:iD482BB16BD5A898A
GO
Isoform 3A (identifier: O60716-21) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     937-965: Missing.

Note: Contains a phosphothreonine at position 809 (PubMed:18669648). Contains a nuclear localization signal (NLS) domain at positions 521-528.Combined sourcesBy similarity
Show »
Length:832
Mass (Da):92,675
Checksum:iFAB29A345A6AABBC
GO
Isoform 3B (identifier: O60716-22) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     880-900: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 521-528.By similarity
Show »
Length:840
Mass (Da):93,478
Checksum:i0F78D45C15426031
GO
Isoform 3C (identifier: O60716-23) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:817
Mass (Da):91,105
Checksum:i7308172E06E2AC56
GO
Isoform 3 (identifier: O60716-24) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     880-900: Missing.
     937-965: Missing.

Note: Contains a phosphothreonine at position 788 (PubMed:18669648). Contains a nuclear localization signal (NLS) domain at positions 521-528 (By similarity).Combined sourcesBy similarity
Show »
Length:811
Mass (Da):90,284
Checksum:i3EB46C6A74AA396C
GO
Isoform 4ABC (identifier: O60716-25) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.

Show »
Length:645
Mass (Da):72,045
Checksum:iDD32175D2F59D40D
GO
Isoform 4AB (identifier: O60716-26) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 299-306 (By similarity).By similarity
Show »
Length:639
Mass (Da):71,225
Checksum:iF45EA4D758555CE3
GO
Isoform 4AC (identifier: O60716-27) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     937-965: Missing.

Show »
Length:616
Mass (Da):68,852
Checksum:iE1014C183DAFB90D
GO
Isoform 4BC (identifier: O60716-28) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     880-900: Missing.

Show »
Length:624
Mass (Da):69,655
Checksum:iEEDFAEC10BE108A5
GO
Isoform 4A (identifier: O60716-29) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     937-965: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 299-306 (By similarity).Combined sourcesBy similarity
Show »
Length:610
Mass (Da):68,031
Checksum:i402B89CAE47E6A8E
GO
Isoform 4B (identifier: O60716-30) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     880-900: Missing.

Note: Contains a nuclear localization signal (NLS) domain at positions 299-306 (By similarity).By similarity
Show »
Length:618
Mass (Da):68,834
Checksum:iAE57FD1DC87F15AF
GO
Isoform 4C (identifier: O60716-31) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:595
Mass (Da):66,461
Checksum:iC93D22BB614EA62B
GO
Isoform 4 (identifier: O60716-32) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     880-900: Missing.
     937-965: Missing.

Note: Contains a phosphothreonine at position 566 (PubMed:18669648). Contains a nuclear localization signal (NLS) domain at positions 299-306 (By similarity).Combined sourcesBy similarity
Show »
Length:589
Mass (Da):65,641
Checksum:i34C9A6E2B5944D2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZR2C9JZR2_HUMAN
Catenin delta-1
CTNND1
938Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC95H0YC95_HUMAN
Catenin delta-1
CTNND1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKY0E9PKY0_HUMAN
Catenin delta-1
CTNND1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRE2E9PRE2_HUMAN
Catenin delta-1
CTNND1
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKL1E9PKL1_HUMAN
Catenin delta-1
CTNND1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20838 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti319R → M in BAA20838 (PubMed:9205841).Curated1
Sequence conflicti380D → G in AAH75795 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038255171S → F. Corresponds to variant dbSNP:rs11229133Ensembl.1
Natural variantiVAR_020929217Y → C1 PublicationCorresponds to variant dbSNP:rs11570194Ensembl.1
Natural variantiVAR_079395365 – 968Missing in BCDS2. 1 PublicationAdd BLAST604
Natural variantiVAR_020930464R → C1 PublicationCorresponds to variant dbSNP:rs11570199Ensembl.1
Natural variantiVAR_079396700 – 968Missing in BCDS2. 1 PublicationAdd BLAST269
Natural variantiVAR_020931915R → K1 PublicationCorresponds to variant dbSNP:rs11570222Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0067421 – 323Missing in isoform 4ABC, isoform 4AB, isoform 4AC, isoform 4BC, isoform 4A, isoform 4B, isoform 4C and isoform 4. CuratedAdd BLAST323
Alternative sequenceiVSP_0067411 – 101Missing in isoform 3ABC, isoform 3AB, isoform 3AC, isoform 3BC, isoform 3A, isoform 3B, isoform 3C and isoform 3. CuratedAdd BLAST101
Alternative sequenceiVSP_0067401 – 54Missing in isoform 2ABC, isoform 2AB, isoform 2AC, isoform 2BC, isoform 2A, isoform 2B, isoform 2C and isoform 2. CuratedAdd BLAST54
Alternative sequenceiVSP_006743626 – 631Missing in isoform 1AB, isoform 1A, isoform 1B, isoform 1, isoform 2AB, isoform 2A, isoform 2B, isoform 2, isoform 3AB, isoform 3A, isoform 3B, isoform 3, isoform 4AB, isoform 4A, isoform 4B and isoform 4. 1 Publication6
Alternative sequenceiVSP_006744880 – 900Missing in isoform 1BC, isoform 1B, isoform 1C, isoform 1, isoform 2BC, isoform 2B, isoform 2C, isoform 2, isoform 3BC, isoform 3B, isoform 3C, isoform 3, isoform 4BC, isoform 4B, isoform 4C and isoform 4. CuratedAdd BLAST21
Alternative sequenceiVSP_006745937 – 965Missing in isoform 1AC, isoform 1A, isoform 1C, isoform 1, isoform 2AC, isoform 2A, isoform 2C, isoform 2, isoform 3AC, isoform 3A, isoform 3C, isoform 3, isoform 4AC, isoform 4A, isoform 4C and isoform 4. 3 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF062319 mRNA Translation: AAC39804.1
AF062323 mRNA Translation: AAC39808.1
AF062341 mRNA Translation: AAC39826.1
AF062342 mRNA Translation: AAC39827.1
AF062322 mRNA Translation: AAC39807.1
AF062326 mRNA Translation: AAC39811.1
AF062328 mRNA Translation: AAC39813.1
AF062338 mRNA Translation: AAC39823.1
AF062324 mRNA Translation: AAC39809.1
AF062327 mRNA Translation: AAC39812.1
AF062329 mRNA Translation: AAC39814.1
AF062330 mRNA Translation: AAC39815.1
AF062331 mRNA Translation: AAC39816.1
AF062333 mRNA Translation: AAC39818.1
AF062334 mRNA Translation: AAC39819.1
AF062335 mRNA Translation: AAC39820.1
AF062336 mRNA Translation: AAC39821.1
AF062339 mRNA Translation: AAC39824.1
AF062340 mRNA Translation: AAC39825.1
AF062343 mRNA Translation: AAC39828.1
AF062317 mRNA Translation: AAC39802.1
AF062325 mRNA Translation: AAC39810.1
AF062332 mRNA Translation: AAC39817.1
AF062344 mRNA Translation: AAC39829.1
AF062321 mRNA Translation: AAC39806.1
AF062320 mRNA Translation: AAC39805.1
AF062337 mRNA Translation: AAC39822.1
AF062318 mRNA Translation: AAC39803.1
AB002382 mRNA Translation: BAA20838.2 Different initiation.
AK292554 mRNA Translation: BAF85243.1
AY505564 Genomic DNA Translation: AAR84236.1
AP001931 Genomic DNA No translation available.
BC075795 mRNA Translation: AAH75795.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44604.1 [O60716-1]
CCDS44605.1 [O60716-2]
CCDS44606.1 [O60716-5]
CCDS44607.1 [O60716-6]
CCDS44608.1 [O60716-17]
CCDS44609.1 [O60716-21]
CCDS53632.1 [O60716-19]
CCDS53633.1 [O60716-18]
CCDS53634.1 [O60716-22]
CCDS55763.1 [O60716-9]
CCDS55764.1 [O60716-11]
CCDS55765.1 [O60716-10]
CCDS55766.1 [O60716-13]
CCDS55767.1 [O60716-14]
CCDS73290.1 [O60716-3]

NCBI Reference Sequences

More...RefSeqi		NP_001078927.1, NM_001085458.1 [O60716-1]
NP_001078928.1, NM_001085459.1 [O60716-2]
NP_001078929.1, NM_001085460.1 [O60716-5]
NP_001078930.1, NM_001085461.1 [O60716-5]
NP_001078931.1, NM_001085462.1 [O60716-5]
NP_001078932.1, NM_001085463.1 [O60716-17]
NP_001078933.1, NM_001085464.1 [O60716-18]
NP_001078934.1, NM_001085465.1 [O60716-22]
NP_001078935.1, NM_001085466.1 [O60716-19]
NP_001078936.1, NM_001085467.1 [O60716-21]
NP_001078937.1, NM_001085468.1 [O60716-21]
NP_001078938.1, NM_001085469.1 [O60716-21]
NP_001193812.1, NM_001206883.1 [O60716-9]
NP_001193813.1, NM_001206884.1 [O60716-11]
NP_001193814.1, NM_001206885.1 [O60716-3]
NP_001193815.1, NM_001206886.1 [O60716-10]
NP_001193816.1, NM_001206887.1 [O60716-14]
NP_001193817.1, NM_001206888.1 [O60716-13]
NP_001193818.1, NM_001206889.1 [O60716-13]
NP_001193819.1, NM_001206890.1 [O60716-21]
NP_001193820.1, NM_001206891.1 [O60716-13]
NP_001322.1, NM_001331.2 [O60716-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000358694; ENSP00000351527; ENSG00000198561 [O60716-5]
ENST00000361332; ENSP00000354823; ENSG00000198561 [O60716-2]
ENST00000361391; ENSP00000354785; ENSG00000198561 [O60716-6]
ENST00000361796; ENSP00000354907; ENSG00000198561 [O60716-3]
ENST00000399050; ENSP00000382004; ENSG00000198561 [O60716-1]
ENST00000415361; ENSP00000403518; ENSG00000198561 [O60716-17]
ENST00000426142; ENSP00000409930; ENSG00000198561 [O60716-21]
ENST00000428599; ENSP00000413586; ENSG00000198561 [O60716-5]
ENST00000524630; ENSP00000436543; ENSG00000198561 [O60716-5]
ENST00000525902; ENSP00000434672; ENSG00000198561 [O60716-27]
ENST00000526357; ENSP00000433334; ENSG00000198561 [O60716-10]
ENST00000526772; ENSP00000433158; ENSG00000198561 [O60716-29]
ENST00000526938; ENSP00000432041; ENSG00000198561 [O60716-7]
ENST00000527467; ENSP00000434900; ENSG00000198561 [O60716-25]
ENST00000528232; ENSP00000435266; ENSG00000198561 [O60716-19]
ENST00000528621; ENSP00000432243; ENSG00000198561 [O60716-13]
ENST00000529526; ENSP00000436323; ENSG00000198561 [O60716-13]
ENST00000529873; ENSP00000435494; ENSG00000198561 [O60716-14]
ENST00000529986; ENSP00000437156; ENSG00000198561 [O60716-21]
ENST00000530094; ENSP00000437327; ENSG00000198561 [O60716-18]
ENST00000530748; ENSP00000436744; ENSG00000198561 [O60716-11]
ENST00000531014; ENSP00000432623; ENSG00000198561 [O60716-26]
ENST00000532245; ENSP00000434017; ENSG00000198561 [O60716-21]
ENST00000532463; ENSP00000432075; ENSG00000198561 [O60716-21]
ENST00000532649; ENSP00000435379; ENSG00000198561 [O60716-13]
ENST00000532787; ENSP00000434949; ENSG00000198561 [O60716-22]
ENST00000532844; ENSP00000433276; ENSG00000198561 [O60716-9]
ENST00000533667; ENSP00000437051; ENSG00000198561 [O60716-30]
ENST00000534579; ENSP00000435789; ENSG00000198561 [O60716-13]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1500

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1500

UCSC genome browser

More...UCSCi		uc001nli.5 human [O60716-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062319 mRNA Translation: AAC39804.1
AF062323 mRNA Translation: AAC39808.1
AF062341 mRNA Translation: AAC39826.1
AF062342 mRNA Translation: AAC39827.1
AF062322 mRNA Translation: AAC39807.1
AF062326 mRNA Translation: AAC39811.1
AF062328 mRNA Translation: AAC39813.1
AF062338 mRNA Translation: AAC39823.1
AF062324 mRNA Translation: AAC39809.1
AF062327 mRNA Translation: AAC39812.1
AF062329 mRNA Translation: AAC39814.1
AF062330 mRNA Translation: AAC39815.1
AF062331 mRNA Translation: AAC39816.1
AF062333 mRNA Translation: AAC39818.1
AF062334 mRNA Translation: AAC39819.1
AF062335 mRNA Translation: AAC39820.1
AF062336 mRNA Translation: AAC39821.1
AF062339 mRNA Translation: AAC39824.1
AF062340 mRNA Translation: AAC39825.1
AF062343 mRNA Translation: AAC39828.1
AF062317 mRNA Translation: AAC39802.1
AF062325 mRNA Translation: AAC39810.1
AF062332 mRNA Translation: AAC39817.1
AF062344 mRNA Translation: AAC39829.1
AF062321 mRNA Translation: AAC39806.1
AF062320 mRNA Translation: AAC39805.1
AF062337 mRNA Translation: AAC39822.1
AF062318 mRNA Translation: AAC39803.1
AB002382 mRNA Translation: BAA20838.2 Different initiation.
AK292554 mRNA Translation: BAF85243.1
AY505564 Genomic DNA Translation: AAR84236.1
AP001931 Genomic DNA No translation available.
BC075795 mRNA Translation: AAH75795.1
CCDSiCCDS44604.1 [O60716-1]
CCDS44605.1 [O60716-2]
CCDS44606.1 [O60716-5]
CCDS44607.1 [O60716-6]
CCDS44608.1 [O60716-17]
CCDS44609.1 [O60716-21]
CCDS53632.1 [O60716-19]
CCDS53633.1 [O60716-18]
CCDS53634.1 [O60716-22]
CCDS55763.1 [O60716-9]
CCDS55764.1 [O60716-11]
CCDS55765.1 [O60716-10]
CCDS55766.1 [O60716-13]
CCDS55767.1 [O60716-14]
CCDS73290.1 [O60716-3]
RefSeqiNP_001078927.1, NM_001085458.1 [O60716-1]
NP_001078928.1, NM_001085459.1 [O60716-2]
NP_001078929.1, NM_001085460.1 [O60716-5]
NP_001078930.1, NM_001085461.1 [O60716-5]
NP_001078931.1, NM_001085462.1 [O60716-5]
NP_001078932.1, NM_001085463.1 [O60716-17]
NP_001078933.1, NM_001085464.1 [O60716-18]
NP_001078934.1, NM_001085465.1 [O60716-22]
NP_001078935.1, NM_001085466.1 [O60716-19]
NP_001078936.1, NM_001085467.1 [O60716-21]
NP_001078937.1, NM_001085468.1 [O60716-21]
NP_001078938.1, NM_001085469.1 [O60716-21]
NP_001193812.1, NM_001206883.1 [O60716-9]
NP_001193813.1, NM_001206884.1 [O60716-11]
NP_001193814.1, NM_001206885.1 [O60716-3]
NP_001193815.1, NM_001206886.1 [O60716-10]
NP_001193816.1, NM_001206887.1 [O60716-14]
NP_001193817.1, NM_001206888.1 [O60716-13]
NP_001193818.1, NM_001206889.1 [O60716-13]
NP_001193819.1, NM_001206890.1 [O60716-21]
NP_001193820.1, NM_001206891.1 [O60716-13]
NP_001322.1, NM_001331.2 [O60716-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L6XX-ray2.40A324-937[»]
3L6YX-ray3.00A/C/E324-937[»]
SMRiO60716
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107881, 83 interactors
CORUMiO60716
DIPiDIP-33850N
ELMiO60716
IntActiO60716, 65 interactors
MINTiO60716
STRINGi9606.ENSP00000382004

PTM databases

CarbonylDBiO60716
GlyConnecti1078
iPTMnetiO60716
PhosphoSitePlusiO60716
SwissPalmiO60716

Polymorphism and mutation databases

BioMutaiCTNND1

Proteomic databases

EPDiO60716
jPOSTiO60716
MassIVEiO60716
MaxQBiO60716
PaxDbiO60716
PeptideAtlasiO60716
PRIDEiO60716
ProteomicsDBi49537 [O60716-1]
49538 [O60716-10]
49539 [O60716-11]
49540 [O60716-12]
49541 [O60716-13]
49542 [O60716-14]
49543 [O60716-15]
49544 [O60716-16]
49545 [O60716-17]
49546 [O60716-18]
49547 [O60716-19]
49548 [O60716-2]
49549 [O60716-20]
49550 [O60716-21]
49551 [O60716-22]
49552 [O60716-23]
49553 [O60716-24]
49554 [O60716-25]
49555 [O60716-26]
49556 [O60716-27]
49557 [O60716-28]
49558 [O60716-29]
49559 [O60716-3]
49560 [O60716-30]
49561 [O60716-31]
49562 [O60716-32]
49563 [O60716-4]
49564 [O60716-5]
49565 [O60716-6]
49566 [O60716-7]
49567 [O60716-8]
49568 [O60716-9]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1500

Genome annotation databases

EnsembliENST00000358694; ENSP00000351527; ENSG00000198561 [O60716-5]
ENST00000361332; ENSP00000354823; ENSG00000198561 [O60716-2]
ENST00000361391; ENSP00000354785; ENSG00000198561 [O60716-6]
ENST00000361796; ENSP00000354907; ENSG00000198561 [O60716-3]
ENST00000399050; ENSP00000382004; ENSG00000198561 [O60716-1]
ENST00000415361; ENSP00000403518; ENSG00000198561 [O60716-17]
ENST00000426142; ENSP00000409930; ENSG00000198561 [O60716-21]
ENST00000428599; ENSP00000413586; ENSG00000198561 [O60716-5]
ENST00000524630; ENSP00000436543; ENSG00000198561 [O60716-5]
ENST00000525902; ENSP00000434672; ENSG00000198561 [O60716-27]
ENST00000526357; ENSP00000433334; ENSG00000198561 [O60716-10]
ENST00000526772; ENSP00000433158; ENSG00000198561 [O60716-29]
ENST00000526938; ENSP00000432041; ENSG00000198561 [O60716-7]
ENST00000527467; ENSP00000434900; ENSG00000198561 [O60716-25]
ENST00000528232; ENSP00000435266; ENSG00000198561 [O60716-19]
ENST00000528621; ENSP00000432243; ENSG00000198561 [O60716-13]
ENST00000529526; ENSP00000436323; ENSG00000198561 [O60716-13]
ENST00000529873; ENSP00000435494; ENSG00000198561 [O60716-14]
ENST00000529986; ENSP00000437156; ENSG00000198561 [O60716-21]
ENST00000530094; ENSP00000437327; ENSG00000198561 [O60716-18]
ENST00000530748; ENSP00000436744; ENSG00000198561 [O60716-11]
ENST00000531014; ENSP00000432623; ENSG00000198561 [O60716-26]
ENST00000532245; ENSP00000434017; ENSG00000198561 [O60716-21]
ENST00000532463; ENSP00000432075; ENSG00000198561 [O60716-21]
ENST00000532649; ENSP00000435379; ENSG00000198561 [O60716-13]
ENST00000532787; ENSP00000434949; ENSG00000198561 [O60716-22]
ENST00000532844; ENSP00000433276; ENSG00000198561 [O60716-9]
ENST00000533667; ENSP00000437051; ENSG00000198561 [O60716-30]
ENST00000534579; ENSP00000435789; ENSG00000198561 [O60716-13]
GeneIDi1500
KEGGihsa:1500
UCSCiuc001nli.5 human [O60716-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1500
DisGeNETi1500

GeneCards: human genes, protein and diseases

More...GeneCardsi		CTNND1
HGNCiHGNC:2515 CTNND1
HPAiCAB003837
HPA015954
HPA015955
MalaCardsiCTNND1
MIMi601045 gene
617681 phenotype
neXtProtiNX_O60716
OpenTargetsiENSG00000198561
Orphaneti1997 Blepharo-cheilo-odontic syndrome
PharmGKBiPA27016

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00940000156045
InParanoidiO60716
KOiK05690
OMAiTMDRNFR
OrthoDBi233858at2759
PhylomeDBiO60716
TreeFamiTF321877

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells
SignaLinkiO60716
SIGNORiO60716

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CTNND1 human
EvolutionaryTraceiO60716

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CTNND1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1500
PharosiO60716

Protein Ontology

More...PROi		PR:O60716

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198561 Expressed in 235 organ(s), highest expression level in ectocervix
ExpressionAtlasiO60716 baseline and differential
GenevisibleiO60716 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028439 Catenin_d1
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF6 PTHR10372:SF6, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 3 hits
SMARTiView protein in SMART
SM00185 ARM, 7 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTND1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60716
Secondary accession number(s): A8K939
, O15088, O60713, O60714, O60715, O60935, Q6DHZ7, Q6RBX8, Q9UP71, Q9UP72, Q9UP73
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: August 1, 1998
Last modified: October 16, 2019
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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