UniProtKB - O60716 (CTND1_HUMAN)
Catenin delta-1
CTNND1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 401 | Essential for interaction with cadherins1 Publication | 1 | |
Sitei | 478 | Essential for interaction with cadherins1 Publication | 1 |
GO - Molecular functioni
- cadherin binding Source: UniProtKB
- protein kinase binding Source: Ensembl
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- adherens junction organization Source: Reactome
- brain development Source: Ensembl
- cell-cell adhesion Source: GO_Central
- cell-cell adhesion mediated by cadherin Source: UniProtKB
- cell-cell junction assembly Source: GO_Central
- entry of bacterium into host cell Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- protein stabilization Source: UniProtKB
- regulation of postsynaptic membrane neurotransmitter receptor levels Source: SynGO
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Cell adhesion, Transcription, Transcription regulation, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | O60716 |
Reactomei | R-HSA-418990, Adherens junctions interactions R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-8876493, InlA-mediated entry of Listeria monocytogenes into host cells |
SignaLinki | O60716 |
SIGNORi | O60716 |
Names & Taxonomyi
Protein namesi | Recommended name: Catenin delta-1Alternative name(s): Cadherin-associated Src substrate Short name: CAS p120 catenin Short name: p120(ctn) p120(cas) |
Gene namesi | Name:CTNND1 Synonyms:KIAA0384 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2515, CTNND1 |
MIMi | 601045, gene |
neXtProti | NX_O60716 |
VEuPathDBi | HostDB:ENSG00000198561.13 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Nucleus
- Nucleus 2 Publications
Other locations
- adherens junction 1 Publication
- Cytoplasm 2 Publications
Note: Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187).By similarity3 Publications
Nucleus
- Nucleus 1 Publication
Nucleus
- Nucleus 1 Publication
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: BHF-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: BHF-UCL
Plasma Membrane
- catenin complex Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: GO_Central
- cell-cell junction Source: UniProtKB
- cytoplasm Source: UniProtKB
- dendritic spine Source: Ensembl
- glutamatergic synapse Source: Ensembl
- growth cone Source: Ensembl
- hippocampal mossy fiber to CA3 synapse Source: Ensembl
- lamellipodium Source: Ensembl
- midbody Source: UniProtKB
- postsynaptic density, intracellular component Source: Ensembl
- presynaptic active zone cytoplasmic component Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
- zonula adherens Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Blepharocheilodontic syndrome 2 (BCDS2)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079395 | 365 – 968 | Missing in BCDS2. 1 PublicationAdd BLAST | 604 | |
Natural variantiVAR_079396 | 700 – 968 | Missing in BCDS2. 1 PublicationAdd BLAST | 269 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 363 | W → A: Severely disrupts cadherin interaction. 1 Publication | 1 | |
Mutagenesisi | 401 | K → M: Complete loss of cadherin interaction. 1 Publication | 1 | |
Mutagenesisi | 444 | K → M: Severely disrupts cadherin interaction. 1 Publication | 1 | |
Mutagenesisi | 477 | W → A: Severely disrupts cadherin interaction. 1 Publication | 1 | |
Mutagenesisi | 478 | N → A: Complete loss of cadherin interaction. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Ectodermal dysplasiaOrganism-specific databases
DisGeNETi | 1500 |
MalaCardsi | CTNND1 |
MIMi | 617681, phenotype |
OpenTargetsi | ENSG00000198561 |
Orphaneti | 1997, Blepharo-cheilo-odontic syndrome |
PharmGKBi | PA27016 |
Miscellaneous databases
Pharosi | O60716, Tbio |
Genetic variation databases
BioMutai | CTNND1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064296 | 1 – 968 | Catenin delta-1Add BLAST | 968 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
Modified residuei | 4 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 47 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 59 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 112 | Phosphotyrosine; by FYN1 Publication | 1 | ||
Modified residuei | 125 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 217 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 221 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 225 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 228 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 230 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 252 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 257 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 268 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 269 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 280 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 288 | Phosphoserine; by PAK5Combined sources1 Publication | 1 | ||
Modified residuei | 291 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 300 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 304 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 320 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 346 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 349 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 352 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 421 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 517 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 617 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 713 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 811 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 847 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 857 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 859 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 861 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 864 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 865 | PhosphotyrosineCombined sources | 1 | ||
Modified residuei | 868 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 869 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 879 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 882 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 899 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 904 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 906 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 916 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 920 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 943 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: O60716-32) | |||||
Modified residuei | 566 | Phosphothreonine1 Publication | 1 | ||
Isoform 4C (identifier: O60716-31) | |||||
Modified residuei | 572 | PhosphothreonineCombined sources | 1 | ||
Isoform 4A (identifier: O60716-29) | |||||
Modified residuei | 587 | PhosphothreonineCombined sources | 1 | ||
Isoform 4AC (identifier: O60716-27) | |||||
Modified residuei | 593 | PhosphothreonineCombined sources | 1 | ||
Isoform 3 (identifier: O60716-24) | |||||
Modified residuei | 788 | Phosphothreonine1 Publication | 1 | ||
Isoform 3C (identifier: O60716-23) | |||||
Modified residuei | 794 | PhosphothreonineCombined sources | 1 | ||
Isoform 3A (identifier: O60716-21) | |||||
Modified residuei | 809 | Phosphothreonine1 Publication | 1 | ||
Isoform 3AC (identifier: O60716-19) | |||||
Modified residuei | 815 | PhosphothreonineCombined sources | 1 | ||
Isoform 2 (identifier: O60716-16) | |||||
Modified residuei | 835 | PhosphothreonineCombined sources | 1 | ||
Isoform 2C (identifier: O60716-15) | |||||
Modified residuei | 841 | PhosphothreonineCombined sources | 1 | ||
Isoform 2A (identifier: O60716-13) | |||||
Modified residuei | 856 | Phosphothreonine1 Publication | 1 | ||
Isoform 2AC (identifier: O60716-11) | |||||
Modified residuei | 862 | PhosphothreonineCombined sources | 1 | ||
Isoform 1 (identifier: O60716-8) | |||||
Modified residuei | 889 | PhosphothreonineCombined sources | 1 | ||
Isoform 1C (identifier: O60716-7) | |||||
Modified residuei | 895 | PhosphothreonineCombined sources | 1 | ||
Isoform 1A (identifier: O60716-5) | |||||
Modified residuei | 910 | Phosphothreonine1 Publication | 1 | ||
Isoform 1AC (identifier: O60716-3) | |||||
Modified residuei | 916 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O60716 |
jPOSTi | O60716 |
MassIVEi | O60716 |
MaxQBi | O60716 |
PaxDbi | O60716 |
PeptideAtlasi | O60716 |
PRIDEi | O60716 |
ProteomicsDBi | 49537 [O60716-1] 49538 [O60716-10] 49539 [O60716-11] 49540 [O60716-12] 49541 [O60716-13] 49542 [O60716-14] 49543 [O60716-15] 49544 [O60716-16] 49545 [O60716-17] 49546 [O60716-18] 49547 [O60716-19] 49548 [O60716-2] 49549 [O60716-20] 49550 [O60716-21] 49551 [O60716-22] 49552 [O60716-23] 49553 [O60716-24] 49554 [O60716-25] 49555 [O60716-26] 49556 [O60716-27] 49557 [O60716-28] 49558 [O60716-29] 49559 [O60716-3] 49560 [O60716-30] 49561 [O60716-31] 49562 [O60716-32] 49563 [O60716-4] 49564 [O60716-5] 49565 [O60716-6] 49566 [O60716-7] 49567 [O60716-8] 49568 [O60716-9] |
PTM databases
CarbonylDBi | O60716 |
GlyConnecti | 1078, 4 N-Linked glycans (1 site) |
GlyGeni | O60716, 1 site |
iPTMneti | O60716 |
MetOSitei | O60716 |
PhosphoSitePlusi | O60716 |
SwissPalmi | O60716 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000198561, Expressed in ventricular zone and 244 other tissues |
ExpressionAtlasi | O60716, baseline and differential |
Genevisiblei | O60716, HS |
Organism-specific databases
HPAi | ENSG00000198561, Low tissue specificity |
Interactioni
Subunit structurei
Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin/CDH1, alpha-catenin/CTNNA1, beta-catenin/CTNNB1, and gamma-catenin/JUP (PubMed:20371349, PubMed:15240885).
Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (PubMed:28051089). Binds to the C-terminal fragment of PSEN1 and mutually competes for CDH1.
Interacts with ZBTB33 (PubMed:10207085).
Interacts with GLIS2 (PubMed:17344476).
Interacts with FER (PubMed:7623846).
Interacts with NANOS1 (via N-terminal region) (PubMed:17047063).
Interacts (via N-terminus) with GNA12; the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885).
Interacts with GNA13 (PubMed:15240885).
Interacts with CCDC85B (PubMed:25009281).
Interacts with PLPP3; negatively regulates the PLPP3-mediated stabilization of CTNNB1 (PubMed:20123964).
9 PublicationsBinary interactionsi
Hide detailsO60716
With | #Exp. | IntAct |
---|---|---|
EGFR [P00533] | 5 | EBI-701927,EBI-297353 |
FRMD5 [Q7Z6J6] | 3 | EBI-701927,EBI-727282 |
PLEKHA7 [Q6IQ23] | 3 | EBI-701927,EBI-2125301 |
PLPP3 [O14495] | 9 | EBI-701927,EBI-766232 |
PTPRJ [Q12913] | 5 | EBI-701927,EBI-2264500 |
Isoform 1A [O60716-5]
With | #Exp. | IntAct |
---|---|---|
KCTD6 [Q8NC69] | 3 | EBI-701963,EBI-2511344 |
ZBTB33 [Q86T24] | 3 | EBI-701963,EBI-2515625 |
Isoform 3A [O60716-21]
With | #Exp. | IntAct |
---|---|---|
NANOS1 [Q8WY41] | 2 | EBI-9634525,EBI-9630165 |
Isoform 4A [O60716-29]
With | #Exp. | IntAct |
---|---|---|
KCTD6 [Q8NC69] | 3 | EBI-702059,EBI-2511344 |
Cdh1 [P09803] from Mus musculus. | 3 | EBI-702059,EBI-984420 |
GO - Molecular functioni
- cadherin binding Source: UniProtKB
- protein kinase binding Source: Ensembl
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107881, 104 interactors |
CORUMi | O60716 |
DIPi | DIP-33850N |
ELMi | O60716 |
IntActi | O60716, 69 interactors |
MINTi | O60716 |
STRINGi | 9606.ENSP00000382004 |
Miscellaneous databases
RNActi | O60716, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O60716 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60716 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 358 – 395 | ARM 1Add BLAST | 38 | |
Repeati | 398 – 437 | ARM 2Add BLAST | 40 | |
Repeati | 441 – 475 | ARM 3Add BLAST | 35 | |
Repeati | 476 – 516 | ARM 4Add BLAST | 41 | |
Repeati | 534 – 573 | ARM 5Add BLAST | 40 | |
Repeati | 583 – 624 | ARM 6Add BLAST | 42 | |
Repeati | 653 – 693 | ARM 7Add BLAST | 41 | |
Repeati | 700 – 739 | ARM 8Add BLAST | 40 | |
Repeati | 740 – 780 | ARM 9Add BLAST | 41 | |
Repeati | 781 – 826 | ARM 10Add BLAST | 46 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 357 | Necessary and sufficient for interaction with CCDC85B1 PublicationAdd BLAST | 357 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 10 – 46 | Sequence analysisAdd BLAST | 37 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 4AB (identifier: O60716-26) | |||||
Motifi | 299 – 306 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 4A (identifier: O60716-29) | |||||
Motifi | 299 – 306 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 4B (identifier: O60716-30) | |||||
Motifi | 299 – 306 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 4 (identifier: O60716-32) | |||||
Motifi | 299 – 306 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 3AB (identifier: O60716-18) | |||||
Motifi | 521 – 528 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 3A (identifier: O60716-21) | |||||
Motifi | 521 – 528 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 3B (identifier: O60716-22) | |||||
Motifi | 521 – 528 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 3 (identifier: O60716-24) | |||||
Motifi | 521 – 528 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 2AB (identifier: O60716-10) | |||||
Motifi | 568 – 575 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 1AB (identifier: O60716-2) | |||||
Motifi | 622 – 629 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 1A (identifier: O60716-5) | |||||
Motifi | 622 – 629 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 1B (identifier: O60716-6) | |||||
Motifi | 622 – 629 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 1 (identifier: O60716-8) | |||||
Motifi | 622 – 629 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 2A (identifier: O60716-13) | |||||
Motifi | 622 – 629 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 2B (identifier: O60716-14) | |||||
Motifi | 622 – 629 | Nuclear localization signal (NLS)By similarity | 8 | ||
Isoform 2 (identifier: O60716-16) | |||||
Motifi | 622 – 629 | Nuclear localization signal (NLS)By similarity | 8 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1048, Eukaryota |
GeneTreei | ENSGT00940000156045 |
HOGENOMi | CLU_009111_4_1_1 |
InParanoidi | O60716 |
OMAi | GDQMSYP |
OrthoDBi | 233858at2759 |
PhylomeDBi | O60716 |
TreeFami | TF321877 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR028439, Catenin_d1 IPR028435, Plakophilin/d_Catenin |
PANTHERi | PTHR10372, PTHR10372, 1 hit PTHR10372:SF6, PTHR10372:SF6, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 3 hits |
SMARTi | View protein in SMART SM00185, ARM, 7 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits |
s (32+)i Sequence
Sequence statusi: Complete.
This entry describes 32 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 32 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD
60 70 80 90 100
ANPLMANGTL TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP
110 120 130 140 150
RMQEPGQIVE TYTEEDPEGA MSVVSVETSD DGTTRRTETT VKKVVKTVTT
160 170 180 190 200
RTVQPVAMGP DGLPVDASSV SNNYIQTLGR DFRKNGNGGP GPYVGQAGTA
210 220 230 240 250
TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER YRPSMEGYRA
260 270 280 290 300
PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS
310 320 330 340 350
DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL
360 370 380 390 400
DSLRKGGPPP PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV
410 420 430 440 450
KTDVRKLKGI PVLVGLLDHP KKEVHLGACG ALKNISFGRD QDNKIAIKNC
460 470 480 490 500
DGVPALVRLL RKARDMDLTE VITGTLWNLS SHDSIKMEIV DHALHALTDE
510 520 530 540 550
VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE RSEARRKLRE
560 570 580 590 600
CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY
610 620 630 640 650
QEAAPNVANN TGPHAASCFG AKKGKDEWFS RGKKPIEDPA NDTVDFPKRT
660 670 680 690 700
SPARGYELLF QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR
710 720 730 740 750
YIRSALRQEK ALSAIADLLT NEHERVVKAA SGALRNLAVD ARNKELIGKH
760 770 780 790 800
AIPNLVKNLP GGQQNSSWNF SEDTVISILN TINEVIAENL EAAKKLRETQ
810 820 830 840 850
GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE KEGWKKSDFQ
860 870 880 890 900
VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIQM SNMGSNTKSL
910 920 930 940 950
DNNYSTPNER GDHNRTLDRS GDLGDMEPLK GTTPLMQDEG QESLEEELDV
960
LVLDDEGGQV SYPSMQKI
The sequence of this isoform differs from the canonical sequence as follows:
626-631: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
880-900: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
626-631: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
626-631: Missing.
880-900: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
880-900: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-54: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-54: Missing.
626-631: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-54: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-54: Missing.
880-900: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-54: Missing.
626-631: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-54: Missing.
626-631: Missing.
880-900: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-54: Missing.
880-900: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-101: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-101: Missing.
626-631: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-101: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-101: Missing.
880-900: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-101: Missing.
626-631: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-101: Missing.
626-631: Missing.
880-900: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-101: Missing.
880-900: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-323: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-323: Missing.
626-631: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-323: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-323: Missing.
880-900: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-323: Missing.
626-631: Missing.
937-965: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-323: Missing.
626-631: Missing.
880-900: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-323: Missing.
880-900: Missing.
937-965: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JZR2 | C9JZR2_HUMAN | Catenin delta-1 | CTNND1 | 938 | Annotation score: | ||
A0A669KB05 | A0A669KB05_HUMAN | Catenin delta-1 | CTNND1 | 915 | Annotation score: | ||
A0A669KB62 | A0A669KB62_HUMAN | Catenin delta-1 | CTNND1 | 888 | Annotation score: | ||
E9PKY0 | E9PKY0_HUMAN | Catenin delta-1 | CTNND1 | 126 | Annotation score: | ||
H0YC95 | H0YC95_HUMAN | Catenin delta-1 | CTNND1 | 123 | Annotation score: | ||
E9PKL1 | E9PKL1_HUMAN | Catenin delta-1 | CTNND1 | 128 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 319 | R → M in BAA20838 (PubMed:9205841).Curated | 1 | |
Sequence conflicti | 380 | D → G in AAH75795 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038255 | 171 | S → F. Corresponds to variant dbSNP:rs11229133Ensembl. | 1 | |
Natural variantiVAR_020929 | 217 | Y → C1 PublicationCorresponds to variant dbSNP:rs11570194Ensembl. | 1 | |
Natural variantiVAR_079395 | 365 – 968 | Missing in BCDS2. 1 PublicationAdd BLAST | 604 | |
Natural variantiVAR_020930 | 464 | R → C1 PublicationCorresponds to variant dbSNP:rs11570199EnsemblClinVar. | 1 | |
Natural variantiVAR_079396 | 700 – 968 | Missing in BCDS2. 1 PublicationAdd BLAST | 269 | |
Natural variantiVAR_020931 | 915 | R → K1 PublicationCorresponds to variant dbSNP:rs11570222Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006742 | 1 – 323 | Missing in isoform 4ABC, isoform 4AB, isoform 4AC, isoform 4BC, isoform 4A, isoform 4B, isoform 4C and isoform 4. CuratedAdd BLAST | 323 | |
Alternative sequenceiVSP_006741 | 1 – 101 | Missing in isoform 3ABC, isoform 3AB, isoform 3AC, isoform 3BC, isoform 3A, isoform 3B, isoform 3C and isoform 3. CuratedAdd BLAST | 101 | |
Alternative sequenceiVSP_006740 | 1 – 54 | Missing in isoform 2ABC, isoform 2AB, isoform 2AC, isoform 2BC, isoform 2A, isoform 2B, isoform 2C and isoform 2. CuratedAdd BLAST | 54 | |
Alternative sequenceiVSP_006743 | 626 – 631 | Missing in isoform 1AB, isoform 1A, isoform 1B, isoform 1, isoform 2AB, isoform 2A, isoform 2B, isoform 2, isoform 3AB, isoform 3A, isoform 3B, isoform 3, isoform 4AB, isoform 4A, isoform 4B and isoform 4. 1 Publication | 6 | |
Alternative sequenceiVSP_006744 | 880 – 900 | Missing in isoform 1BC, isoform 1B, isoform 1C, isoform 1, isoform 2BC, isoform 2B, isoform 2C, isoform 2, isoform 3BC, isoform 3B, isoform 3C, isoform 3, isoform 4BC, isoform 4B, isoform 4C and isoform 4. CuratedAdd BLAST | 21 | |
Alternative sequenceiVSP_006745 | 937 – 965 | Missing in isoform 1AC, isoform 1A, isoform 1C, isoform 1, isoform 2AC, isoform 2A, isoform 2C, isoform 2, isoform 3AC, isoform 3A, isoform 3C, isoform 3, isoform 4AC, isoform 4A, isoform 4C and isoform 4. 3 PublicationsAdd BLAST | 29 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3L6X | X-ray | 2.40 | A | 324-937 | [»] | |
3L6Y | X-ray | 3.00 | A/C/E | 324-937 | [»] | |
SMRi | O60716 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107881, 104 interactors |
CORUMi | O60716 |
DIPi | DIP-33850N |
ELMi | O60716 |
IntActi | O60716, 69 interactors |
MINTi | O60716 |
STRINGi | 9606.ENSP00000382004 |
PTM databases
CarbonylDBi | O60716 |
GlyConnecti | 1078, 4 N-Linked glycans (1 site) |
GlyGeni | O60716, 1 site |
iPTMneti | O60716 |
MetOSitei | O60716 |
PhosphoSitePlusi | O60716 |
SwissPalmi | O60716 |
Genetic variation databases
BioMutai | CTNND1 |
Proteomic databases
EPDi | O60716 |
jPOSTi | O60716 |
MassIVEi | O60716 |
MaxQBi | O60716 |
PaxDbi | O60716 |
PeptideAtlasi | O60716 |
PRIDEi | O60716 |
ProteomicsDBi | 49537 [O60716-1] 49538 [O60716-10] 49539 [O60716-11] 49540 [O60716-12] 49541 [O60716-13] 49542 [O60716-14] 49543 [O60716-15] 49544 [O60716-16] 49545 [O60716-17] 49546 [O60716-18] 49547 [O60716-19] 49548 [O60716-2] 49549 [O60716-20] 49550 [O60716-21] 49551 [O60716-22] 49552 [O60716-23] 49553 [O60716-24] 49554 [O60716-25] 49555 [O60716-26] 49556 [O60716-27] 49557 [O60716-28] 49558 [O60716-29] 49559 [O60716-3] 49560 [O60716-30] 49561 [O60716-31] 49562 [O60716-32] 49563 [O60716-4] 49564 [O60716-5] 49565 [O60716-6] 49566 [O60716-7] 49567 [O60716-8] 49568 [O60716-9] |
Protocols and materials databases
Antibodypediai | 2886, 1051 antibodies |
DNASUi | 1500 |
Genome annotation databases
Organism-specific databases
CTDi | 1500 |
DisGeNETi | 1500 |
GeneCardsi | CTNND1 |
HGNCi | HGNC:2515, CTNND1 |
HPAi | ENSG00000198561, Low tissue specificity |
MalaCardsi | CTNND1 |
MIMi | 601045, gene 617681, phenotype |
neXtProti | NX_O60716 |
OpenTargetsi | ENSG00000198561 |
Orphaneti | 1997, Blepharo-cheilo-odontic syndrome |
PharmGKBi | PA27016 |
VEuPathDBi | HostDB:ENSG00000198561.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1048, Eukaryota |
GeneTreei | ENSGT00940000156045 |
HOGENOMi | CLU_009111_4_1_1 |
InParanoidi | O60716 |
OMAi | GDQMSYP |
OrthoDBi | 233858at2759 |
PhylomeDBi | O60716 |
TreeFami | TF321877 |
Enzyme and pathway databases
PathwayCommonsi | O60716 |
Reactomei | R-HSA-418990, Adherens junctions interactions R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-8876493, InlA-mediated entry of Listeria monocytogenes into host cells |
SignaLinki | O60716 |
SIGNORi | O60716 |
Miscellaneous databases
BioGRID-ORCSi | 1500, 17 hits in 884 CRISPR screens |
ChiTaRSi | CTNND1, human |
EvolutionaryTracei | O60716 |
GeneWikii | CTNND1 |
GenomeRNAii | 1500 |
Pharosi | O60716, Tbio |
PROi | PR:O60716 |
RNActi | O60716, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198561, Expressed in ventricular zone and 244 other tissues |
ExpressionAtlasi | O60716, baseline and differential |
Genevisiblei | O60716, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR028439, Catenin_d1 IPR028435, Plakophilin/d_Catenin |
PANTHERi | PTHR10372, PTHR10372, 1 hit PTHR10372:SF6, PTHR10372:SF6, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 3 hits |
SMARTi | View protein in SMART SM00185, ARM, 7 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTND1_HUMAN | |
Accessioni | O60716Primary (citable) accession number: O60716 Secondary accession number(s): A8K939 Q9UP73 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 206 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families