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Protein

UDP-glucose 6-dehydrogenase

Gene

UGDH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Activity regulationi

UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch.1 Publication

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (UGDH)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NAD1 Publication1
Binding sitei41NAD1 Publication1
Binding sitei165NAD1 Publication1
Binding sitei260Substrate1 Publication1
Active sitei276Nucleophile3 Publications1
Binding sitei346NAD1 Publication1
Binding sitei442Substrate1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NAD1 Publication6
Nucleotide bindingi89 – 93NAD1 Publication5
Nucleotide bindingi130 – 131NAD1 Publication2
Nucleotide bindingi276 – 279NAD1 Publication4

GO - Molecular functioni

  • electron transfer activity Source: UniProtKB
  • NAD binding Source: InterPro
  • UDP-glucose 6-dehydrogenase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.1.1.22 2681
ReactomeiR-HSA-173599 Formation of the active cofactor, UDP-glucuronate
SABIO-RKiO60701
UniPathwayi
UPA00038;UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:UGDH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109814.11
HGNCiHGNC:12525 UGDH
MIMi603370 gene
neXtProtiNX_O60701

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7358
OpenTargetsiENSG00000109814
PharmGKBiPA37170

Chemistry databases

DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiUGDH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740601 – 494UDP-glucose 6-dehydrogenaseAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107N6-acetyllysineCombined sources1
Modified residuei476PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60701
MaxQBiO60701
PaxDbiO60701
PeptideAtlasiO60701
PRIDEiO60701
ProteomicsDBi49530
49531 [O60701-2]

2D gel databases

REPRODUCTION-2DPAGEiO60701

PTM databases

iPTMnetiO60701
PhosphoSitePlusiO60701
SwissPalmiO60701

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000109814 Expressed in 220 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_UGDH
ExpressionAtlasiO60701 baseline and differential
GenevisibleiO60701 HS

Organism-specific databases

HPAiCAB034444
HPA036656
HPA036657

Interactioni

Subunit structurei

Homohexamer.3 Publications

Protein-protein interaction databases

BioGridi113205, 45 interactors
IntActiO60701, 6 interactors
STRINGi9606.ENSP00000319501

Structurei

Secondary structure

1494
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60701
SMRiO60701
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60701

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 165Substrate binding1 Publication5
Regioni220 – 224Substrate binding1 Publication5
Regioni267 – 273Substrate binding1 Publication7
Regioni338 – 339Substrate binding1 Publication2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
GeneTreeiENSGT00390000015355
HOGENOMiHOG000153773
HOVERGENiHBG003512
InParanoidiO60701
KOiK00012
OMAiRIITTNT
OrthoDBiEOG091G05RK
PhylomeDBiO60701
TreeFamiTF105671

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60701-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL
60 70 80 90 100
PIYEPGLKEV VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK
110 120 130 140 150
GRAADLKYIE ACARRIVQNS NGYKIVTEKS TVPVRAAESI RRIFDANTKP
160 170 180 190 200
NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDETPEGQR AVQALCAVYE
210 220 230 240 250
HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL CEATGADVEE
260 270 280 290 300
VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
310 320 330 340 350
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS
360 370 380 390 400
IYISKYLMDE GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD
410 420 430 440 450
PYEACDGAHA VVICTEWDMF KELDYERIHK KMLKPAFIFD GRRVLDGLHN
460 470 480 490
ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP KFSLQDPPNK KPKV
Length:494
Mass (Da):55,024
Last modified:August 1, 1998 - v1
Checksum:i9C9DA5E1227D65CC
GO
Isoform 2 (identifier: O60701-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-155: Missing.

Note: No experimental confirmation available.
Show »
Length:427
Mass (Da):47,603
Checksum:iDC9E41480CA48E40
GO
Isoform 3 (identifier: O60701-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):44,415
Checksum:i7CD01E38C0B0D6F5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EV97E7EV97_HUMAN
UDP-glucose 6-dehydrogenase
UGDH
181Annotation score:
E7ER83E7ER83_HUMAN
UDP-glucose 6-dehydrogenase
UGDH
130Annotation score:
D6RHF4D6RHF4_HUMAN
UDP-glucose 6-dehydrogenase
UGDH
53Annotation score:
E7ETF4E7ETF4_HUMAN
UDP-glucose 6-dehydrogenase
UGDH
153Annotation score:
E9PBD2E9PBD2_HUMAN
UDP-glucose 6-dehydrogenase
UGDH
55Annotation score:
E7ER95E7ER95_HUMAN
UDP-glucose 6-dehydrogenase
UGDH
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338F → V in AAC05135 (Ref. 8) Curated1
Sequence conflicti377V → A in AAC05135 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462341 – 97Missing in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_04255089 – 155Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061016 mRNA Translation: AAC36095.1
AJ007702 mRNA Translation: CAA07609.1
AJ272274
, AJ272275, AJ272276, AJ272277, AJ272278, AJ272279, AJ272280, AJ272281 Genomic DNA Translation: CAB75891.1
AK097930 mRNA Translation: BAG53554.1
AK297737 mRNA Translation: BAG60087.1
AC021148 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92937.1
BC022781 mRNA Translation: AAH22781.1
AF049126 mRNA Translation: AAC05135.1
CCDSiCCDS3455.1 [O60701-1]
CCDS54757.1 [O60701-3]
CCDS54758.1 [O60701-2]
PIRiJE0353
RefSeqiNP_001171629.1, NM_001184700.1 [O60701-2]
NP_001171630.1, NM_001184701.1 [O60701-3]
NP_003350.1, NM_003359.3 [O60701-1]
UniGeneiHs.572518

Genome annotation databases

EnsembliENST00000316423; ENSP00000319501; ENSG00000109814 [O60701-1]
ENST00000501493; ENSP00000422909; ENSG00000109814 [O60701-2]
ENST00000506179; ENSP00000421757; ENSG00000109814 [O60701-1]
ENST00000507089; ENSP00000426560; ENSG00000109814 [O60701-3]
GeneIDi7358
KEGGihsa:7358
UCSCiuc003guk.3 human [O60701-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061016 mRNA Translation: AAC36095.1
AJ007702 mRNA Translation: CAA07609.1
AJ272274
, AJ272275, AJ272276, AJ272277, AJ272278, AJ272279, AJ272280, AJ272281 Genomic DNA Translation: CAB75891.1
AK097930 mRNA Translation: BAG53554.1
AK297737 mRNA Translation: BAG60087.1
AC021148 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92937.1
BC022781 mRNA Translation: AAH22781.1
AF049126 mRNA Translation: AAC05135.1
CCDSiCCDS3455.1 [O60701-1]
CCDS54757.1 [O60701-3]
CCDS54758.1 [O60701-2]
PIRiJE0353
RefSeqiNP_001171629.1, NM_001184700.1 [O60701-2]
NP_001171630.1, NM_001184701.1 [O60701-3]
NP_003350.1, NM_003359.3 [O60701-1]
UniGeneiHs.572518

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q3EX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L1-466[»]
2QG4X-ray2.10A/B/C/D/E/F/G/H1-466[»]
3ITKX-ray2.40A/B/C/D/E/F1-466[»]
3KHUX-ray2.30A/B/C/D/E/F1-466[»]
3PRJX-ray3.10A/B/C/D/E/F1-494[»]
3PTZX-ray2.50A/B/C/D/E/F1-494[»]
3TDKX-ray2.80A/B/C/D/E/F/G/H/I/J/K/L1-487[»]
3TF5X-ray2.30A/B/C1-494[»]
4EDFX-ray2.08A/B/C/D1-494[»]
4RJTX-ray2.70A/B/C1-494[»]
5TJHX-ray2.05A/B/C/D/E/F1-494[»]
5VR8X-ray2.00A/B/C/D/E/F1-466[»]
5W4XX-ray2.65A/B/C1-494[»]
6C4JX-ray2.53A/B/C/D/E/F/G/H/I/J/K/L1-494[»]
6C4KX-ray2.65A/B/C1-494[»]
ProteinModelPortaliO60701
SMRiO60701
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113205, 45 interactors
IntActiO60701, 6 interactors
STRINGi9606.ENSP00000319501

Chemistry databases

DrugBankiDB00157 NADH

PTM databases

iPTMnetiO60701
PhosphoSitePlusiO60701
SwissPalmiO60701

Polymorphism and mutation databases

BioMutaiUGDH

2D gel databases

REPRODUCTION-2DPAGEiO60701

Proteomic databases

EPDiO60701
MaxQBiO60701
PaxDbiO60701
PeptideAtlasiO60701
PRIDEiO60701
ProteomicsDBi49530
49531 [O60701-2]

Protocols and materials databases

DNASUi7358
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316423; ENSP00000319501; ENSG00000109814 [O60701-1]
ENST00000501493; ENSP00000422909; ENSG00000109814 [O60701-2]
ENST00000506179; ENSP00000421757; ENSG00000109814 [O60701-1]
ENST00000507089; ENSP00000426560; ENSG00000109814 [O60701-3]
GeneIDi7358
KEGGihsa:7358
UCSCiuc003guk.3 human [O60701-1]

Organism-specific databases

CTDi7358
DisGeNETi7358
EuPathDBiHostDB:ENSG00000109814.11
GeneCardsiUGDH
HGNCiHGNC:12525 UGDH
HPAiCAB034444
HPA036656
HPA036657
MIMi603370 gene
neXtProtiNX_O60701
OpenTargetsiENSG00000109814
PharmGKBiPA37170
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
GeneTreeiENSGT00390000015355
HOGENOMiHOG000153773
HOVERGENiHBG003512
InParanoidiO60701
KOiK00012
OMAiRIITTNT
OrthoDBiEOG091G05RK
PhylomeDBiO60701
TreeFamiTF105671

Enzyme and pathway databases

UniPathwayi
UPA00038;UER00491

BRENDAi1.1.1.22 2681
ReactomeiR-HSA-173599 Formation of the active cofactor, UDP-glucuronate
SABIO-RKiO60701

Miscellaneous databases

ChiTaRSiUGDH human
EvolutionaryTraceiO60701
GeneWikiiUGDH
GenomeRNAii7358
PROiPR:O60701
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109814 Expressed in 220 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_UGDH
ExpressionAtlasiO60701 baseline and differential
GenevisibleiO60701 HS

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUGDH_HUMAN
AccessioniPrimary (citable) accession number: O60701
Secondary accession number(s): B3KUU2, B4DN25, O60589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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