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UniProtKB - O60688 (YPEL1_HUMAN)
Protein
Protein yippee-like 1
Gene
YPEL1
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in epithelioid conversion of fibroblasts.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 23 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 26 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 79 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 82 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O60688 |
SignaLinki | O60688 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein yippee-like 1 |
Gene namesi | Name:YPEL1 ORF Names:FKSG3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12845, YPEL1 |
MIMi | 608082, gene |
neXtProti | NX_O60688 |
VEuPathDBi | HostDB:ENSG00000100027 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 29799 |
OpenTargetsi | ENSG00000100027 |
PharmGKBi | PA37436 |
Miscellaneous databases
Pharosi | O60688, Tbio |
Genetic variation databases
BioMutai | YPEL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212381 | 1 – 119 | Protein yippee-like 1Add BLAST | 119 |
Proteomic databases
MassIVEi | O60688 |
PaxDbi | O60688 |
PeptideAtlasi | O60688 |
PRIDEi | O60688 |
ProteomicsDBi | 49529 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100027, Expressed in forebrain and 190 other tissues |
ExpressionAtlasi | O60688, baseline and differential |
Genevisiblei | O60688, HS |
Organism-specific databases
HPAi | ENSG00000100027, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 118923, 15 interactors |
IntActi | O60688, 6 interactors |
STRINGi | 9606.ENSP00000342832 |
Miscellaneous databases
RNActi | O60688, protein |
Structurei
3D structure databases
AlphaFoldDBi | O60688 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 116 | YippeePROSITE-ProRule annotationAdd BLAST | 98 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 99 – 104 | Nuclear localization signalSequence analysis | 6 |
Sequence similaritiesi
Belongs to the yippee family.Curated
Phylogenomic databases
eggNOGi | KOG3399, Eukaryota |
GeneTreei | ENSGT00940000161453 |
HOGENOMi | CLU_043857_5_2_1 |
InParanoidi | O60688 |
OMAi | HLAFKGH |
OrthoDBi | 1431042at2759 |
PhylomeDBi | O60688 |
TreeFami | TF313936 |
Family and domain databases
InterProi | View protein in InterPro IPR034751, Yippee IPR004910, Yippee/Mis18/Cereblon IPR039058, Yippee_fam |
PANTHERi | PTHR13848, PTHR13848, 1 hit |
Pfami | View protein in Pfam PF03226, Yippee-Mis18, 1 hit |
PROSITEi | View protein in PROSITE PS51792, YIPPEE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O60688-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKMTKSKTF QAYLPNCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY
110
KEGKFIIELA HMIKDNGWE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9ZHD1 | A0A5F9ZHD1_HUMAN | Protein yippee-like | YPEL1 YPEL | 154 | Annotation score: | ||
B5MCX2 | B5MCX2_HUMAN | Protein yippee-like 1 | YPEL1 | 44 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 108 | E → D in AAH74501 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098734 mRNA Translation: BAD51375.1 AB098735 mRNA Translation: BAD51376.1 AF060862 mRNA Translation: AAC15461.1 AF305069 mRNA Translation: AAL09353.1 CR456376 mRNA Translation: CAG30262.1 CR933630 Transcribed RNA Translation: CAI45937.1 BC034486 mRNA Translation: AAH34486.1 BC074501 mRNA Translation: AAH74501.1 |
CCDSi | CCDS13794.1 |
PIRi | T50835 |
RefSeqi | NP_037445.1, NM_013313.4 |
Genome annotation databases
Ensembli | ENST00000339468.8; ENSP00000342832.3; ENSG00000100027.17 |
GeneIDi | 29799 |
KEGGi | hsa:29799 |
MANE-Selecti | ENST00000339468.8; ENSP00000342832.3; NM_013313.5; NP_037445.1 |
UCSCi | uc002zvl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098734 mRNA Translation: BAD51375.1 AB098735 mRNA Translation: BAD51376.1 AF060862 mRNA Translation: AAC15461.1 AF305069 mRNA Translation: AAL09353.1 CR456376 mRNA Translation: CAG30262.1 CR933630 Transcribed RNA Translation: CAI45937.1 BC034486 mRNA Translation: AAH34486.1 BC074501 mRNA Translation: AAH74501.1 |
CCDSi | CCDS13794.1 |
PIRi | T50835 |
RefSeqi | NP_037445.1, NM_013313.4 |
3D structure databases
AlphaFoldDBi | O60688 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 118923, 15 interactors |
IntActi | O60688, 6 interactors |
STRINGi | 9606.ENSP00000342832 |
Genetic variation databases
BioMutai | YPEL1 |
Proteomic databases
MassIVEi | O60688 |
PaxDbi | O60688 |
PeptideAtlasi | O60688 |
PRIDEi | O60688 |
ProteomicsDBi | 49529 |
Protocols and materials databases
Antibodypediai | 45067, 67 antibodies from 21 providers |
DNASUi | 29799 |
Genome annotation databases
Ensembli | ENST00000339468.8; ENSP00000342832.3; ENSG00000100027.17 |
GeneIDi | 29799 |
KEGGi | hsa:29799 |
MANE-Selecti | ENST00000339468.8; ENSP00000342832.3; NM_013313.5; NP_037445.1 |
UCSCi | uc002zvl.4, human |
Organism-specific databases
CTDi | 29799 |
DisGeNETi | 29799 |
GeneCardsi | YPEL1 |
HGNCi | HGNC:12845, YPEL1 |
HPAi | ENSG00000100027, Tissue enhanced (testis) |
MIMi | 608082, gene |
neXtProti | NX_O60688 |
OpenTargetsi | ENSG00000100027 |
PharmGKBi | PA37436 |
VEuPathDBi | HostDB:ENSG00000100027 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3399, Eukaryota |
GeneTreei | ENSGT00940000161453 |
HOGENOMi | CLU_043857_5_2_1 |
InParanoidi | O60688 |
OMAi | HLAFKGH |
OrthoDBi | 1431042at2759 |
PhylomeDBi | O60688 |
TreeFami | TF313936 |
Enzyme and pathway databases
PathwayCommonsi | O60688 |
SignaLinki | O60688 |
Miscellaneous databases
BioGRID-ORCSi | 29799, 114 hits in 1084 CRISPR screens |
ChiTaRSi | YPEL1, human |
GenomeRNAii | 29799 |
Pharosi | O60688, Tbio |
PROi | PR:O60688 |
RNActi | O60688, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100027, Expressed in forebrain and 190 other tissues |
ExpressionAtlasi | O60688, baseline and differential |
Genevisiblei | O60688, HS |
Family and domain databases
InterProi | View protein in InterPro IPR034751, Yippee IPR004910, Yippee/Mis18/Cereblon IPR039058, Yippee_fam |
PANTHERi | PTHR13848, PTHR13848, 1 hit |
Pfami | View protein in Pfam PF03226, Yippee-Mis18, 1 hit |
PROSITEi | View protein in PROSITE PS51792, YIPPEE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YPEL1_HUMAN | |
Accessioni | O60688Primary (citable) accession number: O60688 Secondary accession number(s): Q65ZA1, Q6GLI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | August 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families