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Protein

Importin subunit alpha-7

Gene

KPNA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SignaLinkiO60684
SIGNORiO60684

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-7
Alternative name(s):
Karyopherin subunit alpha-6
Gene namesi
Name:KPNA6
Synonyms:IPOA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000025800.13
HGNCiHGNC:6399 KPNA6
MIMi610563 gene
neXtProtiNX_O60684

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23633
OpenTargetsiENSG00000025800
PharmGKBiPA30190

Polymorphism and mutation databases

BioMutaiKPNA6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207291 – 536Importin subunit alpha-7Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60684
MaxQBiO60684
PaxDbiO60684
PeptideAtlasiO60684
PRIDEiO60684
ProteomicsDBi49527

PTM databases

iPTMnetiO60684
PhosphoSitePlusiO60684
SwissPalmiO60684

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000025800 Expressed in 243 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_KPNA6
ExpressionAtlasiO60684 baseline and differential
GenevisibleiO60684 HS

Organism-specific databases

HPAiHPA018863

Interactioni

Subunit structurei

Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1.By similarity1 Publication
(Microbial infection) Interacts with ebolavirus protein VP24.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi117163, 84 interactors
ComplexPortaliCPX-1064 Importin complex, KPNA6 variant
DIPiDIP-27609N
ELMiO60684
IntActiO60684, 66 interactors
MINTiO60684
STRINGi9606.ENSP00000362728

Structurei

Secondary structure

1536
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60684
SMRiO60684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 60IBBPROSITE-ProRule annotationAdd BLAST60
Repeati76 – 115ARM 1; truncatedAdd BLAST40
Repeati116 – 159ARM 2Add BLAST44
Repeati160 – 204ARM 3Add BLAST45
Repeati205 – 243ARM 4Add BLAST39
Repeati244 – 288ARM 5Add BLAST45
Repeati289 – 328ARM 6Add BLAST40
Repeati329 – 370ARM 7Add BLAST42
Repeati371 – 410ARM 8Add BLAST40
Repeati411 – 453ARM 9Add BLAST43
Repeati457 – 502ARM 10; atypicalAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 239NLS binding site (major)By similarityAdd BLAST93
Regioni316 – 404NLS binding site (minor)By similarityAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 54Nuclear localization signalBy similarity10

Sequence similaritiesi

Belongs to the importin alpha family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
GeneTreeiENSGT00760000119094
HOVERGENiHBG001846
InParanoidiO60684
OMAiSAVCRDY
OrthoDBiEOG091G095Z
PhylomeDBiO60684
TreeFamiTF354205

Family and domain databases

Gene3Di1.20.5.690, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032413 Arm_3
IPR000225 Armadillo
IPR002652 Importin-a_IBB
IPR036975 Importin-a_IBB_sf
IPR024931 Importing_su_alpha
PfamiView protein in Pfam
PF00514 Arm, 8 hits
PF16186 Arm_3, 1 hit
PF01749 IBB, 1 hit
PIRSFiPIRSF005673 Importin_alpha, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits
PS51214 IBB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O60684-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METMASPGKD NYRMKSYKNN ALNPEEMRRR REEEGIQLRK QKREQQLFKR
60 70 80 90 100
RNVELINEEA AMFDSLLMDS YVSSTTGESV ITREMVEMLF SDDSDLQLAT
110 120 130 140 150
TQKFRKLLSK EPSPPIDEVI NTPRVVDRFV EFLKRNENCT LQFEAAWALT
160 170 180 190 200
NIASGTSQQT KIVIEAGAVP IFIELLNSDF EDVQEQAVWA LGNIAGDSSV
210 220 230 240 250
CRDYVLNCSI LNPLLTLLTK STRLTMTRNA VWALSNLCRG KNPPPEFAKV
260 270 280 290 300
SPCLPVLSRL LFSSDSDLLA DACWALSYLS DGPNEKIQAV IDSGVCRRLV
310 320 330 340 350
ELLMHNDYKV ASPALRAVGN IVTGDDIQTQ VILNCSALPC LLHLLSSPKE
360 370 380 390 400
SIRKEACWTI SNITAGNRAQ IQAVIDANIF PVLIEILQKA EFRTRKEAAW
410 420 430 440 450
AITNATSGGT PEQIRYLVSL GCIKPLCDLL TVMDSKIVQV ALNGLENILR
460 470 480 490 500
LGEQEGKRSG SGVNPYCGLI EEAYGLDKIE FLQSHENQEI YQKAFDLIEH
510 520 530
YFGVEDDDSS LAPQVDETQQ QFIFQQPEAP MEGFQL
Length:536
Mass (Da):60,030
Last modified:August 1, 1998 - v1
Checksum:i9D0E27482B9BDED3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3E5S4R3E5_HUMAN
Importin subunit alpha-7
KPNA6
186Annotation score:
Q5TFJ7Q5TFJ7_HUMAN
Importin subunit alpha-7
KPNA6
321Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060543 mRNA Translation: AAC15233.1
AK315490 mRNA Translation: BAG37874.1
BT009843 mRNA Translation: AAP88845.1
AL445248 Genomic DNA No translation available.
AL049795 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07567.1
CH471059 Genomic DNA Translation: EAX07568.1
BC020520 mRNA Translation: AAH20520.1
CCDSiCCDS352.1
RefSeqiNP_036448.1, NM_012316.4
UniGeneiHs.470588
Hs.711019

Genome annotation databases

EnsembliENST00000373625; ENSP00000362728; ENSG00000025800
GeneIDi23633
KEGGihsa:23633
UCSCiuc001bug.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060543 mRNA Translation: AAC15233.1
AK315490 mRNA Translation: BAG37874.1
BT009843 mRNA Translation: AAP88845.1
AL445248 Genomic DNA No translation available.
AL049795 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07567.1
CH471059 Genomic DNA Translation: EAX07568.1
BC020520 mRNA Translation: AAH20520.1
CCDSiCCDS352.1
RefSeqiNP_036448.1, NM_012316.4
UniGeneiHs.470588
Hs.711019

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UADX-ray2.42A59-536[»]
ProteinModelPortaliO60684
SMRiO60684
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117163, 84 interactors
ComplexPortaliCPX-1064 Importin complex, KPNA6 variant
DIPiDIP-27609N
ELMiO60684
IntActiO60684, 66 interactors
MINTiO60684
STRINGi9606.ENSP00000362728

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO60684
PhosphoSitePlusiO60684
SwissPalmiO60684

Polymorphism and mutation databases

BioMutaiKPNA6

Proteomic databases

EPDiO60684
MaxQBiO60684
PaxDbiO60684
PeptideAtlasiO60684
PRIDEiO60684
ProteomicsDBi49527

Protocols and materials databases

DNASUi23633
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373625; ENSP00000362728; ENSG00000025800
GeneIDi23633
KEGGihsa:23633
UCSCiuc001bug.4 human

Organism-specific databases

CTDi23633
DisGeNETi23633
EuPathDBiHostDB:ENSG00000025800.13
GeneCardsiKPNA6
HGNCiHGNC:6399 KPNA6
HPAiHPA018863
MIMi610563 gene
neXtProtiNX_O60684
OpenTargetsiENSG00000025800
PharmGKBiPA30190
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
GeneTreeiENSGT00760000119094
HOVERGENiHBG001846
InParanoidiO60684
OMAiSAVCRDY
OrthoDBiEOG091G095Z
PhylomeDBiO60684
TreeFamiTF354205

Enzyme and pathway databases

SignaLinkiO60684
SIGNORiO60684

Miscellaneous databases

ChiTaRSiKPNA6 human
GeneWikiiKPNA6
GenomeRNAii23633
PROiPR:O60684
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000025800 Expressed in 243 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_KPNA6
ExpressionAtlasiO60684 baseline and differential
GenevisibleiO60684 HS

Family and domain databases

Gene3Di1.20.5.690, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032413 Arm_3
IPR000225 Armadillo
IPR002652 Importin-a_IBB
IPR036975 Importin-a_IBB_sf
IPR024931 Importing_su_alpha
PfamiView protein in Pfam
PF00514 Arm, 8 hits
PF16186 Arm_3, 1 hit
PF01749 IBB, 1 hit
PIRSFiPIRSF005673 Importin_alpha, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits
PS51214 IBB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIMA7_HUMAN
AccessioniPrimary (citable) accession number: O60684
Secondary accession number(s): B2RDC7, D3DPP5, Q5VVU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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