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Protein

Cystatin-8

Gene

CST8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Performs a specialized role during sperm development and maturation.

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: ProtInc

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.027

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-8
Alternative name(s):
Cystatin-related epididymal spermatogenic protein
Gene namesi
Name:CST8
Synonyms:CRES
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125815.8
HGNCiHGNC:2480 CST8
MIMi608683 gene
neXtProtiNX_O60676

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10047
OpenTargetsiENSG00000125815
PharmGKBiPA26981

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000665322 – 142Cystatin-8Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi95 ↔ 105By similarity
Disulfide bondi119 ↔ 139By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60676
PeptideAtlasiO60676
PRIDEiO60676
ProteomicsDBi49521

PTM databases

iPTMnetiO60676
PhosphoSitePlusiO60676

Expressioni

Tissue specificityi

Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium.

Gene expression databases

BgeeiENSG00000125815 Expressed in 12 organ(s), highest expression level in right testis
CleanExiHS_CST8
ExpressionAtlasiO60676 baseline and differential
GenevisibleiO60676 HS

Interactioni

Protein-protein interaction databases

BioGridi115358, 35 interactors
STRINGi9606.ENSP00000246012

Structurei

3D structure databases

ProteinModelPortaliO60676
SMRiO60676
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 81Secondary area of contactSequence analysis5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXH4 Eukaryota
ENOG41113F6 LUCA
GeneTreeiENSGT00910000144251
HOGENOMiHOG000231754
HOVERGENiHBG095685
InParanoidiO60676
KOiK13904
OMAiKQCLWFA
OrthoDBiEOG091G0TP1
PhylomeDBiO60676

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60676-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRCRWLSLI LLTIPLALVA RKDPKKNETG VLRKLKPVNA SNANVKQCLW
60 70 80 90 100
FAMQEYNKES EDKYVFLVVK TLQAQLQVTN LLEYLIDVEI ARSDCRKPLS
110 120 130 140
TNEICAIQEN SKLKRKLSCS FLVGALPWNG EFTVMEKKCE DA
Length:142
Mass (Da):16,275
Last modified:August 1, 1998 - v1
Checksum:i9A3512757E0F4ECD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2N0A2A2N0_HUMAN
Cystatin
CST8
134Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06113052A → V. Corresponds to variant dbSNP:rs35190670Ensembl.1
Natural variantiVAR_014527142A → P. Corresponds to variant dbSNP:rs1054633Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059244 mRNA Translation: AAC14707.1
AL109954 Genomic DNA No translation available.
BC069496 mRNA Translation: AAH69496.1
BC105113 mRNA Translation: AAI05114.1
BC105119 mRNA Translation: AAI05120.1
CCDSiCCDS13156.1
RefSeqiNP_001268659.1, NM_001281730.1
NP_005483.1, NM_005492.3
UniGeneiHs.121602

Genome annotation databases

EnsembliENST00000246012; ENSP00000246012; ENSG00000125815
GeneIDi10047
KEGGihsa:10047
UCSCiuc002wth.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059244 mRNA Translation: AAC14707.1
AL109954 Genomic DNA No translation available.
BC069496 mRNA Translation: AAH69496.1
BC105113 mRNA Translation: AAI05114.1
BC105119 mRNA Translation: AAI05120.1
CCDSiCCDS13156.1
RefSeqiNP_001268659.1, NM_001281730.1
NP_005483.1, NM_005492.3
UniGeneiHs.121602

3D structure databases

ProteinModelPortaliO60676
SMRiO60676
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115358, 35 interactors
STRINGi9606.ENSP00000246012

Protein family/group databases

MEROPSiI25.027

PTM databases

iPTMnetiO60676
PhosphoSitePlusiO60676

Proteomic databases

PaxDbiO60676
PeptideAtlasiO60676
PRIDEiO60676
ProteomicsDBi49521

Protocols and materials databases

DNASUi10047
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246012; ENSP00000246012; ENSG00000125815
GeneIDi10047
KEGGihsa:10047
UCSCiuc002wth.3 human

Organism-specific databases

CTDi10047
DisGeNETi10047
EuPathDBiHostDB:ENSG00000125815.8
GeneCardsiCST8
HGNCiHGNC:2480 CST8
MIMi608683 gene
neXtProtiNX_O60676
OpenTargetsiENSG00000125815
PharmGKBiPA26981
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXH4 Eukaryota
ENOG41113F6 LUCA
GeneTreeiENSGT00910000144251
HOGENOMiHOG000231754
HOVERGENiHBG095685
InParanoidiO60676
KOiK13904
OMAiKQCLWFA
OrthoDBiEOG091G0TP1
PhylomeDBiO60676

Miscellaneous databases

GeneWikiiCST8_(gene)
GenomeRNAii10047
PROiPR:O60676
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125815 Expressed in 12 organ(s), highest expression level in right testis
CleanExiHS_CST8
ExpressionAtlasiO60676 baseline and differential
GenevisibleiO60676 HS

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCST8_HUMAN
AccessioniPrimary (citable) accession number: O60676
Secondary accession number(s): Q2M2X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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