UniProtKB - O60674 (JAK2_HUMAN)
Tyrosine-protein kinase JAK2
JAK2
Functioni
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558).
Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263).
Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206).
In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430).
Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214).
Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980).
7 PublicationsCatalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation2 PublicationsEC:2.7.10.2PROSITE-ProRule annotation2 Publications
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 882 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 976 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 855 – 863 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- acetylcholine receptor binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- growth hormone receptor binding Source: BHF-UCL
- heme binding Source: UniProtKB
- histone binding Source: UniProtKB
- histone kinase activity (H3-Y41 specific) Source: UniProtKB
- identical protein binding Source: IntAct
- insulin receptor substrate binding Source: Ensembl
- interleukin-12 receptor binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: Reactome
- peptide hormone receptor binding Source: Ensembl
- phosphatidylinositol 3-kinase binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein kinase activity Source: ProtInc
- protein kinase binding Source: BHF-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: CACAO
- SH2 domain binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- type 1 angiotensin receptor binding Source: Ensembl
GO - Biological processi
- actin filament polymerization Source: BHF-UCL
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: BHF-UCL
- activation of Janus kinase activity Source: UniProtKB
- adaptive immune response Source: UniProtKB-KW
- apoptotic process Source: BHF-UCL
- axon regeneration Source: Ensembl
- cell differentiation Source: BHF-UCL
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to interleukin-3 Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- cellular response to virus Source: ComplexPortal
- chromatin organization Source: UniProtKB-KW
- collagen-activated signaling pathway Source: ARUK-UCL
- cytokine-mediated signaling pathway Source: BHF-UCL
- enzyme linked receptor protein signaling pathway Source: BHF-UCL
- erythrocyte differentiation Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: Ensembl
- granulocyte-macrophage colony-stimulating factor signaling pathway Source: ComplexPortal
- growth hormone receptor signaling pathway Source: BHF-UCL
- growth hormone receptor signaling pathway via JAK-STAT Source: UniProtKB
- histone H3-Y41 phosphorylation Source: UniProtKB
- immune response Source: ComplexPortal
- interferon-gamma-mediated signaling pathway Source: Reactome
- interleukin-12-mediated signaling pathway Source: BHF-UCL
- interleukin-35-mediated signaling pathway Source: Reactome
- interleukin-6-mediated signaling pathway Source: Reactome
- intracellular signal transduction Source: BHF-UCL
- intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
- mammary gland epithelium development Source: BHF-UCL
- mesoderm development Source: ProtInc
- microglial cell activation Source: ARUK-UCL
- mineralocorticoid receptor signaling pathway Source: Ensembl
- modulation of chemical synaptic transmission Source: Ensembl
- negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
- negative regulation of cell-cell adhesion Source: Ensembl
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of DNA binding Source: BHF-UCL
- negative regulation of heart contraction Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- peptidyl-tyrosine phosphorylation Source: BHF-UCL
- platelet-derived growth factor receptor signaling pathway Source: Ensembl
- positive regulation of apoptotic signaling pathway Source: Ensembl
- positive regulation of cell differentiation Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of cell-substrate adhesion Source: BHF-UCL
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of DNA binding Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: Ensembl
- positive regulation of epithelial cell apoptotic process Source: Ensembl
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation Source: Ensembl
- positive regulation of growth hormone receptor signaling pathway Source: BHF-UCL
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of insulin secretion Source: Ensembl
- positive regulation of interferon-gamma production Source: ComplexPortal
- positive regulation of interleukin-17 production Source: ComplexPortal
- positive regulation of interleukin-1 beta production Source: ARUK-UCL
- positive regulation of leukocyte proliferation Source: ComplexPortal
- positive regulation of MAPK cascade Source: Ensembl
- positive regulation of MHC class II biosynthetic process Source: ARUK-UCL
- positive regulation of natural killer cell proliferation Source: ComplexPortal
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of nitric-oxide synthase biosynthetic process Source: ARUK-UCL
- positive regulation of NK T cell proliferation Source: ComplexPortal
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of phosphoprotein phosphatase activity Source: Ensembl
- positive regulation of platelet activation Source: ARUK-UCL
- positive regulation of platelet aggregation Source: ARUK-UCL
- positive regulation of protein import into nucleus Source: Ensembl
- positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
- positive regulation of signaling receptor activity Source: ARUK-UCL
- positive regulation of SMAD protein signal transduction Source: MGI
- positive regulation of T cell proliferation Source: ComplexPortal
- positive regulation of T-helper 17 type immune response Source: ComplexPortal
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of tumor necrosis factor production Source: ARUK-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- post-embryonic hemopoiesis Source: Ensembl
- postsynapse to nucleus signaling pathway Source: Ensembl
- programmed cell death induced by symbiont Source: Ensembl
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: ComplexPortal
- receptor signaling pathway via JAK-STAT Source: ARUK-UCL
- regulation of apoptotic process Source: GO_Central
- regulation of inflammatory response Source: BHF-UCL
- regulation of nitric oxide biosynthetic process Source: ARUK-UCL
- regulation of receptor signaling pathway via JAK-STAT Source: BHF-UCL
- response to amine Source: Ensembl
- response to antibiotic Source: MGI
- response to hydroperoxide Source: Ensembl
- response to interleukin-12 Source: BHF-UCL
- response to lipopolysaccharide Source: BHF-UCL
- response to tumor necrosis factor Source: BHF-UCL
- signal transduction Source: UniProtKB
- tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
- tyrosine phosphorylation of STAT protein Source: BHF-UCL
Keywordsi
Molecular function | Chromatin regulator, Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Adaptive immunity, Immunity, Innate immunity |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | O60674 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-110056, MAPK3 (ERK1) activation R-HSA-112411, MAPK1 (ERK2) activation R-HSA-1170546, Prolactin receptor signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-2586552, Signaling by Leptin R-HSA-3214858, RMTs methylate histone arginines R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-5673000, RAF activation R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-6788467, IL-6-type cytokine receptor ligand interactions R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-69231, Cyclin D associated events in G1 R-HSA-877300, Interferon gamma signaling R-HSA-877312, Regulation of IFNG signaling R-HSA-8854691, Interleukin-20 family signaling R-HSA-8984722, Interleukin-35 Signalling R-HSA-9006335, Signaling by Erythropoietin R-HSA-9020591, Interleukin-12 signaling R-HSA-9020933, Interleukin-23 signaling R-HSA-9020956, Interleukin-27 signaling R-HSA-9027276, Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027277, Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027283, Erythropoietin activates STAT5 R-HSA-9027284, Erythropoietin activates RAS R-HSA-912526, Interleukin receptor SHC signaling R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9674555, Signaling by CSF3 (G-CSF) R-HSA-9679191, Potential therapeutics for SARS R-HSA-9705462, Inactivation of CSF3 (G-CSF) signaling R-HSA-982772, Growth hormone receptor signaling R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | O60674 |
SIGNORi | O60674 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase JAK2Curated (EC:2.7.10.23 Publications)Alternative name(s): Janus kinase 2 Short name: JAK-2 |
Gene namesi | Name:JAK2Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6192, JAK2 |
MIMi | 147796, gene |
neXtProti | NX_O60674 |
VEuPathDBi | HostDB:ENSG00000096968 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- Endomembrane system By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- cytoskeleton Source: InterPro
Cytosol
- cytosol Source: Reactome
Endosome
- endosome lumen Source: Reactome
Nucleus
- nucleolus Source: Ensembl
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- caveola Source: BHF-UCL
- granulocyte macrophage colony-stimulating factor receptor complex Source: ComplexPortal
- interleukin-12 receptor complex Source: ComplexPortal
- interleukin-23 receptor complex Source: ComplexPortal
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: BHF-UCL
- euchromatin Source: Ensembl
- focal adhesion Source: HPA
- glutamatergic synapse Source: Ensembl
- membrane raft Source: BHF-UCL
- postsynapse Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Budd-Chiari syndrome (BDCHS)1 Publication
Polycythemia vera (PV)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032697 | 617 | V → F in PV, THCYT3 and AML; associated with susceptibility to Budd-Chiari syndrome; somatic mutation in a high percentage of patients with essential thrombocythemia or myelofibrosis; leads to constitutive tyrosine phosphorylation activity that promotes cytokine hypersensitivity. 6 PublicationsCorresponds to variant dbSNP:rs77375493EnsemblClinVar. | 1 |
Thrombocythemia 3 (THCYT3)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067534 | 617 | V → I in THCYT3. 1 PublicationCorresponds to variant dbSNP:rs77375493EnsemblClinVar. | 1 |
Myelofibrosis (MYELOF)
Leukemia, acute myelogenous (AML)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032696 | 607 | K → N in AML. 1 PublicationCorresponds to variant dbSNP:rs121912472EnsemblClinVar. | 1 | |
Natural variantiVAR_032697 | 617 | V → F in PV, THCYT3 and AML; associated with susceptibility to Budd-Chiari syndrome; somatic mutation in a high percentage of patients with essential thrombocythemia or myelofibrosis; leads to constitutive tyrosine phosphorylation activity that promotes cytokine hypersensitivity. 6 PublicationsCorresponds to variant dbSNP:rs77375493EnsemblClinVar. | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 352 – 353 | Breakpoint for translocation to form PCM1-JAK2 fusion protein | 2 | |
Sitei | 442 – 443 | Breakpoint for translocation to form PCM1-JAK2 fusion protein | 2 | |
Sitei | 450 – 451 | Breakpoint for translocation to form PCM1-JAK2 fusion protein | 2 | |
Sitei | 504 – 505 | Breakpoint for translocation to form PCM1-JAK2 fusion protein | 2 | |
Sitei | 710 – 711 | Breakpoint for translocation to form PCM1-JAK2 fusion protein | 2 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 3717 |
MalaCardsi | JAK2 |
MIMi | 254450, phenotype 263300, phenotype 600880, phenotype 601626, phenotype 614521, phenotype |
OpenTargetsi | ENSG00000096968 |
Orphaneti | 131, Budd-Chiari syndrome 3318, Essential thrombocythemia 71493, Familial thrombocytosis 729, Polycythemia vera 824, Primary myelofibrosis |
PharmGKBi | PA29989 |
Miscellaneous databases
Pharosi | O60674, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2971 |
DrugBanki | DB04716, 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one DB07162, 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide DB08067, 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM DB07161, 5-phenyl-1H-indazol-3-amine DB11817, Baricitinib DB11986, Entrectinib DB12500, Fedratinib DB12010, Fostamatinib DB15822, Pralsetinib DB08877, Ruxolitinib DB08895, Tofacitinib DB05243, XL019 DB15035, Zanubrutinib |
DrugCentrali | O60674 |
GuidetoPHARMACOLOGYi | 2048 |
Genetic variation databases
BioMutai | JAK2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088112 | 1 – 1132 | Tyrosine-protein kinase JAK2Add BLAST | 1132 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 119 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 372 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 373 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 523 | PhosphoserineBy similarity | 1 | |
Modified residuei | 570 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 813 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 868 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 966 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 972 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1007 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1008 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1252 |
EPDi | O60674 |
jPOSTi | O60674 |
MassIVEi | O60674 |
MaxQBi | O60674 |
PaxDbi | O60674 |
PeptideAtlasi | O60674 |
PRIDEi | O60674 |
ProteomicsDBi | 49519 |
PTM databases
iPTMneti | O60674 |
PhosphoSitePlusi | O60674 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000096968, Expressed in calcaneal tendon and 223 other tissues |
ExpressionAtlasi | O60674, baseline and differential |
Genevisiblei | O60674, HS |
Organism-specific databases
HPAi | ENSG00000096968, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with EPOR, LYN, SIRPA, SH2B1 and TEC (By similarity).
Interacts with IL23R (PubMed:12023369).
Interacts with SKB1 (PubMed:10531356).
Interacts with STAM2 (PubMed:10899310).
Interacts with IFNGR2 (via intracellular domain) (PubMed:7673114, PubMed:7615558).
Interacts with LEPR (Isoform B) (By similarity).
Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner (PubMed:20353823).
Interacts with STRA6 (PubMed:21368206).
Interacts with RHEX; this interaction occurs in a erythropoietin (EPO)-dependent manner (PubMed:25092874).
Interacts with ASB2; the interaction targets JAK2 for Notch-induced proteasomal degradation (PubMed:21119685).
By similarity10 PublicationsBinary interactionsi
O60674
GO - Molecular functioni
- acetylcholine receptor binding Source: Ensembl
- growth hormone receptor binding Source: BHF-UCL
- histone binding Source: UniProtKB
- identical protein binding Source: IntAct
- insulin receptor substrate binding Source: Ensembl
- interleukin-12 receptor binding Source: BHF-UCL
- peptide hormone receptor binding Source: Ensembl
- phosphatidylinositol 3-kinase binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein kinase binding Source: BHF-UCL
- SH2 domain binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- type 1 angiotensin receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109920, 148 interactors |
ComplexPortali | CPX-382, Interleukin-12-receptor complex CPX-383, Interleukin-23-receptor complex CPX-512, Granulocyte-macrophage colony-stimulating factor-receptor complex CPX-6015, Interferon gamma receptor-ligand complex |
CORUMi | O60674 |
DIPi | DIP-33880N |
IntActi | O60674, 43 interactors |
MINTi | O60674 |
STRINGi | 9606.ENSP00000371067 |
Chemistry databases
BindingDBi | O60674 |
Miscellaneous databases
RNActi | O60674, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O60674 |
SMRi | O60674 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60674 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 380 | FERMPROSITE-ProRule annotationAdd BLAST | 344 | |
Domaini | 401 – 482 | SH2; atypicalPROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 545 – 809 | Protein kinase 1PROSITE-ProRule annotationAdd BLAST | 265 | |
Domaini | 849 – 1124 | Protein kinase 2PROSITE-ProRule annotationAdd BLAST | 276 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 239 | Interaction with cytokine/interferon/growth hormone receptorsBy similarityAdd BLAST | 239 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SH2 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000155640 |
HOGENOMi | CLU_008155_1_0_1 |
InParanoidi | O60674 |
OMAi | ICAVACK |
OrthoDBi | 58906at2759 |
PhylomeDBi | O60674 |
TreeFami | TF327041 |
Family and domain databases
CDDi | cd13333, FERM_C_JAK2, 1 hit cd05078, PTK_Jak2_rpt1, 1 hit cd14205, PTKc_Jak2_rpt2, 1 hit cd10379, SH2_Jak2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR035963, FERM_2 IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR037838, JAK2_FERM_C-lobe IPR035860, JAK2_SH2 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR035588, PTK_Jak2_rpt1 IPR035589, PTKc_Jak2_rpt2 IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020693, Tyr_kinase_non-rcpt_Jak2 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits PF00017, SH2, 1 hit |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01825, JANUSKINASE2 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHSLGKS
60 70 80 90 100
EADYLTFPSG EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH
110 120 130 140 150
VFHIDESTRH NVLYRIRFYF PRWYCSGSNR AYRHGISRGA EAPLLDDFVM
160 170 180 190 200
SYLFAQWRHD FVHGWIKVPV THETQEECLG MAVLDMMRIA KENDQTPLAI
210 220 230 240 250
YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF SQCKATARNL
260 270 280 290 300
KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR
310 320 330 340 350
GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK
360 370 380 390 400
NLEIELSSLR EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIQSNC
410 420 430 440 450
HGPISMDFAI SKLKKAGNQT GLYVLRCSPK DFNKYFLTFA VERENVIEYK
460 470 480 490 500
HCLITKNENE EYNLSGTKKN FSSLKDLLNC YQMETVRSDN IIFQFTKCCP
510 520 530 540 550
PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI RNEDLIFNES
560 570 580 590 600
LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM
610 620 630 640 650
MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK
660 670 680 690 700
LEVAKQLAWA MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP
710 720 730 740 750
GISITVLPKD ILQERIPWVP PECIENPKNL NLATDKWSFG TTLWEICSGG
760 770 780 790 800
DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL ANLINNCMDY EPDFRPSFRA
810 820 830 840 850
IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD PTQFEERHLK
860 870 880 890 900
FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE
910 920 930 940 950
ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH
960 970 980 990 1000
IKLLQYTSQI CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV
1010 1020 1030 1040 1050
LPQDKEYYKV KEPGESPIFW YAPESLTESK FSVASDVWSF GVVLYELFTY
1060 1070 1080 1090 1100
IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE LLKNNGRLPR PDGCPDEIYM
1110 1120 1130
IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GTR9 | A0A1B0GTR9_HUMAN | Tyrosine-protein kinase | JAK2 | 710 | Annotation score: | ||
A0A1B0GVR5 | A0A1B0GVR5_HUMAN | Tyrosine-protein kinase JAK2 | JAK2 | 26 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 321 | P → S in AAC23982 (PubMed:9618263).Curated | 1 | |
Sequence conflicti | 1126 | I → V in AAC23653 (PubMed:9446644).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041716 | 127 | G → D1 PublicationCorresponds to variant dbSNP:rs56118985EnsemblClinVar. | 1 | |
Natural variantiVAR_041717 | 191 | K → Q in an ovarian serous carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041718 | 346 | K → R1 PublicationCorresponds to variant dbSNP:rs55667734Ensembl. | 1 | |
Natural variantiVAR_041719 | 377 | A → E1 PublicationCorresponds to variant dbSNP:rs55953208Ensembl. | 1 | |
Natural variantiVAR_041720 | 393 | L → V1 PublicationCorresponds to variant dbSNP:rs2230723EnsemblClinVar. | 1 | |
Natural variantiVAR_032693 | 537 – 539 | FHK → L in myeloproliferative disorder with erythrocytosis. 1 Publication | 3 | |
Natural variantiVAR_032694 | 538 – 539 | HK → QL in myeloproliferative disorder with erythrocytosis. | 2 | |
Natural variantiVAR_032695 | 539 | K → L in myeloproliferative disorder with erythrocytosis; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs121912473Ensembl. | 1 | |
Natural variantiVAR_043129 | 584 | D → E. Corresponds to variant dbSNP:rs17490221Ensembl. | 1 | |
Natural variantiVAR_032696 | 607 | K → N in AML. 1 PublicationCorresponds to variant dbSNP:rs121912472EnsemblClinVar. | 1 | |
Natural variantiVAR_032697 | 617 | V → F in PV, THCYT3 and AML; associated with susceptibility to Budd-Chiari syndrome; somatic mutation in a high percentage of patients with essential thrombocythemia or myelofibrosis; leads to constitutive tyrosine phosphorylation activity that promotes cytokine hypersensitivity. 6 PublicationsCorresponds to variant dbSNP:rs77375493EnsemblClinVar. | 1 | |
Natural variantiVAR_067534 | 617 | V → I in THCYT3. 1 PublicationCorresponds to variant dbSNP:rs77375493EnsemblClinVar. | 1 | |
Natural variantiVAR_041721 | 1063 | R → H1 PublicationCorresponds to variant dbSNP:rs41316003EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF058925 mRNA Translation: AAC23982.1 AF001362 mRNA Translation: AAC23653.1 AF005216 mRNA Translation: AAB82092.1 AL161450 Genomic DNA No translation available. |
CCDSi | CCDS6457.1 |
PIRi | JW0091 |
RefSeqi | NP_001309123.1, NM_001322194.1 NP_001309124.1, NM_001322195.1 NP_001309125.1, NM_001322196.1 NP_001309133.1, NM_001322204.1 NP_004963.1, NM_004972.3 |
Genome annotation databases
Ensembli | ENST00000381652.4; ENSP00000371067.4; ENSG00000096968.14 |
GeneIDi | 3717 |
KEGGi | hsa:3717 |
MANE-Selecti | ENST00000381652.4; ENSP00000371067.4; NM_004972.4; NP_004963.1 |
UCSCi | uc003ziw.3, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF058925 mRNA Translation: AAC23982.1 AF001362 mRNA Translation: AAC23653.1 AF005216 mRNA Translation: AAB82092.1 AL161450 Genomic DNA No translation available. |
CCDSi | CCDS6457.1 |
PIRi | JW0091 |
RefSeqi | NP_001309123.1, NM_001322194.1 NP_001309124.1, NM_001322195.1 NP_001309125.1, NM_001322196.1 NP_001309133.1, NM_001322204.1 NP_004963.1, NM_004972.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B7A | X-ray | 2.00 | A/B | 840-1132 | [»] | |
2W1I | X-ray | 2.60 | A/B | 835-1132 | [»] | |
2XA4 | X-ray | 2.04 | A/B | 835-1132 | [»] | |
3E62 | X-ray | 1.92 | A | 839-1131 | [»] | |
3E63 | X-ray | 1.90 | A | 839-1131 | [»] | |
3E64 | X-ray | 1.80 | A | 839-1131 | [»] | |
3FUP | X-ray | 2.40 | A/B | 840-1132 | [»] | |
3IO7 | X-ray | 2.60 | A | 842-1132 | [»] | |
3IOK | X-ray | 2.10 | A | 842-1132 | [»] | |
3JY9 | X-ray | 2.10 | A | 842-1130 | [»] | |
3KCK | X-ray | 2.20 | A | 842-1132 | [»] | |
3KRR | X-ray | 1.80 | A | 840-1132 | [»] | |
3LPB | X-ray | 2.00 | A/B | 840-1132 | [»] | |
3Q32 | X-ray | 2.50 | A/B | 839-1132 | [»] | |
3RVG | X-ray | 2.50 | A | 835-1132 | [»] | |
3TJC | X-ray | 2.40 | A/B | 837-1132 | [»] | |
3TJD | X-ray | 2.90 | A/B | 837-1132 | [»] | |
3UGC | X-ray | 1.34 | A | 840-1132 | [»] | |
3ZMM | X-ray | 2.51 | A/B | 835-1132 | [»] | |
4AQC | X-ray | 1.90 | A/B | 835-1132 | [»] | |
4BBE | X-ray | 1.90 | A/B/C/D | 839-1132 | [»] | |
4BBF | X-ray | 2.00 | A/B/C/D | 839-1132 | [»] | |
4C61 | X-ray | 2.45 | A/B | 835-1132 | [»] | |
4C62 | X-ray | 2.75 | A/B | 835-1132 | [»] | |
4D0W | X-ray | 1.77 | A | 835-1132 | [»] | |
4D0X | X-ray | 1.82 | A | 835-1132 | [»] | |
4D1S | X-ray | 1.66 | A | 835-1132 | [»] | |
4E4M | X-ray | 2.25 | A/B/D/E | 833-1132 | [»] | |
4E6D | X-ray | 2.22 | A/B | 835-1132 | [»] | |
4E6Q | X-ray | 1.95 | A/B | 835-1132 | [»] | |
4F08 | X-ray | 2.82 | A/B | 833-1132 | [»] | |
4F09 | X-ray | 2.40 | A | 833-1132 | [»] | |
4FVP | X-ray | 2.01 | A | 536-812 | [»] | |
4FVQ | X-ray | 1.75 | A | 536-812 | [»] | |
4FVR | X-ray | 2.00 | A | 536-812 | [»] | |
4GFM | X-ray | 2.30 | A | 833-1132 | [»] | |
4GMY | X-ray | 2.40 | A | 833-1132 | [»] | |
4HGE | X-ray | 2.30 | A/B | 833-1132 | [»] | |
4IVA | X-ray | 1.50 | A | 833-1132 | [»] | |
4JI9 | X-ray | 2.40 | A/B | 833-1132 | [»] | |
4JIA | X-ray | 1.85 | A | 833-1132 | [»] | |
4P7E | X-ray | 2.40 | A/B | 840-1132 | [»] | |
4YTC | X-ray | 2.16 | A | 842-1132 | [»] | |
4YTF | X-ray | 1.78 | A | 842-1132 | [»] | |
4YTH | X-ray | 2.04 | A | 842-1132 | [»] | |
4YTI | X-ray | 2.52 | A | 842-1132 | [»] | |
4Z32 | X-ray | 3.04 | A/B/C/D/E/F/G/H | 31-516 | [»] | |
4ZIM | X-ray | 2.65 | A/B | 839-1132 | [»] | |
5AEP | X-ray | 1.95 | A | 835-1132 | [»] | |
5CF4 | X-ray | 2.38 | A/B | 839-1132 | [»] | |
5CF5 | X-ray | 2.45 | A/B | 839-1132 | [»] | |
5CF6 | X-ray | 2.50 | A/B | 839-1132 | [»] | |
5CF8 | X-ray | 1.80 | A/B | 839-1132 | [»] | |
5HEZ | X-ray | 2.66 | A/B/C/D | 833-1132 | [»] | |
5I4N | X-ray | 1.54 | A | 535-812 | [»] | |
5L3A | X-ray | 1.98 | A | 840-1132 | [»] | |
5TQ3 | X-ray | 2.69 | A/B | 837-1132 | [»] | |
5TQ4 | X-ray | 2.30 | A | 837-1132 | [»] | |
5TQ5 | X-ray | 2.30 | A | 837-1132 | [»] | |
5TQ6 | X-ray | 2.06 | A/B | 837-1132 | [»] | |
5TQ7 | X-ray | 2.10 | A/B | 837-1132 | [»] | |
5TQ8 | X-ray | 1.59 | A | 837-1132 | [»] | |
5USY | X-ray | 2.00 | A/B | 840-1132 | [»] | |
5USZ | X-ray | 2.10 | A | 536-812 | [»] | |
5UT0 | X-ray | 2.10 | A | 536-812 | [»] | |
5UT1 | X-ray | 1.95 | A | 536-812 | [»] | |
5UT2 | X-ray | 1.75 | A | 536-812 | [»] | |
5UT3 | X-ray | 1.50 | A | 536-812 | [»] | |
5UT4 | X-ray | 2.00 | A | 536-812 | [»] | |
5UT5 | X-ray | 1.90 | A | 536-812 | [»] | |
5UT6 | X-ray | 1.65 | A | 536-812 | [»] | |
5WEV | X-ray | 1.85 | A | 833-1132 | [»] | |
5WIJ | X-ray | 2.04 | A | 536-812 | [»] | |
5WIK | X-ray | 2.60 | B | 536-812 | [»] | |
5WIL | X-ray | 2.20 | A | 536-812 | [»] | |
5WIM | X-ray | 2.55 | A | 536-812 | [»] | |
5WIN | X-ray | 2.38 | A | 536-812 | [»] | |
6AAJ | X-ray | 2.37 | A/B | 834-1132 | [»] | |
6BBV | X-ray | 1.80 | A | 837-1132 | [»] | |
6BRW | X-ray | 2.03 | A | 536-812 | [»] | |
6BS0 | X-ray | 1.54 | A | 536-812 | [»] | |
6BSS | X-ray | 2.10 | A | 536-812 | [»] | |
6D2I | X-ray | 3.19 | A/B | 536-808 | [»] | |
6DRW | X-ray | 2.30 | A | 840-1132 | [»] | |
6E2P | X-ray | 2.83 | A/B | 36-514 | [»] | |
6E2Q | X-ray | 2.65 | A/B/C/D | 36-514 | [»] | |
6G3C | X-ray | 1.60 | A/B | 537-808 | [»] | |
6M9H | X-ray | 1.79 | A | 536-812 | [»] | |
6OAV | X-ray | 1.94 | A | 536-812 | [»] | |
6OBB | X-ray | 1.90 | A | 536-812 | [»] | |
6OBF | X-ray | 1.71 | A | 536-812 | [»] | |
6OBL | X-ray | 2.06 | A | 536-812 | [»] | |
6OCC | X-ray | 2.03 | A | 536-812 | [»] | |
6TPD | X-ray | 1.99 | A | 842-1130 | [»] | |
6VGL | X-ray | 1.90 | A/B/C/D | 840-1132 | [»] | |
6VN8 | X-ray | 1.90 | A/B | 840-1132 | [»] | |
6VNB | X-ray | 2.19 | A/B | 840-1132 | [»] | |
6VNC | X-ray | 2.30 | A/B | 840-1132 | [»] | |
6VNE | X-ray | 2.32 | A/B | 840-1132 | [»] | |
6VNF | X-ray | 2.06 | A/B | 840-1132 | [»] | |
6VNG | X-ray | 2.50 | A/B | 840-1132 | [»] | |
6VNH | X-ray | 2.40 | A/B | 840-1132 | [»] | |
6VNI | X-ray | 2.10 | A/B | 840-1132 | [»] | |
6VNJ | X-ray | 1.90 | A/B | 840-1132 | [»] | |
6VNK | X-ray | 2.00 | A/B/C/D | 840-1132 | [»] | |
6VNL | X-ray | 2.40 | A/B/C/D | 840-1132 | [»] | |
6VNM | X-ray | 2.20 | A/B | 840-1132 | [»] | |
6VS3 | X-ray | 2.00 | A/B | 840-1132 | [»] | |
6VSN | X-ray | 2.50 | A/B/C/D | 840-1132 | [»] | |
6WTN | X-ray | 1.83 | A | 835-1132 | [»] | |
6WTO | X-ray | 1.74 | A | 835-1132 | [»] | |
6WTP | X-ray | 2.50 | A | 835-1132 | [»] | |
6WTQ | X-ray | 1.80 | A | 835-1132 | [»] | |
6X8E | X-ray | 1.75 | A/B | 837-1132 | [»] | |
6XJK | X-ray | 2.02 | A | 536-812 | [»] | |
7JYO | X-ray | 2.16 | A | 536-812 | [»] | |
7JYQ | X-ray | 1.86 | A | 536-812 | [»] | |
7LL4 | X-ray | 1.31 | A | 839-1132 | [»] | |
7LL5 | X-ray | 1.50 | A | 840-1132 | [»] | |
7REE | X-ray | 1.38 | A | 839-1132 | [»] | |
7RN6 | X-ray | 1.50 | A | 839-1132 | [»] | |
AlphaFoldDBi | O60674 | |||||
SMRi | O60674 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109920, 148 interactors |
ComplexPortali | CPX-382, Interleukin-12-receptor complex CPX-383, Interleukin-23-receptor complex CPX-512, Granulocyte-macrophage colony-stimulating factor-receptor complex CPX-6015, Interferon gamma receptor-ligand complex |
CORUMi | O60674 |
DIPi | DIP-33880N |
IntActi | O60674, 43 interactors |
MINTi | O60674 |
STRINGi | 9606.ENSP00000371067 |
Chemistry databases
BindingDBi | O60674 |
ChEMBLi | CHEMBL2971 |
DrugBanki | DB04716, 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one DB07162, 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide DB08067, 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM DB07161, 5-phenyl-1H-indazol-3-amine DB11817, Baricitinib DB11986, Entrectinib DB12500, Fedratinib DB12010, Fostamatinib DB15822, Pralsetinib DB08877, Ruxolitinib DB08895, Tofacitinib DB05243, XL019 DB15035, Zanubrutinib |
DrugCentrali | O60674 |
GuidetoPHARMACOLOGYi | 2048 |
PTM databases
iPTMneti | O60674 |
PhosphoSitePlusi | O60674 |
Genetic variation databases
BioMutai | JAK2 |
Proteomic databases
CPTACi | CPTAC-1252 |
EPDi | O60674 |
jPOSTi | O60674 |
MassIVEi | O60674 |
MaxQBi | O60674 |
PaxDbi | O60674 |
PeptideAtlasi | O60674 |
PRIDEi | O60674 |
ProteomicsDBi | 49519 |
Protocols and materials databases
Antibodypediai | 24086, 1211 antibodies from 48 providers |
DNASUi | 3717 |
Genome annotation databases
Ensembli | ENST00000381652.4; ENSP00000371067.4; ENSG00000096968.14 |
GeneIDi | 3717 |
KEGGi | hsa:3717 |
MANE-Selecti | ENST00000381652.4; ENSP00000371067.4; NM_004972.4; NP_004963.1 |
UCSCi | uc003ziw.3, human |
Organism-specific databases
CTDi | 3717 |
DisGeNETi | 3717 |
GeneCardsi | JAK2 |
HGNCi | HGNC:6192, JAK2 |
HPAi | ENSG00000096968, Low tissue specificity |
MalaCardsi | JAK2 |
MIMi | 147796, gene 254450, phenotype 263300, phenotype 600880, phenotype 601626, phenotype 614521, phenotype |
neXtProti | NX_O60674 |
OpenTargetsi | ENSG00000096968 |
Orphaneti | 131, Budd-Chiari syndrome 3318, Essential thrombocythemia 71493, Familial thrombocytosis 729, Polycythemia vera 824, Primary myelofibrosis |
PharmGKBi | PA29989 |
VEuPathDBi | HostDB:ENSG00000096968 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000155640 |
HOGENOMi | CLU_008155_1_0_1 |
InParanoidi | O60674 |
OMAi | ICAVACK |
OrthoDBi | 58906at2759 |
PhylomeDBi | O60674 |
TreeFami | TF327041 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | O60674 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-110056, MAPK3 (ERK1) activation R-HSA-112411, MAPK1 (ERK2) activation R-HSA-1170546, Prolactin receptor signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-2586552, Signaling by Leptin R-HSA-3214858, RMTs methylate histone arginines R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-5673000, RAF activation R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-6788467, IL-6-type cytokine receptor ligand interactions R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-69231, Cyclin D associated events in G1 R-HSA-877300, Interferon gamma signaling R-HSA-877312, Regulation of IFNG signaling R-HSA-8854691, Interleukin-20 family signaling R-HSA-8984722, Interleukin-35 Signalling R-HSA-9006335, Signaling by Erythropoietin R-HSA-9020591, Interleukin-12 signaling R-HSA-9020933, Interleukin-23 signaling R-HSA-9020956, Interleukin-27 signaling R-HSA-9027276, Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027277, Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027283, Erythropoietin activates STAT5 R-HSA-9027284, Erythropoietin activates RAS R-HSA-912526, Interleukin receptor SHC signaling R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9674555, Signaling by CSF3 (G-CSF) R-HSA-9679191, Potential therapeutics for SARS R-HSA-9705462, Inactivation of CSF3 (G-CSF) signaling R-HSA-982772, Growth hormone receptor signaling R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | O60674 |
SIGNORi | O60674 |
Miscellaneous databases
BioGRID-ORCSi | 3717, 29 hits in 1121 CRISPR screens |
ChiTaRSi | JAK2, human |
EvolutionaryTracei | O60674 |
GeneWikii | Janus_kinase_2 |
GenomeRNAii | 3717 |
Pharosi | O60674, Tclin |
PROi | PR:O60674 |
RNActi | O60674, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000096968, Expressed in calcaneal tendon and 223 other tissues |
ExpressionAtlasi | O60674, baseline and differential |
Genevisiblei | O60674, HS |
Family and domain databases
CDDi | cd13333, FERM_C_JAK2, 1 hit cd05078, PTK_Jak2_rpt1, 1 hit cd14205, PTKc_Jak2_rpt2, 1 hit cd10379, SH2_Jak2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR035963, FERM_2 IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR037838, JAK2_FERM_C-lobe IPR035860, JAK2_SH2 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR035588, PTK_Jak2_rpt1 IPR035589, PTKc_Jak2_rpt2 IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020693, Tyr_kinase_non-rcpt_Jak2 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits PF00017, SH2, 1 hit |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01825, JANUSKINASE2 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JAK2_HUMAN | |
Accessioni | O60674Primary (citable) accession number: O60674 Secondary accession number(s): O14636, O75297 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 24, 2001 | |
Last modified: | May 25, 2022 | |
This is version 231 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families