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Entry version 171 (08 May 2019)
Sequence version 2 (03 Apr 2007)
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Protein

DNA polymerase zeta catalytic subunit

Gene

REV3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.31 min(-1) for DNA synthesis by Pol-zeta4. kcat is 0.05 min(-1) for DNA synthesis by Pol-zeta2.1 Publication
  1. KM=5.71 µM for dATP (for Pol-zeta2)
  2. KM=1.17 µM for dATP (for Pol-zeta4)

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3042ZincBy similarity1
    Metal bindingi3045ZincBy similarity1
    Metal bindingi3054ZincBy similarity1
    Metal bindingi3057ZincBy similarity1
    Metal bindingi3086Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi3089Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi3099Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi3104Iron-sulfur (4Fe-4S)By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3042 – 3057CysA-typeAdd BLAST16

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
    Biological processDNA damage, DNA repair, DNA replication
    Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-110312 Translesion synthesis by REV1
    R-HSA-5655862 Translesion synthesis by POLK
    R-HSA-5656121 Translesion synthesis by POLI

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    DNA polymerase zeta catalytic subunit (EC:2.7.7.7)
    Alternative name(s):
    Protein reversionless 3-like
    Short name:
    REV3-like
    Short name:
    hREV3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:REV3L
    Synonyms:POLZ, REV3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:9968 REV3L

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602776 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O60673

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2614D → N: Loss of DNA polymerase catalytic activity; when associated with N-2783. 1 Publication1
    Mutagenesisi2783D → N: Loss of DNA polymerase catalytic activity; when associated with N-2614. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5980

    MalaCards human disease database

    More...
    MalaCardsi
    REV3L

    Open Targets

    More...
    OpenTargetsi
    ENSG00000009413

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    570 Moebius syndrome

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA34337

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    REV3L

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000464681 – 3130DNA polymerase zeta catalytic subunitAdd BLAST3130

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1030PhosphoserineCombined sources1
    Modified residuei1041PhosphothreonineCombined sources1
    Modified residuei1724PhosphoserineCombined sources1
    Modified residuei1967PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O60673

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O60673

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O60673

    PeptideAtlas

    More...
    PeptideAtlasi
    O60673

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O60673

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    49517
    49518 [O60673-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O60673

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O60673

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitously expressed.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000009413 Expressed in 227 organ(s), highest expression level in female reproductive system

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O60673 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O60673 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA064853
    HPA069382

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAD2L2Q9UI955EBI-2871302,EBI-77889

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    111912, 30 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    O60673

    Protein interaction database and analysis system

    More...
    IntActi
    O60673, 11 interactors

    Molecular INTeraction database

    More...
    MINTi
    O60673

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000351697

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    13130
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3ABDX-ray1.90X/Y1847-1898[»]
    3ABEX-ray2.60Z1847-1898[»]
    3VU7X-ray2.80Z1847-1898[»]
    4EXTX-ray1.90B1873-1895[»]
    4GK0X-ray2.70C/D1847-1898[»]
    4GK5X-ray3.21C/D1847-1898[»]
    5O8KX-ray1.80B1873-1898[»]
    6BC8X-ray1.68B1987-2014[»]
    6BCDX-ray1.43B1987-2014[»]
    6BI7X-ray2.80B/D/F/H1987-2014[»]
    6EKMX-ray2.76B1989-2014[»]

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O60673

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    O60673

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1847 – 1898Mediates interaction with MAD2L21 PublicationAdd BLAST52

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3086 – 3104CysB motifAdd BLAST19

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.
    The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.By similarity

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the DNA polymerase type-B family.Curated

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri3042 – 3057CysA-typeAdd BLAST16

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0968 Eukaryota
    COG0417 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156226

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000112263

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O60673

    KEGG Orthology (KO)

    More...
    KOi
    K02350

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    CSKCRSQ

    Database of Orthologous Groups

    More...
    OrthoDBi
    20210at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O60673

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF101072

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.132.60, 1 hit
    3.30.420.10, 1 hit
    3.90.1600.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006172 DNA-dir_DNA_pol_B
    IPR017964 DNA-dir_DNA_pol_B_CS
    IPR006133 DNA-dir_DNA_pol_B_exonuc
    IPR006134 DNA-dir_DNA_pol_B_multi_dom
    IPR042087 DNA_pol_B_C
    IPR023211 DNA_pol_palm_dom_sf
    IPR032757 DUF4683
    IPR030559 PolZ_Rev3
    IPR012337 RNaseH-like_sf
    IPR036397 RNaseH_sf
    IPR025687 Znf-C4pol

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR45812 PTHR45812, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00136 DNA_pol_B, 1 hit
    PF03104 DNA_pol_B_exo1, 2 hits
    PF15735 DUF4683, 1 hit
    PF14260 zf-C4pol, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00106 DNAPOLB

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00486 POLBc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53098 SSF53098, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00116 DNA_POLYMERASE_B, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: O60673-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MFSVRIVTAD YYMASPLQGL DTCQSPLTQA PVKKVPVVRV FGATPAGQKT
    60 70 80 90 100
    CLHLHGIFPY LYVPYDGYGQ QPESYLSQMA FSIDRALNVA LGNPSSTAQH
    110 120 130 140 150
    VFKVSLVSGM PFYGYHEKER HFMKIYLYNP TMVKRICELL QSGAIMNKFY
    160 170 180 190 200
    QPHEAHIPYL LQLFIDYNLY GMNLINLAAV KFRKARRKSN TLHATGSCKN
    210 220 230 240 250
    HLSGNSLADT LFRWEQDEIP SSLILEGVEP QSTCELEVDA VAADILNRLD
    260 270 280 290 300
    IEAQIGGNPG LQAIWEDEKQ RRRNRNETSQ MSQPESQDHR FVPATESEKK
    310 320 330 340 350
    FQKRLQEILK QNDFSVTLSG SVDYSDGSQE FSAELTLHSE VLSPEMLQCT
    360 370 380 390 400
    PANMVEVHKD KESSKGHTRH KVEEALINEE AILNLMENSQ TFQPLTQRLS
    410 420 430 440 450
    ESPVFMDSSP DEALVHLLAG LESDGYRGER NRMPSPCRSF GNNKYPQNSD
    460 470 480 490 500
    DEENEPQIEK EEMELSLVMS QRWDSNIEEH CAKKRSLCRN THRSSTEDDD
    510 520 530 540 550
    SSSGEEMEWS DNSLLLASLS IPQLDGTADE NSDNPLNNEN SRTHSSVIAT
    560 570 580 590 600
    SKLSVKPSIF HKDAATLEPS SSAKITFQCK HTSALSSHVL NKEDLIEDLS
    610 620 630 640 650
    QTNKNTEKGL DNSVTSFTNE STYSMKYPGS LSSTVHSENS HKENSKKEIL
    660 670 680 690 700
    PVSSCESSIF DYEEDIPSVT RQVPSRKYTN IRKIEKDSPF IHMHRHPNEN
    710 720 730 740 750
    TLGKNSFNFS DLNHSKNKVS SEGNEKGNST ALSSLFPSSF TENCELLSCS
    760 770 780 790 800
    GENRTMVHSL NSTADESGLN KLKIRYEEFQ EHKTEKPSLS QQAAHYMFFP
    810 820 830 840 850
    SVVLSNCLTR PQKLSPVTYK LQPGNKPSRL KLNKRKLAGH QETSTKSSET
    860 870 880 890 900
    GSTKDNFIQN NPCNSNPEKD NALASDLTKT TRGAFENKTP TDGFIDCHFG
    910 920 930 940 950
    DGTLETEQSF GLYGNKYTLR AKRKVNYETE DSESSFVTHN SKISLPHPME
    960 970 980 990 1000
    IGESLDGTLK SRKRRKMSKK LPPVIIKYII INRFRGRKNM LVKLGKIDSK
    1010 1020 1030 1040 1050
    EKQVILTEEK MELYKKLAPL KDFWPKVPDS PATKYPIYPL TPKKSHRRKS
    1060 1070 1080 1090 1100
    KHKSAKKKTG KQQRTNNENI KRTLSFRKKR SHAILSPPSP SYNAETEDCD
    1110 1120 1130 1140 1150
    LNYSDVMSKL GFLSERSTSP INSSPPRCWS PTDPRAEEIM AAAEKEAMLF
    1160 1170 1180 1190 1200
    KGPNVYKKTV NSRIGKTSRA RAQIKKSKAK LANPSIVTKK RNKRNQTNKL
    1210 1220 1230 1240 1250
    VDDGKKKPRA KQKTNEKGTS RKHTTLKDEK IKSQSGAEVK FVLKHQNVSE
    1260 1270 1280 1290 1300
    FASSSGGSQL LFKQKDMPLM GSAVDHPLSA SLPTGINAQQ KLSGCFSSFL
    1310 1320 1330 1340 1350
    ESKKSVDLQT FPSSRDDLHP SVVCNSIGPG VSKINVQRPH NQSAMFTLKE
    1360 1370 1380 1390 1400
    STLIQKNIFD LSNHLSQVAQ NTQISSGMSS KIEDNANNIQ RNYLSSIGKL
    1410 1420 1430 1440 1450
    SEYRNSLESK LDQAYTPNFL HCKDSQQQIV CIAEQSKHSE TCSPGNTASE
    1460 1470 1480 1490 1500
    ESQMPNNCFV TSLRSPIKQI AWEQKQRGFI LDMSNFKPER VKPRSLSEAI
    1510 1520 1530 1540 1550
    SQTKALSQCK NRNVSTPSAF GEGQSGLAVL KELLQKRQQK AQNANTTQDP
    1560 1570 1580 1590 1600
    LSNKHQPNKN ISGSLEHNKA NKRTRSVTSP RKPRTPRSTK QKEKIPKLLK
    1610 1620 1630 1640 1650
    VDSLNLQNSS QLDNSVSDDS PIFFSDPGFE SCYSLEDSLS PEHNYNFDIN
    1660 1670 1680 1690 1700
    TIGQTGFCSF YSGSQFVPAD QNLPQKFLSD AVQDLFPGQA IEKNEFLSHD
    1710 1720 1730 1740 1750
    NQKCDEDKHH TTDSASWIRS GTLSPEIFEK STIDSNENRR HNQWKNSFHP
    1760 1770 1780 1790 1800
    LTTRSNSIMD SFCVQQAEDC LSEKSRLNRS SVSKEVFLSL PQPNNSDWIQ
    1810 1820 1830 1840 1850
    GHTRKEMGQS LDSANTSFTA ILSSPDGELV DVACEDLELY VSRNNDMLTP
    1860 1870 1880 1890 1900
    TPDSSPRSTS SPSQSKNGSF TPRTANILKP LMSPPSREEI MATLLDHDLS
    1910 1920 1930 1940 1950
    ETIYQEPFCS NPSDVPEKPR EIGGRLLMVE TRLANDLAEF EGDFSLEGLR
    1960 1970 1980 1990 2000
    LWKTAFSAMT QNPRPGSPLR SGQGVVNKGS SNSPKMVEDK KIVIMPCKCA
    2010 2020 2030 2040 2050
    PSRQLVQVWL QAKEEYERSK KLPKTKPTGV VKSAENFSSS VNPDDKPVVP
    2060 2070 2080 2090 2100
    PKMDVSPCIL PTTAHTKEDV DNSQIALQAP TTGCSQTASE SQMLPPVASA
    2110 2120 2130 2140 2150
    SDPEKDEDDD DNYYISYSSP DSPVIPPWQQ PISPDSKALN GDDRPSSPVE
    2160 2170 2180 2190 2200
    ELPSLAFENF LKPIKDGIQK SPCSEPQEPL VISPINTRAR TGKCESLCFH
    2210 2220 2230 2240 2250
    STPIIQRKLL ERLPEAPGLS PLSTEPKTQK LSNKKGSNTD TLRRVLLTQA
    2260 2270 2280 2290 2300
    KNQFAAVNTP QKETSQIDGP SLNNTYGFKV SIQNLQEAKA LHEIQNLTLI
    2310 2320 2330 2340 2350
    SVELHARTRR DLEPDPEFDP ICALFYCISS DTPLPDTEKT ELTGVIVIDK
    2360 2370 2380 2390 2400
    DKTVFSQDIR YQTPLLIRSG ITGLEVTYAA DEKALFHEIA NIIKRYDPDI
    2410 2420 2430 2440 2450
    LLGYEIQMHS WGYLLQRAAA LSIDLCRMIS RVPDDKIENR FAAERDEYGS
    2460 2470 2480 2490 2500
    YTMSEINIVG RITLNLWRIM RNEVALTNYT FENVSFHVLH QRFPLFTFRV
    2510 2520 2530 2540 2550
    LSDWFDNKTD LYRWKMVDHY VSRVRGNLQM LEQLDLIGKT SEMARLFGIQ
    2560 2570 2580 2590 2600
    FLHVLTRGSQ YRVESMMLRI AKPMNYIPVT PSVQQRSQMR APQCVPLIME
    2610 2620 2630 2640 2650
    PESRFYSNSV LVLDFQSLYP SIVIAYNYCF STCLGHVENL GKYDEFKFGC
    2660 2670 2680 2690 2700
    TSLRVPPDLL YQVRHDITVS PNGVAFVKPS VRKGVLPRML EEILKTRFMV
    2710 2720 2730 2740 2750
    KQSMKAYKQD RALSRMLDAR QLGLKLIANV TFGYTSANFS GRMPCIEVGD
    2760 2770 2780 2790 2800
    SIVHKARETL ERAIKLVNDT KKWGARVVYG DTDSMFVLLK GATKEQSFKI
    2810 2820 2830 2840 2850
    GQEIAEAVTA TNPKPVKLKF EKVYLPCVLQ TKKRYVGYMY ETLDQKDPVF
    2860 2870 2880 2890 2900
    DAKGIETVRR DSCPAVSKIL ERSLKLLFET RDISLIKQYV QRQCMKLLEG
    2910 2920 2930 2940 2950
    KASIQDFIFA KEYRGSFSYK PGACVPALEL TRKMLTYDRR SEPQVGERVP
    2960 2970 2980 2990 3000
    YVIIYGTPGV PLIQLVRRPV EVLQDPTLRL NATYYITKQI LPPLARIFSL
    3010 3020 3030 3040 3050
    IGIDVFSWYH ELPRIHKATS SSRSEPEGRK GTISQYFTTL HCPVCDDLTQ
    3060 3070 3080 3090 3100
    HGICSKCRSQ PQHVAVILNQ EIRELERQQE QLVKICKNCT GCFDRHIPCV
    3110 3120 3130
    SLNCPVLFKL SRVNRELSKA PYLRQLLDQF
    Length:3,130
    Mass (Da):352,776
    Last modified:April 3, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FBAA214639DF3C6
    GO
    Isoform 2 (identifier: O60673-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-78: Missing.

    Show »
    Length:3,052
    Mass (Da):344,154
    Checksum:iB6983F80F81AB4AF
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A087WZU4A0A087WZU4_HUMAN
    DNA polymerase zeta catalytic subun...
    REV3L
    323Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y5T4H0Y5T4_HUMAN
    DNA polymerase zeta catalytic subun...
    REV3L
    184Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F2Z3A1F2Z3A1_HUMAN
    DNA polymerase zeta catalytic subun...
    REV3L
    47Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti237E → Q in AAC28460 (PubMed:9925914).Curated1
    Sequence conflicti237E → Q in AAB88486 (PubMed:10660610).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_008516231Q → H2 PublicationsCorresponds to variant dbSNP:rs1053911Ensembl.1
    Natural variantiVAR_008517389S → T. 1
    Natural variantiVAR_022226397Q → P1 PublicationCorresponds to variant dbSNP:rs3218579Ensembl.1
    Natural variantiVAR_048883633S → G. Corresponds to variant dbSNP:rs3218598Ensembl.1
    Natural variantiVAR_022227693M → T1 PublicationCorresponds to variant dbSNP:rs3218593Ensembl.1
    Natural variantiVAR_022228962R → Q1 PublicationCorresponds to variant dbSNP:rs17539588Ensembl.1
    Natural variantiVAR_0222291156Y → C3 PublicationsCorresponds to variant dbSNP:rs458017Ensembl.1
    Natural variantiVAR_0488841220S → L. Corresponds to variant dbSNP:rs3218600Ensembl.1
    Natural variantiVAR_0222301224T → I6 PublicationsCorresponds to variant dbSNP:rs462779Ensembl.1
    Natural variantiVAR_0488851284T → P. Corresponds to variant dbSNP:rs3218578Ensembl.1
    Natural variantiVAR_0222311302S → T1 PublicationCorresponds to variant dbSNP:rs3218597Ensembl.1
    Natural variantiVAR_0222321309Q → H1 PublicationCorresponds to variant dbSNP:rs3218595Ensembl.1
    Natural variantiVAR_0222331339P → T1 PublicationCorresponds to variant dbSNP:rs17539616Ensembl.1
    Natural variantiVAR_0222341469Q → P1 PublicationCorresponds to variant dbSNP:rs3218572Ensembl.1
    Natural variantiVAR_0085181540K → E2 PublicationsCorresponds to variant dbSNP:rs1053913Ensembl.1
    Natural variantiVAR_0222351576S → L1 PublicationCorresponds to variant dbSNP:rs3218582Ensembl.1
    Natural variantiVAR_0222361713D → N1 PublicationCorresponds to variant dbSNP:rs3218585Ensembl.1
    Natural variantiVAR_0222371724S → T1 PublicationCorresponds to variant dbSNP:rs17539644Ensembl.1
    Natural variantiVAR_0222381791P → S1 PublicationCorresponds to variant dbSNP:rs17539651Ensembl.1
    Natural variantiVAR_0222391812D → H1 PublicationCorresponds to variant dbSNP:rs3218599Ensembl.1
    Natural variantiVAR_0222401923G → R1 PublicationCorresponds to variant dbSNP:rs3218604Ensembl.1
    Natural variantiVAR_0222411970R → H1 PublicationCorresponds to variant dbSNP:rs3218606Ensembl.1
    Natural variantiVAR_0222422015E → V1 PublicationCorresponds to variant dbSNP:rs17539692Ensembl.1
    Natural variantiVAR_0222432075I → M1 PublicationCorresponds to variant dbSNP:rs17510963Ensembl.1
    Natural variantiVAR_0085192607S → T. 1
    Natural variantiVAR_0222442762R → Q1 PublicationCorresponds to variant dbSNP:rs3218592Ensembl.1
    Natural variantiVAR_0161473064V → I1 PublicationCorresponds to variant dbSNP:rs3204953Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0241211 – 78Missing in isoform 2. 1 PublicationAdd BLAST78

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF058701 mRNA Translation: AAC24357.1
    AF071798 mRNA Translation: AAC24009.1
    AF157476 mRNA Translation: AAD40184.1
    AF179428 mRNA Translation: AAG09402.1
    AF179429 mRNA Translation: AAG09403.1
    AF078695 mRNA Translation: AAC28460.1
    AY684169 Genomic DNA Translation: AAT74627.1
    AL080317 Genomic DNA No translation available.
    AL136310 Genomic DNA No translation available.
    AL512325 Genomic DNA No translation available.
    AF035537 mRNA Translation: AAB88486.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS5091.2 [O60673-1]
    CCDS69177.1 [O60673-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001273360.1, NM_001286431.1 [O60673-2]
    NP_001273361.1, NM_001286432.1 [O60673-2]
    NP_002903.3, NM_002912.4 [O60673-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000358835; ENSP00000351697; ENSG00000009413 [O60673-1]
    ENST00000368802; ENSP00000357792; ENSG00000009413 [O60673-1]
    ENST00000368805; ENSP00000357795; ENSG00000009413 [O60673-1]
    ENST00000435970; ENSP00000402003; ENSG00000009413 [O60673-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5980

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5980

    UCSC genome browser

    More...
    UCSCi
    uc003puy.6 human [O60673-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF058701 mRNA Translation: AAC24357.1
    AF071798 mRNA Translation: AAC24009.1
    AF157476 mRNA Translation: AAD40184.1
    AF179428 mRNA Translation: AAG09402.1
    AF179429 mRNA Translation: AAG09403.1
    AF078695 mRNA Translation: AAC28460.1
    AY684169 Genomic DNA Translation: AAT74627.1
    AL080317 Genomic DNA No translation available.
    AL136310 Genomic DNA No translation available.
    AL512325 Genomic DNA No translation available.
    AF035537 mRNA Translation: AAB88486.1
    CCDSiCCDS5091.2 [O60673-1]
    CCDS69177.1 [O60673-2]
    RefSeqiNP_001273360.1, NM_001286431.1 [O60673-2]
    NP_001273361.1, NM_001286432.1 [O60673-2]
    NP_002903.3, NM_002912.4 [O60673-1]

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3ABDX-ray1.90X/Y1847-1898[»]
    3ABEX-ray2.60Z1847-1898[»]
    3VU7X-ray2.80Z1847-1898[»]
    4EXTX-ray1.90B1873-1895[»]
    4GK0X-ray2.70C/D1847-1898[»]
    4GK5X-ray3.21C/D1847-1898[»]
    5O8KX-ray1.80B1873-1898[»]
    6BC8X-ray1.68B1987-2014[»]
    6BCDX-ray1.43B1987-2014[»]
    6BI7X-ray2.80B/D/F/H1987-2014[»]
    6EKMX-ray2.76B1989-2014[»]
    SMRiO60673
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111912, 30 interactors
    CORUMiO60673
    IntActiO60673, 11 interactors
    MINTiO60673
    STRINGi9606.ENSP00000351697

    PTM databases

    iPTMnetiO60673
    PhosphoSitePlusiO60673

    Polymorphism and mutation databases

    BioMutaiREV3L

    Proteomic databases

    jPOSTiO60673
    MaxQBiO60673
    PaxDbiO60673
    PeptideAtlasiO60673
    PRIDEiO60673
    ProteomicsDBi49517
    49518 [O60673-2]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000358835; ENSP00000351697; ENSG00000009413 [O60673-1]
    ENST00000368802; ENSP00000357792; ENSG00000009413 [O60673-1]
    ENST00000368805; ENSP00000357795; ENSG00000009413 [O60673-1]
    ENST00000435970; ENSP00000402003; ENSG00000009413 [O60673-2]
    GeneIDi5980
    KEGGihsa:5980
    UCSCiuc003puy.6 human [O60673-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5980
    DisGeNETi5980

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    REV3L

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0017582
    HGNCiHGNC:9968 REV3L
    HPAiHPA064853
    HPA069382
    MalaCardsiREV3L
    MIMi602776 gene
    neXtProtiNX_O60673
    OpenTargetsiENSG00000009413
    Orphaneti570 Moebius syndrome
    PharmGKBiPA34337

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0968 Eukaryota
    COG0417 LUCA
    GeneTreeiENSGT00940000156226
    HOGENOMiHOG000112263
    InParanoidiO60673
    KOiK02350
    OMAiCSKCRSQ
    OrthoDBi20210at2759
    PhylomeDBiO60673
    TreeFamiTF101072

    Enzyme and pathway databases

    ReactomeiR-HSA-110312 Translesion synthesis by REV1
    R-HSA-5655862 Translesion synthesis by POLK
    R-HSA-5656121 Translesion synthesis by POLI

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    REV3L human
    EvolutionaryTraceiO60673

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    REV3L

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5980

    Protein Ontology

    More...
    PROi
    PR:O60673

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000009413 Expressed in 227 organ(s), highest expression level in female reproductive system
    ExpressionAtlasiO60673 baseline and differential
    GenevisibleiO60673 HS

    Family and domain databases

    Gene3Di1.10.132.60, 1 hit
    3.30.420.10, 1 hit
    3.90.1600.10, 1 hit
    InterProiView protein in InterPro
    IPR006172 DNA-dir_DNA_pol_B
    IPR017964 DNA-dir_DNA_pol_B_CS
    IPR006133 DNA-dir_DNA_pol_B_exonuc
    IPR006134 DNA-dir_DNA_pol_B_multi_dom
    IPR042087 DNA_pol_B_C
    IPR023211 DNA_pol_palm_dom_sf
    IPR032757 DUF4683
    IPR030559 PolZ_Rev3
    IPR012337 RNaseH-like_sf
    IPR036397 RNaseH_sf
    IPR025687 Znf-C4pol
    PANTHERiPTHR45812 PTHR45812, 1 hit
    PfamiView protein in Pfam
    PF00136 DNA_pol_B, 1 hit
    PF03104 DNA_pol_B_exo1, 2 hits
    PF15735 DUF4683, 1 hit
    PF14260 zf-C4pol, 1 hit
    PRINTSiPR00106 DNAPOLB
    SMARTiView protein in SMART
    SM00486 POLBc, 1 hit
    SUPFAMiSSF53098 SSF53098, 1 hit
    PROSITEiView protein in PROSITE
    PS00116 DNA_POLYMERASE_B, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREV3L_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60673
    Secondary accession number(s): O43214, Q5TC33
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: April 3, 2007
    Last modified: May 8, 2019
    This is version 171 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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