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Protein

Cell cycle checkpoint protein RAD1

Gene

RAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 3'-5' exonuclease activity Source: UniProtKB
  • damaged DNA binding Source: ProtInc
  • exodeoxyribonuclease III activity Source: UniProtKB-EC

GO - Biological processi

  • cellular response to DNA damage stimulus Source: ProtInc
  • cellular response to ionizing radiation Source: UniProtKB
  • DNA damage checkpoint Source: UniProtKB
  • DNA repair Source: ProtInc
  • meiotic recombination checkpoint Source: UniProtKB
  • substantia nigra development Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60671

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell cycle checkpoint protein RAD1 (EC:3.1.11.21 Publication)
Short name:
hRAD1
Alternative name(s):
DNA repair exonuclease rad1 homolog
Rad1-like DNA damage checkpoint protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD1
Synonyms:REC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000113456.18

Human Gene Nomenclature Database

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HGNCi
HGNC:9806 RAD1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603153 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60671

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi226 – 233SLLKPSTK → AAAAAAAA: Abolishes association of the 9-1-1 complex with RAD17. 1 Publication8

Organism-specific databases

DisGeNET

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DisGeNETi
5810

Open Targets

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OpenTargetsi
ENSG00000113456

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34166

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3309116

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAD1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002250051 – 282Cell cycle checkpoint protein RAD1Add BLAST282

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60671

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60671

MaxQB - The MaxQuant DataBase

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MaxQBi
O60671

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60671

PeptideAtlas

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PeptideAtlasi
O60671

PRoteomics IDEntifications database

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PRIDEi
O60671

ProteomicsDB human proteome resource

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ProteomicsDBi
49514
49515 [O60671-2]
49516 [O60671-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60671

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60671

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000113456 Expressed in 243 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_RAD1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60671 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60671 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA006692

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1 (PubMed:10846170, PubMed:10884395). The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2 (PubMed:10846170, PubMed:10884395, PubMed:15314187, PubMed:15556996, PubMed:15871698, PubMed:15897895, PubMed:16216273). The 9-1-1 complex associates with the RAD17-RFC complex (PubMed:12578958). RAD1 interacts with POLB, FEN1, HUS1, HUS1B, RAD9A and RAD9B (PubMed:10359610, PubMed:10777662, PubMed:11944979, PubMed:14500360, PubMed:14611806, PubMed:15314187, PubMed:15556996, PubMed:16216273). Interacts with DNAJC7 (PubMed:11573955).14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111771, 19 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1829 Checkpoint clamp complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O60671

Database of interacting proteins

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DIPi
DIP-46061N

Protein interaction database and analysis system

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IntActi
O60671, 6 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000340879

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O60671

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A1JX-ray2.50C13-275[»]
3G65X-ray2.90B1-282[»]
3GGRX-ray3.20C1-282[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60671

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60671

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O60671

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rad1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3194 Eukaryota
ENOG410YHQU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00500000044913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000008015

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053058

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60671

KEGG Orthology (KO)

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KOi
K02830

Identification of Orthologs from Complete Genome Data

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OMAi
CKVSVRT

Database of Orthologous Groups

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OrthoDBi
1440961at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60671

TreeFam database of animal gene trees

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TreeFami
TF101211

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003011 Cell_cycle_checkpoint_Rad1
IPR003021 Rad1_Rec1_Rad17

The PANTHER Classification System

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PANTHERi
PTHR10870 PTHR10870, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02144 Rad1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01245 RAD1REC1
PR01246 RAD1REPAIR

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O60671-1) [UniParc]FASTAAdd to basket
Also known as: Hrad1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLLTQQIQD EDDQYSLVAS LDNVRNLSTI LKAIHFREHA TCFATKNGIK
60 70 80 90 100
VTVENAKCVQ ANAFIQAGIF QEFKVQEESV TFRINLTVLL DCLSIFGSSP
110 120 130 140 150
MPGTLTALRM CYQGYGYPLM LFLEEGGVVT VCKINTQEPE ETLDFDFCST
160 170 180 190 200
NVINKIILQS EGLREAFSEL DMTSEVLQIT MSPDKPYFRL STFGNAGSSH
210 220 230 240 250
LDYPKDSDLM EAFHCNQTQV NRYKISLLKP STKALVLSCK VSIRTDNRGF
260 270 280
LSLQYMIRNE DGQICFVEYY CCPDEEVPES ES
Length:282
Mass (Da):31,827
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i075FBD4CF8A4FDB2
GO
Isoform 2 (identifier: O60671-2) [UniParc]FASTAAdd to basket
Also known as: Hrad1B

The sequence of this isoform differs from the canonical sequence as follows:
     67-102: Missing.

Show »
Length:246
Mass (Da):27,828
Checksum:iE96C130821B8D2D0
GO
Isoform 3 (identifier: O60671-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-68: AG → GL
     69-282: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:68
Mass (Da):7,576
Checksum:i12B4E5E1CA5B9703
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9A1D6R9A1_HUMAN
Cell cycle checkpoint protein RAD1
RAD1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC35550 differs from that shown. Reason: Frameshift at position 103.Curated
The sequence AAC35550 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA06249 differs from that shown. Reason: Frameshift at position 103.Curated
The sequence CAA06249 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135N → T in AAC95466 (PubMed:9828137).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05171833A → G. Corresponds to variant dbSNP:rs2308951Ensembl.1
Natural variantiVAR_05537639H → Q1 PublicationCorresponds to variant dbSNP:rs41271673Ensembl.1
Natural variantiVAR_051719104T → S. Corresponds to variant dbSNP:rs1805328Ensembl.1
Natural variantiVAR_051720114G → D. Corresponds to variant dbSNP:rs2308957Ensembl.1
Natural variantiVAR_051721281E → G1 PublicationCorresponds to variant dbSNP:rs1805327Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01733467 – 102Missing in isoform 2. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_01733567 – 68AG → GL in isoform 3. 1 Publication2
Alternative sequenceiVSP_01733669 – 282Missing in isoform 3. 1 PublicationAdd BLAST214

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF074717 mRNA Translation: AAC98093.1
AF073524 mRNA Translation: AAC95466.1
AF030933 mRNA Translation: AAC95427.1
AF076841 mRNA Translation: AAC95523.1
AF090170 mRNA Translation: AAC95603.1
AJ004974 mRNA Translation: CAA06248.1
AJ004975 mRNA Translation: CAA06249.1 Sequence problems.
AF011905 mRNA Translation: AAC27243.1
AF058392 mRNA Translation: AAC14138.1
AF084512 mRNA Translation: AAC35549.1
AF084513 mRNA Translation: AAC35550.1 Sequence problems.
AK002112 mRNA Translation: BAG51017.1
BT006908 mRNA Translation: AAP35554.1
DQ451401 Genomic DNA Translation: ABD96829.1
CH471119 Genomic DNA Translation: EAW55904.1
BC006837 mRNA Translation: AAH06837.1
BC009804 mRNA Translation: AAH09804.1
BC037857 mRNA Translation: AAH37857.1
AB183821 Genomic DNA Translation: BAD86789.1
AB183822 Genomic DNA Translation: BAD86790.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3905.1 [O60671-1]

NCBI Reference Sequences

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RefSeqi
NP_002844.1, NM_002853.3 [O60671-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.38114

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000325577; ENSP00000313467; ENSG00000113456 [O60671-3]
ENST00000341754; ENSP00000340879; ENSG00000113456 [O60671-1]
ENST00000382038; ENSP00000371469; ENSG00000113456 [O60671-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5810

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5810

UCSC genome browser

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UCSCi
uc003jix.4 human [O60671-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074717 mRNA Translation: AAC98093.1
AF073524 mRNA Translation: AAC95466.1
AF030933 mRNA Translation: AAC95427.1
AF076841 mRNA Translation: AAC95523.1
AF090170 mRNA Translation: AAC95603.1
AJ004974 mRNA Translation: CAA06248.1
AJ004975 mRNA Translation: CAA06249.1 Sequence problems.
AF011905 mRNA Translation: AAC27243.1
AF058392 mRNA Translation: AAC14138.1
AF084512 mRNA Translation: AAC35549.1
AF084513 mRNA Translation: AAC35550.1 Sequence problems.
AK002112 mRNA Translation: BAG51017.1
BT006908 mRNA Translation: AAP35554.1
DQ451401 Genomic DNA Translation: ABD96829.1
CH471119 Genomic DNA Translation: EAW55904.1
BC006837 mRNA Translation: AAH06837.1
BC009804 mRNA Translation: AAH09804.1
BC037857 mRNA Translation: AAH37857.1
AB183821 Genomic DNA Translation: BAD86789.1
AB183822 Genomic DNA Translation: BAD86790.1
CCDSiCCDS3905.1 [O60671-1]
RefSeqiNP_002844.1, NM_002853.3 [O60671-1]
UniGeneiHs.38114

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A1JX-ray2.50C13-275[»]
3G65X-ray2.90B1-282[»]
3GGRX-ray3.20C1-282[»]
ProteinModelPortaliO60671
SMRiO60671
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111771, 19 interactors
ComplexPortaliCPX-1829 Checkpoint clamp complex
CORUMiO60671
DIPiDIP-46061N
IntActiO60671, 6 interactors
STRINGi9606.ENSP00000340879

Chemistry databases

BindingDBiO60671
ChEMBLiCHEMBL3309116

PTM databases

iPTMnetiO60671
PhosphoSitePlusiO60671

Polymorphism and mutation databases

BioMutaiRAD1

Proteomic databases

EPDiO60671
jPOSTiO60671
MaxQBiO60671
PaxDbiO60671
PeptideAtlasiO60671
PRIDEiO60671
ProteomicsDBi49514
49515 [O60671-2]
49516 [O60671-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5810
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325577; ENSP00000313467; ENSG00000113456 [O60671-3]
ENST00000341754; ENSP00000340879; ENSG00000113456 [O60671-1]
ENST00000382038; ENSP00000371469; ENSG00000113456 [O60671-1]
GeneIDi5810
KEGGihsa:5810
UCSCiuc003jix.4 human [O60671-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5810
DisGeNETi5810
EuPathDBiHostDB:ENSG00000113456.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RAD1
HGNCiHGNC:9806 RAD1
HPAiHPA006692
MIMi603153 gene
neXtProtiNX_O60671
OpenTargetsiENSG00000113456
PharmGKBiPA34166

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3194 Eukaryota
ENOG410YHQU LUCA
GeneTreeiENSGT00500000044913
HOGENOMiHOG000008015
HOVERGENiHBG053058
InParanoidiO60671
KOiK02830
OMAiCKVSVRT
OrthoDBi1440961at2759
PhylomeDBiO60671
TreeFamiTF101211

Enzyme and pathway databases

ReactomeiR-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SIGNORiO60671

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAD1 human
EvolutionaryTraceiO60671

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAD1_homolog

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5810

Protein Ontology

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PROi
PR:O60671

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113456 Expressed in 243 organ(s), highest expression level in secondary oocyte
CleanExiHS_RAD1
ExpressionAtlasiO60671 baseline and differential
GenevisibleiO60671 HS

Family and domain databases

InterProiView protein in InterPro
IPR003011 Cell_cycle_checkpoint_Rad1
IPR003021 Rad1_Rec1_Rad17
PANTHERiPTHR10870 PTHR10870, 1 hit
PfamiView protein in Pfam
PF02144 Rad1, 1 hit
PRINTSiPR01245 RAD1REC1
PR01246 RAD1REPAIR

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60671
Secondary accession number(s): O75572
, O95304, Q1W161, Q5KSM0, Q5KSM1, Q9UEP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 1, 1998
Last modified: January 16, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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