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Protein

Monocarboxylate transporter 2

Gene

SLC16A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lactate transmembrane transporter activity Source: UniProtKB
  • monocarboxylic acid transmembrane transporter activity Source: GO_Central
  • pyruvate secondary active transmembrane transporter activity Source: ProtInc
  • pyruvate transmembrane transporter activity Source: UniProtKB
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • lactate transmembrane transport Source: UniProtKB
  • monocarboxylic acid transport Source: GO_Central
  • pyruvate transmembrane transport Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-433692 Proton-coupled monocarboxylate transport

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O60669

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.13.5 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Monocarboxylate transporter 2
Short name:
MCT 2
Alternative name(s):
Solute carrier family 16 member 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC16A7
Synonyms:MCT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118596.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10928 SLC16A7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603654 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60669

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 59ExtracellularSequence analysisAdd BLAST23
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 89CytoplasmicSequence analysis9
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 115ExtracellularSequence analysis5
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 148CytoplasmicSequence analysisAdd BLAST12
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 173ExtracellularSequence analysis4
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 246CytoplasmicSequence analysisAdd BLAST52
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 282ExtracellularSequence analysisAdd BLAST15
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 312CytoplasmicSequence analysis9
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 338ExtracellularSequence analysis5
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 373CytoplasmicSequence analysisAdd BLAST14
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 406ExtracellularSequence analysisAdd BLAST12
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 478CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9194

Open Targets

More...
OpenTargetsi
ENSG00000118596

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35819

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073704

Drug and drug target database

More...
DrugBanki
DB04319 6-Deoxyglucose
DB01762 Acetoacetic Acid
DB04074 Alpha-ketoisovalerate
DB03066 D-Lactic Acid
DB01440 Gamma Hydroxybutyric Acid
DB04398 Lactic Acid
DB04552 Niflumic Acid
DB01032 Probenecid
DB00119 Pyruvic acid
DB04216 Quercetin

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
990

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC16A7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002113851 – 478Monocarboxylate transporter 2Add BLAST478

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60669

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60669

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60669

PeptideAtlas

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PeptideAtlasi
O60669

PRoteomics IDEntifications database

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PRIDEi
O60669

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49513

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60669

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60669

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118596 Expressed in 236 organ(s), highest expression level in heart left ventricle

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC16A7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60669 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60669 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005911

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GRID2IP.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114629, 2 interactors

Protein interaction database and analysis system

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IntActi
O60669, 13 interactors

Molecular INTeraction database

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MINTi
O60669

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261187

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60669

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMVS Eukaryota
ENOG4111F0K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157309

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000280688

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006384

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60669

KEGG Orthology (KO)

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KOi
K08184

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQYKYMY

Database of Orthologous Groups

More...
OrthoDBi
916876at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60669

TreeFam database of animal gene trees

More...
TreeFami
TF313792

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004743 MCT
IPR027178 MCT2
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11360:SF25 PTHR11360:SF25, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690 MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00892 2A0113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

O60669-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI
60 70 80 90 100
FHTTYSEIAW ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM
110 120 130 140 150
VLASFSSSVV QLYLTMGFIT GLGLAFNLQP ALTIIGKYFY RKRPMANGLA
160 170 180 190 200
MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI LGSLLLNACV AGSLMRPLGP
210 220 230 240 250
NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS LFKHRGFLIY
260 270 280 290 300
LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV
310 320 330 340 350
GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG
360 370 380 390 400
FGSVSSVLFE TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT
410 420 430 440 450
GEYKYMYMSC GAIVVAASVW LLIGNAINYR LLAKERKEEN ARQKTRESEP
460 470
LSKSKHSEDV NVKVSNAQSV TSERETNI
Length:478
Mass (Da):52,200
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE508D650E8D7DE98
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W0N3F8W0N3_HUMAN
Monocarboxylate transporter 2
SLC16A7
435Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS95F8VS95_HUMAN
Monocarboxylate transporter 2
SLC16A7
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXG4F8VXG4_HUMAN
Monocarboxylate transporter 2
SLC16A7
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1M4F8W1M4_HUMAN
Monocarboxylate transporter 2
SLC16A7
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYZ2F8VYZ2_HUMAN
Monocarboxylate transporter 2
SLC16A7
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQS4F8VQS4_HUMAN
Monocarboxylate transporter 2
SLC16A7
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0U4F8W0U4_HUMAN
Monocarboxylate transporter 2
SLC16A7
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVU7F8VVU7_HUMAN
Monocarboxylate transporter 2
SLC16A7
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26A → T in AAC70919 (Ref. 2) Curated1
Sequence conflicti154S → N in AAC70919 (Ref. 2) Curated1
Sequence conflicti268L → P in AAC70919 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031660445T → S1 PublicationCorresponds to variant dbSNP:rs3763980Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF049608 mRNA Translation: AAC70919.1
AF058056 mRNA Translation: AAC13721.1
AK313345 mRNA Translation: BAG36148.1
AC079905 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97096.1
BC030693 mRNA Translation: AAH30693.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8961.1

NCBI Reference Sequences

More...
RefSeqi
NP_001257551.1, NM_001270622.1
NP_001257552.1, NM_001270623.1
NP_004722.2, NM_004731.4
XP_005269288.1, XM_005269231.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.439643
Hs.88156

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261187; ENSP00000261187; ENSG00000118596
ENST00000547379; ENSP00000448071; ENSG00000118596
ENST00000552024; ENSP00000448742; ENSG00000118596
ENST00000552432; ENSP00000449547; ENSG00000118596

Database of genes from NCBI RefSeq genomes

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GeneIDi
9194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9194

UCSC genome browser

More...
UCSCi
uc001sqs.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049608 mRNA Translation: AAC70919.1
AF058056 mRNA Translation: AAC13721.1
AK313345 mRNA Translation: BAG36148.1
AC079905 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97096.1
BC030693 mRNA Translation: AAH30693.1
CCDSiCCDS8961.1
RefSeqiNP_001257551.1, NM_001270622.1
NP_001257552.1, NM_001270623.1
NP_004722.2, NM_004731.4
XP_005269288.1, XM_005269231.4
UniGeneiHs.439643
Hs.88156

3D structure databases

ProteinModelPortaliO60669
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114629, 2 interactors
IntActiO60669, 13 interactors
MINTiO60669
STRINGi9606.ENSP00000261187

Chemistry databases

ChEMBLiCHEMBL2073704
DrugBankiDB04319 6-Deoxyglucose
DB01762 Acetoacetic Acid
DB04074 Alpha-ketoisovalerate
DB03066 D-Lactic Acid
DB01440 Gamma Hydroxybutyric Acid
DB04398 Lactic Acid
DB04552 Niflumic Acid
DB01032 Probenecid
DB00119 Pyruvic acid
DB04216 Quercetin
GuidetoPHARMACOLOGYi990

Protein family/group databases

TCDBi2.A.1.13.5 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO60669
PhosphoSitePlusiO60669

Polymorphism and mutation databases

BioMutaiSLC16A7

Proteomic databases

EPDiO60669
jPOSTiO60669
PaxDbiO60669
PeptideAtlasiO60669
PRIDEiO60669
ProteomicsDBi49513

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9194
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261187; ENSP00000261187; ENSG00000118596
ENST00000547379; ENSP00000448071; ENSG00000118596
ENST00000552024; ENSP00000448742; ENSG00000118596
ENST00000552432; ENSP00000449547; ENSG00000118596
GeneIDi9194
KEGGihsa:9194
UCSCiuc001sqs.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9194
DisGeNETi9194
EuPathDBiHostDB:ENSG00000118596.11

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC16A7

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0010769
HGNCiHGNC:10928 SLC16A7
HPAiHPA005911
MIMi603654 gene
neXtProtiNX_O60669
OpenTargetsiENSG00000118596
PharmGKBiPA35819

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMVS Eukaryota
ENOG4111F0K LUCA
GeneTreeiENSGT00940000157309
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO60669
KOiK08184
OMAiGQYKYMY
OrthoDBi916876at2759
PhylomeDBiO60669
TreeFamiTF313792

Enzyme and pathway databases

ReactomeiR-HSA-433692 Proton-coupled monocarboxylate transport
SABIO-RKiO60669

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC16A7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9194

Protein Ontology

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PROi
PR:O60669

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118596 Expressed in 236 organ(s), highest expression level in heart left ventricle
CleanExiHS_SLC16A7
ExpressionAtlasiO60669 baseline and differential
GenevisibleiO60669 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR027178 MCT2
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF25 PTHR11360:SF25, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60669
Secondary accession number(s): Q8NEM3, Q9UPB3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: January 16, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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