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Protein

Monocarboxylate transporter 2

Gene

SLC16A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

  • lactate transmembrane transport Source: UniProtKB
  • pyruvate transmembrane transport Source: UniProtKB

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-433692 Proton-coupled monocarboxylate transport
SABIO-RKiO60669

Protein family/group databases

TCDBi2.A.1.13.5 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 2
Short name:
MCT 2
Alternative name(s):
Solute carrier family 16 member 7
Gene namesi
Name:SLC16A7
Synonyms:MCT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000118596.11
HGNCiHGNC:10928 SLC16A7
MIMi603654 gene
neXtProtiNX_O60669

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 59ExtracellularSequence analysisAdd BLAST23
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 89CytoplasmicSequence analysis9
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 115ExtracellularSequence analysis5
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 148CytoplasmicSequence analysisAdd BLAST12
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 173ExtracellularSequence analysis4
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 246CytoplasmicSequence analysisAdd BLAST52
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 282ExtracellularSequence analysisAdd BLAST15
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 312CytoplasmicSequence analysis9
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 338ExtracellularSequence analysis5
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 373CytoplasmicSequence analysisAdd BLAST14
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 406ExtracellularSequence analysisAdd BLAST12
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 478CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9194
OpenTargetsiENSG00000118596
PharmGKBiPA35819

Chemistry databases

ChEMBLiCHEMBL2073704
DrugBankiDB04319 6-Deoxyglucose
DB01762 Acetoacetic Acid
DB04074 Alpha-ketoisovalerate
DB03066 D-Lactic Acid
DB01440 Gamma Hydroxybutyric Acid
DB04398 Lactic Acid
DB04552 Niflumic Acid
DB01032 Probenecid
DB00119 Pyruvic acid
DB04216 Quercetin
GuidetoPHARMACOLOGYi990

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113851 – 478Monocarboxylate transporter 2Add BLAST478

Proteomic databases

EPDiO60669
PaxDbiO60669
PeptideAtlasiO60669
PRIDEiO60669
ProteomicsDBi49513

PTM databases

iPTMnetiO60669
PhosphoSitePlusiO60669

Expressioni

Tissue specificityi

Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000118596 Expressed in 236 organ(s), highest expression level in heart left ventricle
CleanExiHS_SLC16A7
ExpressionAtlasiO60669 baseline and differential
GenevisibleiO60669 HS

Organism-specific databases

HPAiHPA005911

Interactioni

Subunit structurei

Interacts with GRID2IP.By similarity

Protein-protein interaction databases

BioGridi114629, 2 interactors
IntActiO60669, 10 interactors
MINTiO60669
STRINGi9606.ENSP00000261187

Structurei

3D structure databases

ProteinModelPortaliO60669
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVS Eukaryota
ENOG4111F0K LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO60669
KOiK08184
OMAiQPALTMI
OrthoDBiEOG091G05SW
PhylomeDBiO60669
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR027178 MCT2
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF25 PTHR11360:SF25, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

O60669-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI
60 70 80 90 100
FHTTYSEIAW ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM
110 120 130 140 150
VLASFSSSVV QLYLTMGFIT GLGLAFNLQP ALTIIGKYFY RKRPMANGLA
160 170 180 190 200
MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI LGSLLLNACV AGSLMRPLGP
210 220 230 240 250
NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS LFKHRGFLIY
260 270 280 290 300
LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV
310 320 330 340 350
GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG
360 370 380 390 400
FGSVSSVLFE TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT
410 420 430 440 450
GEYKYMYMSC GAIVVAASVW LLIGNAINYR LLAKERKEEN ARQKTRESEP
460 470
LSKSKHSEDV NVKVSNAQSV TSERETNI
Length:478
Mass (Da):52,200
Last modified:November 30, 2010 - v2
Checksum:iE508D650E8D7DE98
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W0N3F8W0N3_HUMAN
Monocarboxylate transporter 2
SLC16A7
435Annotation score:
F8VS95F8VS95_HUMAN
Monocarboxylate transporter 2
SLC16A7
131Annotation score:
F8VXG4F8VXG4_HUMAN
Monocarboxylate transporter 2
SLC16A7
83Annotation score:
F8VYZ2F8VYZ2_HUMAN
Monocarboxylate transporter 2
SLC16A7
84Annotation score:
F8VQS4F8VQS4_HUMAN
Monocarboxylate transporter 2
SLC16A7
97Annotation score:
F8W0U4F8W0U4_HUMAN
Monocarboxylate transporter 2
SLC16A7
78Annotation score:
F8W1M4F8W1M4_HUMAN
Monocarboxylate transporter 2
SLC16A7
141Annotation score:
F8VVU7F8VVU7_HUMAN
Monocarboxylate transporter 2
SLC16A7
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26A → T in AAC70919 (Ref. 2) Curated1
Sequence conflicti154S → N in AAC70919 (Ref. 2) Curated1
Sequence conflicti268L → P in AAC70919 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031660445T → S1 PublicationCorresponds to variant dbSNP:rs3763980Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049608 mRNA Translation: AAC70919.1
AF058056 mRNA Translation: AAC13721.1
AK313345 mRNA Translation: BAG36148.1
AC079905 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97096.1
BC030693 mRNA Translation: AAH30693.1
CCDSiCCDS8961.1
RefSeqiNP_001257551.1, NM_001270622.1
NP_001257552.1, NM_001270623.1
NP_004722.2, NM_004731.4
XP_005269288.1, XM_005269231.4
UniGeneiHs.439643
Hs.88156

Genome annotation databases

EnsembliENST00000261187; ENSP00000261187; ENSG00000118596
ENST00000547379; ENSP00000448071; ENSG00000118596
ENST00000552024; ENSP00000448742; ENSG00000118596
ENST00000552432; ENSP00000449547; ENSG00000118596
GeneIDi9194
KEGGihsa:9194
UCSCiuc001sqs.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049608 mRNA Translation: AAC70919.1
AF058056 mRNA Translation: AAC13721.1
AK313345 mRNA Translation: BAG36148.1
AC079905 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97096.1
BC030693 mRNA Translation: AAH30693.1
CCDSiCCDS8961.1
RefSeqiNP_001257551.1, NM_001270622.1
NP_001257552.1, NM_001270623.1
NP_004722.2, NM_004731.4
XP_005269288.1, XM_005269231.4
UniGeneiHs.439643
Hs.88156

3D structure databases

ProteinModelPortaliO60669
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114629, 2 interactors
IntActiO60669, 10 interactors
MINTiO60669
STRINGi9606.ENSP00000261187

Chemistry databases

ChEMBLiCHEMBL2073704
DrugBankiDB04319 6-Deoxyglucose
DB01762 Acetoacetic Acid
DB04074 Alpha-ketoisovalerate
DB03066 D-Lactic Acid
DB01440 Gamma Hydroxybutyric Acid
DB04398 Lactic Acid
DB04552 Niflumic Acid
DB01032 Probenecid
DB00119 Pyruvic acid
DB04216 Quercetin
GuidetoPHARMACOLOGYi990

Protein family/group databases

TCDBi2.A.1.13.5 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO60669
PhosphoSitePlusiO60669

Proteomic databases

EPDiO60669
PaxDbiO60669
PeptideAtlasiO60669
PRIDEiO60669
ProteomicsDBi49513

Protocols and materials databases

DNASUi9194
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261187; ENSP00000261187; ENSG00000118596
ENST00000547379; ENSP00000448071; ENSG00000118596
ENST00000552024; ENSP00000448742; ENSG00000118596
ENST00000552432; ENSP00000449547; ENSG00000118596
GeneIDi9194
KEGGihsa:9194
UCSCiuc001sqs.5 human

Organism-specific databases

CTDi9194
DisGeNETi9194
EuPathDBiHostDB:ENSG00000118596.11
GeneCardsiSLC16A7
H-InvDBiHIX0010769
HGNCiHGNC:10928 SLC16A7
HPAiHPA005911
MIMi603654 gene
neXtProtiNX_O60669
OpenTargetsiENSG00000118596
PharmGKBiPA35819
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMVS Eukaryota
ENOG4111F0K LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO60669
KOiK08184
OMAiQPALTMI
OrthoDBiEOG091G05SW
PhylomeDBiO60669
TreeFamiTF313792

Enzyme and pathway databases

ReactomeiR-HSA-433692 Proton-coupled monocarboxylate transport
SABIO-RKiO60669

Miscellaneous databases

ChiTaRSiSLC16A7 human
GenomeRNAii9194
PROiPR:O60669
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118596 Expressed in 236 organ(s), highest expression level in heart left ventricle
CleanExiHS_SLC16A7
ExpressionAtlasiO60669 baseline and differential
GenevisibleiO60669 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR027178 MCT2
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF25 PTHR11360:SF25, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT2_HUMAN
AccessioniPrimary (citable) accession number: O60669
Secondary accession number(s): Q8NEM3, Q9UPB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: October 10, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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