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Protein

Fas apoptotic inhibitory molecule 3

Gene

FCMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.1 Publication

Miscellaneous

'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.

GO - Biological processi

  • cellular defense response Source: ProtInc
  • immune system process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: ProtInc

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 3Curated
Alternative name(s):
IgM Fc fragment receptorImported
Regulator of Fas-induced apoptosis Toso1 Publication
Gene namesi
Name:FCMRImported
Synonyms:FAIM3, TOSO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162894.11
HGNCiHGNC:14315 FCMR
MIMi606015 gene
neXtProtiNX_O60667

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 251ExtracellularSequence analysisAdd BLAST234
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 390CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9214
OpenTargetsiENSG00000162894
PharmGKBiPA142671899

Polymorphism and mutation databases

BioMutaiFAIM3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028442118 – 390Fas apoptotic inhibitory molecule 3Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 104By similarity
Modified residuei92PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO60667
PeptideAtlasiO60667
PRIDEiO60667
ProteomicsDBi49511
49512 [O60667-2]

PTM databases

iPTMnetiO60667
PhosphoSitePlusiO60667

Expressioni

Tissue specificityi

Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.2 Publications

Inductioni

By T-cell activation.1 Publication

Gene expression databases

BgeeiENSG00000162894 Expressed in 153 organ(s), highest expression level in blood
CleanExiHS_FAIM3
ExpressionAtlasiO60667 baseline and differential
GenevisibleiO60667 HS

Organism-specific databases

HPAiHPA003910

Interactioni

Protein-protein interaction databases

BioGridi114648, 3 interactors
IntActiO60667, 1 interactor
STRINGi9606.ENSP00000356058

Structurei

3D structure databases

ProteinModelPortaliO60667
SMRiO60667
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 105Ig-likeAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi274 – 323Arg-richAdd BLAST50

Domaini

The Ig-like domain is required for the anti-apoptotic ability.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ2J Eukaryota
ENOG41113GQ LUCA
GeneTreeiENSGT00530000063436
HOGENOMiHOG000013142
HOVERGENiHBG107910
InParanoidiO60667
OMAiTIECPLP
OrthoDBiEOG091G0K4T
PhylomeDBiO60667
TreeFamiTF338713

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60667-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFWLWPLYF LPVSGALRIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR
60 70 80 90 100
EMAGSGTCGT VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG
110 120 130 140 150
VYACGAGMNT DRGKTQKVTL NVHSEYEPSW EEQPMPETPK WFHLPYLFQM
160 170 180 190 200
PAYASSSKFV TRVTTPAQRG KVPPVHHSSP TTQITHRPRV SRASSVAGDK
210 220 230 240 250
PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD YGSQSGREGQ
260 270 280 290 300
GFHILIPTIL GLFLLALLGL VVKRAVERRK ALSRRARRLA VRMRALESSQ
310 320 330 340 350
RPRGSPRPRS QNNIYSACPR RARGADAAGT GEAPVPGPGA PLPPAPLQVS
360 370 380 390
ESPWLHAPSL KTSCEYVSLY HQPAAMMEDS DSDDYINVPA
Length:390
Mass (Da):43,146
Last modified:August 1, 1998 - v1
Checksum:iFE91D217EECA99C6
GO
Isoform 2 (identifier: O60667-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-124: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):31,029
Checksum:i653219845F8B508A
GO
Isoform 3 (identifier: O60667-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-245: RALDYGSQS → SPLQAGPPT
     249-390: GQGFHILIPT...DSDDYINVPA → DARPGELPEA...AVAPRPAAGV

Show »
Length:306
Mass (Da):33,828
Checksum:iC24B05122E5DD4C8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMT7E9PMT7_HUMAN
Fas apoptotic inhibitory molecule 3
FCMR
147Annotation score:
E9PN59E9PN59_HUMAN
Fas apoptotic inhibitory molecule 3
FCMR
151Annotation score:
E9PQG1E9PQG1_HUMAN
Fas apoptotic inhibitory molecule 3
FCMR
125Annotation score:
E9PPV1E9PPV1_HUMAN
Fas apoptotic inhibitory molecule 3
FCMR
141Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04294713 – 124Missing in isoform 2. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_045188237 – 245RALDYGSQS → SPLQAGPPT in isoform 3. 1 Publication9
Alternative sequenceiVSP_045189249 – 390GQGFH…INVPA → DARPGELPEAPRVAATALPK QHLQRLPAARSWSGRCRHRG GPRSRPRSAVAPRPAAGV in isoform 3. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057557 mRNA Translation: AAC18830.1
HM480394 mRNA Translation: ADK11426.1
BT006797 mRNA Translation: AAP35443.1
AK292007 mRNA Translation: BAF84696.1
AK301187 mRNA Translation: BAH13426.1
AK316336 mRNA Translation: BAH14707.1
AC098935 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93517.1
BC006401 mRNA Translation: AAH06401.1
CCDSiCCDS1473.1 [O60667-1]
CCDS44304.1 [O60667-2]
CCDS53467.1 [O60667-3]
RefSeqiNP_001135945.1, NM_001142473.1 [O60667-2]
NP_001180267.1, NM_001193338.1 [O60667-3]
NP_005440.1, NM_005449.4 [O60667-1]
UniGeneiHs.58831
Hs.744273

Genome annotation databases

EnsembliENST00000367091; ENSP00000356058; ENSG00000162894 [O60667-1]
ENST00000442471; ENSP00000404136; ENSG00000162894 [O60667-2]
ENST00000628511; ENSP00000485739; ENSG00000162894 [O60667-3]
GeneIDi9214
KEGGihsa:9214
UCSCiuc001hey.4 human [O60667-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057557 mRNA Translation: AAC18830.1
HM480394 mRNA Translation: ADK11426.1
BT006797 mRNA Translation: AAP35443.1
AK292007 mRNA Translation: BAF84696.1
AK301187 mRNA Translation: BAH13426.1
AK316336 mRNA Translation: BAH14707.1
AC098935 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93517.1
BC006401 mRNA Translation: AAH06401.1
CCDSiCCDS1473.1 [O60667-1]
CCDS44304.1 [O60667-2]
CCDS53467.1 [O60667-3]
RefSeqiNP_001135945.1, NM_001142473.1 [O60667-2]
NP_001180267.1, NM_001193338.1 [O60667-3]
NP_005440.1, NM_005449.4 [O60667-1]
UniGeneiHs.58831
Hs.744273

3D structure databases

ProteinModelPortaliO60667
SMRiO60667
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114648, 3 interactors
IntActiO60667, 1 interactor
STRINGi9606.ENSP00000356058

PTM databases

iPTMnetiO60667
PhosphoSitePlusiO60667

Polymorphism and mutation databases

BioMutaiFAIM3

Proteomic databases

PaxDbiO60667
PeptideAtlasiO60667
PRIDEiO60667
ProteomicsDBi49511
49512 [O60667-2]

Protocols and materials databases

DNASUi9214
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367091; ENSP00000356058; ENSG00000162894 [O60667-1]
ENST00000442471; ENSP00000404136; ENSG00000162894 [O60667-2]
ENST00000628511; ENSP00000485739; ENSG00000162894 [O60667-3]
GeneIDi9214
KEGGihsa:9214
UCSCiuc001hey.4 human [O60667-1]

Organism-specific databases

CTDi9214
DisGeNETi9214
EuPathDBiHostDB:ENSG00000162894.11
GeneCardsiFCMR
HGNCiHGNC:14315 FCMR
HPAiHPA003910
MIMi606015 gene
neXtProtiNX_O60667
OpenTargetsiENSG00000162894
PharmGKBiPA142671899
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ2J Eukaryota
ENOG41113GQ LUCA
GeneTreeiENSGT00530000063436
HOGENOMiHOG000013142
HOVERGENiHBG107910
InParanoidiO60667
OMAiTIECPLP
OrthoDBiEOG091G0K4T
PhylomeDBiO60667
TreeFamiTF338713

Miscellaneous databases

ChiTaRSiFCMR human
GenomeRNAii9214
PROiPR:O60667
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162894 Expressed in 153 organ(s), highest expression level in blood
CleanExiHS_FAIM3
ExpressionAtlasiO60667 baseline and differential
GenevisibleiO60667 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAIM3_HUMAN
AccessioniPrimary (citable) accession number: O60667
Secondary accession number(s): A8K7J2, B7Z6Z0, D9MWM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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