Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Perilipin-3

Gene

PLIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • vesicle-mediated transport Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163560 Triglyceride catabolism
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60664

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Perilipin-3
Alternative name(s):
47 kDa mannose 6-phosphate receptor-binding protein
Short name:
47 kDa MPR-binding protein
Cargo selection protein TIP47
Mannose-6-phosphate receptor-binding protein 1
Placental protein 17
Short name:
PP17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLIN3
Synonyms:M6PRBP1, TIP47
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105355.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16893 PLIN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602702 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60664

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Lipid droplet, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10226

Open Targets

More...
OpenTargetsi
ENSG00000105355

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165394001

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01279 Galsulfase
DB01271 Idursulfase

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLIN3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000998902 – 434Perilipin-3Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei65N6-acetyllysineCombined sources1
Modified residuei91PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei130PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei170PhosphothreonineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei216PhosphothreonineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60664

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60664

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60664

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60664

PeptideAtlas

More...
PeptideAtlasi
O60664

PRoteomics IDEntifications database

More...
PRIDEi
O60664

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49508
49509 [O60664-2]
49510 [O60664-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O60664-1 [O60664-1]
O60664-2 [O60664-2]
O60664-3 [O60664-3]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00303882

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60664

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60664

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60664

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O60664

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105355 Expressed in 237 organ(s), highest expression level in mouth mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_M6PRBP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60664 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60664 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006427
HPA066538

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain). Isoform 2 may exist as a homodimer (known as PP17C).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115520, 73 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O60664

Protein interaction database and analysis system

More...
IntActi
O60664, 37 interactors

Molecular INTeraction database

More...
MINTi
O60664

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221957

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60664

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60664

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili252 – 277Sequence analysisAdd BLAST26
Coiled coili353 – 377Sequence analysisAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJG1 Eukaryota
ENOG410XTQ5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154162

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033816

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002935

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60664

KEGG Orthology (KO)

More...
KOi
K20287

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEEWVDN

Database of Orthologous Groups

More...
OrthoDBi
1437332at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60664

TreeFam database of animal gene trees

More...
TreeFami
TF328397

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004279 Perilipin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03036 Perilipin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036881 PAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60664-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK
60 70 80 90 100
ESYPHIKTVC DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL
110 120 130 140 150
DKLEENLPIL QQPTEKVLAD TKELVSSKVS GAQEMVSSAK DTVATQLSEA
160 170 180 190 200
VDATRGAVQS GVDKTKSVVT GGVQSVMGSR LGQMVLSGVD TVLGKSEEWA
210 220 230 240 250
DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG SLSERLRQHA
260 270 280 290 300
YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM
310 320 330 340 350
WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG
360 370 380 390 400
LPTNVKDQVQ QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA
410 420 430
LDHMVEYVAQ NTPVTWLVGP FAPGITEKAP EEKK
Note: PP17b.
Length:434
Mass (Da):47,075
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67B2B9CDBC523043
GO
Isoform 2 (identifier: O60664-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Note: PP17a.
Show »
Length:251
Mass (Da):28,158
Checksum:i3C7AEC3FBE9429DF
GO
Isoform 3 (identifier: O60664-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-321: Missing.

Show »
Length:433
Mass (Da):46,947
Checksum:i8716B72B11C7FE65
GO
Isoform 4 (identifier: O60664-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-127: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):45,803
Checksum:iDB98F133BF2A206E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERZ3K7ERZ3_HUMAN
Perilipin-3
PLIN3
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER39K7ER39_HUMAN
Perilipin-3
PLIN3
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL96K7EL96_HUMAN
Perilipin-3
PLIN3
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJD0K7EJD0_HUMAN
Perilipin-3
PLIN3
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77G → W in AAD11622 (PubMed:9874244).Curated1
Sequence conflicti109 – 111ILQ → MLR in AAD11622 (PubMed:9874244).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02278056I → V4 PublicationsCorresponds to variant dbSNP:rs8289Ensembl.1
Natural variantiVAR_024559275V → A7 PublicationsCorresponds to variant dbSNP:rs9973235Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0046641 – 183Missing in isoform 2. 2 PublicationsAdd BLAST183
Alternative sequenceiVSP_047038116 – 127Missing in isoform 4. CuratedAdd BLAST12
Alternative sequenceiVSP_040325321Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF057140 mRNA Translation: AAC39751.1
AF055574 mRNA Translation: AAD11622.1
AF051314 mRNA Translation: AAD11619.1
AF051315 mRNA Translation: AAD11620.1
BT007235 mRNA Translation: AAP35899.1
AK291104 mRNA Translation: BAF83793.1
AK223054 mRNA Translation: BAD96774.1
AK225045 mRNA No translation available.
AC027319 Genomic DNA No translation available.
BC001590 mRNA Translation: AAH01590.1
BC005818 mRNA Translation: AAH05818.1
BC007566 mRNA Translation: AAH07566.1
BC019278 mRNA Translation: AAH19278.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12137.1 [O60664-1]
CCDS59337.1 [O60664-4]
CCDS59338.1 [O60664-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001157661.1, NM_001164189.1 [O60664-3]
NP_001157666.1, NM_001164194.1 [O60664-4]
NP_005808.3, NM_005817.4 [O60664-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.140452

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000221957; ENSP00000221957; ENSG00000105355 [O60664-1]
ENST00000585479; ENSP00000465596; ENSG00000105355 [O60664-3]
ENST00000592528; ENSP00000467803; ENSG00000105355 [O60664-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10226

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10226

UCSC genome browser

More...
UCSCi
uc002mbj.3 human [O60664-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057140 mRNA Translation: AAC39751.1
AF055574 mRNA Translation: AAD11622.1
AF051314 mRNA Translation: AAD11619.1
AF051315 mRNA Translation: AAD11620.1
BT007235 mRNA Translation: AAP35899.1
AK291104 mRNA Translation: BAF83793.1
AK223054 mRNA Translation: BAD96774.1
AK225045 mRNA No translation available.
AC027319 Genomic DNA No translation available.
BC001590 mRNA Translation: AAH01590.1
BC005818 mRNA Translation: AAH05818.1
BC007566 mRNA Translation: AAH07566.1
BC019278 mRNA Translation: AAH19278.1
CCDSiCCDS12137.1 [O60664-1]
CCDS59337.1 [O60664-4]
CCDS59338.1 [O60664-3]
RefSeqiNP_001157661.1, NM_001164189.1 [O60664-3]
NP_001157666.1, NM_001164194.1 [O60664-4]
NP_005808.3, NM_005817.4 [O60664-1]
UniGeneiHs.140452

3D structure databases

ProteinModelPortaliO60664
SMRiO60664
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115520, 73 interactors
CORUMiO60664
IntActiO60664, 37 interactors
MINTiO60664
STRINGi9606.ENSP00000221957

Chemistry databases

DrugBankiDB01279 Galsulfase
DB01271 Idursulfase

PTM databases

iPTMnetiO60664
PhosphoSitePlusiO60664
SwissPalmiO60664

Polymorphism and mutation databases

BioMutaiPLIN3

2D gel databases

REPRODUCTION-2DPAGEiIPI00303882

Proteomic databases

EPDiO60664
jPOSTiO60664
MaxQBiO60664
PaxDbiO60664
PeptideAtlasiO60664
PRIDEiO60664
ProteomicsDBi49508
49509 [O60664-2]
49510 [O60664-3]
TopDownProteomicsiO60664-1 [O60664-1]
O60664-2 [O60664-2]
O60664-3 [O60664-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10226
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221957; ENSP00000221957; ENSG00000105355 [O60664-1]
ENST00000585479; ENSP00000465596; ENSG00000105355 [O60664-3]
ENST00000592528; ENSP00000467803; ENSG00000105355 [O60664-4]
GeneIDi10226
KEGGihsa:10226
UCSCiuc002mbj.3 human [O60664-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10226
DisGeNETi10226
EuPathDBiHostDB:ENSG00000105355.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLIN3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0014673
HGNCiHGNC:16893 PLIN3
HPAiHPA006427
HPA066538
MIMi602702 gene
neXtProtiNX_O60664
OpenTargetsiENSG00000105355
PharmGKBiPA165394001

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJG1 Eukaryota
ENOG410XTQ5 LUCA
GeneTreeiENSGT00940000154162
HOGENOMiHOG000033816
HOVERGENiHBG002935
InParanoidiO60664
KOiK20287
OMAiSEEWVDN
OrthoDBi1437332at2759
PhylomeDBiO60664
TreeFamiTF328397

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiO60664

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLIN3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
M6PRBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10226
PMAP-CutDBiO60664

Protein Ontology

More...
PROi
PR:O60664

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105355 Expressed in 237 organ(s), highest expression level in mouth mucosa
CleanExiHS_M6PRBP1
ExpressionAtlasiO60664 baseline and differential
GenevisibleiO60664 HS

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLIN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60664
Secondary accession number(s): A8K4Y9
, K7EQF4, Q53G77, Q9BS03, Q9UBD7, Q9UP92
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 175 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again