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Protein

Perilipin-3

Gene

PLIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.1 Publication

GO - Molecular functioni

GO - Biological processi

  • vesicle-mediated transport Source: ProtInc

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiO60664

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-3
Alternative name(s):
47 kDa mannose 6-phosphate receptor-binding protein
Short name:
47 kDa MPR-binding protein
Cargo selection protein TIP47
Mannose-6-phosphate receptor-binding protein 1
Placental protein 17
Short name:
PP17
Gene namesi
Name:PLIN3
Synonyms:M6PRBP1, TIP47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105355.8
HGNCiHGNC:16893 PLIN3
MIMi602702 gene
neXtProtiNX_O60664

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10226
OpenTargetsiENSG00000105355
PharmGKBiPA165394001

Chemistry databases

DrugBankiDB01279 Galsulfase
DB01271 Idursulfase

Polymorphism and mutation databases

BioMutaiPLIN3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000998902 – 434Perilipin-3Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei65N6-acetyllysineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei130PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei170PhosphothreonineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei216PhosphothreonineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO60664
MaxQBiO60664
PaxDbiO60664
PeptideAtlasiO60664
PRIDEiO60664
ProteomicsDBi49508
49509 [O60664-2]
49510 [O60664-3]
TopDownProteomicsiO60664-1 [O60664-1]
O60664-2 [O60664-2]
O60664-3 [O60664-3]

2D gel databases

REPRODUCTION-2DPAGEiIPI00303882

PTM databases

iPTMnetiO60664
PhosphoSitePlusiO60664
SwissPalmiO60664

Miscellaneous databases

PMAP-CutDBiO60664

Expressioni

Gene expression databases

BgeeiENSG00000105355 Expressed in 237 organ(s), highest expression level in mouth mucosa
CleanExiHS_M6PRBP1
ExpressionAtlasiO60664 baseline and differential
GenevisibleiO60664 HS

Organism-specific databases

HPAiHPA006427
HPA066538

Interactioni

Subunit structurei

Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain). Isoform 2 may exist as a homodimer (known as PP17C).1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115520, 72 interactors
CORUMiO60664
IntActiO60664, 37 interactors
MINTiO60664
STRINGi9606.ENSP00000221957

Structurei

3D structure databases

ProteinModelPortaliO60664
SMRiO60664
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili252 – 277Sequence analysisAdd BLAST26
Coiled coili353 – 377Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJG1 Eukaryota
ENOG410XTQ5 LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000033816
HOVERGENiHBG002935
InParanoidiO60664
KOiK20287
OMAiSEEWVDN
OrthoDBiEOG091G0D6Q
PhylomeDBiO60664
TreeFamiTF328397

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60664-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK
60 70 80 90 100
ESYPHIKTVC DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL
110 120 130 140 150
DKLEENLPIL QQPTEKVLAD TKELVSSKVS GAQEMVSSAK DTVATQLSEA
160 170 180 190 200
VDATRGAVQS GVDKTKSVVT GGVQSVMGSR LGQMVLSGVD TVLGKSEEWA
210 220 230 240 250
DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG SLSERLRQHA
260 270 280 290 300
YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM
310 320 330 340 350
WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG
360 370 380 390 400
LPTNVKDQVQ QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA
410 420 430
LDHMVEYVAQ NTPVTWLVGP FAPGITEKAP EEKK
Note: PP17b.
Length:434
Mass (Da):47,075
Last modified:January 11, 2011 - v3
Checksum:i67B2B9CDBC523043
GO
Isoform 2 (identifier: O60664-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Note: PP17a.
Show »
Length:251
Mass (Da):28,158
Checksum:i3C7AEC3FBE9429DF
GO
Isoform 3 (identifier: O60664-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-321: Missing.

Show »
Length:433
Mass (Da):46,947
Checksum:i8716B72B11C7FE65
GO
Isoform 4 (identifier: O60664-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-127: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):45,803
Checksum:iDB98F133BF2A206E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERZ3K7ERZ3_HUMAN
Perilipin-3
PLIN3
292Annotation score:
K7ER39K7ER39_HUMAN
Perilipin-3
PLIN3
168Annotation score:
K7EL96K7EL96_HUMAN
Perilipin-3
PLIN3
172Annotation score:
K7EJD0K7EJD0_HUMAN
Perilipin-3
PLIN3
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77G → W in AAD11622 (PubMed:9874244).Curated1
Sequence conflicti109 – 111ILQ → MLR in AAD11622 (PubMed:9874244).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02278056I → V4 PublicationsCorresponds to variant dbSNP:rs8289Ensembl.1
Natural variantiVAR_024559275V → A7 PublicationsCorresponds to variant dbSNP:rs9973235Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0046641 – 183Missing in isoform 2. 2 PublicationsAdd BLAST183
Alternative sequenceiVSP_047038116 – 127Missing in isoform 4. CuratedAdd BLAST12
Alternative sequenceiVSP_040325321Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057140 mRNA Translation: AAC39751.1
AF055574 mRNA Translation: AAD11622.1
AF051314 mRNA Translation: AAD11619.1
AF051315 mRNA Translation: AAD11620.1
BT007235 mRNA Translation: AAP35899.1
AK291104 mRNA Translation: BAF83793.1
AK223054 mRNA Translation: BAD96774.1
AK225045 mRNA No translation available.
AC027319 Genomic DNA No translation available.
BC001590 mRNA Translation: AAH01590.1
BC005818 mRNA Translation: AAH05818.1
BC007566 mRNA Translation: AAH07566.1
BC019278 mRNA Translation: AAH19278.1
CCDSiCCDS12137.1 [O60664-1]
CCDS59337.1 [O60664-4]
CCDS59338.1 [O60664-3]
RefSeqiNP_001157661.1, NM_001164189.1 [O60664-3]
NP_001157666.1, NM_001164194.1 [O60664-4]
NP_005808.3, NM_005817.4 [O60664-1]
UniGeneiHs.140452

Genome annotation databases

EnsembliENST00000221957; ENSP00000221957; ENSG00000105355 [O60664-1]
ENST00000585479; ENSP00000465596; ENSG00000105355 [O60664-3]
ENST00000592528; ENSP00000467803; ENSG00000105355 [O60664-4]
GeneIDi10226
KEGGihsa:10226
UCSCiuc002mbj.3 human [O60664-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057140 mRNA Translation: AAC39751.1
AF055574 mRNA Translation: AAD11622.1
AF051314 mRNA Translation: AAD11619.1
AF051315 mRNA Translation: AAD11620.1
BT007235 mRNA Translation: AAP35899.1
AK291104 mRNA Translation: BAF83793.1
AK223054 mRNA Translation: BAD96774.1
AK225045 mRNA No translation available.
AC027319 Genomic DNA No translation available.
BC001590 mRNA Translation: AAH01590.1
BC005818 mRNA Translation: AAH05818.1
BC007566 mRNA Translation: AAH07566.1
BC019278 mRNA Translation: AAH19278.1
CCDSiCCDS12137.1 [O60664-1]
CCDS59337.1 [O60664-4]
CCDS59338.1 [O60664-3]
RefSeqiNP_001157661.1, NM_001164189.1 [O60664-3]
NP_001157666.1, NM_001164194.1 [O60664-4]
NP_005808.3, NM_005817.4 [O60664-1]
UniGeneiHs.140452

3D structure databases

ProteinModelPortaliO60664
SMRiO60664
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115520, 72 interactors
CORUMiO60664
IntActiO60664, 37 interactors
MINTiO60664
STRINGi9606.ENSP00000221957

Chemistry databases

DrugBankiDB01279 Galsulfase
DB01271 Idursulfase

PTM databases

iPTMnetiO60664
PhosphoSitePlusiO60664
SwissPalmiO60664

Polymorphism and mutation databases

BioMutaiPLIN3

2D gel databases

REPRODUCTION-2DPAGEiIPI00303882

Proteomic databases

EPDiO60664
MaxQBiO60664
PaxDbiO60664
PeptideAtlasiO60664
PRIDEiO60664
ProteomicsDBi49508
49509 [O60664-2]
49510 [O60664-3]
TopDownProteomicsiO60664-1 [O60664-1]
O60664-2 [O60664-2]
O60664-3 [O60664-3]

Protocols and materials databases

DNASUi10226
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221957; ENSP00000221957; ENSG00000105355 [O60664-1]
ENST00000585479; ENSP00000465596; ENSG00000105355 [O60664-3]
ENST00000592528; ENSP00000467803; ENSG00000105355 [O60664-4]
GeneIDi10226
KEGGihsa:10226
UCSCiuc002mbj.3 human [O60664-1]

Organism-specific databases

CTDi10226
DisGeNETi10226
EuPathDBiHostDB:ENSG00000105355.8
GeneCardsiPLIN3
H-InvDBiHIX0014673
HGNCiHGNC:16893 PLIN3
HPAiHPA006427
HPA066538
MIMi602702 gene
neXtProtiNX_O60664
OpenTargetsiENSG00000105355
PharmGKBiPA165394001
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJG1 Eukaryota
ENOG410XTQ5 LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000033816
HOVERGENiHBG002935
InParanoidiO60664
KOiK20287
OMAiSEEWVDN
OrthoDBiEOG091G0D6Q
PhylomeDBiO60664
TreeFamiTF328397

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiO60664

Miscellaneous databases

ChiTaRSiPLIN3 human
GeneWikiiM6PRBP1
GenomeRNAii10226
PMAP-CutDBiO60664
PROiPR:O60664
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105355 Expressed in 237 organ(s), highest expression level in mouth mucosa
CleanExiHS_M6PRBP1
ExpressionAtlasiO60664 baseline and differential
GenevisibleiO60664 HS

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN3_HUMAN
AccessioniPrimary (citable) accession number: O60664
Secondary accession number(s): A8K4Y9
, K7EQF4, Q53G77, Q9BS03, Q9UBD7, Q9UP92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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