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Protein

UDP-glucuronosyltransferase 1-9

Gene

UGT1A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.1 Publication

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.2 Publications

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • enzyme inhibitor activity Source: BHF-UCL
  • glucuronosyltransferase activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • retinoic acid binding Source: BHF-UCL
  • UDP-glycosyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation
R-HSA-1989781 PPARA activates gene expression
SABIO-RKiO60656
SIGNORiO60656

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsiSLP:000001713 [O60656-1]

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-9 (EC:2.4.1.17)
Short name:
UDPGT 1-9
Short name:
UGT1*9
Short name:
UGT1-09
Short name:
UGT1.9
Alternative name(s):
UDP-glucuronosyltransferase 1-I
Short name:
UGT-1I
Short name:
UGT1I
UDP-glucuronosyltransferase 1A9
lugP4
Gene namesi
Name:UGT1A9
Synonyms:GNT1, UGT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000241119.1
HGNCiHGNC:12541 UGT1A9
MIMi191740 gene
606434 gene
neXtProtiNX_O60656

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei488 – 504HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi54600
OpenTargetsiENSG00000241119
PharmGKBiPA419

Chemistry databases

ChEMBLiCHEMBL1743319
DrugBankiDB00316 Acetaminophen
DB06403 Ambrisentan
DB00921 Buprenorphine
DB08907 Canagliflozin
DB06695 Dabigatran etexilate
DB06292 Dapagliflozin
DB00494 Entacapone
DB00749 Etodolac
DB04953 Ezogabine
DB00712 Flurbiprofen
DB06741 Gavestinel
DB00502 Haloperidol
DB00062 Human Serum Albumin
DB00327 Hydromorphone
DB01050 Ibuprofen
DB00328 Indomethacin
DB00762 Irinotecan
DB06738 Ketobemidone
DB01283 Lumiracoxib
DB00688 Mycophenolate mofetil
DB01024 Mycophenolic acid
DB00731 Nateglinide
DB04552 Niflumic Acid
DB00842 Oxazepam
DB04824 Phenolphthalein
DB00818 Propofol
DB08896 Regorafenib
DB00398 Sorafenib
DB01015 Sulfamethoxazole
DB06204 Tapentadol
DB00197 Troglitazone
DB00580 Valdecoxib
DB00313 Valproic Acid
DB00744 Zileuton

Polymorphism and mutation databases

BioMutaiUGT1A9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003600826 – 530UDP-glucuronosyltransferase 1-9Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei99N6-succinyllysineBy similarity1
Glycosylationi292N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi344N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60656
PeptideAtlasiO60656
PRIDEiO60656
ProteomicsDBi49498

PTM databases

GlyConnecti1881
iPTMnetiO60656
PhosphoSitePlusiO60656

Expressioni

Tissue specificityi

Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000241119 Expressed in 25 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiO60656 baseline and differential
GenevisibleiO60656 HS

Interactioni

Subunit structurei

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120073, 6 interactors
IntActiO60656, 7 interactors
STRINGi9606.ENSP00000346768

Chemistry databases

BindingDBiO60656

Structurei

3D structure databases

ProteinModelPortaliO60656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00900000141038
HOGENOMiHOG000220832
HOVERGENiHBG004033
InParanoidiO60656
KOiK00699
OMAiLMGSYND
OrthoDBiEOG091G06JC
PhylomeDBiO60656
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60656-1) [UniParc]FASTAAdd to basket
Also known as: i1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACTGWTSPL PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MRSVVEKLIL
60 70 80 90 100
RGHEVVVVMP EVSWQLGRSL NCTVKTYSTS YTLEDLDREF KAFAHAQWKA
110 120 130 140 150
QVRSIYSLLM GSYNDIFDLF FSNCRSLFKD KKLVEYLKES SFDAVFLDPF
160 170 180 190 200
DNCGLIVAKY FSLPSVVFAR GILCHYLEEG AQCPAPLSYV PRILLGFSDA
210 220 230 240 250
MTFKERVRNH IMHLEEHLLC HRFFKNALEI ASEILQTPVT EYDLYSHTSI
260 270 280 290 300
WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV
310 320 330 340 350
VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK
360 370 380 390 400
WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR
410 420 430 440 450
METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE
460 470 480 490 500
PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA
510 520 530
FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Length:530
Mass (Da):59,941
Last modified:August 1, 1998 - v1
Checksum:iC417B9E86B403078
GO
Isoform 2 (identifier: O60656-2) [UniParc]FASTAAdd to basket
Also known as: i2, UGT1A9s

The sequence of this isoform differs from the canonical sequence as follows:
     432-530: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:441
Mass (Da):49,718
Checksum:i2A0722CDA3A85E9E
GO

Sequence cautioni

The sequence AAB19791 differs from that shown. Reason: Frameshift at positions 59 and 82.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29L → V in AAB19791 (PubMed:1910331).Curated1
Sequence conflicti200A → D in AAB19791 (PubMed:1910331).Curated1
Sequence conflicti279 – 282QGKP → ERKA in AAB19791 (PubMed:1910331).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05858733M → T1 PublicationCorresponds to variant dbSNP:rs72551330Ensembl.1
Natural variantiVAR_036035442S → I in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053965432 – 530SYKEN…KSKTH → RKKQQSGRQM in isoform 2. CuratedAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S55985 mRNA Translation: AAB19791.2 Frameshift.
AF056188 mRNA Translation: AAC31425.1
AF297093 Genomic DNA Translation: AAG30418.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC058844 mRNA Translation: AAH58844.1
AF297091 Genomic DNA Translation: AAG29816.1
DQ364246 mRNA Translation: ABC96770.1
CCDSiCCDS2505.1 [O60656-1]
PIRiS17512
RefSeqiNP_066307.1, NM_021027.2 [O60656-1]
UniGeneiHs.554822

Genome annotation databases

EnsembliENST00000354728; ENSP00000346768; ENSG00000241119 [O60656-1]
GeneIDi54600
KEGGihsa:54600

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S55985 mRNA Translation: AAB19791.2 Frameshift.
AF056188 mRNA Translation: AAC31425.1
AF297093 Genomic DNA Translation: AAG30418.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC058844 mRNA Translation: AAH58844.1
AF297091 Genomic DNA Translation: AAG29816.1
DQ364246 mRNA Translation: ABC96770.1
CCDSiCCDS2505.1 [O60656-1]
PIRiS17512
RefSeqiNP_066307.1, NM_021027.2 [O60656-1]
UniGeneiHs.554822

3D structure databases

ProteinModelPortaliO60656
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120073, 6 interactors
IntActiO60656, 7 interactors
STRINGi9606.ENSP00000346768

Chemistry databases

BindingDBiO60656
ChEMBLiCHEMBL1743319
DrugBankiDB00316 Acetaminophen
DB06403 Ambrisentan
DB00921 Buprenorphine
DB08907 Canagliflozin
DB06695 Dabigatran etexilate
DB06292 Dapagliflozin
DB00494 Entacapone
DB00749 Etodolac
DB04953 Ezogabine
DB00712 Flurbiprofen
DB06741 Gavestinel
DB00502 Haloperidol
DB00062 Human Serum Albumin
DB00327 Hydromorphone
DB01050 Ibuprofen
DB00328 Indomethacin
DB00762 Irinotecan
DB06738 Ketobemidone
DB01283 Lumiracoxib
DB00688 Mycophenolate mofetil
DB01024 Mycophenolic acid
DB00731 Nateglinide
DB04552 Niflumic Acid
DB00842 Oxazepam
DB04824 Phenolphthalein
DB00818 Propofol
DB08896 Regorafenib
DB00398 Sorafenib
DB01015 Sulfamethoxazole
DB06204 Tapentadol
DB00197 Troglitazone
DB00580 Valdecoxib
DB00313 Valproic Acid
DB00744 Zileuton
SwissLipidsiSLP:000001713 [O60656-1]

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

PTM databases

GlyConnecti1881
iPTMnetiO60656
PhosphoSitePlusiO60656

Polymorphism and mutation databases

BioMutaiUGT1A9

Proteomic databases

PaxDbiO60656
PeptideAtlasiO60656
PRIDEiO60656
ProteomicsDBi49498

Protocols and materials databases

DNASUi54600
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354728; ENSP00000346768; ENSG00000241119 [O60656-1]
GeneIDi54600
KEGGihsa:54600

Organism-specific databases

CTDi54600
DisGeNETi54600
EuPathDBiHostDB:ENSG00000241119.1
GeneCardsiUGT1A9
HGNCiHGNC:12541 UGT1A9
MIMi191740 gene
606434 gene
neXtProtiNX_O60656
OpenTargetsiENSG00000241119
PharmGKBiPA419
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00900000141038
HOGENOMiHOG000220832
HOVERGENiHBG004033
InParanoidiO60656
KOiK00699
OMAiLMGSYND
OrthoDBiEOG091G06JC
PhylomeDBiO60656
TreeFamiTF315472

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation
R-HSA-1989781 PPARA activates gene expression
SABIO-RKiO60656
SIGNORiO60656

Miscellaneous databases

GeneWikiiUGT1A9
GenomeRNAii54600
PROiPR:O60656
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241119 Expressed in 25 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiO60656 baseline and differential
GenevisibleiO60656 HS

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUD19_HUMAN
AccessioniPrimary (citable) accession number: O60656
Secondary accession number(s): B8K285, P36509, Q9HAX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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