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Entry version 173 (17 Jun 2020)
Sequence version 1 (01 Aug 1998)
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Protein

UDP-glucuronosyltransferase 1-9

Gene

UGT1A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.1 Publication

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.17 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156588 Glucuronidation
R-HSA-1989781 PPARA activates gene expression

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O60656

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60656

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001713 [O60656-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-9 (EC:2.4.1.17)
Short name:
UDPGT 1-9
Short name:
UGT1*9
Short name:
UGT1-09
Short name:
UGT1.9
Alternative name(s):
UDP-glucuronosyltransferase 1-I
Short name:
UGT-1I
Short name:
UGT1I
UDP-glucuronosyltransferase 1A9
lugP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGT1A9
Synonyms:GNT1, UGT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000241119.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12541 UGT1A9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
191740 gene
606434 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60656

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei488 – 504HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54600

Open Targets

More...
OpenTargetsi
ENSG00000241119

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA419

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60656 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1743319

Drug and drug target database

More...
DrugBanki
DB00316 Acetaminophen
DB06403 Ambrisentan
DB11638 Artenimol
DB05016 Ataluren
DB08907 Canagliflozin
DB14635 Curcumin sulfate
DB06695 Dabigatran etexilate
DB06292 Dapagliflozin
DB12941 Darolutamide
DB01609 Deferasirox
DB09213 Dexibuprofen
DB00586 Diclofenac
DB00861 Diflunisal
DB08930 Dolutegravir
DB06210 Eltrombopag
DB13874 Enasidenib
DB00494 Entacapone
DB11827 Ertugliflozin
DB00749 Etodolac
DB04953 Ezogabine
DB01039 Fenofibrate
DB00712 Flurbiprofen
DB01320 Fosphenytoin
DB12010 Fostamatinib
DB06741 Gavestinel
DB01241 Gemfibrozil
DB11978 Glasdegib
DB00502 Haloperidol
DB01050 Ibuprofen
DB00328 Indomethacin
DB00762 Irinotecan
DB11633 Isavuconazole
DB06738 Ketobemidone
DB00598 Labetalol
DB01283 Lumiracoxib
DB00784 Mefenamic acid
DB09285 Morniflumate
DB00688 Mycophenolate mofetil
DB01024 Mycophenolic acid
DB00788 Naproxen
DB00731 Nateglinide
DB04552 Niflumic acid
DB00842 Oxazepam
DB04824 Phenolphthalein
DB00252 Phenytoin
DB09288 Propacetamol
DB00818 Propofol
DB08896 Regorafenib
DB01045 Rifampicin
DB06739 Seratrodast
DB00398 Sorafenib
DB01015 Sulfamethoxazole
DB06204 Tapentadol
DB01685 Topiroxostat
DB00197 Troglitazone
DB06235 Vadimezan
DB00580 Valdecoxib
DB00313 Valproic acid
DB00744 Zileuton

DrugCentral

More...
DrugCentrali
O60656

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UGT1A9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003600826 – 530UDP-glucuronosyltransferase 1-9Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99N6-succinyllysineBy similarity1
Glycosylationi292N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi344N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60656

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O60656

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60656

PeptideAtlas

More...
PeptideAtlasi
O60656

PRoteomics IDEntifications database

More...
PRIDEi
O60656

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49498 [O60656-1]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1881

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60656

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60656

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000241119 Expressed in adult mammalian kidney and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60656 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60656 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000241119 Tissue enriched (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120073, 8 interactors

Protein interaction database and analysis system

More...
IntActi
O60656, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346768

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60656

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O60656 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1192 Eukaryota
COG1819 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000163976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012949_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60656

KEGG Orthology (KO)

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KOi
K00699

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMGSYND

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60656

TreeFam database of animal gene trees

More...
TreeFami
TF315472

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00201 UDPGT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00375 UDPGT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60656-1) [UniParc]FASTAAdd to basket
Also known as: i1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACTGWTSPL PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MRSVVEKLIL
60 70 80 90 100
RGHEVVVVMP EVSWQLGRSL NCTVKTYSTS YTLEDLDREF KAFAHAQWKA
110 120 130 140 150
QVRSIYSLLM GSYNDIFDLF FSNCRSLFKD KKLVEYLKES SFDAVFLDPF
160 170 180 190 200
DNCGLIVAKY FSLPSVVFAR GILCHYLEEG AQCPAPLSYV PRILLGFSDA
210 220 230 240 250
MTFKERVRNH IMHLEEHLLC HRFFKNALEI ASEILQTPVT EYDLYSHTSI
260 270 280 290 300
WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV
310 320 330 340 350
VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK
360 370 380 390 400
WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR
410 420 430 440 450
METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE
460 470 480 490 500
PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA
510 520 530
FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Length:530
Mass (Da):59,941
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC417B9E86B403078
GO
Isoform 2 (identifier: O60656-2) [UniParc]FASTAAdd to basket
Also known as: i2, UGT1A9s

The sequence of this isoform differs from the canonical sequence as follows:
     432-530: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:441
Mass (Da):49,718
Checksum:i2A0722CDA3A85E9E
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB19791 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29L → V in AAB19791 (PubMed:1910331).Curated1
Sequence conflicti200A → D in AAB19791 (PubMed:1910331).Curated1
Sequence conflicti279 – 282QGKP → ERKA in AAB19791 (PubMed:1910331).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05858733M → T1 PublicationCorresponds to variant dbSNP:rs72551330Ensembl.1
Natural variantiVAR_036035442S → I in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053965432 – 530SYKEN…KSKTH → RKKQQSGRQM in isoform 2. CuratedAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S55985 mRNA Translation: AAB19791.2 Frameshift.
AF056188 mRNA Translation: AAC31425.1
AF297093 Genomic DNA Translation: AAG30418.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC058844 mRNA Translation: AAH58844.1
AF297091 Genomic DNA Translation: AAG29816.1
DQ364246 mRNA Translation: ABC96770.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2505.1 [O60656-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S17512

NCBI Reference Sequences

More...
RefSeqi
NP_066307.1, NM_021027.2 [O60656-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354728; ENSP00000346768; ENSG00000241119 [O60656-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54600

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S55985 mRNA Translation: AAB19791.2 Frameshift.
AF056188 mRNA Translation: AAC31425.1
AF297093 Genomic DNA Translation: AAG30418.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC058844 mRNA Translation: AAH58844.1
AF297091 Genomic DNA Translation: AAG29816.1
DQ364246 mRNA Translation: ABC96770.1
CCDSiCCDS2505.1 [O60656-1]
PIRiS17512
RefSeqiNP_066307.1, NM_021027.2 [O60656-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120073, 8 interactors
IntActiO60656, 9 interactors
STRINGi9606.ENSP00000346768

Chemistry databases

BindingDBiO60656
ChEMBLiCHEMBL1743319
DrugBankiDB00316 Acetaminophen
DB06403 Ambrisentan
DB11638 Artenimol
DB05016 Ataluren
DB08907 Canagliflozin
DB14635 Curcumin sulfate
DB06695 Dabigatran etexilate
DB06292 Dapagliflozin
DB12941 Darolutamide
DB01609 Deferasirox
DB09213 Dexibuprofen
DB00586 Diclofenac
DB00861 Diflunisal
DB08930 Dolutegravir
DB06210 Eltrombopag
DB13874 Enasidenib
DB00494 Entacapone
DB11827 Ertugliflozin
DB00749 Etodolac
DB04953 Ezogabine
DB01039 Fenofibrate
DB00712 Flurbiprofen
DB01320 Fosphenytoin
DB12010 Fostamatinib
DB06741 Gavestinel
DB01241 Gemfibrozil
DB11978 Glasdegib
DB00502 Haloperidol
DB01050 Ibuprofen
DB00328 Indomethacin
DB00762 Irinotecan
DB11633 Isavuconazole
DB06738 Ketobemidone
DB00598 Labetalol
DB01283 Lumiracoxib
DB00784 Mefenamic acid
DB09285 Morniflumate
DB00688 Mycophenolate mofetil
DB01024 Mycophenolic acid
DB00788 Naproxen
DB00731 Nateglinide
DB04552 Niflumic acid
DB00842 Oxazepam
DB04824 Phenolphthalein
DB00252 Phenytoin
DB09288 Propacetamol
DB00818 Propofol
DB08896 Regorafenib
DB01045 Rifampicin
DB06739 Seratrodast
DB00398 Sorafenib
DB01015 Sulfamethoxazole
DB06204 Tapentadol
DB01685 Topiroxostat
DB00197 Troglitazone
DB06235 Vadimezan
DB00580 Valdecoxib
DB00313 Valproic acid
DB00744 Zileuton
DrugCentraliO60656
SwissLipidsiSLP:000001713 [O60656-1]

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

PTM databases

GlyConnecti1881
iPTMnetiO60656
PhosphoSitePlusiO60656

Polymorphism and mutation databases

BioMutaiUGT1A9

Proteomic databases

jPOSTiO60656
MassIVEiO60656
PaxDbiO60656
PeptideAtlasiO60656
PRIDEiO60656
ProteomicsDBi49498 [O60656-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
35060 225 antibodies

The DNASU plasmid repository

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DNASUi
54600

Genome annotation databases

EnsembliENST00000354728; ENSP00000346768; ENSG00000241119 [O60656-1]
GeneIDi54600
KEGGihsa:54600

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54600
DisGeNETi54600
EuPathDBiHostDB:ENSG00000241119.1

GeneCards: human genes, protein and diseases

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GeneCardsi
UGT1A9
HGNCiHGNC:12541 UGT1A9
HPAiENSG00000241119 Tissue enriched (kidney)
MIMi191740 gene
606434 gene
neXtProtiNX_O60656
OpenTargetsiENSG00000241119
PharmGKBiPA419

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00940000163976
HOGENOMiCLU_012949_3_1_1
InParanoidiO60656
KOiK00699
OMAiLMGSYND
PhylomeDBiO60656
TreeFamiTF315472

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation
R-HSA-1989781 PPARA activates gene expression
SABIO-RKiO60656
SIGNORiO60656

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54600 14 hits in 762 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
UGT1A9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54600
PharosiO60656 Tbio

Protein Ontology

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PROi
PR:O60656
RNActiO60656 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000241119 Expressed in adult mammalian kidney and 24 other tissues
ExpressionAtlasiO60656 baseline and differential
GenevisibleiO60656 HS

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUD19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60656
Secondary accession number(s): B8K285, P36509, Q9HAX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: August 1, 1998
Last modified: June 17, 2020
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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