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Protein

Clathrin coat assembly protein AP180

Gene

SNAP91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • clathrin coat assembly Source: InterPro
  • protein transport Source: UniProtKB-KW
  • regulation of clathrin-dependent endocytosis Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin coat assembly protein AP180
Alternative name(s):
91 kDa synaptosomal-associated protein
Clathrin coat-associated protein AP180
Phosphoprotein F1-20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNAP91
Synonyms:KIAA0656
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000065609.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14986 SNAP91

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607923 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60641

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9892

Open Targets

More...
OpenTargetsi
ENSG00000065609

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37956

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNAP91

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001938641 – 907Clathrin coat assembly protein AP180Add BLAST907

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei296PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei306PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi310O-linked (GlcNAc) threonineBy similarity1
Modified residuei313PhosphoserineBy similarity1
Modified residuei317PhosphothreonineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei602PhosphoserineBy similarity1
Modified residuei623PhosphoserineBy similarity1
Modified residuei629PhosphoserineBy similarity1
Modified residuei763PhosphoserineBy similarity1
Modified residuei865Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei865Omega-N-methylarginine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Thr-310 can be modified by the addition of N-acetylglucosamine which can be further phosphorylated. There is no evidence for direct Thr-310 phosphorylation (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60641

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60641

MaxQB - The MaxQuant DataBase

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MaxQBi
O60641

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60641

PeptideAtlas

More...
PeptideAtlasi
O60641

PRoteomics IDEntifications database

More...
PRIDEi
O60641

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49493
49494 [O60641-2]
49495 [O60641-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60641

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60641

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60641

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000065609 Expressed in 140 organ(s), highest expression level in Brodmann (1909) area 23

CleanEx database of gene expression profiles

More...
CleanExi
HS_SNAP91

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60641 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60641 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009745
HPA029632
HPA029633

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds AP2A2. Interacts with AP2B1; clathrin competes with SNAP91 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Necap1Q9CR952EBI-1105187,EBI-7592476From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115222, 11 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
O60641

Protein interaction database and analysis system

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IntActi
O60641, 8 interactors

Molecular INTeraction database

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MINTi
O60641

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358708

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60641

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60641

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 145ENTHPROSITE-ProRule annotationAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi361 – 583Ala-richAdd BLAST223
Compositional biasi536 – 556Thr-richAdd BLAST21
Compositional biasi809 – 897Pro-richAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues).

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PICALM/SNAP91 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0251 Eukaryota
ENOG410XQ90 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155630

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015763

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG049391

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60641

KEGG Orthology (KO)

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KOi
K20043

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRFREPN

Database of Orthologous Groups

More...
OrthoDBi
1592722at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60641

TreeFam database of animal gene trees

More...
TreeFami
TF314861

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.150, 1 hit
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011417 ANTH_dom
IPR014712 Clathrin_AP_dom2
IPR013809 ENTH
IPR008942 ENTH_VHS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07651 ANTH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00273 ENTH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464 SSF48464, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50942 ENTH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60641-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGQTLTDRI AAAQYSVTGS AVARAVCKAT THEVMGPKKK HLDYLIQATN
60 70 80 90 100
ETNVNIPQMA DTLFERATNS SWVVVFKALV TTHHLMVHGN ERFIQYLASR
110 120 130 140 150
NTLFNLSNFL DKSGSHGYDM STFIRRYSRY LNEKAFSYRQ MAFDFARVKK
160 170 180 190 200
GADGVMRTMA PEKLLKSMPI LQGQIDALLE FDVHPNELTN GVINAAFMLL
210 220 230 240 250
FKDLIKLFAC YNDGVINLLE KFFEMKKGQC KDALEIYKRF LTRMTRVSEF
260 270 280 290 300
LKVAEQVGID KGDIPDLTQA PSSLMETLEQ HLNTLEGKKP GNNEGSGAPS
310 320 330 340 350
PLSKSSPATT VTSPNSTPAK TIDTSPPVDL FATASAAVPV STSKPSSDLL
360 370 380 390 400
DLQPDFSSGG AAAAAAPAPP PPAGGATAWG DLLGEDSLAA LSSVPSEAQI
410 420 430 440 450
SDPFAPEPTP PTTTAEIATA SASASTTTTV TAVTAEVDLF GDAFAASPGE
460 470 480 490 500
APAASEGAAA PATPTPVAAA LDACSGNDPF APSEGSAEAA PELDLFAMKP
510 520 530 540 550
PETSVPVVTP TASTAPPVPA TAPSPAPAVA AAAAATTAAT AAATTTTTTS
560 570 580 590 600
AATATTAPPA LDIFGDLFES TPEVAAAPKP DAAPSIDLFS TDAFSSPPQG
610 620 630 640 650
ASPVPESSLT ADLLSVDAFA APSPATTASP AKVDSSGVID LFGDAFGSSA
660 670 680 690 700
SEPQPASQAA SSSSASADLL AGFGGSFMAP SPSPVTPAQN NLLQPNFEAA
710 720 730 740 750
FGTTPSTSSS SSFDPSVFDG LGDLLMPTMA PAGQPAPVSM VPPSPAMAAS
760 770 780 790 800
KALGSDLDSS LASLVGNLGI SGTTTKKGDL QWNAGEKKLT GGANWQPKVA
810 820 830 840 850
PATWSAGVPP SAPLQGAVPP TSSVPPVAGA PSVGQPGAGF GMPPAGTGMP
860 870 880 890 900
MMPQQPVMFA QPMMRPPFGA AAVPGTQLSP SPTPASQSPK KPPAKDPLAD

LNIKDFL
Length:907
Mass (Da):92,502
Last modified:August 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23959C2B54F5EBF1
GO
Isoform 2 (identifier: O60641-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-907: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:58
Mass (Da):6,230
Checksum:i22EBDA4093641147
GO
Isoform 3 (identifier: O60641-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-269: Missing.
     293-295: NEG → K
     381-671: Missing.

Show »
Length:600
Mass (Da):63,128
Checksum:i0B92B5140631B77F
GO
Isoform 4 (identifier: O60641-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-295: NEG → K
     616-643: Missing.

Note: Gene prediction based on EST data.
Show »
Length:877
Mass (Da):89,656
Checksum:iA9A46C044BE55582
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDG8E9PDG8_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
902Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGY9E5RGY9_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIJ5E5RIJ5_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFC6E5RFC6_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHK9E5RHK9_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFU0E5RFU0_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK51E5RK51_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJY3E5RJY3_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK53E5RK53_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGP8E5RGP8_HUMAN
Clathrin coat assembly protein AP18...
SNAP91
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31631 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH18201 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4Q → R in AAH60818 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02099759 – 907Missing in isoform 2. 1 PublicationAdd BLAST849
Alternative sequenceiVSP_020998256 – 269Missing in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_020999293 – 295NEG → K in isoform 3 and isoform 4. 1 Publication3
Alternative sequenceiVSP_021000381 – 671Missing in isoform 3. 1 PublicationAdd BLAST291
Alternative sequenceiVSP_047049616 – 643Missing in isoform 4. CuratedAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB014556 mRNA Translation: BAA31631.2 Different initiation.
AK289582 mRNA Translation: BAF82271.1
CR749348 mRNA Translation: CAH18201.1 Sequence problems.
AL109915 Genomic DNA No translation available.
AL136972 Genomic DNA No translation available.
AF054993 mRNA Translation: AAC09352.1
BC060818 mRNA Translation: AAH60818.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47455.1 [O60641-1]
CCDS56437.1 [O60641-3]
CCDS56438.1 [O60641-4]

NCBI Reference Sequences

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RefSeqi
NP_001229721.1, NM_001242792.1 [O60641-1]
NP_001229722.1, NM_001242793.1 [O60641-4]
NP_001229723.1, NM_001242794.1 [O60641-3]
NP_001243646.1, NM_001256717.1
NP_001243647.1, NM_001256718.1
NP_055656.1, NM_014841.2 [O60641-1]
XP_005248827.1, XM_005248770.4 [O60641-1]
XP_006715678.1, XM_006715615.1 [O60641-1]
XP_011534567.1, XM_011536265.1 [O60641-1]
XP_011534568.1, XM_011536266.1 [O60641-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.368046

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369694; ENSP00000358708; ENSG00000065609 [O60641-1]
ENST00000439399; ENSP00000400459; ENSG00000065609 [O60641-1]
ENST00000520213; ENSP00000428026; ENSG00000065609 [O60641-3]
ENST00000520302; ENSP00000428511; ENSG00000065609 [O60641-4]
ENST00000521743; ENSP00000428215; ENSG00000065609 [O60641-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9892

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9892

UCSC genome browser

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UCSCi
uc003pkc.4 human [O60641-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014556 mRNA Translation: BAA31631.2 Different initiation.
AK289582 mRNA Translation: BAF82271.1
CR749348 mRNA Translation: CAH18201.1 Sequence problems.
AL109915 Genomic DNA No translation available.
AL136972 Genomic DNA No translation available.
AF054993 mRNA Translation: AAC09352.1
BC060818 mRNA Translation: AAH60818.1
CCDSiCCDS47455.1 [O60641-1]
CCDS56437.1 [O60641-3]
CCDS56438.1 [O60641-4]
RefSeqiNP_001229721.1, NM_001242792.1 [O60641-1]
NP_001229722.1, NM_001242793.1 [O60641-4]
NP_001229723.1, NM_001242794.1 [O60641-3]
NP_001243646.1, NM_001256717.1
NP_001243647.1, NM_001256718.1
NP_055656.1, NM_014841.2 [O60641-1]
XP_005248827.1, XM_005248770.4 [O60641-1]
XP_006715678.1, XM_006715615.1 [O60641-1]
XP_011534567.1, XM_011536265.1 [O60641-1]
XP_011534568.1, XM_011536266.1 [O60641-1]
UniGeneiHs.368046

3D structure databases

ProteinModelPortaliO60641
SMRiO60641
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115222, 11 interactors
ELMiO60641
IntActiO60641, 8 interactors
MINTiO60641
STRINGi9606.ENSP00000358708

PTM databases

iPTMnetiO60641
PhosphoSitePlusiO60641
SwissPalmiO60641

Polymorphism and mutation databases

BioMutaiSNAP91

Proteomic databases

EPDiO60641
jPOSTiO60641
MaxQBiO60641
PaxDbiO60641
PeptideAtlasiO60641
PRIDEiO60641
ProteomicsDBi49493
49494 [O60641-2]
49495 [O60641-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369694; ENSP00000358708; ENSG00000065609 [O60641-1]
ENST00000439399; ENSP00000400459; ENSG00000065609 [O60641-1]
ENST00000520213; ENSP00000428026; ENSG00000065609 [O60641-3]
ENST00000520302; ENSP00000428511; ENSG00000065609 [O60641-4]
ENST00000521743; ENSP00000428215; ENSG00000065609 [O60641-1]
GeneIDi9892
KEGGihsa:9892
UCSCiuc003pkc.4 human [O60641-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9892
DisGeNETi9892
EuPathDBiHostDB:ENSG00000065609.14

GeneCards: human genes, protein and diseases

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GeneCardsi
SNAP91

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0006038
HGNCiHGNC:14986 SNAP91
HPAiCAB009745
HPA029632
HPA029633
MIMi607923 gene
neXtProtiNX_O60641
OpenTargetsiENSG00000065609
PharmGKBiPA37956

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0251 Eukaryota
ENOG410XQ90 LUCA
GeneTreeiENSGT00940000155630
HOGENOMiHOG000015763
HOVERGENiHBG049391
InParanoidiO60641
KOiK20043
OMAiPRFREPN
OrthoDBi1592722at2759
PhylomeDBiO60641
TreeFamiTF314861

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNAP91 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SNAP91

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9892

Protein Ontology

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PROi
PR:O60641

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000065609 Expressed in 140 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_SNAP91
ExpressionAtlasiO60641 baseline and differential
GenevisibleiO60641 HS

Family and domain databases

Gene3Di1.20.58.150, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR011417 ANTH_dom
IPR014712 Clathrin_AP_dom2
IPR013809 ENTH
IPR008942 ENTH_VHS
PfamiView protein in Pfam
PF07651 ANTH, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP180_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60641
Secondary accession number(s): A8K0L7
, E5RI02, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: August 1, 1999
Last modified: January 16, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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