Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 163 (16 Oct 2019)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Tetraspanin-3

Gene

TSPAN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell migration Source: GO_Central

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.40.1.16 the tetraspanin (tetraspanin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetraspanin-3
Short name:
Tspan-3
Alternative name(s):
Tetraspanin TM4-A
Transmembrane 4 superfamily member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPAN3
Synonyms:TM4SF8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17752 TSPAN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613134 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60637

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 50ExtracellularSequence analysisAdd BLAST18
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 85CytoplasmicSequence analysisAdd BLAST14
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 212ExtracellularSequence analysisAdd BLAST106
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 253CytoplasmicSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10099

Open Targets

More...
OpenTargetsi
ENSG00000140391

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134913500

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60637

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSPAN3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192391 – 253Tetraspanin-3Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60637

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O60637

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60637

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60637

PeptideAtlas

More...
PeptideAtlasi
O60637

PRoteomics IDEntifications database

More...
PRIDEi
O60637

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49490 [O60637-1]
49491 [O60637-2]
49492 [O60637-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
710

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60637

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60637

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60637

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
O60637

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140391 Expressed in 231 organ(s), highest expression level in parietal pleura

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60637 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60637 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015996

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with claudin-11/CLDN11 and integrins.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115406, 55 interactors

Protein interaction database and analysis system

More...
IntActi
O60637, 50 interactors

Molecular INTeraction database

More...
MINTi
O60637

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000267970

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3882 Eukaryota
ENOG4111IRY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154954

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230654

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60637

KEGG Orthology (KO)

More...
KOi
K17293

Identification of Orthologs from Complete Genome Data

More...
OMAi
CCQPSIS

Database of Orthologous Groups

More...
OrthoDBi
1406905at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60637

TreeFam database of animal gene trees

More...
TreeFami
TF316345

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00335 Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002419 Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00259 TMFOUR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48652 SSF48652, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00421 TM4_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT
60 70 80 90 100
LIPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVIIL LLVFVTEVVV
110 120 130 140 150
VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN PDAASRAIDY VQRQLHCCGI
160 170 180 190 200
HNYSDWENTD WFKETKNQSV PLSCCRETAS NCNGSLAHPS DLYAEGCEAL
210 220 230 240 250
VVKKLQEIMM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG

TYA
Length:253
Mass (Da):28,018
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE074A4CD57229EC6
GO
Isoform 2 (identifier: O60637-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-110: Missing.

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):25,183
Checksum:iF44F7EAD2803A735
GO
Isoform 3 (identifier: O60637-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-85: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):21,184
Checksum:iAD906FFB870A639D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKJ9H0YKJ9_HUMAN
Tetraspanin-3
TSPAN3
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMH8H0YMH8_HUMAN
Tetraspanin-3
TSPAN3
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85Missing in AAH00704 (PubMed:15489334).Curated1
Sequence conflicti236R → G in BAA91613 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04351922 – 85Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_04267986 – 110Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF054840 mRNA Translation: AAC69716.1
AF133423 mRNA Translation: AAF08362.1
AK001326 mRNA Translation: BAA91627.1
AK001305 mRNA Translation: BAA91613.1
AK001310 mRNA Translation: BAA91615.1
AK075336 mRNA Translation: BAG52114.1
AK075482 mRNA Translation: BAG52152.1
AK298157 mRNA Translation: BAG60431.1
AC090181 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99209.1
CH471136 Genomic DNA Translation: EAW99210.1
CH471136 Genomic DNA Translation: EAW99211.1
BC000704 mRNA Translation: AAH00704.1
BC004280 mRNA Translation: AAH04280.1
BC009248 mRNA Translation: AAH09248.1
BC011206 mRNA Translation: AAH11206.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10292.1 [O60637-1]
CCDS10293.1 [O60637-2]
CCDS53963.1 [O60637-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A59264

NCBI Reference Sequences

More...
RefSeqi
NP_001161884.1, NM_001168412.1 [O60637-3]
NP_005715.1, NM_005724.5 [O60637-1]
NP_944492.1, NM_198902.2 [O60637-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267970; ENSP00000267970; ENSG00000140391 [O60637-1]
ENST00000346495; ENSP00000341329; ENSG00000140391 [O60637-2]
ENST00000424443; ENSP00000407243; ENSG00000140391 [O60637-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10099

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10099

UCSC genome browser

More...
UCSCi
uc002bcj.4 human [O60637-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054840 mRNA Translation: AAC69716.1
AF133423 mRNA Translation: AAF08362.1
AK001326 mRNA Translation: BAA91627.1
AK001305 mRNA Translation: BAA91613.1
AK001310 mRNA Translation: BAA91615.1
AK075336 mRNA Translation: BAG52114.1
AK075482 mRNA Translation: BAG52152.1
AK298157 mRNA Translation: BAG60431.1
AC090181 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99209.1
CH471136 Genomic DNA Translation: EAW99210.1
CH471136 Genomic DNA Translation: EAW99211.1
BC000704 mRNA Translation: AAH00704.1
BC004280 mRNA Translation: AAH04280.1
BC009248 mRNA Translation: AAH09248.1
BC011206 mRNA Translation: AAH11206.1
CCDSiCCDS10292.1 [O60637-1]
CCDS10293.1 [O60637-2]
CCDS53963.1 [O60637-3]
PIRiA59264
RefSeqiNP_001161884.1, NM_001168412.1 [O60637-3]
NP_005715.1, NM_005724.5 [O60637-1]
NP_944492.1, NM_198902.2 [O60637-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115406, 55 interactors
IntActiO60637, 50 interactors
MINTiO60637
STRINGi9606.ENSP00000267970

Protein family/group databases

TCDBi8.A.40.1.16 the tetraspanin (tetraspanin) family

PTM databases

GlyConnecti710
iPTMnetiO60637
PhosphoSitePlusiO60637
SwissPalmiO60637
UniCarbKBiO60637

Polymorphism and mutation databases

BioMutaiTSPAN3

Proteomic databases

jPOSTiO60637
MassIVEiO60637
MaxQBiO60637
PaxDbiO60637
PeptideAtlasiO60637
PRIDEiO60637
ProteomicsDBi49490 [O60637-1]
49491 [O60637-2]
49492 [O60637-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10099

Genome annotation databases

EnsembliENST00000267970; ENSP00000267970; ENSG00000140391 [O60637-1]
ENST00000346495; ENSP00000341329; ENSG00000140391 [O60637-2]
ENST00000424443; ENSP00000407243; ENSG00000140391 [O60637-3]
GeneIDi10099
KEGGihsa:10099
UCSCiuc002bcj.4 human [O60637-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10099
DisGeNETi10099

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSPAN3
HGNCiHGNC:17752 TSPAN3
HPAiHPA015996
MIMi613134 gene
neXtProtiNX_O60637
OpenTargetsiENSG00000140391
PharmGKBiPA134913500

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00940000154954
HOGENOMiHOG000230654
InParanoidiO60637
KOiK17293
OMAiCCQPSIS
OrthoDBi1406905at2759
PhylomeDBiO60637
TreeFamiTF316345

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSPAN3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TSPAN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10099
PharosiO60637

Protein Ontology

More...
PROi
PR:O60637

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140391 Expressed in 231 organ(s), highest expression level in parietal pleura
ExpressionAtlasiO60637 baseline and differential
GenevisibleiO60637 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspanin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60637
Secondary accession number(s): A6NEH4
, B3KQQ2, B4DP19, Q9BW22, Q9NVX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: October 16, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again