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Protein

Tetraspanin-3

Gene

TSPAN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.By similarity

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central

Protein family/group databases

TCDBi8.A.40.1.16 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-3
Short name:
Tspan-3
Alternative name(s):
Tetraspanin TM4-A
Transmembrane 4 superfamily member 8
Gene namesi
Name:TSPAN3
Synonyms:TM4SF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140391.14
HGNCiHGNC:17752 TSPAN3
MIMi613134 gene
neXtProtiNX_O60637

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 50ExtracellularSequence analysisAdd BLAST18
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 85CytoplasmicSequence analysisAdd BLAST14
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 212ExtracellularSequence analysisAdd BLAST106
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 253CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10099
OpenTargetsiENSG00000140391
PharmGKBiPA134913500

Polymorphism and mutation databases

BioMutaiTSPAN3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192391 – 253Tetraspanin-3Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO60637
MaxQBiO60637
PaxDbiO60637
PeptideAtlasiO60637
PRIDEiO60637
ProteomicsDBi49490
49491 [O60637-2]
49492 [O60637-3]

PTM databases

GlyConnecti710
iPTMnetiO60637
PhosphoSitePlusiO60637
SwissPalmiO60637
UniCarbKBiO60637

Expressioni

Gene expression databases

BgeeiENSG00000140391 Expressed in 231 organ(s), highest expression level in parietal pleura
CleanExiHS_TSPAN3
ExpressionAtlasiO60637 baseline and differential
GenevisibleiO60637 HS

Organism-specific databases

HPAiHPA015996

Interactioni

Subunit structurei

Interacts with claudin-11/CLDN11 and integrins.By similarity

Protein-protein interaction databases

BioGridi115406, 55 interactors
IntActiO60637, 3 interactors
STRINGi9606.ENSP00000267970

Structurei

3D structure databases

ProteinModelPortaliO60637
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230654
HOVERGENiHBG104967
InParanoidiO60637
KOiK17293
OMAiDLYSEGC
OrthoDBiEOG091G0INM
PhylomeDBiO60637
TreeFamiTF316345

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT
60 70 80 90 100
LIPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVIIL LLVFVTEVVV
110 120 130 140 150
VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN PDAASRAIDY VQRQLHCCGI
160 170 180 190 200
HNYSDWENTD WFKETKNQSV PLSCCRETAS NCNGSLAHPS DLYAEGCEAL
210 220 230 240 250
VVKKLQEIMM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG

TYA
Length:253
Mass (Da):28,018
Last modified:August 1, 1998 - v1
Checksum:iE074A4CD57229EC6
GO
Isoform 2 (identifier: O60637-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-110: Missing.

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):25,183
Checksum:iF44F7EAD2803A735
GO
Isoform 3 (identifier: O60637-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-85: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):21,184
Checksum:iAD906FFB870A639D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKJ9H0YKJ9_HUMAN
Tetraspanin-3
TSPAN3
164Annotation score:
H0YMH8H0YMH8_HUMAN
Tetraspanin-3
TSPAN3
45Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85Missing in AAH00704 (PubMed:15489334).Curated1
Sequence conflicti236R → G in BAA91613 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04351922 – 85Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_04267986 – 110Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054840 mRNA Translation: AAC69716.1
AF133423 mRNA Translation: AAF08362.1
AK001326 mRNA Translation: BAA91627.1
AK001305 mRNA Translation: BAA91613.1
AK001310 mRNA Translation: BAA91615.1
AK075336 mRNA Translation: BAG52114.1
AK075482 mRNA Translation: BAG52152.1
AK298157 mRNA Translation: BAG60431.1
AC090181 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99209.1
CH471136 Genomic DNA Translation: EAW99210.1
CH471136 Genomic DNA Translation: EAW99211.1
BC000704 mRNA Translation: AAH00704.1
BC004280 mRNA Translation: AAH04280.1
BC009248 mRNA Translation: AAH09248.1
BC011206 mRNA Translation: AAH11206.1
CCDSiCCDS10292.1 [O60637-1]
CCDS10293.1 [O60637-2]
CCDS53963.1 [O60637-3]
PIRiA59264
RefSeqiNP_001161884.1, NM_001168412.1 [O60637-3]
NP_005715.1, NM_005724.5 [O60637-1]
NP_944492.1, NM_198902.2 [O60637-2]
UniGeneiHs.744863

Genome annotation databases

EnsembliENST00000267970; ENSP00000267970; ENSG00000140391 [O60637-1]
ENST00000346495; ENSP00000341329; ENSG00000140391 [O60637-2]
ENST00000424443; ENSP00000407243; ENSG00000140391 [O60637-3]
GeneIDi10099
KEGGihsa:10099
UCSCiuc002bcj.4 human [O60637-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054840 mRNA Translation: AAC69716.1
AF133423 mRNA Translation: AAF08362.1
AK001326 mRNA Translation: BAA91627.1
AK001305 mRNA Translation: BAA91613.1
AK001310 mRNA Translation: BAA91615.1
AK075336 mRNA Translation: BAG52114.1
AK075482 mRNA Translation: BAG52152.1
AK298157 mRNA Translation: BAG60431.1
AC090181 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99209.1
CH471136 Genomic DNA Translation: EAW99210.1
CH471136 Genomic DNA Translation: EAW99211.1
BC000704 mRNA Translation: AAH00704.1
BC004280 mRNA Translation: AAH04280.1
BC009248 mRNA Translation: AAH09248.1
BC011206 mRNA Translation: AAH11206.1
CCDSiCCDS10292.1 [O60637-1]
CCDS10293.1 [O60637-2]
CCDS53963.1 [O60637-3]
PIRiA59264
RefSeqiNP_001161884.1, NM_001168412.1 [O60637-3]
NP_005715.1, NM_005724.5 [O60637-1]
NP_944492.1, NM_198902.2 [O60637-2]
UniGeneiHs.744863

3D structure databases

ProteinModelPortaliO60637
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115406, 55 interactors
IntActiO60637, 3 interactors
STRINGi9606.ENSP00000267970

Protein family/group databases

TCDBi8.A.40.1.16 the tetraspanin (tetraspanin) family

PTM databases

GlyConnecti710
iPTMnetiO60637
PhosphoSitePlusiO60637
SwissPalmiO60637
UniCarbKBiO60637

Polymorphism and mutation databases

BioMutaiTSPAN3

Proteomic databases

EPDiO60637
MaxQBiO60637
PaxDbiO60637
PeptideAtlasiO60637
PRIDEiO60637
ProteomicsDBi49490
49491 [O60637-2]
49492 [O60637-3]

Protocols and materials databases

DNASUi10099
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267970; ENSP00000267970; ENSG00000140391 [O60637-1]
ENST00000346495; ENSP00000341329; ENSG00000140391 [O60637-2]
ENST00000424443; ENSP00000407243; ENSG00000140391 [O60637-3]
GeneIDi10099
KEGGihsa:10099
UCSCiuc002bcj.4 human [O60637-1]

Organism-specific databases

CTDi10099
DisGeNETi10099
EuPathDBiHostDB:ENSG00000140391.14
GeneCardsiTSPAN3
HGNCiHGNC:17752 TSPAN3
HPAiHPA015996
MIMi613134 gene
neXtProtiNX_O60637
OpenTargetsiENSG00000140391
PharmGKBiPA134913500
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230654
HOVERGENiHBG104967
InParanoidiO60637
KOiK17293
OMAiDLYSEGC
OrthoDBiEOG091G0INM
PhylomeDBiO60637
TreeFamiTF316345

Miscellaneous databases

ChiTaRSiTSPAN3 human
GeneWikiiTSPAN3
GenomeRNAii10099
PROiPR:O60637
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140391 Expressed in 231 organ(s), highest expression level in parietal pleura
CleanExiHS_TSPAN3
ExpressionAtlasiO60637 baseline and differential
GenevisibleiO60637 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN3_HUMAN
AccessioniPrimary (citable) accession number: O60637
Secondary accession number(s): A6NEH4
, B3KQQ2, B4DP19, Q9BW22, Q9NVX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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