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Protein

Tetraspanin-2

Gene

TSPAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-2
Short name:
Tspan-2
Alternative name(s):
Tetraspan NET-3
Gene namesi
Name:TSPAN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134198.9
HGNCiHGNC:20659 TSPAN2
MIMi613133 gene
neXtProtiNX_O60636

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 54ExtracellularSequence analysisAdd BLAST20
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 90CytoplasmicSequence analysisAdd BLAST15
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 188ExtracellularSequence analysisAdd BLAST77
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 221CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10100
OpenTargetsiENSG00000134198
PharmGKBiPA134938787

Polymorphism and mutation databases

BioMutaiTSPAN2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192361 – 221Tetraspanin-2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60636
PaxDbiO60636
PeptideAtlasiO60636
PRIDEiO60636
ProteomicsDBi49489

PTM databases

iPTMnetiO60636
PhosphoSitePlusiO60636

Expressioni

Gene expression databases

BgeeiENSG00000134198 Expressed in 176 organ(s), highest expression level in body of uterus
CleanExiHS_TSPAN2
ExpressionAtlasiO60636 baseline and differential
GenevisibleiO60636 HS

Organism-specific databases

HPAiHPA015640

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115407, 23 interactors
IntActiO60636, 21 interactors
STRINGi9606.ENSP00000358529

Structurei

3D structure databases

ProteinModelPortaliO60636
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiO60636
KOiK17354
OMAiQSTCPKE
OrthoDBiEOG091G0K9H
PhylomeDBiO60636
TreeFamiTF352895

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60636-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK
60 70 80 90 100
SPEYFYVGLY VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA
110 120 130 140 150
AEVTTGVFAF IGKGVAIRHV QTMYEEAYND YLKDRGKGNG TLITFHSTFQ
160 170 180 190 200
CCGKESSEQV QPTCPKELLG HKNCIDEIET IISVKLQLIG IVGIGIAGLT
210 220
IFGMIFSMVL CCAIRNSRDV I
Length:221
Mass (Da):24,148
Last modified:September 19, 2002 - v2
Checksum:i8973B46795901802
GO
Isoform 2 (identifier: O60636-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-200: Missing.

Show »
Length:193
Mass (Da):21,269
Checksum:i342623BF9BCCD1AD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AKP1B1AKP1_HUMAN
Tetraspanin
TSPAN2
196Annotation score:
B1AKP2B1AKP2_HUMAN
Tetraspanin
TSPAN2
187Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80 – 82AMR → PCW in AAC69715 (PubMed:9714763).Curated3
Sequence conflicti146 – 148HST → PLQH in AAC69715 (PubMed:9714763).Curated3
Sequence conflicti170G → R in AAC69715 (PubMed:9714763).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052328118R → L. Corresponds to variant dbSNP:rs9659602Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047734173 – 200Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054839 mRNA Translation: AAC69715.1
GU971730 mRNA Translation: ADF80915.1
AL109660 Genomic DNA No translation available.
BC021675 mRNA Translation: AAH21675.1
CCDSiCCDS881.1 [O60636-1]
PIRiA59263
RefSeqiNP_001295245.1, NM_001308316.1 [O60636-2]
NP_005716.2, NM_005725.5 [O60636-1]
UniGeneiHs.310458

Genome annotation databases

EnsembliENST00000369516; ENSP00000358529; ENSG00000134198 [O60636-1]
GeneIDi10100
KEGGihsa:10100
UCSCiuc001eft.5 human [O60636-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054839 mRNA Translation: AAC69715.1
GU971730 mRNA Translation: ADF80915.1
AL109660 Genomic DNA No translation available.
BC021675 mRNA Translation: AAH21675.1
CCDSiCCDS881.1 [O60636-1]
PIRiA59263
RefSeqiNP_001295245.1, NM_001308316.1 [O60636-2]
NP_005716.2, NM_005725.5 [O60636-1]
UniGeneiHs.310458

3D structure databases

ProteinModelPortaliO60636
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115407, 23 interactors
IntActiO60636, 21 interactors
STRINGi9606.ENSP00000358529

PTM databases

iPTMnetiO60636
PhosphoSitePlusiO60636

Polymorphism and mutation databases

BioMutaiTSPAN2

Proteomic databases

MaxQBiO60636
PaxDbiO60636
PeptideAtlasiO60636
PRIDEiO60636
ProteomicsDBi49489

Protocols and materials databases

DNASUi10100
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369516; ENSP00000358529; ENSG00000134198 [O60636-1]
GeneIDi10100
KEGGihsa:10100
UCSCiuc001eft.5 human [O60636-1]

Organism-specific databases

CTDi10100
DisGeNETi10100
EuPathDBiHostDB:ENSG00000134198.9
GeneCardsiTSPAN2
HGNCiHGNC:20659 TSPAN2
HPAiHPA015640
MIMi613133 gene
neXtProtiNX_O60636
OpenTargetsiENSG00000134198
PharmGKBiPA134938787
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiO60636
KOiK17354
OMAiQSTCPKE
OrthoDBiEOG091G0K9H
PhylomeDBiO60636
TreeFamiTF352895

Miscellaneous databases

ChiTaRSiTSPAN2 human
GeneWikiiTSPAN2
GenomeRNAii10100
PROiPR:O60636
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134198 Expressed in 176 organ(s), highest expression level in body of uterus
CleanExiHS_TSPAN2
ExpressionAtlasiO60636 baseline and differential
GenevisibleiO60636 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN2_HUMAN
AccessioniPrimary (citable) accession number: O60636
Secondary accession number(s): D6PTH4, Q5TET2, Q8WU05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2002
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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