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Entry version 154 (07 Oct 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Tetraspanin-1

Gene

TSPAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O60635

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetraspanin-1
Short name:
Tspan-1
Alternative name(s):
Tetraspan NET-1
Tetraspanin TM4-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPAN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117472.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20657, TSPAN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613170, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60635

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 52ExtracellularSequence analysisAdd BLAST20
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 88CytoplasmicSequence analysisAdd BLAST15
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 211ExtracellularSequence analysisAdd BLAST102
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 241CytoplasmicSequence analysis9

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi141N → A: Loss of glycosylation. 1 Publication1
Mutagenesisi154N → A: Loss of glycosylation. 1 Publication1
Mutagenesisi178N → A: Loss of glycosylation. 1 Publication1
Mutagenesisi184N → A: Loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10103

Open Targets

More...
OpenTargetsi
ENSG00000117472

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938100

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60635, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSPAN1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192341 – 241Tetraspanin-1Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi154N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi178N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60635

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60635

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O60635

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60635

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60635

PeptideAtlas

More...
PeptideAtlasi
O60635

PRoteomics IDEntifications database

More...
PRIDEi
O60635

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49488

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1797, 9 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O60635, 4 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60635

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60635

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117472, Expressed in bronchial epithelial cell and 150 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60635, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000117472, Tissue enhanced (intestine, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115410, 19 interactors

Protein interaction database and analysis system

More...
IntActi
O60635, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361072

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O60635, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3882, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_055524_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60635

KEGG Orthology (KO)

More...
KOi
K17348

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGCFKQL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60635

TreeFam database of animal gene trees

More...
TreeFami
TF352892

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000301, Tetraspanin
IPR018499, Tetraspanin/Peripherin
IPR018503, Tetraspanin_CS
IPR008952, Tetraspanin_EC2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00335, Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002419, Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00259, TMFOUR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48652, SSF48652, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00421, TM4_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O60635-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQCFSFIKTM MILFNLLIFL CGAALLAVGI WVSIDGASFL KIFGPLSSSA
60 70 80 90 100
MQFVNVGYFL IAAGVVVFAL GFLGCYGAKT ESKCALVTFF FILLLIFIAE
110 120 130 140 150
VAAAVVALVY TTMAEHFLTL LVVPAIKKDY GSQEDFTQVW NTTMKGLKCC
160 170 180 190 200
GFTNYTDFED SPYFKENSAF PPFCCNDNVT NTANETCTKQ KAHDQKVEGC
210 220 230 240
FNQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL Q
Length:241
Mass (Da):26,301
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF938AD7147CB884
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti189K → E in AAC69714 (PubMed:9714763).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05232738S → F. Corresponds to variant dbSNP:rs2234267Ensembl.1
Natural variantiVAR_03457387V → M. Corresponds to variant dbSNP:rs2234268Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF054838 mRNA Translation: AAC69714.1
AF065388 mRNA Translation: AAC17119.1
AF133425 mRNA Translation: AAF08364.1
AK313774 mRNA Translation: BAG36512.1
AL672043 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06938.1
CH471059 Genomic DNA Translation: EAX06939.1
CH471059 Genomic DNA Translation: EAX06940.1
BC007290 mRNA Translation: AAH07290.1
BC013404 mRNA Translation: AAH13404.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS530.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A59262

NCBI Reference Sequences

More...
RefSeqi
NP_005718.2, NM_005727.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372003; ENSP00000361072; ENSG00000117472

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10103

UCSC genome browser

More...
UCSCi
uc001cpd.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054838 mRNA Translation: AAC69714.1
AF065388 mRNA Translation: AAC17119.1
AF133425 mRNA Translation: AAF08364.1
AK313774 mRNA Translation: BAG36512.1
AL672043 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06938.1
CH471059 Genomic DNA Translation: EAX06939.1
CH471059 Genomic DNA Translation: EAX06940.1
BC007290 mRNA Translation: AAH07290.1
BC013404 mRNA Translation: AAH13404.1
CCDSiCCDS530.1
PIRiA59262
RefSeqiNP_005718.2, NM_005727.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115410, 19 interactors
IntActiO60635, 3 interactors
STRINGi9606.ENSP00000361072

PTM databases

GlyConnecti1797, 9 N-Linked glycans (2 sites)
GlyGeniO60635, 4 sites, 1 N-linked glycan (1 site)
iPTMnetiO60635
PhosphoSitePlusiO60635

Polymorphism and mutation databases

BioMutaiTSPAN1

Proteomic databases

EPDiO60635
jPOSTiO60635
MassIVEiO60635
MaxQBiO60635
PaxDbiO60635
PeptideAtlasiO60635
PRIDEiO60635
ProteomicsDBi49488

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32752, 254 antibodies

The DNASU plasmid repository

More...
DNASUi
10103

Genome annotation databases

EnsembliENST00000372003; ENSP00000361072; ENSG00000117472
GeneIDi10103
KEGGihsa:10103
UCSCiuc001cpd.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10103
DisGeNETi10103
EuPathDBiHostDB:ENSG00000117472.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSPAN1
HGNCiHGNC:20657, TSPAN1
HPAiENSG00000117472, Tissue enhanced (intestine, testis)
MIMi613170, gene
neXtProtiNX_O60635
OpenTargetsiENSG00000117472
PharmGKBiPA134938100

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3882, Eukaryota
GeneTreeiENSGT00940000158851
HOGENOMiCLU_055524_4_1_1
InParanoidiO60635
KOiK17348
OMAiQGCFKQL
PhylomeDBiO60635
TreeFamiTF352892

Enzyme and pathway databases

PathwayCommonsiO60635

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10103, 5 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSPAN1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10103
PharosiO60635, Tbio

Protein Ontology

More...
PROi
PR:O60635
RNActiO60635, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117472, Expressed in bronchial epithelial cell and 150 other tissues
GenevisibleiO60635, HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301, Tetraspanin
IPR018499, Tetraspanin/Peripherin
IPR018503, Tetraspanin_CS
IPR008952, Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335, Tetraspanin, 1 hit
PIRSFiPIRSF002419, Tetraspanin, 1 hit
PRINTSiPR00259, TMFOUR
SUPFAMiSSF48652, SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421, TM4_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60635
Secondary accession number(s): D3DQ14, O60745, Q5VST0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 7, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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