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Protein

Selenoprotein F

Gene

SELENOF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • 'de novo' posttranslational protein folding Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Selenoprotein F1 Publication
Alternative name(s):
15 kDa selenoprotein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SELENOF1 PublicationImported
Synonyms:SEP151 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183291.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17705 SELENOF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606254 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60613

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9403

Open Targets

More...
OpenTargetsi
ENSG00000183291

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SELENOF

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002230732 – 165Selenoprotein FAdd BLAST134

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60613

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60613

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60613

PeptideAtlas

More...
PeptideAtlasi
O60613

PRoteomics IDEntifications database

More...
PRIDEi
O60613

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49486
49487 [O60613-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60613

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60613

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60613

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Higher levels in prostate and thyroid gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183291 Expressed in 237 organ(s), highest expression level in palpebral conjunctiva

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054937

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a tight complex with UGGT1/UGCGL1.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RDH11Q8TC125EBI-1052797,EBI-2823756

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114800, 26 interactors

Protein interaction database and analysis system

More...
IntActi
O60613, 11 interactors

Molecular INTeraction database

More...
MINTi
O60613

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328729

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60613

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the selenoprotein M/F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3384 Eukaryota
ENOG4111MSS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154284

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000238561

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108472

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60613

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCTCKFG

Database of Orthologous Groups

More...
OrthoDBi
1393196at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60613

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.30.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038219 Sep15/SelM_sf
IPR039992 Sep15_SelM
IPR014912 Sep15_SelM_dom
IPR036249 Thioredoxin-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13077 PTHR13077, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08806 Sep15_SelM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60613-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAMAAGPSG CLVPAFGLRL LLATVLQAVS AFGAEFSSEA CRELGFSSNL
60 70 80 90 100
LCSSCDLLGQ FNLLQLDPDC RGCCQEEAQF ETKKLYAGAI LEVCGUKLGR
110 120 130 140 150
FPQVQAFVRS DKPKLFRGLQ IKYVRGSDPV LKLLDDNGNI AEELSILKWN
160
TDSVEEFLSE KLERI
Length:165
Mass (Da):18,092
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE20C44FAB97AD336
GO
Isoform 2 (identifier: O60613-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-124: AFVRSDKPKLFRGLQIKYV → VCPWFRPCIKAFGRQWEHC
     125-165: Missing.

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):13,521
Checksum:iA8B6EDCF4046249D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1G7A0A087X1G7_HUMAN
Selenoprotein F
SELENOF
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MZD0A8MZD0_HUMAN
Selenoprotein F
SELENOF
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1T0A0A0B4J1T0_HUMAN
Selenoprotein F
SELENOF
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXL0A0A087WXL0_HUMAN
Selenoprotein F
SELENOF
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IT39A0A3B3IT39_HUMAN
Selenoprotein F
SELENOF
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX89A0A0J9YX89_HUMAN
Selenoprotein F
SELENOF
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXM9A0A0J9YXM9_HUMAN
Selenoprotein F
SELENOF
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC15478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF78966 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG31556 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG31557 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAJ18323 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 14870 Da from positions 29 - 165. Determined by ESI. 1 Publication
Molecular mass is 14830 Da from positions 29 - 165. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014695106 – 124AFVRS…QIKYV → VCPWFRPCIKAFGRQWEHC in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_014696125 – 165Missing in isoform 2. 1 PublicationAdd BLAST41

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei96Selenocysteine1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF288991 mRNA Translation: AAG31556.1 Different initiation.
AF288992 Genomic DNA Translation: AAG31557.1 Different initiation.
AF267982 Genomic DNA Translation: AAF78966.1 Different initiation.
AL833575 mRNA Translation: CAJ18323.1 Different initiation.
AL121989 Genomic DNA No translation available.
BC005294 mRNA Translation: AAH05294.3
BC016359 mRNA Translation: AAH16359.3
BC021697 mRNA Translation: AAH21697.3
AF051894 mRNA Translation: AAC15478.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS76177.1 [O60613-2]
CCDS76178.1 [O60613-1]

NCBI Reference Sequences

More...
RefSeqi
NP_004252.2, NM_004261.4 [O60613-1]
NP_976086.1, NM_203341.2 [O60613-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.362728

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331835; ENSP00000328729; ENSG00000183291 [O60613-1]
ENST00000370554; ENSP00000359585; ENSG00000183291 [O60613-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9403

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9403

Keywords - Coding sequence diversityi

Alternative splicing, Selenocysteine

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288991 mRNA Translation: AAG31556.1 Different initiation.
AF288992 Genomic DNA Translation: AAG31557.1 Different initiation.
AF267982 Genomic DNA Translation: AAF78966.1 Different initiation.
AL833575 mRNA Translation: CAJ18323.1 Different initiation.
AL121989 Genomic DNA No translation available.
BC005294 mRNA Translation: AAH05294.3
BC016359 mRNA Translation: AAH16359.3
BC021697 mRNA Translation: AAH21697.3
AF051894 mRNA Translation: AAC15478.1 Different initiation.
CCDSiCCDS76177.1 [O60613-2]
CCDS76178.1 [O60613-1]
RefSeqiNP_004252.2, NM_004261.4 [O60613-1]
NP_976086.1, NM_203341.2 [O60613-2]
UniGeneiHs.362728

3D structure databases

ProteinModelPortaliO60613
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114800, 26 interactors
IntActiO60613, 11 interactors
MINTiO60613
STRINGi9606.ENSP00000328729

PTM databases

iPTMnetiO60613
PhosphoSitePlusiO60613
SwissPalmiO60613

Polymorphism and mutation databases

BioMutaiSELENOF

Proteomic databases

EPDiO60613
jPOSTiO60613
PaxDbiO60613
PeptideAtlasiO60613
PRIDEiO60613
ProteomicsDBi49486
49487 [O60613-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9403
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331835; ENSP00000328729; ENSG00000183291 [O60613-1]
ENST00000370554; ENSP00000359585; ENSG00000183291 [O60613-2]
GeneIDi9403
KEGGihsa:9403

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9403
DisGeNETi9403
EuPathDBiHostDB:ENSG00000183291.15

GeneCards: human genes, protein and diseases

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GeneCardsi
SELENOF
HGNCiHGNC:17705 SELENOF
HPAiHPA054937
MIMi606254 gene
neXtProtiNX_O60613
OpenTargetsiENSG00000183291

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3384 Eukaryota
ENOG4111MSS LUCA
GeneTreeiENSGT00940000154284
HOGENOMiHOG000238561
HOVERGENiHBG108472
InParanoidiO60613
OMAiVCTCKFG
OrthoDBi1393196at2759
PhylomeDBiO60613

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SELENOF human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SEP15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9403

Protein Ontology

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PROi
PR:O60613

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000183291 Expressed in 237 organ(s), highest expression level in palpebral conjunctiva

Family and domain databases

Gene3Di3.40.30.50, 1 hit
InterProiView protein in InterPro
IPR038219 Sep15/SelM_sf
IPR039992 Sep15_SelM
IPR014912 Sep15_SelM_dom
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR13077 PTHR13077, 1 hit
PfamiView protein in Pfam
PF08806 Sep15_SelM, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEP15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60613
Secondary accession number(s): A0A0B4J1S4
, Q4GZG7, Q8WU00, Q9BS64, Q9GZW0, Q9NR01
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 28, 2018
Last modified: January 16, 2019
This is version 162 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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