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Protein

Selenoprotein F

Gene

SELENOF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

GO - Biological processi

  • 'de novo' posttranslational protein folding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein F1 Publication
Alternative name(s):
15 kDa selenoprotein1 Publication
Gene namesi
Name:SELENOF1 PublicationImported
Synonyms:SEP151 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183291.15
HGNCiHGNC:17705 SELENOF
MIMi606254 gene
neXtProtiNX_O60613

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi9403
OpenTargetsiENSG00000183291

Polymorphism and mutation databases

BioMutaiSEPTIN15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000002230732 – 165Selenoprotein FAdd BLAST134

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

EPDiO60613
PaxDbiO60613
PeptideAtlasiO60613
PRIDEiO60613
ProteomicsDBi49486
49487 [O60613-2]

PTM databases

iPTMnetiO60613
PhosphoSitePlusiO60613
SwissPalmiO60613

Expressioni

Tissue specificityi

Higher levels in prostate and thyroid gland.1 Publication

Gene expression databases

BgeeiENSG00000183291 Expressed in 237 organ(s), highest expression level in palpebral conjunctiva

Organism-specific databases

HPAiHPA054937

Interactioni

Subunit structurei

Forms a tight complex with UGGT1/UGCGL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RDH11Q8TC125EBI-1052797,EBI-2823756

Protein-protein interaction databases

BioGridi114800, 26 interactors
IntActiO60613, 11 interactors
MINTiO60613
STRINGi9606.ENSP00000328729

Structurei

3D structure databases

ProteinModelPortaliO60613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein M/F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3384 Eukaryota
ENOG4111MSS LUCA
GeneTreeiENSGT00390000005531
HOGENOMiHOG000238561
HOVERGENiHBG108472
InParanoidiO60613
OMAiVCTCKFG
OrthoDBiEOG091G1AT7
PhylomeDBiO60613

Family and domain databases

Gene3Di3.40.30.50, 1 hit
InterProiView protein in InterPro
IPR038219 Sep15/SelM_sf
IPR039992 Sep15_SelM
IPR014912 Sep15_SelM_dom
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR13077 PTHR13077, 1 hit
PfamiView protein in Pfam
PF08806 Sep15_SelM, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60613-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAMAAGPSG CLVPAFGLRL LLATVLQAVS AFGAEFSSEA CRELGFSSNL
60 70 80 90 100
LCSSCDLLGQ FNLLQLDPDC RGCCQEEAQF ETKKLYAGAI LEVCGUKLGR
110 120 130 140 150
FPQVQAFVRS DKPKLFRGLQ IKYVRGSDPV LKLLDDNGNI AEELSILKWN
160
TDSVEEFLSE KLERI
Length:165
Mass (Da):18,092
Last modified:March 28, 2018 - v4
Checksum:iE20C44FAB97AD336
GO
Isoform 2 (identifier: O60613-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-124: AFVRSDKPKLFRGLQIKYV → VCPWFRPCIKAFGRQWEHC
     125-165: Missing.

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):13,521
Checksum:iA8B6EDCF4046249D
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1G7A0A087X1G7_HUMAN
Selenoprotein F
SELENOF
164Annotation score:
A8MZD0A8MZD0_HUMAN
Selenoprotein F
SELENOF
144Annotation score:
A0A0B4J1T0A0A0B4J1T0_HUMAN
Selenoprotein F
SELENOF
124Annotation score:
A0A087WXL0A0A087WXL0_HUMAN
Selenoprotein F
SELENOF
123Annotation score:
A0A0J9YX89A0A0J9YX89_HUMAN
Selenoprotein F
SELENOF
88Annotation score:
A0A0J9YXM9A0A0J9YXM9_HUMAN
Selenoprotein F
SELENOF
31Annotation score:

Sequence cautioni

The sequence AAC15478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF78966 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG31556 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG31557 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAJ18323 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Mass spectrometryi

Molecular mass is 14870 Da from positions 29 - 165. Determined by ESI. 1 Publication
Molecular mass is 14830 Da from positions 29 - 165. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014695106 – 124AFVRS…QIKYV → VCPWFRPCIKAFGRQWEHC in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_014696125 – 165Missing in isoform 2. 1 PublicationAdd BLAST41

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei96Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288991 mRNA Translation: AAG31556.1 Different initiation.
AF288992 Genomic DNA Translation: AAG31557.1 Different initiation.
AF267982 Genomic DNA Translation: AAF78966.1 Different initiation.
AL833575 mRNA Translation: CAJ18323.1 Different initiation.
AL121989 Genomic DNA No translation available.
BC005294 mRNA Translation: AAH05294.3
BC016359 mRNA Translation: AAH16359.3
BC021697 mRNA Translation: AAH21697.3
AF051894 mRNA Translation: AAC15478.1 Different initiation.
CCDSiCCDS76177.1 [O60613-2]
CCDS76178.1 [O60613-1]
RefSeqiNP_004252.2, NM_004261.4 [O60613-1]
NP_976086.1, NM_203341.2 [O60613-2]
UniGeneiHs.362728

Genome annotation databases

EnsembliENST00000331835; ENSP00000328729; ENSG00000183291 [O60613-1]
ENST00000370554; ENSP00000359585; ENSG00000183291 [O60613-2]
GeneIDi9403
KEGGihsa:9403

Keywords - Coding sequence diversityi

Alternative splicing, Selenocysteine

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288991 mRNA Translation: AAG31556.1 Different initiation.
AF288992 Genomic DNA Translation: AAG31557.1 Different initiation.
AF267982 Genomic DNA Translation: AAF78966.1 Different initiation.
AL833575 mRNA Translation: CAJ18323.1 Different initiation.
AL121989 Genomic DNA No translation available.
BC005294 mRNA Translation: AAH05294.3
BC016359 mRNA Translation: AAH16359.3
BC021697 mRNA Translation: AAH21697.3
AF051894 mRNA Translation: AAC15478.1 Different initiation.
CCDSiCCDS76177.1 [O60613-2]
CCDS76178.1 [O60613-1]
RefSeqiNP_004252.2, NM_004261.4 [O60613-1]
NP_976086.1, NM_203341.2 [O60613-2]
UniGeneiHs.362728

3D structure databases

ProteinModelPortaliO60613
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114800, 26 interactors
IntActiO60613, 11 interactors
MINTiO60613
STRINGi9606.ENSP00000328729

PTM databases

iPTMnetiO60613
PhosphoSitePlusiO60613
SwissPalmiO60613

Polymorphism and mutation databases

BioMutaiSEPTIN15

Proteomic databases

EPDiO60613
PaxDbiO60613
PeptideAtlasiO60613
PRIDEiO60613
ProteomicsDBi49486
49487 [O60613-2]

Protocols and materials databases

DNASUi9403
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331835; ENSP00000328729; ENSG00000183291 [O60613-1]
ENST00000370554; ENSP00000359585; ENSG00000183291 [O60613-2]
GeneIDi9403
KEGGihsa:9403

Organism-specific databases

CTDi9403
DisGeNETi9403
EuPathDBiHostDB:ENSG00000183291.15
GeneCardsiSELENOF
HGNCiHGNC:17705 SELENOF
HPAiHPA054937
MIMi606254 gene
neXtProtiNX_O60613
OpenTargetsiENSG00000183291
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3384 Eukaryota
ENOG4111MSS LUCA
GeneTreeiENSGT00390000005531
HOGENOMiHOG000238561
HOVERGENiHBG108472
InParanoidiO60613
OMAiVCTCKFG
OrthoDBiEOG091G1AT7
PhylomeDBiO60613

Miscellaneous databases

ChiTaRSiSELENOF human
GeneWikiiSEP15
GenomeRNAii9403
PROiPR:O60613
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183291 Expressed in 237 organ(s), highest expression level in palpebral conjunctiva

Family and domain databases

Gene3Di3.40.30.50, 1 hit
InterProiView protein in InterPro
IPR038219 Sep15/SelM_sf
IPR039992 Sep15_SelM
IPR014912 Sep15_SelM_dom
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR13077 PTHR13077, 1 hit
PfamiView protein in Pfam
PF08806 Sep15_SelM, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEP15_HUMAN
AccessioniPrimary (citable) accession number: O60613
Secondary accession number(s): A0A0B4J1S4
, Q4GZG7, Q8WU00, Q9BS64, Q9GZW0, Q9NR01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 160 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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