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Protein

GDNF family receptor alpha-3

Gene

GFRA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling
SIGNORiO60609

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-3
Short name:
GDNF receptor alpha-3
Short name:
GDNFR-alpha-3
Short name:
GFR-alpha-3
Gene namesi
Name:GFRA3
ORF Names:UNQ339/PRO538/PRO3664
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000146013.10
HGNCiHGNC:4245 GFRA3
MIMi605710 gene
neXtProtiNX_O60609

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2676
OpenTargetsiENSG00000146013
PharmGKBiPA28655

Polymorphism and mutation databases

BioMutaiGFRA3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000001078932 – 374GDNF family receptor alpha-3Add BLAST343
PropeptideiPRO_0000010790375 – 400Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagine1 Publication1
Lipidationi374GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO60609
PeptideAtlasiO60609
PRIDEiO60609
ProteomicsDBi49482
49483 [O60609-2]

PTM databases

iPTMnetiO60609
PhosphoSitePlusiO60609

Expressioni

Tissue specificityi

Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.1 Publication

Gene expression databases

BgeeiENSG00000146013 Expressed in 108 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_GFRA3
ExpressionAtlasiO60609 baseline and differential
GenevisibleiO60609 HS

Organism-specific databases

HPAiHPA020731

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARTNQ5T4W74EBI-15586309,EBI-15586241

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108944, 1 interactor
DIPiDIP-29114N
IntActiO60609, 1 interactor
STRINGi9606.ENSP00000274721

Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60609
SMRiO60609
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60609

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIBW Eukaryota
ENOG4111VG4 LUCA
GeneTreeiENSGT00550000074579
HOGENOMiHOG000059598
HOVERGENiHBG051726
InParanoidiO60609
OMAiKAYGEAC
OrthoDBiEOG091G087B
PhylomeDBiO60609
TreeFamiTF331647

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003505 GDNF_rcpt_A3
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PRINTSiPR01319 GDNFRALPHA3
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60609-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRPLNPRPL PPVVLMLLLL LPPSPLPLAA GDPLPTESRL MNSCLQARRK
60 70 80 90 100
CQADPTCSAA YHHLDSCTSS ISTPLPSEEP SVPADCLEAA QQLRNSSLIG
110 120 130 140 150
CMCHRRMKNQ VACLDIYWTV HRARSLGNYE LDVSPYEDTV TSKPWKMNLS
160 170 180 190 200
KLNMLKPDSD LCLKFAMLCT LNDKCDRLRK AYGEACSGPH CQRHVCLRQL
210 220 230 240 250
LTFFEKAAEP HAQGLLLCPC APNDRGCGER RRNTIAPNCA LPPVAPNCLE
260 270 280 290 300
LRRLCFSDPL CRSRLVDFQT HCHPMDILGT CATEQSRCLR AYLGLIGTAM
310 320 330 340 350
TPNFVSNVNT SVALSCTCRG SGNLQEECEM LEGFFSHNPC LTEAIAAKMR
360 370 380 390 400
FHSQLFSQDW PHPTFAVMAH QNENPAVRPQ PWVPSLFSCT LPLILLLSLW
Length:400
Mass (Da):44,511
Last modified:July 19, 2004 - v2
Checksum:iB0BC252FE1F072C7
GO
Isoform 2 (identifier: O60609-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-157: Missing.

Show »
Length:369
Mass (Da):40,930
Checksum:i43DEAB2E6B900CE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108K → R in AAC24355 (PubMed:9576965).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010942127 – 157Missing in isoform 2. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051767 mRNA Translation: AAC24355.1
AY358997 mRNA Translation: AAQ89356.1
AY359037 mRNA Translation: AAQ89396.1
AK297693 mRNA Translation: BAG60051.1
AK314022 mRNA Translation: BAG36733.1
CH471062 Genomic DNA Translation: EAW62152.1
CH471062 Genomic DNA Translation: EAW62153.1
BC037951 mRNA Translation: AAH37951.1
CCDSiCCDS4201.1 [O60609-1]
RefSeqiNP_001487.2, NM_001496.3 [O60609-1]
UniGeneiHs.58042

Genome annotation databases

EnsembliENST00000274721; ENSP00000274721; ENSG00000146013 [O60609-1]
ENST00000378362; ENSP00000367613; ENSG00000146013 [O60609-2]
GeneIDi2676
KEGGihsa:2676
UCSCiuc003lcn.4 human [O60609-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051767 mRNA Translation: AAC24355.1
AY358997 mRNA Translation: AAQ89356.1
AY359037 mRNA Translation: AAQ89396.1
AK297693 mRNA Translation: BAG60051.1
AK314022 mRNA Translation: BAG36733.1
CH471062 Genomic DNA Translation: EAW62152.1
CH471062 Genomic DNA Translation: EAW62153.1
BC037951 mRNA Translation: AAH37951.1
CCDSiCCDS4201.1 [O60609-1]
RefSeqiNP_001487.2, NM_001496.3 [O60609-1]
UniGeneiHs.58042

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GH0X-ray1.92A/B151-363[»]
ProteinModelPortaliO60609
SMRiO60609
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108944, 1 interactor
DIPiDIP-29114N
IntActiO60609, 1 interactor
STRINGi9606.ENSP00000274721

PTM databases

iPTMnetiO60609
PhosphoSitePlusiO60609

Polymorphism and mutation databases

BioMutaiGFRA3

Proteomic databases

PaxDbiO60609
PeptideAtlasiO60609
PRIDEiO60609
ProteomicsDBi49482
49483 [O60609-2]

Protocols and materials databases

DNASUi2676
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274721; ENSP00000274721; ENSG00000146013 [O60609-1]
ENST00000378362; ENSP00000367613; ENSG00000146013 [O60609-2]
GeneIDi2676
KEGGihsa:2676
UCSCiuc003lcn.4 human [O60609-1]

Organism-specific databases

CTDi2676
DisGeNETi2676
EuPathDBiHostDB:ENSG00000146013.10
GeneCardsiGFRA3
HGNCiHGNC:4245 GFRA3
HPAiHPA020731
MIMi605710 gene
neXtProtiNX_O60609
OpenTargetsiENSG00000146013
PharmGKBiPA28655
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBW Eukaryota
ENOG4111VG4 LUCA
GeneTreeiENSGT00550000074579
HOGENOMiHOG000059598
HOVERGENiHBG051726
InParanoidiO60609
OMAiKAYGEAC
OrthoDBiEOG091G087B
PhylomeDBiO60609
TreeFamiTF331647

Enzyme and pathway databases

ReactomeiR-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling
SIGNORiO60609

Miscellaneous databases

ChiTaRSiGFRA3 human
EvolutionaryTraceiO60609
GeneWikiiGFRA3
GenomeRNAii2676
PROiPR:O60609
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146013 Expressed in 108 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_GFRA3
ExpressionAtlasiO60609 baseline and differential
GenevisibleiO60609 HS

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003505 GDNF_rcpt_A3
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PRINTSiPR01319 GDNFRALPHA3
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGFRA3_HUMAN
AccessioniPrimary (citable) accession number: O60609
Secondary accession number(s): B2RA36
, B4DMY9, Q6UW20, Q8IUZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 19, 2004
Last modified: September 12, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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