UniProtKB - O60603 (TLR2_HUMAN)
Toll-like receptor 2
TLR2
Functioni
Catalytic activityi
- EC:3.2.2.6PROSITE-ProRule annotationThis reaction proceeds in the forwardPROSITE-ProRule annotation direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 716 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- amyloid-beta binding Source: ARUK-UCL
- identical protein binding Source: IntAct
- lipopolysaccharide binding Source: UniProtKB
- lipopolysaccharide immune receptor activity Source: UniProtKB
- NAD(P)+ nucleosidase activity Source: UniProtKB-EC
- NAD+ nucleotidase, cyclic ADP-ribose generating Source: UniProtKB-EC
- pattern recognition receptor activity Source: UniProtKB
- peptidoglycan binding Source: UniProtKB
- protein-containing complex binding Source: ARUK-UCL
- signaling receptor activity Source: GO_Central
- Toll-like receptor binding Source: UniProtKB
- transmembrane signaling receptor activity Source: InterPro
- triacyl lipopeptide binding Source: MGI
GO - Biological processi
- apoptotic process Source: ProtInc
- cell activation Source: AgBase
- cellular response to bacterial lipopeptide Source: BHF-UCL
- cellular response to diacyl bacterial lipopeptide Source: UniProtKB
- cellular response to interferon-gamma Source: UniProtKB
- cellular response to lipoteichoic acid Source: MGI
- cellular response to triacyl bacterial lipopeptide Source: UniProtKB
- central nervous system myelin formation Source: Ensembl
- cytokine secretion involved in immune response Source: CACAO
- defense response to Gram-positive bacterium Source: UniProtKB
- detection of diacyl bacterial lipopeptide Source: MGI
- detection of triacyl bacterial lipopeptide Source: MGI
- I-kappaB phosphorylation Source: BHF-UCL
- immune response Source: ProtInc
- inflammatory response Source: GO_Central
- innate immune response Source: BHF-UCL
- interleukin-10 production Source: CACAO
- learning Source: ARUK-UCL
- leukotriene metabolic process Source: Ensembl
- microglia development Source: ARUK-UCL
- microglial cell activation Source: Ensembl
- MyD88-dependent toll-like receptor signaling pathway Source: Reactome
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of phagocytosis Source: ARUK-UCL
- negative regulation of synapse assembly Source: ARUK-UCL
- neutrophil degranulation Source: Reactome
- nitric oxide metabolic process Source: Ensembl
- positive regulation of cellular response to macrophage colony-stimulating factor stimulus Source: UniProtKB
- positive regulation of chemokine production Source: BHF-UCL
- positive regulation of gene expression Source: UniProtKB
- positive regulation of inflammatory response Source: ARUK-UCL
- positive regulation of interferon-beta production Source: BHF-UCL
- positive regulation of interleukin-10 production Source: Ensembl
- positive regulation of interleukin-12 production Source: BHF-UCL
- positive regulation of interleukin-18 production Source: BHF-UCL
- positive regulation of interleukin-6 production Source: BHF-UCL
- positive regulation of interleukin-8 production Source: BHF-UCL
- positive regulation of matrix metallopeptidase secretion Source: ARUK-UCL
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL
- positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- positive regulation of toll-like receptor signaling pathway Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of tumor necrosis factor production Source: BHF-UCL
- positive regulation of Wnt signaling pathway Source: BHF-UCL
- regulation of cytokine secretion Source: InterPro
- response to fatty acid Source: Ensembl
- response to hypoxia Source: Ensembl
- response to insulin Source: Ensembl
- response to progesterone Source: Ensembl
- response to toxic substance Source: Ensembl
- signal transduction Source: UniProtKB
- toll-like receptor 2 signaling pathway Source: InterPro
- toll-like receptor signaling pathway Source: GO_Central
- toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
- toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
- tumor necrosis factor production Source: ARUK-UCL
Keywordsi
Molecular function | Hydrolase, Receptor |
Biological process | Immunity, Inflammatory response, Innate immunity |
Ligand | NAD |
Enzyme and pathway databases
PathwayCommonsi | O60603 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-1461957, Beta defensins R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188, Toll Like Receptor TLR6:TLR2 Cascade R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6798695, Neutrophil degranulation R-HSA-9637628, Modulation by Mtb of host immune system |
SignaLinki | O60603 |
SIGNORi | O60603 |
Protein family/group databases
TCDBi | 8.A.43.1.16, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family |
Names & Taxonomyi
Protein namesi | Recommended name: Toll-like receptor 2 (EC:3.2.2.6PROSITE-ProRule annotation)Alternative name(s): Toll/interleukin-1 receptor-like protein 4 CD_antigen: CD282 |
Gene namesi | Name:TLR2 Synonyms:TIL4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137462.6 |
HGNCi | HGNC:11848, TLR2 |
MIMi | 603028, gene |
neXtProti | NX_O60603 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein Sequence analysis
- phagosome membrane By similarity; Single-pass type I membrane protein Sequence analysis
- Membrane raft 1 Publication
Note: Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.1 Publication
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: ARUK-UCL
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: BHF-UCL
- Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI
Other locations
- cell body Source: Ensembl
- cell projection Source: Ensembl
- cell surface Source: UniProtKB
- cytoplasm Source: BHF-UCL
- membrane raft Source: UniProtKB
- phagocytic vesicle membrane Source: UniProtKB-SubCell
- secretory granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 588 | ExtracellularSequence analysisAdd BLAST | 568 | |
Transmembranei | 589 – 609 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 610 – 784 | CytoplasmicSequence analysisAdd BLAST | 175 |
Keywords - Cellular componenti
Cytoplasmic vesicle, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 114 | N → S: Prevents addition of N-glycans. Reduces secretion of the N-terminal ectodomain. 1 Publication | 1 | |
Mutagenesisi | 199 | N → D: Prevents addition of N-glycans. Reduces secretion of the N-terminal ectodomain. 1 Publication | 1 | |
Mutagenesisi | 416 | T → A: Prevents addition of N-glycans. Reduces secretion of the N-terminal ectodomain. 1 Publication | 1 | |
Mutagenesisi | 442 | N → D: Prevents addition of N-glycans. Prevents secretion of the N-terminal ectodomain. 1 Publication | 1 | |
Mutagenesisi | 681 | P → F: Abolishes the interaction with MYD88. No effect on oligomerization or on the structure of the TIR domain. 1 Publication | 1 | |
Mutagenesisi | 709 | K → R: Reduced protein stability. 1 Publication | 1 | |
Mutagenesisi | 714 | K → R: Reduced protein stability. 1 Publication | 1 | |
Mutagenesisi | 742 – 743 | KK → RR: Reduced protein stability. 1 Publication | 2 | |
Mutagenesisi | 751 | K → R: Reduced protein stability. 1 Publication | 1 | |
Mutagenesisi | 754 | K → R: Loss of PPP1R11-mediated ubiquitination and degradation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7097 |
MalaCardsi | TLR2 |
MIMi | 246300, phenotype |
OpenTargetsi | ENSG00000137462 |
PharmGKBi | PA36550 |
Miscellaneous databases
Pharosi | O60603, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4163 |
DrugBanki | DB00210, Adapalene DB05475, Golotimod DB00045, Lyme disease vaccine (recombinant OspA) DB03963, S-(Dimethylarsenic)Cysteine DB11601, Tuberculin purified protein derivative |
GuidetoPHARMACOLOGYi | 1752 |
Polymorphism and mutation databases
BioMutai | TLR2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000034710 | 21 – 784 | Toll-like receptor 2Add BLAST | 764 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 36 | 1 Publication | ||
Glycosylationi | 114 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 199 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 353 ↔ 382 | 1 Publication | ||
Glycosylationi | 414 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 432 ↔ 454 | 1 Publication | ||
Glycosylationi | 442 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Cross-linki | 754 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | O60603 |
jPOSTi | O60603 |
MassIVEi | O60603 |
PaxDbi | O60603 |
PeptideAtlasi | O60603 |
PRIDEi | O60603 |
ProteomicsDBi | 49481 |
PTM databases
GlyConnecti | 1816, 3 N-Linked glycans (1 site) |
GlyGeni | O60603, 4 sites |
iPTMneti | O60603 |
PhosphoSitePlusi | O60603 |
SwissPalmi | O60603 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000137462, Expressed in blood and 173 other tissues |
ExpressionAtlasi | O60603, baseline and differential |
Genevisiblei | O60603, HS |
Organism-specific databases
HPAi | ENSG00000137462, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Interacts with LY96, TLR1 and TLR6 (via extracellular domain) (PubMed:17889651). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211). Binds MYD88 (via TIR domain).
Interacts with TICAM1 (PubMed:12471095).
Interacts with CNPY3 (By similarity).
Interacts with ATG16L1 (PubMed:23376921).
Interacts with PPP1R11 (By similarity).
Interacts with TICAM2 (PubMed:25385819).
By similarity5 Publications(Microbial infection) Interacts with M.tuberculosis EsxA.
1 Publication(Microbial infection) Interacts with M.bovis MPB83.
1 Publication(Microbial infection) Interacts with Staphylococcus aureus protein SSL5.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 349 | Interaction with bacterial lipopeptide | 1 |
Binary interactionsi
Hide detailsO60603
GO - Molecular functioni
- identical protein binding Source: IntAct
- Toll-like receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112952, 29 interactors |
CORUMi | O60603 |
DIPi | DIP-35138N |
IntActi | O60603, 40 interactors |
MINTi | O60603 |
STRINGi | 9606.ENSP00000260010 |
Chemistry databases
BindingDBi | O60603 |
Miscellaneous databases
RNActi | O60603, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O60603 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60603 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 54 – 77 | LRR 1Add BLAST | 24 | |
Repeati | 78 – 101 | LRR 2Add BLAST | 24 | |
Repeati | 102 – 125 | LRR 3Add BLAST | 24 | |
Repeati | 126 – 150 | LRR 4Add BLAST | 25 | |
Repeati | 151 – 175 | LRR 5Add BLAST | 25 | |
Repeati | 176 – 199 | LRR 6Add BLAST | 24 | |
Repeati | 200 – 223 | LRR 7Add BLAST | 24 | |
Repeati | 224 – 250 | LRR 8Add BLAST | 27 | |
Repeati | 251 – 278 | LRR 9Add BLAST | 28 | |
Repeati | 279 – 308 | LRR 10Add BLAST | 30 | |
Repeati | 309 – 337 | LRR 11Add BLAST | 29 | |
Repeati | 338 – 361 | LRR 12Add BLAST | 24 | |
Repeati | 362 – 388 | LRR 13Add BLAST | 27 | |
Repeati | 389 – 414 | LRR 14Add BLAST | 26 | |
Repeati | 415 – 437 | LRR 15Add BLAST | 23 | |
Repeati | 438 – 457 | LRR 16Add BLAST | 20 | |
Repeati | 458 – 478 | LRR 17Add BLAST | 21 | |
Repeati | 479 – 500 | LRR 18Add BLAST | 22 | |
Repeati | 501 – 524 | LRR 19Add BLAST | 24 | |
Domaini | 525 – 579 | LRRCTAdd BLAST | 55 | |
Domaini | 639 – 782 | TIRPROSITE-ProRule annotationAdd BLAST | 144 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 761 – 778 | ATG16L1-binding motifAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4641, Eukaryota |
GeneTreei | ENSGT00940000156323 |
HOGENOMi | CLU_006000_3_0_1 |
InParanoidi | O60603 |
OMAi | CTLNGVG |
OrthoDBi | 282372at2759 |
PhylomeDBi | O60603 |
TreeFami | TF351113 |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR027185, TLR2 IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR24365, PTHR24365, 1 hit PTHR24365:SF17, PTHR24365:SF17, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits PF01463, LRRCT, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037595, Toll-like_receptor, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 11 hits PS50104, TIR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL
60 70 80 90 100
TEAVKSLDLS NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG
110 120 130 140 150
SLEHLDLSYN YLSNLSSSWF KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK
160 170 180 190 200
LQILRVGNMD TFTKIQRKDF AGLTFLEELE IDASDLQSYE PKSLKSIQNV
210 220 230 240 250
SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFHFS ELSTGETNSL
260 270 280 290 300
IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN
310 320 330 340 350
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL
360 370 380 390 400
VPCLLSQHLK SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA
410 420 430 440 450
SLEKTGETLL TLKNLTNIDI SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS
460 470 480 490 500
VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK ELYISRNKLM TLPDASLLPM
510 520 530 540 550
LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE FLSFTQEQQA
560 570 580 590 600
LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL
610 620 630 640 650
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER
660 670 680 690 700
DAYWVENLMV QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV
710 720 730 740 750
FVLSENFVKS EWCKYELDFS HFRLFDENND AAILILLEPI EKKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA AIKS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0S2Z4L7 | A0A0S2Z4L7_HUMAN | Toll-like receptor 2 | TLR2 | 210 | Annotation score: | ||
A0A2R8Y4N9 | A0A2R8Y4N9_HUMAN | Toll-like receptor 2 | TLR2 | 246 | Annotation score: | ||
A0A2R8Y7R7 | A0A2R8Y7R7_HUMAN | Toll-like receptor 2 | TLR2 | 32 | Annotation score: | ||
A0A2R8YHF6 | A0A2R8YHF6_HUMAN | Toll-like receptor 2 | TLR2 | 18 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 | L → Q in AAM23001 (Ref. 8) Curated | 1 | |
Sequence conflicti | 68 | S → C in AAM23001 (Ref. 8) Curated | 1 | |
Sequence conflicti | 726 | D → E in AAC34133 (PubMed:9435236).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066349 | 89 | N → D1 PublicationCorresponds to variant dbSNP:rs137853176EnsemblClinVar. | 1 | |
Natural variantiVAR_026765 | 411 | T → I Reduces TLR2-mediated NF-kappa-B activation. 1 PublicationCorresponds to variant dbSNP:rs5743699Ensembl. | 1 | |
Natural variantiVAR_066350 | 571 | R → H1 PublicationCorresponds to variant dbSNP:rs61735277EnsemblClinVar. | 1 | |
Natural variantiVAR_026766 | 579 | R → H. Corresponds to variant dbSNP:rs5743703EnsemblClinVar. | 1 | |
Natural variantiVAR_024663 | 631 | P → H Reduces TLR2-mediated NF-kappa-B activation. 2 PublicationsCorresponds to variant dbSNP:rs5743704Ensembl. | 1 | |
Natural variantiVAR_066351 | 636 | S → R1 PublicationCorresponds to variant dbSNP:rs137853177EnsemblClinVar. | 1 | |
Natural variantiVAR_031236 | 677 | R → W2 PublicationsCorresponds to variant dbSNP:rs121917864EnsemblClinVar. | 1 | |
Natural variantiVAR_052360 | 715 | Y → N. Corresponds to variant dbSNP:rs5743706Ensembl. | 1 | |
Natural variantiVAR_031237 | 753 | R → Q Reduces TLR2-mediated NF-kappa-B activation. 2 PublicationsCorresponds to variant dbSNP:rs5743708EnsemblClinVar. | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000260010; ENSP00000260010; ENSG00000137462 ENST00000642580; ENSP00000495339; ENSG00000137462 ENST00000642700; ENSP00000494425; ENSG00000137462 |
GeneIDi | 7097 |
KEGGi | hsa:7097 |
UCSCi | uc063aif.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FYW | X-ray | 3.00 | A | 636-784 | [»] | |
1FYX | X-ray | 2.80 | A | 636-784 | [»] | |
1O77 | X-ray | 3.20 | A/B/C/D/E | 639-784 | [»] | |
2Z7X | X-ray | 2.10 | A | 27-506 | [»] | |
2Z80 | X-ray | 1.80 | A/B | 1-284 | [»] | |
6NIG | X-ray | 2.35 | A/B/C/D | 1-507 | [»] | |
SMRi | O60603 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112952, 29 interactors |
CORUMi | O60603 |
DIPi | DIP-35138N |
IntActi | O60603, 40 interactors |
MINTi | O60603 |
STRINGi | 9606.ENSP00000260010 |
Chemistry databases
BindingDBi | O60603 |
ChEMBLi | CHEMBL4163 |
DrugBanki | DB00210, Adapalene DB05475, Golotimod DB00045, Lyme disease vaccine (recombinant OspA) DB03963, S-(Dimethylarsenic)Cysteine DB11601, Tuberculin purified protein derivative |
GuidetoPHARMACOLOGYi | 1752 |
Protein family/group databases
TCDBi | 8.A.43.1.16, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family |
PTM databases
GlyConnecti | 1816, 3 N-Linked glycans (1 site) |
GlyGeni | O60603, 4 sites |
iPTMneti | O60603 |
PhosphoSitePlusi | O60603 |
SwissPalmi | O60603 |
Polymorphism and mutation databases
BioMutai | TLR2 |
Proteomic databases
EPDi | O60603 |
jPOSTi | O60603 |
MassIVEi | O60603 |
PaxDbi | O60603 |
PeptideAtlasi | O60603 |
PRIDEi | O60603 |
ProteomicsDBi | 49481 |
Protocols and materials databases
ABCDi | O60603, 3 sequenced antibodies |
Antibodypediai | 16689, 1339 antibodies |
DNASUi | 7097 |
Genome annotation databases
Ensembli | ENST00000260010; ENSP00000260010; ENSG00000137462 ENST00000642580; ENSP00000495339; ENSG00000137462 ENST00000642700; ENSP00000494425; ENSG00000137462 |
GeneIDi | 7097 |
KEGGi | hsa:7097 |
UCSCi | uc063aif.1, human |
Organism-specific databases
CTDi | 7097 |
DisGeNETi | 7097 |
EuPathDBi | HostDB:ENSG00000137462.6 |
GeneCardsi | TLR2 |
HGNCi | HGNC:11848, TLR2 |
HPAi | ENSG00000137462, Tissue enhanced (blood) |
MalaCardsi | TLR2 |
MIMi | 246300, phenotype 603028, gene |
neXtProti | NX_O60603 |
OpenTargetsi | ENSG00000137462 |
PharmGKBi | PA36550 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4641, Eukaryota |
GeneTreei | ENSGT00940000156323 |
HOGENOMi | CLU_006000_3_0_1 |
InParanoidi | O60603 |
OMAi | CTLNGVG |
OrthoDBi | 282372at2759 |
PhylomeDBi | O60603 |
TreeFami | TF351113 |
Enzyme and pathway databases
PathwayCommonsi | O60603 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-1461957, Beta defensins R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188, Toll Like Receptor TLR6:TLR2 Cascade R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6798695, Neutrophil degranulation R-HSA-9637628, Modulation by Mtb of host immune system |
SignaLinki | O60603 |
SIGNORi | O60603 |
Miscellaneous databases
BioGRID-ORCSi | 7097, 2 hits in 848 CRISPR screens |
EvolutionaryTracei | O60603 |
GeneWikii | TLR_2 |
GenomeRNAii | 7097 |
Pharosi | O60603, Tchem |
PROi | PR:O60603 |
RNActi | O60603, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137462, Expressed in blood and 173 other tissues |
ExpressionAtlasi | O60603, baseline and differential |
Genevisiblei | O60603, HS |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR027185, TLR2 IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR24365, PTHR24365, 1 hit PTHR24365:SF17, PTHR24365:SF17, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits PF01463, LRRCT, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037595, Toll-like_receptor, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 11 hits PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TLR2_HUMAN | |
Accessioni | O60603Primary (citable) accession number: O60603 Secondary accession number(s): B3Y612 Q8NI00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | August 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 220 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries