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UniProtKB - O60602 (TLR5_HUMAN)

Entry version 181 (17 Jun 2020)
Sequence version 4 (25 Nov 2008)
Previous versions | rss
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Protein

Toll-like receptor 5

Gene

TLR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-5602680 MyD88 deficiency (TLR5)
R-HSA-5603037 IRAK4 deficiency (TLR5)
R-HSA-975871 MyD88 cascade initiated on plasma membrane

SIGNOR Signaling Network Open Resource

More...SIGNORi		O60602

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 5
Alternative name(s):
Toll/interleukin-1 receptor-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLR5
Synonyms:TIL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000187554.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:11851 TLR5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603031 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60602

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 639ExtracellularSequence analysisAdd BLAST619
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei640 – 660HelicalSequence analysisAdd BLAST21
Topological domaini661 – 858CytoplasmicSequence analysisAdd BLAST198

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Systemic lupus erythematosus 1 (SLEB1)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Related information in OMIM

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNET

More...DisGeNETi		7100

MalaCards human disease database

More...MalaCardsi		TLR5
MIMi109100 phenotype
601744 phenotype
608556 phenotype
615557 phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36553

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60602 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2176839

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TLR5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003472921 – 858Toll-like receptor 5Add BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi46N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi245N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi342N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi422N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi583 ↔ 6101 Publication
Disulfide bondi585 ↔ 6291 Publication
Glycosylationi595N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi598N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei798Phosphotyrosine1 Publication1
Modified residuei805Phosphoserine; by PKD/PRKD11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.2 Publications
Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60602

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60602

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60602

PeptideAtlas

More...PeptideAtlasi		O60602

PRoteomics IDEntifications database

More...PRIDEi		O60602

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49480

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60602

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60602

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187554 Expressed in blood and 187 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60602 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60602 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187554 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:22173220).

Interacts with MYD88 (via TIR domain) (PubMed:20855887).

Interacts with TICAM1 (via TIR domain) (PubMed:20855887).

Interacts with UNC93B1; this interaction is essential for proper TLR5 localization to the plasma membrane (PubMed:24778236).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112955, 13 interactors

Protein interaction database and analysis system

More...IntActi		O60602, 21 interactors

Molecular INTeraction database

More...MINTi		O60602

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000440643

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O60602

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60602 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60602

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 68LRR 11 PublicationAdd BLAST24
Repeati71 – 93LRR 21 PublicationAdd BLAST23
Repeati95 – 117LRR 31 PublicationAdd BLAST23
Repeati120 – 143LRR 41 PublicationAdd BLAST24
Repeati146 – 166LRR 51 PublicationAdd BLAST21
Repeati171 – 192LRR 61 PublicationAdd BLAST22
Repeati197 – 211LRR 71 PublicationAdd BLAST15
Repeati214 – 229LRR 81 PublicationAdd BLAST16
Repeati234 – 235LRR 91 Publication2
Repeati260 – 284LRR 111 PublicationAdd BLAST25
Repeati289 – 301LRR 121 PublicationAdd BLAST13
Repeati313 – 334LRR 131 PublicationAdd BLAST22
Repeati337 – 355LRR 141 PublicationAdd BLAST19
Repeati385 – 401LRR 161 PublicationAdd BLAST17
Repeati412 – 431LRR 171 PublicationAdd BLAST20
Repeati449 – 470LRR 181 PublicationAdd BLAST22
Repeati474 – 495LRR 191 PublicationAdd BLAST22
Repeati503 – 524LRR 201 PublicationAdd BLAST22
Repeati527 – 546LRR 211 PublicationAdd BLAST20
Repeati549 – 567LRR 221 PublicationAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini579 – 631LRRCTAdd BLAST53
Domaini691 – 836TIRPROSITE-ProRule annotationAdd BLAST146

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4641 Eukaryota
COG4886 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006000_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60602

KEGG Orthology (KO)

More...KOi		K10168

Database of Orthologous Groups

More...OrthoDBi		282372at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60602

TreeFam database of animal gene trees

More...TreeFami		TF351113

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10140, 1 hit
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027176 TLR5
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR24365:SF525 PTHR24365:SF525, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855 LRR_8, 5 hits
PF01582 TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450 LRR, 12 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O60602-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDHLDLLLG VVLMAGPVFG IPSCSFDGRI AFYRFCNLTQ VPQVLNTTER 
        60         70         80         90        100
LLLSFNYIRT VTASSFPFLE QLQLLELGSQ YTPLTIDKEA FRNLPNLRIL 
       110        120        130        140        150
DLGSSKIYFL HPDAFQGLFH LFELRLYFCG LSDAVLKDGY FRNLKALTRL 
       160        170        180        190        200
DLSKNQIRSL YLHPSFGKLN SLKSIDFSSN QIFLVCEHEL EPLQGKTLSF 
       210        220        230        240        250
FSLAANSLYS RVSVDWGKCM NPFRNMVLEI LDVSGNGWTV DITGNFSNAI 
       260        270        280        290        300
SKSQAFSLIL AHHIMGAGFG FHNIKDPDQN TFAGLARSSV RHLDLSHGFV 
       310        320        330        340        350
FSLNSRVFET LKDLKVLNLA YNKINKIADE AFYGLDNLQV LNLSYNLLGE 
       360        370        380        390        400
LYSSNFYGLP KVAYIDLQKN HIAIIQDQTF KFLEKLQTLD LRDNALTTIH 
       410        420        430        440        450
FIPSIPDIFL SGNKLVTLPK INLTANLIHL SENRLENLDI LYFLLRVPHL 
       460        470        480        490        500
QILILNQNRF SSCSGDQTPS ENPSLEQLFL GENMLQLAWE TELCWDVFEG 
       510        520        530        540        550
LSHLQVLYLN HNYLNSLPPG VFSHLTALRG LSLNSNRLTV LSHNDLPANL 
       560        570        580        590        600
EILDISRNQL LAPNPDVFVS LSVLDITHNK FICECELSTF INWLNHTNVT 
       610        620        630        640        650
IAGPPADIYC VYPDSFSGVS LFSLSTEGCD EEEVLKSLKF SLFIVCTVTL 
       660        670        680        690        700
TLFLMTILTV TKFRGFCFIC YKTAQRLVFK DHPQGTEPDM YKYDAYLCFS 
       710        720        730        740        750
SKDFTWVQNA LLKHLDTQYS DQNRFNLCFE ERDFVPGENR IANIQDAIWN 
       760        770        780        790        800
SRKIVCLVSR HFLRDGWCLE AFSYAQGRCL SDLNSALIMV VVGSLSQYQL 
       810        820        830        840        850
MKHQSIRGFV QKQQYLRWPE DFQDVGWFLH KLSQQILKKE KEKKKDNNIP 

LQTVATIS
Length:858
Mass (Da):97,834
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EE0AB6EEFEA9051
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7Z4A0A2R8Y7Z4_HUMAN
Toll-like receptor 5
TLR5
858Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4Q2A0A2R8Y4Q2_HUMAN
Toll-like receptor 5
TLR5
775Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AZ06B1AZ06_HUMAN
Toll-like receptor 5
TLR5
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231L → V in AAC34376 (PubMed:9596645).Curated1
Sequence conflicti352Y → C in AAC34376 (PubMed:9596645).Curated1
Sequence conflicti387Q → R in AAI09120 (PubMed:15489334).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila [MIMi:608556]. It also provides protection against systemic lupus erythematosus.
A nonsense TLR5 polymorphism, resulting in p.Arg392Ter, confers resistance to melioidosis [MIMi:615557], an infection caused by the Gram-negative, flagellated soil saprophyte Burkholderia pseudomallei. Carriers of this hypofunctional TLR5 variant may generate impaired inflammatory responses during melioidosis infection that result in reduced organ failure and lower mortality.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03245582T → I. Corresponds to variant dbSNP:rs764535Ensembl.1
Natural variantiVAR_032456112P → A. Corresponds to variant dbSNP:rs5744166Ensembl.1
Natural variantiVAR_061856143N → T. Corresponds to variant dbSNP:rs5744167Ensembl.1
Natural variantiVAR_061857181Q → K. Corresponds to variant dbSNP:rs45528236Ensembl.1
Natural variantiVAR_018398392 – 858Missing in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1. 1 PublicationAdd BLAST467
Natural variantiVAR_018399592N → S2 PublicationsCorresponds to variant dbSNP:rs2072493EnsemblClinVar.1
Natural variantiVAR_018400616F → L3 PublicationsCorresponds to variant dbSNP:rs5744174Ensembl.1
Natural variantiVAR_070457644I → F1 PublicationCorresponds to variant dbSNP:rs5744175EnsemblClinVar.1
Natural variantiVAR_061858769L → F. Corresponds to variant dbSNP:rs56243703Ensembl.1
Natural variantiVAR_047454822F → L8 PublicationsCorresponds to variant dbSNP:rs7512943Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF051151 mRNA Translation: AAC34376.1
AB060695 mRNA Translation: BAB43955.1
AB445645 mRNA Translation: BAG55042.1
FJ556976 Genomic DNA Translation: ACM69019.1
FJ556977 Genomic DNA Translation: ACM69020.1
FJ556979 Genomic DNA Translation: ACM69022.1
FJ556980 Genomic DNA Translation: ACM69023.1
FJ556987 Genomic DNA Translation: ACM69030.1
FJ556989 Genomic DNA Translation: ACM69032.1
DQ026408 Genomic DNA Translation: AAZ17463.1
DQ026409 Genomic DNA Translation: AAZ17464.1
DQ026415 Genomic DNA Translation: AAZ17469.1
AL929091 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93262.1
CH471100 Genomic DNA Translation: EAW93263.1
BC109118 mRNA Translation: AAI09119.1
BC109119 mRNA Translation: AAI09120.1
U88881 mRNA Translation: AAC34136.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31033.1

NCBI Reference Sequences

More...RefSeqi		NP_003259.2, NM_003268.5
XP_005273298.2, XM_005273241.4
XP_005273299.2, XM_005273242.4
XP_005273300.2, XM_005273243.4
XP_006711567.1, XM_006711504.3
XP_006711568.1, XM_006711505.3
XP_006711569.1, XM_006711506.3
XP_011508239.1, XM_011509937.2
XP_016857697.1, XM_017002208.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000366881; ENSP00000355846; ENSG00000187554
ENST00000540964; ENSP00000440643; ENSG00000187554

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7100

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7100

UCSC genome browser

More...UCSCi		uc001hnw.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051151 mRNA Translation: AAC34376.1
AB060695 mRNA Translation: BAB43955.1
AB445645 mRNA Translation: BAG55042.1
FJ556976 Genomic DNA Translation: ACM69019.1
FJ556977 Genomic DNA Translation: ACM69020.1
FJ556979 Genomic DNA Translation: ACM69022.1
FJ556980 Genomic DNA Translation: ACM69023.1
FJ556987 Genomic DNA Translation: ACM69030.1
FJ556989 Genomic DNA Translation: ACM69032.1
DQ026408 Genomic DNA Translation: AAZ17463.1
DQ026409 Genomic DNA Translation: AAZ17464.1
DQ026415 Genomic DNA Translation: AAZ17469.1
AL929091 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93262.1
CH471100 Genomic DNA Translation: EAW93263.1
BC109118 mRNA Translation: AAI09119.1
BC109119 mRNA Translation: AAI09120.1
U88881 mRNA Translation: AAC34136.1
CCDSiCCDS31033.1
RefSeqiNP_003259.2, NM_003268.5
XP_005273298.2, XM_005273241.4
XP_005273299.2, XM_005273242.4
XP_005273300.2, XM_005273243.4
XP_006711567.1, XM_006711504.3
XP_006711568.1, XM_006711505.3
XP_006711569.1, XM_006711506.3
XP_011508239.1, XM_011509937.2
XP_016857697.1, XM_017002208.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P95model-B551-560[»]
3J0Aelectron microscopy26.00A/B23-858[»]
SMRiO60602
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112955, 13 interactors
IntActiO60602, 21 interactors
MINTiO60602
STRINGi9606.ENSP00000440643

Chemistry databases

BindingDBiO60602
ChEMBLiCHEMBL2176839

PTM databases

iPTMnetiO60602
PhosphoSitePlusiO60602

Polymorphism and mutation databases

BioMutaiTLR5

Proteomic databases

jPOSTiO60602
MassIVEiO60602
PaxDbiO60602
PeptideAtlasiO60602
PRIDEiO60602
ProteomicsDBi49480

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2711 910 antibodies

The DNASU plasmid repository

More...DNASUi		7100

Genome annotation databases

EnsembliENST00000366881; ENSP00000355846; ENSG00000187554
ENST00000540964; ENSP00000440643; ENSG00000187554
GeneIDi7100
KEGGihsa:7100
UCSCiuc001hnw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7100
DisGeNETi7100
EuPathDBiHostDB:ENSG00000187554.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		TLR5
HGNCiHGNC:11851 TLR5
HPAiENSG00000187554 Low tissue specificity
MalaCardsiTLR5
MIMi109100 phenotype
601744 phenotype
603031 gene
608556 phenotype
615557 phenotype
neXtProtiNX_O60602
PharmGKBiPA36553

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
HOGENOMiCLU_006000_4_1_1
InParanoidiO60602
KOiK10168
OrthoDBi282372at2759
PhylomeDBiO60602
TreeFamiTF351113

Enzyme and pathway databases

ReactomeiR-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-5602680 MyD88 deficiency (TLR5)
R-HSA-5603037 IRAK4 deficiency (TLR5)
R-HSA-975871 MyD88 cascade initiated on plasma membrane
SIGNORiO60602

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7100 2 hits in 782 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TLR_5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7100
PharosiO60602 Tbio

Protein Ontology

More...PROi		PR:O60602
RNActiO60602 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187554 Expressed in blood and 187 other tissues
ExpressionAtlasiO60602 baseline and differential
GenevisibleiO60602 HS

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027176 TLR5
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF525 PTHR24365:SF525, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 5 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLR5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60602
Secondary accession number(s): B1AZ05
, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, Q32MI2, Q32MI3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 25, 2008
Last modified: June 17, 2020
This is version 181 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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