UniProtKB - O60595 (O60595_HUMAN)
Protein
Interleukin-12 subunit alpha
Gene
IL12A
Organism
Homo sapiens (Human)
Status
Functioni
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.ARBA annotation
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-12 beta subunit binding Source: AgBase
- interleukin-12 receptor binding Source: InterPro
- protein heterodimerization activity Source: AgBase
GO - Biological processi
- cell population proliferation Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- defense response to protozoan Source: Ensembl
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of mononuclear cell proliferation Source: AgBase
- positive regulation of T cell differentiation Source: Ensembl
- positive regulation of T cell proliferation Source: Ensembl
- T-helper 1 cell activation Source: Ensembl
- T-helper 1 cell cytokine production Source: Ensembl
Keywordsi
Molecular function | CytokineUniRule annotation, Growth factorUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-12 subunit alphaUniRule annotationShort name: IL-12AUniRule annotation |
Gene namesi | Name:IL12AUniRule annotationImported ORF Names:hCG_1685939Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168811.6 |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- interleukin-12 complex Source: AgBase
Other locations
- cell surface Source: Ensembl
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
SecretedUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000168811, Expressed in lower esophagus mucosa and 103 other tissues |
ExpressionAtlasi | O60595, baseline and differential |
Interactioni
Subunit structurei
Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
UniRule annotationGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-12 beta subunit binding Source: AgBase
- interleukin-12 receptor binding Source: InterPro
- protein heterodimerization activity Source: AgBase
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Pro-richSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Phylogenomic databases
OMAi | MNESCLA |
OrthoDBi | 1409826at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR004281, IL-12_alpha |
Pfami | View protein in Pfam PF03039, IL12, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
i Sequence
Sequence statusi: Complete.
O60595-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL
60 70 80 90 100
DHLSLARNLP VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS
110 120 130 140 150
EEIDHEDITK DKTSTVEACL PLELTKNESC LNSRETSFIT NGSCLASRKT
160 170 180 190 200
SFMMALCLSS IYEDLKMYQV EFKTMNAKLL MDPKRQIFLD QNMLAVIDEL
210 220 230 240 250
MQALNFNSET VPQKSSLEEP DFYKTKIKLC ILLHAFRIRA VTIDRVMSYL
NAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF101062 mRNA Translation: AAD16432.1 AF180562 mRNA Translation: AAD56385.1 BC104982 mRNA Translation: AAI04983.1 BC104984 mRNA Translation: AAI04985.1 CH471052 Genomic DNA Translation: EAW78656.1 |
PIRi | B38957 |
RefSeqi | NP_000873.2, NM_000882.3 |
Genome annotation databases
GeneIDi | 3592 |
KEGGi | hsa:3592 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF101062 mRNA Translation: AAD16432.1 AF180562 mRNA Translation: AAD56385.1 BC104982 mRNA Translation: AAI04983.1 BC104984 mRNA Translation: AAI04985.1 CH471052 Genomic DNA Translation: EAW78656.1 |
PIRi | B38957 |
RefSeqi | NP_000873.2, NM_000882.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 853, 868 antibodies |
Genome annotation databases
GeneIDi | 3592 |
KEGGi | hsa:3592 |
Organism-specific databases
CTDi | 3592 |
EuPathDBi | HostDB:ENSG00000168811.6 |
PharmGKBi | PA29784 |
Phylogenomic databases
OMAi | MNESCLA |
OrthoDBi | 1409826at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3592, 7 hits in 847 CRISPR screens |
GenomeRNAii | 3592 |
Gene expression databases
Bgeei | ENSG00000168811, Expressed in lower esophagus mucosa and 103 other tissues |
ExpressionAtlasi | O60595, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR004281, IL-12_alpha |
Pfami | View protein in Pfam PF03039, IL12, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O60595_HUMAN | |
Accessioni | O60595Primary (citable) accession number: O60595 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 1, 1998 |
Last sequence update: | August 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |