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Protein

Interleukin-12 subunit alpha

Gene

IL12A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • interleukin-12 beta subunit binding Source: AgBase
  • interleukin-12 receptor binding Source: InterPro
  • protein heterodimerization activity Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit alphaUniRule annotation
Short name:
IL-12AUniRule annotation
Gene namesi
Name:IL12AUniRule annotationImported
ORF Names:hCG_1685939Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000168811.6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29784

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PRIDEiO60595

Expressioni

Gene expression databases

BgeeiENSG00000168811
ExpressionAtlasiO60595 baseline and differential

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • interleukin-12 beta subunit binding Source: AgBase
  • interleukin-12 receptor binding Source: InterPro
  • protein heterodimerization activity Source: AgBase

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IVIR Eukaryota
ENOG410ZGHJ LUCA
HOGENOMiHOG000113026
HOVERGENiHBG063691
KOiK05406
OMAiYPCTSEE
OrthoDBiEOG091G13SK

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR004281 IL-12_alpha
PANTHERiPTHR45311 PTHR45311, 1 hit
PfamiView protein in Pfam
PF03039 IL12, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

O60595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL
60 70 80 90 100
DHLSLARNLP VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS
110 120 130 140 150
EEIDHEDITK DKTSTVEACL PLELTKNESC LNSRETSFIT NGSCLASRKT
160 170 180 190 200
SFMMALCLSS IYEDLKMYQV EFKTMNAKLL MDPKRQIFLD QNMLAVIDEL
210 220 230 240 250
MQALNFNSET VPQKSSLEEP DFYKTKIKLC ILLHAFRIRA VTIDRVMSYL

NAS
Length:253
Mass (Da):28,293
Last modified:August 1, 1999 - v2
Checksum:iFAC56ACD2A620BD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101062 mRNA Translation: AAD16432.1
AF180562 mRNA Translation: AAD56385.1
BC104982 mRNA Translation: AAI04983.1
BC104984 mRNA Translation: AAI04985.1
CH471052 Genomic DNA Translation: EAW78656.1
PIRiB38957
RefSeqiNP_000873.2, NM_000882.3
UniGeneiHs.673

Genome annotation databases

GeneIDi3592
KEGGihsa:3592

Similar proteinsi

Entry informationi

Entry nameiO60595_HUMAN
AccessioniPrimary (citable) accession number: O60595
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1999
Last modified: June 20, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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