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Protein

Eukaryotic translation initiation factor 4E type 2

Gene

EIF4E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).By similarity4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1107-methylguanosine-containing mRNA cap1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA 7-methylguanosine cap binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • RNA cap binding Source: ProtInc
  • translation factor activity, RNA binding Source: ProtInc
  • translation initiation factor activity Source: GO_Central
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • in utero embryonic development Source: Ensembl
  • negative regulation of translation Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 2
Short name:
eIF-4E type 2
Short name:
eIF4E type 2
Alternative name(s):
Eukaryotic translation initiation factor 4E homologous protein
Eukaryotic translation initiation factor 4E-like 3
eIF4E-like protein 4E-LP
mRNA cap-binding protein 4EHP
Short name:
h4EHP1 Publication
mRNA cap-binding protein type 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4E2
Synonyms:EIF4EL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000135930.13

Human Gene Nomenclature Database

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HGNCi
HGNC:3293 EIF4E2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605895 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60573

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi63W → A: Unable to bind capped mRNA. 1 Publication1
Mutagenesisi95W → A: Ability to bind capped mRNA reduced to 40% of wild-type. 1 Publication1
Mutagenesisi121K → R: Does not affect ubiquitination by ARIH1; when associated with R-130; R-134 and R-222. 1 Publication1
Mutagenesisi124 – 126WED → FAA: Unable to bind capped mRNA. 1 Publication3
Mutagenesisi124W → A: Ability to bind capped mRNA reduced to less than 10% of wild-type. 1 Publication1
Mutagenesisi124W → F: Ability to bind capped mRNA reduced to 13% of wild-type. 1 Publication1
Mutagenesisi125E → A: Ability to bind capped mRNA reduced to less than 10% of wild-type. 1 Publication1
Mutagenesisi126D → A: Slight reduction in ability to bind capped mRNA. 1 Publication1
Mutagenesisi130K → R: Does not affect ubiquitination by ARIH1; when associated with R-121; R-134 and R-222. 1 Publication1
Mutagenesisi134K → R: Does not affect ubiquitination by ARIH1; when associated with R-121; R-130 and R-222. 1 Publication1
Mutagenesisi135W → A: Unable to bind capped mRNA. 1 Publication1
Mutagenesisi148W → A: Unable to bind capped mRNA. 1 Publication1
Mutagenesisi183W → A: Ability to bind capped mRNA reduced to less than 10% of wild-type. 1 Publication1
Mutagenesisi183W → F: Unable to bind capped mRNA. 1 Publication1
Mutagenesisi222K → R: Does not affect ubiquitination by ARIH1; when associated with R-121; R-130 and R-134. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
9470

Open Targets

More...
OpenTargetsi
ENSG00000135930

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27720

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF4E2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001936641 – 245Eukaryotic translation initiation factor 4E type 2Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineCombined sources1
Modified residuei134N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15); alternate1 Publication
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by ARIH1 (PubMed:14623119, PubMed:25624349). The consequences of ubiquitination are however unclear: according to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report ubiquitination leads to its subsequent degradation (PubMed:14623119).2 Publications
ISGylation enhances its cap structure-binding activity and translation-inhibition activity.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60573

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60573

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60573

PeptideAtlas

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PeptideAtlasi
O60573

PRoteomics IDEntifications database

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PRIDEi
O60573

ProteomicsDB human proteome resource

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ProteomicsDBi
49475

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60573

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60573

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135930 Expressed in 223 organ(s), highest expression level in frontal cortex

CleanEx database of gene expression profiles

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CleanExi
HS_EIF4E2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60573 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60573 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA019253

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (PubMed:15153109, PubMed:17368478). Does not interact with eIF4G (EIF4G1, EIF4G2 or EIF4G3) (By similarity). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598 (PubMed:22751931). Interacts with GIGYF2 (via the 4EHP-binding motif); the interaction is direct (PubMed:22751931).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114856, 147 interactors

Database of interacting proteins

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DIPi
DIP-32578N

Protein interaction database and analysis system

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IntActi
O60573, 53 interactors

Molecular INTeraction database

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MINTi
O60573

STRING: functional protein association networks

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STRINGi
9606.ENSP00000258416

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JGBX-ray1.70A45-234[»]
2JGCX-ray2.40A45-234[»]
5NVKX-ray2.90A/C/E/G52-234[»]
5NVLX-ray2.30A/C52-234[»]
5NVMX-ray2.00A/C52-234[»]
5NVNX-ray1.90A/C52-234[»]
5XLNX-ray1.90A45-234[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60573

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60573

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O60573

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni54 – 57EIF4EBP1/2/3 binding4
Regioni78 – 797-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni95 – 99EIF4EBP1/2/3 binding5
Regioni124 – 1257-methylguanosine-containing mRNA cap binding2
Regioni150 – 157EIF4EBP1/2/3 binding8
Regioni174 – 1797-methylguanosine-containing mRNA cap binding6
Regioni222 – 2247-methylguanosine-containing mRNA cap bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1669 Eukaryota
COG5053 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000186751

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107087

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60573

KEGG Orthology (KO)

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KOi
K03259

Identification of Orthologs from Complete Genome Data

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OMAi
NDIRPEW

Database of Orthologous Groups

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OrthoDBi
1394271at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60573

TreeFam database of animal gene trees

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TreeFami
TF101529

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.760.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS

The PANTHER Classification System

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PANTHERi
PTHR11960 PTHR11960, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01652 IF4E, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55418 SSF55418, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00813 IF4E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60573-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNKFDALKD DDSGDHDQNE ENSTQKDGEK EKTERDKNQS SSKRKAVVPG
60 70 80 90 100
PAEHPLQYNY TFWYSRRTPG RPTSSQSYEQ NIKQIGTFAS VEQFWRFYSH
110 120 130 140 150
MVRPGDLTGH SDFHLFKEGI KPMWEDDANK NGGKWIIRLR KGLASRCWEN
160 170 180 190 200
LILAMLGEQF MVGEEICGAV VSVRFQEDII SIWNKTASDQ ATTARIRDTL
210 220 230 240
RRVLNLPPNT IMEYKTHTDS IKMPGRLGPQ RLLFQNLWKP RLNVP
Length:245
Mass (Da):28,362
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D3075BFA48B3C12
GO
Isoform 2 (identifier: O60573-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-234: MPGRLGPQRLLF → DNSSFRNTKITL
     235-245: Missing.

Note: No experimental confirmation available.
Show »
Length:234
Mass (Da):27,026
Checksum:iC63065135BA86C68
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZ50B8ZZ50_HUMAN
Eukaryotic translation initiation f...
EIF4E2
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9A023B9A023_HUMAN
Eukaryotic translation initiation f...
EIF4E2
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZL3B8ZZL3_HUMAN
Eukaryotic translation initiation f...
EIF4E2
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9A044B9A044_HUMAN
Eukaryotic translation initiation f...
EIF4E2
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E1E4B4E1E4_HUMAN
Eukaryotic translation initiation f...
EIF4E2
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEL3C9JEL3_HUMAN
Eukaryotic translation initiation f...
EIF4E2
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZH2H7BZH2_HUMAN
Eukaryotic translation initiation f...
EIF4E2
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 27MNNKF…STQKD → MMTVGTMIRMKKTAHRKI in AAC39871 (PubMed:9653160).CuratedAdd BLAST27

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054783223 – 234MPGRL…QRLLF → DNSSFRNTKITL in isoform 2. CuratedAdd BLAST12
Alternative sequenceiVSP_054784235 – 245Missing in isoform 2. CuratedAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF047695 mRNA Translation: AAC18565.1
AF068117 mRNA Translation: AAC19374.1
AF038957 mRNA Translation: AAC39871.1
AC073254 Genomic DNA No translation available.
AC092165 Genomic DNA No translation available.
AC093383 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71008.1
BC005392 mRNA Translation: AAH05392.1
BC005874 mRNA Translation: AAH05874.1
BC021226 mRNA Translation: AAH21226.1
BC021690 mRNA Translation: AAH21690.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2496.1 [O60573-1]
CCDS63159.1 [O60573-2]

NCBI Reference Sequences

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RefSeqi
NP_001263265.1, NM_001276336.1 [O60573-2]
NP_004837.1, NM_004846.3 [O60573-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.292026

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000258416; ENSP00000258416; ENSG00000135930 [O60573-1]
ENST00000409098; ENSP00000386996; ENSG00000135930 [O60573-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9470

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9470

UCSC genome browser

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UCSCi
uc002vtb.3 human [O60573-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047695 mRNA Translation: AAC18565.1
AF068117 mRNA Translation: AAC19374.1
AF038957 mRNA Translation: AAC39871.1
AC073254 Genomic DNA No translation available.
AC092165 Genomic DNA No translation available.
AC093383 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71008.1
BC005392 mRNA Translation: AAH05392.1
BC005874 mRNA Translation: AAH05874.1
BC021226 mRNA Translation: AAH21226.1
BC021690 mRNA Translation: AAH21690.1
CCDSiCCDS2496.1 [O60573-1]
CCDS63159.1 [O60573-2]
RefSeqiNP_001263265.1, NM_001276336.1 [O60573-2]
NP_004837.1, NM_004846.3 [O60573-1]
UniGeneiHs.292026

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JGBX-ray1.70A45-234[»]
2JGCX-ray2.40A45-234[»]
5NVKX-ray2.90A/C/E/G52-234[»]
5NVLX-ray2.30A/C52-234[»]
5NVMX-ray2.00A/C52-234[»]
5NVNX-ray1.90A/C52-234[»]
5XLNX-ray1.90A45-234[»]
ProteinModelPortaliO60573
SMRiO60573
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114856, 147 interactors
DIPiDIP-32578N
IntActiO60573, 53 interactors
MINTiO60573
STRINGi9606.ENSP00000258416

PTM databases

iPTMnetiO60573
PhosphoSitePlusiO60573

Polymorphism and mutation databases

BioMutaiEIF4E2

Proteomic databases

EPDiO60573
jPOSTiO60573
PaxDbiO60573
PeptideAtlasiO60573
PRIDEiO60573
ProteomicsDBi49475

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258416; ENSP00000258416; ENSG00000135930 [O60573-1]
ENST00000409098; ENSP00000386996; ENSG00000135930 [O60573-2]
GeneIDi9470
KEGGihsa:9470
UCSCiuc002vtb.3 human [O60573-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9470
DisGeNETi9470
EuPathDBiHostDB:ENSG00000135930.13

GeneCards: human genes, protein and diseases

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GeneCardsi
EIF4E2
HGNCiHGNC:3293 EIF4E2
HPAiHPA019253
MIMi605895 gene
neXtProtiNX_O60573
OpenTargetsiENSG00000135930
PharmGKBiPA27720

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1669 Eukaryota
COG5053 LUCA
GeneTreeiENSGT00940000154694
HOGENOMiHOG000186751
HOVERGENiHBG107087
InParanoidiO60573
KOiK03259
OMAiNDIRPEW
OrthoDBi1394271at2759
PhylomeDBiO60573
TreeFamiTF101529

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EIF4E2 human
EvolutionaryTraceiO60573

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EIF4E2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9470

Protein Ontology

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PROi
PR:O60573

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000135930 Expressed in 223 organ(s), highest expression level in frontal cortex
CleanExiHS_EIF4E2
ExpressionAtlasiO60573 baseline and differential
GenevisibleiO60573 HS

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4E2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60573
Secondary accession number(s): B8ZZJ9, O75349
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: August 1, 1998
Last modified: January 16, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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