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Entry version 194 (13 Feb 2019)
Sequence version 3 (03 Apr 2007)
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Protein

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Gene

BUB1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Kinase activity stimulated by CENPE.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei795ATPBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei882Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi772 – 780ATPBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Cell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.11.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O60566

SIGNOR Signaling Network Open Resource

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SIGNORi
O60566

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC:2.7.11.1)
Alternative name(s):
MAD3/BUB1-related protein kinase
Short name:
hBUBR1
Mitotic checkpoint kinase MAD3L
Protein SSK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BUB1B
Synonyms:BUBR1, MAD3L, SSK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156970.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1149 BUB1B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602860 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O60566

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in BUB1B are associated with tumor formation.
Premature chromatid separation trait (PCS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionConsists of separate and splayed chromatids with discernible centromeres and involves all or most chromosomes of a metaphase. It is found in up to 2% of metaphases in cultured lymphocytes from approximately 40% of normal individuals. When PCS is present in 5% or more of cells, it is known as the heterozygous PCS trait and has no obvious phenotypic effect, although some have reported decreased fertility. Inheritance is autosomal dominant.
See also OMIM:176430
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02892136R → Q in PCS. 1 PublicationCorresponds to variant dbSNP:rs534297115Ensembl.1
Mosaic variegated aneuploidy syndrome 1 (MVA1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. MVA1 is caused by biallelic mutations in the BUB1B gene.
Disease descriptionA severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases.
See also OMIM:257300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028923550R → Q in MVA1; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989187EnsemblClinVar.1
Natural variantiVAR_028924814R → H in MVA1; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989182EnsemblClinVar.1
Natural variantiVAR_028925844L → F in MVA1; associated with H-921; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989181EnsemblClinVar.1
Natural variantiVAR_028926909I → T in MVA1; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989184Ensembl.1
Natural variantiVAR_028927921Q → H in MVA1; associated with F-844; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989183EnsemblClinVar.1
Natural variantiVAR_0289281012L → P in MVA1; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989185EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi159A → W: Loss of interaction with KNL1. 1 Publication1
Mutagenesisi175F → A: Loss of interaction with KNL1. 1 Publication1
Mutagenesisi579D → E: Abolishes the cleavage by caspase-3. 1 Publication1
Mutagenesisi610D → E: Abolishes the cleavage by caspase-3. 1 Publication1
Mutagenesisi620T → A: Induces chromosome congression defects and mitotic delay. 1 Publication1
Mutagenesisi795K → A: Does not abolish the capacity to inhibit APC/CDC20. 2 Publications1
Mutagenesisi795K → R: Inhibits kinase activity. 2 Publications1

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNET

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DisGeNETi
701

MalaCards human disease database

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MalaCardsi
BUB1B
MIMi176430 phenotype
257300 phenotype

Open Targets

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OpenTargetsi
ENSG00000156970

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
1052 Mosaic variegated aneuploidy syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA82

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BUB1B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000856731 – 1050Mitotic checkpoint serine/threonine-protein kinase BUB1 betaAdd BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei250N6-acetyllysine; by PCAF1 Publication1
Modified residuei367PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1 Publication1
Modified residuei543PhosphoserineCombined sources1 Publication1
Modified residuei665PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1 Publication1
Modified residuei676Phosphoserine; by PLK11 Publication1
Modified residuei697PhosphoserineCombined sources1
Modified residuei792Phosphothreonine; by PLK11 Publication1
Modified residuei1008Phosphothreonine; by PLK11 Publication1
Modified residuei1042PhosphothreonineCombined sources1
Modified residuei1043Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by caspase-3 in a cell cycle specific manner. The cleavage might be involved in the durability of the cell cycle delay. Caspase-3 cleavage is associated with abrogation of the mitotic checkpoint. The major site of cleavage is at Asp-610.1 Publication
Acetylation at Lys-250 regulates its degradation and timing in anaphase entry.1 Publication
Ubiquitinated. Degraded by the proteasome.1 Publication
Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association with CENPE at the kinetochore.1 Publication
Autophosphorylated in vitro. Intramolecular autophosphorylation is stimulated by CENPE. Phosphorylated during mitosis and hyperphosphorylated in mitotically arrested cells. Phosphorylation at Ser-670 and Ser-1043 occurs at kinetochores upon mitotic entry with dephosphorylation at the onset of anaphase.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei579 – 580Cleavage; by caspase-31 Publication2
Sitei610 – 611Cleavage; by caspase-31 Publication2

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60566

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60566

MaxQB - The MaxQuant DataBase

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MaxQBi
O60566

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60566

PeptideAtlas

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PeptideAtlasi
O60566

PRoteomics IDEntifications database

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PRIDEi
O60566

ProteomicsDB human proteome resource

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ProteomicsDBi
49471
49472 [O60566-2]
49473 [O60566-3]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1516

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60566

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60566

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced during mitosis.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000156970 Expressed in 147 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60566 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60566 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA008419

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CENPE, CENPF, mitosin, PLK1 and BUB3. Part of a complex containing BUB3, CDC20 and BUB1B. Interacts with anaphase-promoting complex/cyclosome (APC/C). Interacts with KNL1. Interacts with RIPK3 (PubMed:29883609).12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107166, 118 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3946 Mitotic Checkpoint Complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O60566

Database of interacting proteins

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DIPi
DIP-24203N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O60566

Protein interaction database and analysis system

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IntActi
O60566, 75 interactors

Molecular INTeraction database

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MINTi
O60566

STRING: functional protein association networks

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STRINGi
9606.ENSP00000287598

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11050
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WVIX-ray1.80A57-220[»]
3SI5X-ray2.20A/B57-220[»]
4GGDX-ray2.44C/D20-42[»]
5JJAX-ray2.35C/D647-720[»]
5K6SX-ray2.79B663-681[»]
5KHUelectron microscopy4.80Q1-1050[»]
5LCWelectron microscopy4.00S1-560[»]
5SWFX-ray2.82B668-676[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60566

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60566

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O60566

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 226BUB1 N-terminalPROSITE-ProRule annotationAdd BLAST165
Domaini766 – 1050Protein kinaseAdd BLAST285

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 185Necessary for interaction with KNL11 PublicationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi111 – 118Nuclear localization signalSequence analysis8
Motifi224 – 232D-box9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi209 – 215Poly-Glu7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The D-box targets the protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase.Curated
The BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IQA2 Eukaryota
ENOG410XUW7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158912

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050748

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60566

KEGG Orthology (KO)

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KOi
K06637

Identification of Orthologs from Complete Genome Data

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OMAi
DHLCSCY

Database of Orthologous Groups

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OrthoDBi
1284308at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60566

TreeFam database of animal gene trees

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TreeFami
TF105456

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015661 Bub1/Mad3
IPR011009 Kinase-like_dom_sf
IPR013212 Mad3/Bub1_I

The PANTHER Classification System

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PANTHERi
PTHR14030 PTHR14030, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08311 Mad3_BUB1_I, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00777 Mad3_BUB1_I, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51489 BUB1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60566-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA
60 70 80 90 100
CNNTLQQQKR AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST
110 120 130 140 150
LLERAVEALQ GEKRYYSDPR FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS
160 170 180 190 200
LAQFYISWAE EYEARENFRK ADAIFQEGIQ QKAEPLERLQ SQHRQFQARV
210 220 230 240 250
SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA PIIRVGGALK
260 270 280 290 300
APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM
310 320 330 340 350
PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ
360 370 380 390 400
PVMTPCKIEP SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK
410 420 430 440 450
EKIYAGVGEF SFEEIRAEVF RKKLKEQREA ELLTSAEKRA EMQKQIEEME
460 470 480 490 500
KKLKEIQTTQ QERTGDQQEE TMPTKETTKL QIASESQKIP GMTLSSSVCQ
510 520 530 540 550
VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK NKSPPADPPR
560 570 580 590 600
VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT
610 620 630 640 650
ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE
660 670 680 690 700
DQQTACGTIY SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC
710 720 730 740 750
LQIPEKLELT NETSENPTQS PWCSQYRRQL LKSLPELSAS AELCIEDRPM
760 770 780 790 800
PKLEIEKEIE LGNEDYCIKR EYLICEDYKL FWVAPRNSAE LTVIKVSSQP
810 820 830 840 850
VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN CFTLQDLLQH
860 870 880 890 900
SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC
910 920 930 940 950
NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ
960 970 980 990 1000
VDLFGIADLA HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI
1010 1020 1030 1040 1050
LNANDEATVS VLGELAAEMN GVFDTTFQSH LNKALWKVGK LTSPGALLFQ
Length:1,050
Mass (Da):119,545
Last modified:April 3, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7871103A56E6B46
GO
Isoform 2 (identifier: O60566-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-166: Missing.
     522-522: K → KVSLSL
     608-675: Missing.

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):105,890
Checksum:i81D1307E360D7B67
GO
Isoform 3 (identifier: O60566-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-80: R → RWVFLFHKDNRNINR

Note: No experimental confirmation available.
Show »
Length:1,064
Mass (Da):121,386
Checksum:iFB6C9F104164FBEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMK5H0YMK5_HUMAN
Mitotic checkpoint serine/threonine...
BUB1B
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN44H0YN44_HUMAN
Mitotic checkpoint serine/threonine...
BUB1B
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92019 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti248 – 249AL → VF in AAC23736 (PubMed:9618306).Curated2
Sequence conflicti283S → P in BAG35587 (PubMed:14702039).Curated1
Sequence conflicti788S → F in AAC06260 (PubMed:9660858).Curated1
Sequence conflicti1018E → K in AAC33435 (PubMed:9763420).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00885215M → T in a colorectal cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs1392369693Ensembl.1
Natural variantiVAR_02892136R → Q in PCS. 1 PublicationCorresponds to variant dbSNP:rs534297115Ensembl.1
Natural variantiVAR_04040240T → M1 PublicationCorresponds to variant dbSNP:rs56079734EnsemblClinVar.1
Natural variantiVAR_008853349R → Q9 PublicationsCorresponds to variant dbSNP:rs1801376Ensembl.1
Natural variantiVAR_054549378P → S1 PublicationCorresponds to variant dbSNP:rs17851677Ensembl.1
Natural variantiVAR_028922390E → D1 PublicationCorresponds to variant dbSNP:rs1017842EnsemblClinVar.1
Natural variantiVAR_028923550R → Q in MVA1; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989187EnsemblClinVar.1
Natural variantiVAR_008854618V → A in colorectal cancer. 2 PublicationsCorresponds to variant dbSNP:rs1801528EnsemblClinVar.1
Natural variantiVAR_028924814R → H in MVA1; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989182EnsemblClinVar.1
Natural variantiVAR_028925844L → F in MVA1; associated with H-921; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989181EnsemblClinVar.1
Natural variantiVAR_028926909I → T in MVA1; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989184Ensembl.1
Natural variantiVAR_028927921Q → H in MVA1; associated with F-844; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989183EnsemblClinVar.1
Natural variantiVAR_0289281012L → P in MVA1; heterozygous compound with nonsense mutation. 1 PublicationCorresponds to variant dbSNP:rs28989185EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03647380R → RWVFLFHKDNRNINR in isoform 3. 1 Publication1
Alternative sequenceiVSP_036474113 – 166Missing in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_036475522K → KVSLSL in isoform 2. 1 Publication1
Alternative sequenceiVSP_036476608 – 675Missing in isoform 2. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF053306 mRNA Translation: AAC06260.1
AF046918 mRNA Translation: AAC33435.1
AF046079 mRNA Translation: AAC12730.2
AF107297 mRNA Translation: AAD11941.1
AF035933 mRNA Translation: AAC23736.1
AF068760 mRNA Translation: AAC19118.1
AF310214
, AF310192, AF310193, AF310194, AF310195, AF310196, AF310197, AF310198, AF310199, AF310200, AF310201, AF310202, AF310203, AF310204, AF310205, AF310206, AF310207, AF310208, AF310209, AF310210, AF310211, AF310212, AF310213 Genomic DNA Translation: AAL10712.1
AK296795 mRNA Translation: BAG59371.1
AK296984 mRNA Translation: BAG59525.1
AK312709 mRNA Translation: BAG35587.1
AB208782 mRNA Translation: BAD92019.1 Different initiation.
BC018739 mRNA Translation: AAH18739.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10053.1 [O60566-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JW0092

NCBI Reference Sequences

More...
RefSeqi
NP_001202.4, NM_001211.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.513645

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287598; ENSP00000287598; ENSG00000156970 [O60566-1]
ENST00000412359; ENSP00000398470; ENSG00000156970 [O60566-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:701

UCSC genome browser

More...
UCSCi
uc001zkx.5 human [O60566-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053306 mRNA Translation: AAC06260.1
AF046918 mRNA Translation: AAC33435.1
AF046079 mRNA Translation: AAC12730.2
AF107297 mRNA Translation: AAD11941.1
AF035933 mRNA Translation: AAC23736.1
AF068760 mRNA Translation: AAC19118.1
AF310214
, AF310192, AF310193, AF310194, AF310195, AF310196, AF310197, AF310198, AF310199, AF310200, AF310201, AF310202, AF310203, AF310204, AF310205, AF310206, AF310207, AF310208, AF310209, AF310210, AF310211, AF310212, AF310213 Genomic DNA Translation: AAL10712.1
AK296795 mRNA Translation: BAG59371.1
AK296984 mRNA Translation: BAG59525.1
AK312709 mRNA Translation: BAG35587.1
AB208782 mRNA Translation: BAD92019.1 Different initiation.
BC018739 mRNA Translation: AAH18739.1
CCDSiCCDS10053.1 [O60566-1]
PIRiJW0092
RefSeqiNP_001202.4, NM_001211.5
UniGeneiHs.513645

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WVIX-ray1.80A57-220[»]
3SI5X-ray2.20A/B57-220[»]
4GGDX-ray2.44C/D20-42[»]
5JJAX-ray2.35C/D647-720[»]
5K6SX-ray2.79B663-681[»]
5KHUelectron microscopy4.80Q1-1050[»]
5LCWelectron microscopy4.00S1-560[»]
5SWFX-ray2.82B668-676[»]
ProteinModelPortaliO60566
SMRiO60566
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107166, 118 interactors
ComplexPortaliCPX-3946 Mitotic Checkpoint Complex
CORUMiO60566
DIPiDIP-24203N
ELMiO60566
IntActiO60566, 75 interactors
MINTiO60566
STRINGi9606.ENSP00000287598

PTM databases

GlyConnecti1516
iPTMnetiO60566
PhosphoSitePlusiO60566

Polymorphism and mutation databases

BioMutaiBUB1B

Proteomic databases

EPDiO60566
jPOSTiO60566
MaxQBiO60566
PaxDbiO60566
PeptideAtlasiO60566
PRIDEiO60566
ProteomicsDBi49471
49472 [O60566-2]
49473 [O60566-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
701
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287598; ENSP00000287598; ENSG00000156970 [O60566-1]
ENST00000412359; ENSP00000398470; ENSG00000156970 [O60566-3]
GeneIDi701
KEGGihsa:701
UCSCiuc001zkx.5 human [O60566-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
701
DisGeNETi701
EuPathDBiHostDB:ENSG00000156970.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BUB1B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0012121
HGNCiHGNC:1149 BUB1B
HPAiHPA008419
MalaCardsiBUB1B
MIMi176430 phenotype
257300 phenotype
602860 gene
neXtProtiNX_O60566
OpenTargetsiENSG00000156970
Orphaneti1052 Mosaic variegated aneuploidy syndrome
PharmGKBiPA82

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQA2 Eukaryota
ENOG410XUW7 LUCA
GeneTreeiENSGT00940000158912
HOVERGENiHBG050748
InParanoidiO60566
KOiK06637
OMAiDHLCSCY
OrthoDBi1284308at2759
PhylomeDBiO60566
TreeFamiTF105456

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
SignaLinkiO60566
SIGNORiO60566

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BUB1B human
EvolutionaryTraceiO60566

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BUB1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
701

Protein Ontology

More...
PROi
PR:O60566

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156970 Expressed in 147 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiO60566 baseline and differential
GenevisibleiO60566 HS

Family and domain databases

InterProiView protein in InterPro
IPR015661 Bub1/Mad3
IPR011009 Kinase-like_dom_sf
IPR013212 Mad3/Bub1_I
PANTHERiPTHR14030 PTHR14030, 1 hit
PfamiView protein in Pfam
PF08311 Mad3_BUB1_I, 1 hit
SMARTiView protein in SMART
SM00777 Mad3_BUB1_I, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51489 BUB1_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBUB1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60566
Secondary accession number(s): B2R6U0
, B4DL09, B4DLG3, O60501, O60627, O60758, O75389, Q59HH6, Q8WV50, Q96KM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 3, 2007
Last modified: February 13, 2019
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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