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Protein

Glycylpeptide N-tetradecanoyltransferase 2

Gene

NMT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.2 Publications

Caution

Sequence AAF36406.2 was incorrectly indicated as originating from bovine.Curated

Catalytic activityi

Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein].2 Publications

GO - Molecular functioni

  • glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.97 2681
ReactomeiR-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 2 (EC:2.3.1.972 Publications)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 2
Short name:
NMT 2
Peptide N-myristoyltransferase 2
Type II N-myristoyltransferase
Gene namesi
Name:NMT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000152465.17
HGNCiHGNC:7858 NMT2
MIMi603801 gene
neXtProtiNX_O60551

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9397
OpenTargetsiENSG00000152465
PharmGKBiPA31662

Chemistry databases

ChEMBLiCHEMBL2849
DrugBankiDB07838 (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE
DB02180 Myristoyl-Coa
DB02271 S-(2-Oxo)Pentadecylcoa

Polymorphism and mutation databases

BioMutaiNMT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642261 – 498Glycylpeptide N-tetradecanoyltransferase 2Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60551
MaxQBiO60551
PaxDbiO60551
PeptideAtlasiO60551
PRIDEiO60551
ProteomicsDBi49467

PTM databases

iPTMnetiO60551
PhosphoSitePlusiO60551
SwissPalmiO60551

Expressioni

Gene expression databases

BgeeiENSG00000152465 Expressed in 218 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_NMT2
ExpressionAtlasiO60551 baseline and differential
GenevisibleiO60551 HS

Organism-specific databases

HPAiHPA001303

Interactioni

Protein-protein interaction databases

BioGridi114794, 38 interactors
IntActiO60551, 12 interactors
MINTiO60551
STRINGi9606.ENSP00000367407

Chemistry databases

BindingDBiO60551

Structurei

Secondary structure

1498
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60551
SMRiO60551
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 122Myristoyl-CoA binding1 Publication3
Regioni250 – 252Myristoyl-CoA binding1 Publication3
Regioni258 – 262Myristoyl-CoA binding1 Publication5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 56Poly-LysAdd BLAST11

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiKOG2779 Eukaryota
COG5092 LUCA
GeneTreeiENSGT00390000017837
HOGENOMiHOG000189123
HOVERGENiHBG003404
InParanoidiO60551
KOiK00671
OMAiKNPAIPM
OrthoDBiEOG091G06JB
PhylomeDBiO60551
TreeFamiTF300701

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N
PANTHERiPTHR11377 PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit
PIRSFiPIRSF015892 N-myristl_transf, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60551-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK
60 70 80 90 100
KQKRKKEKPN SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL
110 120 130 140 150
LSACQGPARN IDEAAKHRYQ FWDTQPVPKL DEVITSHGAI EPDKDNVRQE
160 170 180 190 200
PYSLPQGFMW DTLDLSDAEV LKELYTLLNE NYVEDDDNMF RFDYSPEFLL
210 220 230 240 250
WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS VKKMVEINFL
260 270 280 290 300
CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH
310 320 330 340 350
RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS
360 370 380 390 400
VRELINTYLK QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL
410 420 430 440 450
SFYTLPSTVM HHPAHKSLKA AYSFYNIHTE TPLLDLMSDA LILAKSKGFD
460 470 480 490
VFNALDLMEN KTFLEKLKFG IGDGNLQYYL YNWRCPGTDS EKVGLVLQ
Length:498
Mass (Da):56,980
Last modified:August 1, 1998 - v1
Checksum:i1B1486CC6559B6A9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VUC6Q5VUC6_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT2
485Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti306R → K in AAP35670 (Ref. 3) Curated1
Sequence conflicti306R → K in AAH06376 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043325 mRNA Translation: AAC09295.1
AF232826 mRNA Translation: AAF36406.2
BT007024 mRNA Translation: AAP35670.1
EF445001 Genomic DNA Translation: ACA06028.1
EF445001 Genomic DNA Translation: ACA06029.1
AL590365 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86238.1
BC006376 mRNA Translation: AAH06376.1
CCDSiCCDS7109.1
RefSeqiNP_001295224.1, NM_001308295.1
NP_004799.1, NM_004808.2
UniGeneiHs.60339

Genome annotation databases

EnsembliENST00000378165; ENSP00000367407; ENSG00000152465
GeneIDi9397
KEGGihsa:9397
UCSCiuc001inz.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043325 mRNA Translation: AAC09295.1
AF232826 mRNA Translation: AAF36406.2
BT007024 mRNA Translation: AAP35670.1
EF445001 Genomic DNA Translation: ACA06028.1
EF445001 Genomic DNA Translation: ACA06029.1
AL590365 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86238.1
BC006376 mRNA Translation: AAH06376.1
CCDSiCCDS7109.1
RefSeqiNP_001295224.1, NM_001308295.1
NP_004799.1, NM_004808.2
UniGeneiHs.60339

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C2XX-ray2.33A112-498[»]
ProteinModelPortaliO60551
SMRiO60551
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114794, 38 interactors
IntActiO60551, 12 interactors
MINTiO60551
STRINGi9606.ENSP00000367407

Chemistry databases

BindingDBiO60551
ChEMBLiCHEMBL2849
DrugBankiDB07838 (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE
DB02180 Myristoyl-Coa
DB02271 S-(2-Oxo)Pentadecylcoa

PTM databases

iPTMnetiO60551
PhosphoSitePlusiO60551
SwissPalmiO60551

Polymorphism and mutation databases

BioMutaiNMT2

Proteomic databases

EPDiO60551
MaxQBiO60551
PaxDbiO60551
PeptideAtlasiO60551
PRIDEiO60551
ProteomicsDBi49467

Protocols and materials databases

DNASUi9397
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378165; ENSP00000367407; ENSG00000152465
GeneIDi9397
KEGGihsa:9397
UCSCiuc001inz.2 human

Organism-specific databases

CTDi9397
DisGeNETi9397
EuPathDBiHostDB:ENSG00000152465.17
GeneCardsiNMT2
HGNCiHGNC:7858 NMT2
HPAiHPA001303
MIMi603801 gene
neXtProtiNX_O60551
OpenTargetsiENSG00000152465
PharmGKBiPA31662
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2779 Eukaryota
COG5092 LUCA
GeneTreeiENSGT00390000017837
HOGENOMiHOG000189123
HOVERGENiHBG003404
InParanoidiO60551
KOiK00671
OMAiKNPAIPM
OrthoDBiEOG091G06JB
PhylomeDBiO60551
TreeFamiTF300701

Enzyme and pathway databases

BRENDAi2.3.1.97 2681
ReactomeiR-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Miscellaneous databases

ChiTaRSiNMT2 human
GeneWikiiNMT2
GenomeRNAii9397
PROiPR:O60551
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152465 Expressed in 218 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_NMT2
ExpressionAtlasiO60551 baseline and differential
GenevisibleiO60551 HS

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N
PANTHERiPTHR11377 PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit
PIRSFiPIRSF015892 N-myristl_transf, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNMT2_HUMAN
AccessioniPrimary (citable) accession number: O60551
Secondary accession number(s): B0YJ49
, Q53Y38, Q5VUC8, Q9BRB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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