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Protein

Forkhead box protein D2

Gene

FOXD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in embryogenesis and somatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi126 – 217Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D2
Alternative name(s):
Forkhead-related protein FKHL17
Forkhead-related transcription factor 9
Short name:
FREAC-9
Gene namesi
Name:FOXD2
Synonyms:FKHL17, FREAC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186564.5
HGNCiHGNC:3803 FOXD2
MIMi602211 gene
neXtProtiNX_O60548

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2306
OpenTargetsiENSG00000186564
PharmGKBiPA28220

Polymorphism and mutation databases

BioMutaiFOXD2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918151 – 495Forkhead box protein D2Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60548
PaxDbiO60548
PeptideAtlasiO60548
PRIDEiO60548
ProteomicsDBi49466

PTM databases

iPTMnetiO60548
PhosphoSitePlusiO60548

Expressioni

Tissue specificityi

Kidney specific.1 Publication

Gene expression databases

BgeeiENSG00000186564
CleanExiHS_FOXD2
GenevisibleiO60548 HS

Interactioni

Protein-protein interaction databases

BioGridi108595, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliO60548
SMRiO60548
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi227 – 353Pro-richAdd BLAST127
Compositional biasi247 – 464Ala-richAdd BLAST218
Compositional biasi342 – 447Gly-richAdd BLAST106

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00920000148947
HOGENOMiHOG000231285
InParanoidiO60548
KOiK09397
OMAiCEIMSSE
OrthoDBiEOG091G0HW9
PhylomeDBiO60548
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

O60548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLGSCCCEI MSSESSPAAL SEADADIDVV GGGSGGGELP ARSGPRAPRD
60 70 80 90 100
VLPHGHEPPA EEAEADLAED EEESGGCSDG EPRALASRGA AAAAGSPGPG
110 120 130 140 150
AAAARGAAGP GPGPPSGGAA TRSPLVKPPY SYIALITMAI LQSPKKRLTL
160 170 180 190 200
SEICEFISGR FPYYREKFPA WQNSIRHNLS LNDCFVKIPR EPGNPGKGNY
210 220 230 240 250
WTLDPESADM FDNGSFLRRR KRFKRQPLPP PHPHPHPHPE LLLRGGAAAA
260 270 280 290 300
GDPGAFLPGF AAYGAYGYGY GLALPAYGAP PPGPAPHPHP HPHAFAFAAA
310 320 330 340 350
AAAAPCQLSV PPGRAAAPPP GPPTASVFAG AGSAPAPAPA SGSGPGPGPA
360 370 380 390 400
GLPAFLGAEL GCAKAFYAAS LSPPAAGTAA GLPTALLRQG LKTDAGGGAG
410 420 430 440 450
GGGAGAGQRP SFSIDHIMGH GGGGAAPPGA GEGSPGPPFA AAAGPGGQAQ
460 470 480 490
VLAMLTAPAL APVAGHIRLS HPGDALLSSG SRFASKVAGL SGCHF
Length:495
Mass (Da):48,748
Last modified:February 26, 2008 - v2
Checksum:iE905950E1FA94565
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293H → HPH in AAC15421 (PubMed:9403061).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061185368A → P1 PublicationCorresponds to variant dbSNP:rs2405913Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042832 mRNA Translation: AAC15421.1
AL607122 Genomic DNA No translation available.
CCDSiCCDS30708.1
RefSeqiNP_004465.3, NM_004474.3
UniGeneiHs.166188

Genome annotation databases

EnsembliENST00000334793; ENSP00000335493; ENSG00000186564
GeneIDi2306
KEGGihsa:2306
UCSCiuc001crm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXD2_HUMAN
AccessioniPrimary (citable) accession number: O60548
Secondary accession number(s): Q5SVZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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