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Protein

Cell death activator CIDE-A

Gene

CIDEA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8964572 Lipid particle organization

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death activator CIDE-A
Alternative name(s):
Cell death-inducing DFFA-like effector A
Gene namesi
Name:CIDEA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000176194.17
HGNCiHGNC:1976 CIDEA
MIMi604440 gene
neXtProtiNX_O60543

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lipid droplet, Nucleus

Pathology & Biotechi

Involvement in diseasei

In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle.1 Publication

Organism-specific databases

DisGeNETi1149
OpenTargetsiENSG00000176194
PharmGKBiPA26514

Polymorphism and mutation databases

BioMutaiCIDEA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447181 – 219Cell death activator CIDE-AAdd BLAST219

Proteomic databases

PaxDbiO60543
PeptideAtlasiO60543
PRIDEiO60543
ProteomicsDBi49464

Expressioni

Tissue specificityi

Expressed in omental and subcutaneous adipose tissue (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000176194 Expressed in 108 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_CIDEA
ExpressionAtlasiO60543 baseline and differential
GenevisibleiO60543 HS

Interactioni

Subunit structurei

Directly interacts with CEBPB (By similarity). Interacts with CIDEC.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107570, 12 interactors
IntActiO60543, 3 interactors
MINTiO60543
STRINGi9606.ENSP00000320209

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60543
SMRiO60543
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60543

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 110CIDE-NPROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

eggNOGiENOG410IVIC Eukaryota
ENOG4111SUV LUCA
GeneTreeiENSGT00390000018596
HOGENOMiHOG000029211
HOVERGENiHBG050961
InParanoidiO60543
OMAiIRPLTFM
OrthoDBiEOG091G0H6W
PhylomeDBiO60543
TreeFamiTF334321

Family and domain databases

InterProiView protein in InterPro
IPR032936 CIDE-A
IPR003508 CIDE-N_dom
PANTHERiPTHR12306:SF8 PTHR12306:SF8, 1 hit
PfamiView protein in Pfam
PF02017 CIDE-N, 1 hit
SMARTiView protein in SMART
SM00266 CAD, 1 hit
PROSITEiView protein in PROSITE
PS51135 CIDE_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60543-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAARDYAGA LIRPLTFMGS QTKRVLFTPL MHPARPFRVS NHDRSSRRGV
60 70 80 90 100
MASSLQELIS KTLDALVIAT GLVTLVLEED GTVVDTEEFF QTLGDNTHFM
110 120 130 140 150
ILEKGQKWMP GSQHVPTCSP PKRSGIARVT FDLYRLNPKD FIGCLNVKAT
160 170 180 190 200
MYEMYSVSYD IRCTGLKGLL RSLLRFLSYS AQVTGQFLIY LGTYMLRVLD
210
DKEERPSLRS QAKGRFTCG
Length:219
Mass (Da):24,687
Last modified:August 1, 1998 - v1
Checksum:i05F704823CE71C0E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJ03E5RJ03_HUMAN
Cell death activator CIDE-A
CIDEA
200Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048738115V → F1 PublicationCorresponds to variant dbSNP:rs11545881Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041378 mRNA Translation: AAC34987.1
AY364639 mRNA Translation: AAQ65241.1
EF444967 Genomic DNA Translation: ACA05966.1
CCDSiCCDS11856.1
RefSeqiNP_001270.1, NM_001279.3
UniGeneiHs.249129

Genome annotation databases

EnsembliENST00000320477; ENSP00000320209; ENSG00000176194
GeneIDi1149
KEGGihsa:1149
UCSCiuc002kqt.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041378 mRNA Translation: AAC34987.1
AY364639 mRNA Translation: AAQ65241.1
EF444967 Genomic DNA Translation: ACA05966.1
CCDSiCCDS11856.1
RefSeqiNP_001270.1, NM_001279.3
UniGeneiHs.249129

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EELNMR-A33-110[»]
ProteinModelPortaliO60543
SMRiO60543
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107570, 12 interactors
IntActiO60543, 3 interactors
MINTiO60543
STRINGi9606.ENSP00000320209

Polymorphism and mutation databases

BioMutaiCIDEA

Proteomic databases

PaxDbiO60543
PeptideAtlasiO60543
PRIDEiO60543
ProteomicsDBi49464

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320477; ENSP00000320209; ENSG00000176194
GeneIDi1149
KEGGihsa:1149
UCSCiuc002kqt.5 human

Organism-specific databases

CTDi1149
DisGeNETi1149
EuPathDBiHostDB:ENSG00000176194.17
GeneCardsiCIDEA
HGNCiHGNC:1976 CIDEA
MIMi604440 gene
neXtProtiNX_O60543
OpenTargetsiENSG00000176194
PharmGKBiPA26514
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVIC Eukaryota
ENOG4111SUV LUCA
GeneTreeiENSGT00390000018596
HOGENOMiHOG000029211
HOVERGENiHBG050961
InParanoidiO60543
OMAiIRPLTFM
OrthoDBiEOG091G0H6W
PhylomeDBiO60543
TreeFamiTF334321

Enzyme and pathway databases

ReactomeiR-HSA-8964572 Lipid particle organization

Miscellaneous databases

EvolutionaryTraceiO60543
GeneWikiiCIDEA
GenomeRNAii1149
PROiPR:O60543
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176194 Expressed in 108 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_CIDEA
ExpressionAtlasiO60543 baseline and differential
GenevisibleiO60543 HS

Family and domain databases

InterProiView protein in InterPro
IPR032936 CIDE-A
IPR003508 CIDE-N_dom
PANTHERiPTHR12306:SF8 PTHR12306:SF8, 1 hit
PfamiView protein in Pfam
PF02017 CIDE-N, 1 hit
SMARTiView protein in SMART
SM00266 CAD, 1 hit
PROSITEiView protein in PROSITE
PS51135 CIDE_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCIDEA_HUMAN
AccessioniPrimary (citable) accession number: O60543
Secondary accession number(s): B0YIY7, Q6UPR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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