Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Persephin

Gene

PSPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.

GO - Molecular functioni

  • growth factor activity Source: UniProtKB-KW
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-419037 NCAM1 interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling
SIGNORiO60542

Names & Taxonomyi

Protein namesi
Recommended name:
Persephin
Short name:
PSP
Gene namesi
Name:PSPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000125650.4
HGNCiHGNC:9579 PSPN
MIMi602921 gene
neXtProtiNX_O60542

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5623
OpenTargetsiENSG00000125650
PharmGKBiPA33930

Polymorphism and mutation databases

BioMutaiPSPN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003401422 – 156PersephinAdd BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 124By similarity
Disulfide bondi93 ↔ 152By similarity
Disulfide bondi97 ↔ 154By similarity
Disulfide bondi123InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO60542
PRIDEiO60542
ProteomicsDBi49463

PTM databases

iPTMnetiO60542
PhosphoSitePlusiO60542

Expressioni

Gene expression databases

BgeeiENSG00000125650 Expressed in 103 organ(s), highest expression level in vagina
CleanExiHS_PSPN
ExpressionAtlasiO60542 baseline and differential
GenevisibleiO60542 HS

Organism-specific databases

HPAiCAB025366

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111607, 2 interactors
STRINGi9606.ENSP00000245810

Structurei

3D structure databases

ProteinModelPortaliO60542
SMRiO60542
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J061 Eukaryota
ENOG4111Y7H LUCA
GeneTreeiENSGT00520000055559
HOGENOMiHOG000220877
HOVERGENiHBG008316
InParanoidiO60542
OMAiTFRYCAG
PhylomeDBiO60542
TreeFamiTF332366

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60542-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG
60 70 80 90 100
THRPLARLRR ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG
110 120 130 140 150
ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA

ACGCGG
Length:156
Mass (Da):16,600
Last modified:August 1, 1998 - v1
Checksum:i6547751653A7044A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYK2M0QYK2_HUMAN
Persephin
PSPN
164Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040962 mRNA Translation: AAC39640.1
CCDSiCCDS12164.1
RefSeqiNP_004149.1, NM_004158.3
UniGeneiHs.248159

Genome annotation databases

EnsembliENST00000245810; ENSP00000245810; ENSG00000125650
GeneIDi5623
KEGGihsa:5623
UCSCiuc010xja.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040962 mRNA Translation: AAC39640.1
CCDSiCCDS12164.1
RefSeqiNP_004149.1, NM_004158.3
UniGeneiHs.248159

3D structure databases

ProteinModelPortaliO60542
SMRiO60542
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111607, 2 interactors
STRINGi9606.ENSP00000245810

PTM databases

iPTMnetiO60542
PhosphoSitePlusiO60542

Polymorphism and mutation databases

BioMutaiPSPN

Proteomic databases

PaxDbiO60542
PRIDEiO60542
ProteomicsDBi49463

Protocols and materials databases

DNASUi5623
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245810; ENSP00000245810; ENSG00000125650
GeneIDi5623
KEGGihsa:5623
UCSCiuc010xja.2 human

Organism-specific databases

CTDi5623
DisGeNETi5623
EuPathDBiHostDB:ENSG00000125650.4
GeneCardsiPSPN
HGNCiHGNC:9579 PSPN
HPAiCAB025366
MIMi602921 gene
neXtProtiNX_O60542
OpenTargetsiENSG00000125650
PharmGKBiPA33930
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J061 Eukaryota
ENOG4111Y7H LUCA
GeneTreeiENSGT00520000055559
HOGENOMiHOG000220877
HOVERGENiHBG008316
InParanoidiO60542
OMAiTFRYCAG
PhylomeDBiO60542
TreeFamiTF332366

Enzyme and pathway databases

ReactomeiR-HSA-419037 NCAM1 interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling
SIGNORiO60542

Miscellaneous databases

GenomeRNAii5623
PROiPR:O60542
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125650 Expressed in 103 organ(s), highest expression level in vagina
CleanExiHS_PSPN
ExpressionAtlasiO60542 baseline and differential
GenevisibleiO60542 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSPN_HUMAN
AccessioniPrimary (citable) accession number: O60542
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again