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Entry version 148 (08 May 2019)
Sequence version 4 (24 Nov 2009)
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Protein

Nuclear export mediator factor NEMF

Gene

NEMF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).2 Publications

Miscellaneous

Active in normal lung tissue, but is inactive in several lung cancer cell lines.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ribosomal large subunit binding Source: GO_Central
  • tRNA binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear export mediator factor NEMF
Alternative name(s):
Antigen NY-CO-1
Serologically defined colon cancer antigen 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEMF
Synonyms:SDCCAG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10663 NEMF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608378 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60524

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9147

Open Targets

More...
OpenTargetsi
ENSG00000165525

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35593

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NEMF

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000976421 – 1076Nuclear export mediator factor NEMFAdd BLAST1076

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphothreonineCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei763PhosphoserineCombined sources1
Modified residuei831PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60524

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60524

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60524

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60524

PeptideAtlas

More...
PeptideAtlasi
O60524

PRoteomics IDEntifications database

More...
PRIDEi
O60524

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49458
49459 [O60524-2]
49460 [O60524-3]
49461 [O60524-4]
49462 [O60524-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60524

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60524

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165525 Expressed in 242 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60524 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60524 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004160

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase LTN1 and NEMF (PubMed:25578875). The complex probably also contains TCF25 as well as VCP/p97 and its ubiquitin-binding cofactors (By similarity). RQC forms a stable complex with 60S ribosomal subunits (PubMed:25578875). Interacts (via its N-terminus) with XPO1 (PubMed:16103875).By similarity2 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O60524, 12 interactors

Molecular INTeraction database

More...
MINTi
O60524

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298310

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J92electron microscopy3.60u/v1-501[»]

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili296 – 359Sequence analysisAdd BLAST64
Coiled coili483 – 514Sequence analysisAdd BLAST32
Coiled coili869 – 894Sequence analysisAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NEMF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2030 Eukaryota
COG1293 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018516

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60524

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEWPKNV

Database of Orthologous Groups

More...
OrthoDBi
131285at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60524

TreeFam database of animal gene trees

More...
TreeFami
TF300515

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021846 NFACT-C
IPR008532 NFACT_RNA-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11923 NFACT-C, 1 hit
PF05670 NFACT-R_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60524-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL
60 70 80 90 100
LLESGIRIHT TEFEWPKNMM PSSFAMKCRK HLKSRRLVSA KQLGVDRIVD
110 120 130 140 150
FQFGSDEAAY HLIIELYDRG NIVLTDYEYV ILNILRFRTD EADDVKFAVR
160 170 180 190 200
ERYPLDHARA AEPLLTLERL TEIVASAPKG ELLKRVLNPL LPYGPALIEH
210 220 230 240 250
CLLENGFSGN VKVDEKLETK DIEKVLVSLQ KAEDYMKTTS NFSGKGYIIQ
260 270 280 290 300
KREIKPSLEA DKPVEDILTY EEFHPFLFSQ HSQCPYIEFE SFDKAVDEFY
310 320 330 340 350
SKIEGQKIDL KALQQEKQAL KKLDNVRKDH ENRLEALQQA QEIDKLKGEL
360 370 380 390 400
IEMNLQIVDR AIQVVRSALA NQIDWTEIGL IVKEAQAQGD PVASAIKELK
410 420 430 440 450
LQTNHVTMLL RNPYLLSEEE DDDVDGDVNV EKNETEPPKG KKKKQKNKQL
460 470 480 490 500
QKPQKNKPLL VDVDLSLSAY ANAKKYYDHK RYAAKKTQKT VEAAEKAFKS
510 520 530 540 550
AEKKTKQTLK EVQTVTSIQK ARKVYWFEKF LWFISSENYL IIGGRDQQQN
560 570 580 590 600
EIIVKRYLTP GDIYVHADLH GATSCVIKNP TGEPIPPRTL TEAGTMALCY
610 620 630 640 650
SAAWDARVIT SAWWVYHHQV SKTAPTGEYL TTGSFMIRGK KNFLPPSYLM
660 670 680 690 700
MGFSFLFKVD ESCVWRHQGE RKVRVQDEDM ETLASCTSEL ISEEMEQLDG
710 720 730 740 750
GDTSSDEDKE EHETPVEVEL MTQVDQEDIT LQSGRDELNE ELIQEESSED
760 770 780 790 800
EGEYEEVRKD QDSVGEMKDE GEETLNYPDT TIDLSHLQPQ RSIQKLASKE
810 820 830 840 850
ESSNSSDSKS QSRRHLSAKE RREMKKKKLP SDSGDLEALE GKDKEKESTV
860 870 880 890 900
HIETHQNTSK NVAAVQPMKR GQKSKMKKMK EKYKDQDEED RELIMKLLGS
910 920 930 940 950
AGSNKEEKGK KGKKGKTKDE PVKKQPQKPR GGQRVSDNIK KETPFLEVIT
960 970 980 990 1000
HELQDFAVDD PHDDKEEQDL DQQGNEENLF DSLTGQPHPE DVLLFAIPIC
1010 1020 1030 1040 1050
APYTTMTNYK YKVKLTPGVQ KKGKAAKTAL NSFMHSKEAT AREKDLFRSV
1060 1070
KDTDLSRNIP GKVKVSAPNL LNVKRK
Length:1,076
Mass (Da):122,954
Last modified:November 24, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCC5F95A0DB22F79
GO
Isoform 2 (identifier: O60524-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MKSRFSTIDLRAVLAELNASL → MPKTCQCYVGTKTTNPSAWPS
     22-821: Missing.

Show »
Length:276
Mass (Da):31,151
Checksum:i49B37757681B0E51
GO
Isoform 3 (identifier: O60524-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     562-582: Missing.

Show »
Length:1,055
Mass (Da):120,761
Checksum:i6D69BA826390F146
GO
Isoform 4 (identifier: O60524-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-119: Missing.

Show »
Length:1,034
Mass (Da):118,025
Checksum:i8B42E666C724AB60
GO
Isoform 5 (identifier: O60524-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-245: Missing.

Note: No experimental confirmation available.
Show »
Length:1,051
Mass (Da):120,140
Checksum:iF0CA1E8446FC3739
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5V3G3V5V3_HUMAN
Nuclear export mediator factor NEMF
NEMF
998Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V547G3V547_HUMAN
Nuclear export mediator factor NEMF
NEMF
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4D9G3V4D9_HUMAN
Nuclear export mediator factor NEMF
NEMF
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC18036 differs from that shown. Reason: Frameshift at position 1065.Curated
The sequence AAH06001 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH20794 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH56687 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI07765 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG52763 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG58070 differs from that shown. Intron retention.Curated
The sequence BAG58070 differs from that shown. Reason: Frameshift at positions 246 and 1025.Curated
The sequence BAG58070 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53E → K in BAG56774 (PubMed:14702039).Curated1
Sequence conflicti438P → S in AAH56687 (PubMed:15489334).Curated1
Sequence conflicti495E → G in BAG56774 (PubMed:14702039).Curated1
Sequence conflicti560P → PV in BAG58070 (PubMed:14702039).Curated1
Sequence conflicti593A → V in CAE45889 (PubMed:17974005).Curated1
Sequence conflicti696E → K in BAG65465 (PubMed:14702039).Curated1
Sequence conflicti766E → V in BX648753 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034488257S → C2 PublicationsCorresponds to variant dbSNP:rs3100906Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0083961 – 21MKSRF…LNASL → MPKTCQCYVGTKTTNPSAWP S in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_01046222 – 821Missing in isoform 2. 1 PublicationAdd BLAST800
Alternative sequenceiVSP_04106478 – 119Missing in isoform 4. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_041065221 – 245Missing in isoform 5. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_041066562 – 582Missing in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000913 mRNA No translation available.
AK093783 mRNA Translation: BAG52763.1 Different initiation.
AK293236 mRNA Translation: BAG56774.1
AK295010 mRNA Translation: BAG58070.1 Sequence problems.
AK304695 mRNA Translation: BAG65465.1
BX640804 mRNA Translation: CAE45886.1
BX640807 mRNA Translation: CAE45889.1
BX648753 mRNA No translation available.
AL591767 Genomic DNA No translation available.
AL627171 Genomic DNA No translation available.
BC006001 mRNA Translation: AAH06001.1 Sequence problems.
BC020794 mRNA Translation: AAH20794.2 Different initiation.
BC056687 mRNA Translation: AAH56687.1 Sequence problems.
BC064364 mRNA Translation: AAH64364.1
BC107764 mRNA Translation: AAI07765.1 Different initiation.
AF039687 mRNA Translation: AAC18036.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9694.1 [O60524-1]

NCBI Reference Sequences

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RefSeqi
NP_001288661.1, NM_001301732.2
NP_004704.2, NM_004713.5 [O60524-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000298310; ENSP00000298310; ENSG00000165525 [O60524-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9147

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9147

UCSC genome browser

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UCSCi
uc001wxc.4 human [O60524-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000913 mRNA No translation available.
AK093783 mRNA Translation: BAG52763.1 Different initiation.
AK293236 mRNA Translation: BAG56774.1
AK295010 mRNA Translation: BAG58070.1 Sequence problems.
AK304695 mRNA Translation: BAG65465.1
BX640804 mRNA Translation: CAE45886.1
BX640807 mRNA Translation: CAE45889.1
BX648753 mRNA No translation available.
AL591767 Genomic DNA No translation available.
AL627171 Genomic DNA No translation available.
BC006001 mRNA Translation: AAH06001.1 Sequence problems.
BC020794 mRNA Translation: AAH20794.2 Different initiation.
BC056687 mRNA Translation: AAH56687.1 Sequence problems.
BC064364 mRNA Translation: AAH64364.1
BC107764 mRNA Translation: AAI07765.1 Different initiation.
AF039687 mRNA Translation: AAC18036.1 Frameshift.
CCDSiCCDS9694.1 [O60524-1]
RefSeqiNP_001288661.1, NM_001301732.2
NP_004704.2, NM_004713.5 [O60524-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J92electron microscopy3.60u/v1-501[»]
ModBaseiSearch...
MobiDBiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

IntActiO60524, 12 interactors
MINTiO60524
STRINGi9606.ENSP00000298310

PTM databases

iPTMnetiO60524
PhosphoSitePlusiO60524

Polymorphism and mutation databases

BioMutaiNEMF

Proteomic databases

EPDiO60524
jPOSTiO60524
MaxQBiO60524
PaxDbiO60524
PeptideAtlasiO60524
PRIDEiO60524
ProteomicsDBi49458
49459 [O60524-2]
49460 [O60524-3]
49461 [O60524-4]
49462 [O60524-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9147
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298310; ENSP00000298310; ENSG00000165525 [O60524-1]
GeneIDi9147
KEGGihsa:9147
UCSCiuc001wxc.4 human [O60524-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9147
DisGeNETi9147

GeneCards: human genes, protein and diseases

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GeneCardsi
NEMF

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0011634
HGNCiHGNC:10663 NEMF
HPAiHPA004160
MIMi608378 gene
neXtProtiNX_O60524
OpenTargetsiENSG00000165525
PharmGKBiPA35593

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2030 Eukaryota
COG1293 LUCA
GeneTreeiENSGT00390000018516
InParanoidiO60524
OMAiFEWPKNV
OrthoDBi131285at2759
PhylomeDBiO60524
TreeFamiTF300515

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NEMF human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9147

Protein Ontology

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PROi
PR:O60524

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165525 Expressed in 242 organ(s), highest expression level in frontal cortex
ExpressionAtlasiO60524 baseline and differential
GenevisibleiO60524 HS

Family and domain databases

InterProiView protein in InterPro
IPR021846 NFACT-C
IPR008532 NFACT_RNA-bd
PfamiView protein in Pfam
PF11923 NFACT-C, 1 hit
PF05670 NFACT-R_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEMF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60524
Secondary accession number(s): A0JLQ3
, B3KSK1, B4DDL3, B4DHA9, B4E3F3, Q32Q66, Q8WW70, Q9NWG1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: November 24, 2009
Last modified: May 8, 2019
This is version 148 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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