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Entry version 157 (08 May 2019)
Sequence version 2 (28 Nov 2006)
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Protein

Tudor domain-containing protein 6

Gene

TDRD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 6
Alternative name(s):
Antigen NY-CO-45
Cancer/testis antigen 41.2
Short name:
CT41.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21339 TDRD6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611200 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60522

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
221400

Open Targets

More...
OpenTargetsi
ENSG00000180113

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134945900

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TDRD6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001831671 – 2096Tudor domain-containing protein 6Add BLAST2096

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei293PhosphothreonineBy similarity1
Modified residuei1722PhosphoserineBy similarity1
Modified residuei2062PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic cleavage near the C-terminal by an unknown protease during the transition from meiosis I to meiosis II in primary spermatocytes.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60522

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60522

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60522

PeptideAtlas

More...
PeptideAtlasi
O60522

PRoteomics IDEntifications database

More...
PRIDEi
O60522

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49457

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60522

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60522

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60522

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180113 Expressed in 149 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60522 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60522 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex, at least composed of PIWIL1, PIWIL2 and TDRD6. Interacts with DDX4 and PIWIL1 (By similarity). Interacts with TEX19 (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128720, 2 interactors

Protein interaction database and analysis system

More...
IntActi
O60522, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346065

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60522

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 120Tudor 1PROSITE-ProRule annotationAdd BLAST56
Domaini310 – 369Tudor 2PROSITE-ProRule annotationAdd BLAST60
Domaini536 – 593Tudor 3PROSITE-ProRule annotationAdd BLAST58
Domaini816 – 875Tudor 4PROSITE-ProRule annotationAdd BLAST60
Domaini1033 – 1088Tudor 5PROSITE-ProRule annotationAdd BLAST56
Domaini1352 – 1411Tudor 6PROSITE-ProRule annotationAdd BLAST60
Domaini1567 – 1626Tudor 7PROSITE-ProRule annotationAdd BLAST60
Domaini2026 – 2084Tudor 8PROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi453 – 458Poly-Glu6

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2039 Eukaryota
ENOG4110W7C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159049

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154540

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60522

KEGG Orthology (KO)

More...
KOi
K18405

Identification of Orthologs from Complete Genome Data

More...
OMAi
THVDDPW

Database of Orthologous Groups

More...
OrthoDBi
496838at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60522

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00567 TUDOR, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333 TUDOR, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50304 TUDOR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O60522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCSTPGMPAP GASLALRVSF VDVHPDVIPV QLWGLVGERR GEYLRLSREI
60 70 80 90 100
QEAAATRGQW ALGSASASPG ELCLVQVGLL WHRCRVVSRQ AQESRVFLLD
110 120 130 140 150
EGRTITAGAG SLAPGRREFF NLPSEVLGCV LAGLVPAGCG AGSGEPPQHW
160 170 180 190 200
PADAVDFLSN LQGKEVHGCV LDVLLLHRLV LLEVPDVFQQ MRELGLARRV
210 220 230 240 250
PDSLFRSLLE RYLTAATASV GSGVPVLSRV PLKQKQPGLD YFYPQLQLGV
260 270 280 290 300
TEAVVITQVC HPHRIHCQLR SVSQEIHRLS ESMAQVYRGS TGTGDENSTS
310 320 330 340 350
ATWEEREESP DKPGSPCASC GLDGHWYRAL LLETFRPQRC AQVLHVDYGR
360 370 380 390 400
KELVSCSSLR YLLPEYFRMP VVTYPCALYG LWDGGRGWSR SQVGDLKTLI
410 420 430 440 450
LGKAVNAKIE FYCSFEHVYY VSLYGEDGIN LNRVFGVQSC CLADRVLQSQ
460 470 480 490 500
ATEEEEPETS QSQSPAEEVD EEISLPALRS IRLKMNAFYD AQVEFVKNPS
510 520 530 540 550
EFWIRLRKHN VTFSKLMRRM CGFYSSASKL DGVVLKPEPD DLCCVKWKEN
560 570 580 590 600
GYYRAIVTKL DDKSVDVFLV DRGNSENVDW YDVRMLLPQF RQLPILAVKC
610 620 630 640 650
TLADIWPLGK TWSQEAVSFF KKTVLHKELV IHILDKQDHQ YVIEILDESR
660 670 680 690 700
TGEENISKVI AQAGYAKYQE FETKENILVN AHSPGHVSNH FTTESNKIPF
710 720 730 740 750
AKTGEGEQKA KRENKTTSVS KALSDTTVVT NGSTELVVQE KVKRASVYFP
760 770 780 790 800
LMQNCLEIKP GSSSKGELEV GSTVEVRVSY VENPGYFWCQ LTRNIQGLKT
810 820 830 840 850
LMSDIQYYCK NTAAPHQRNT LACLAKRTVN RQWSRALISG IQSVEHVNVT
860 870 880 890 900
FVDYGDREMV SVKNIYSISE EFLKVKAQAF RCSLYNLIQP VGQNPFVWDV
910 920 930 940 950
KAIQAFNEFI DNAWQKNLEL KCTIFALASI NEELFNIVDL LTPFQSACHF
960 970 980 990 1000
LVEKRLARPV KLQKPLESSV QLHSYFYSTH DMKIGSEELV YITHIDDPWT
1010 1020 1030 1040 1050
FYCQLARNAN ILEQLSCSIT QLSKVLLNLK TSPLNPGTLC LAKYTDGNWY
1060 1070 1080 1090 1100
RGIVIEKEPK KVFFVDFGNI YVVTSDDLLP IPSDAYDVLL LPMQAVRCSL
1110 1120 1130 1140 1150
SDIPDHIPEE VVVWFQETIL DKSLKALVVA KDPDGTLIIE LYGDNIQISA
1160 1170 1180 1190 1200
SINKKLGLLS YKDRIRKKES EVLCSTTETL EEKNENMKLP CTEYLSKSVG
1210 1220 1230 1240 1250
YKLPNKEILE ESYKPQINSS YKELKLLQSL TKTNLVTQYQ DSVGNKNSQV
1260 1270 1280 1290 1300
FPLTTEKKEE ISAETPLKTA RVEATLSERK IGDSCDKDLP LKFCEFPQKT
1310 1320 1330 1340 1350
IMPGFKTTVY VSHINDLSDF YVQLIEDEAE ISHLSERLNS VKTRPEYYVG
1360 1370 1380 1390 1400
PPLQRGDMIC AVFPEDNLWY RAVIKEQQPN DLLSVQFIDY GNVSVVHTNK
1410 1420 1430 1440 1450
IGRLDLVNAI LPGLCIHCSL QGFEVPDNKN SKKMMHYFSQ RTSEAAIRCE
1460 1470 1480 1490 1500
FVKFQDRWEV ILADEHGIIA DDMISRYALS EKSQVELSTQ VIKSASSKSV
1510 1520 1530 1540 1550
NKSDIDTSVF LNWYNPEKKM IRAYATVIDG PEYFWCQFAD TEKLQCLEVE
1560 1570 1580 1590 1600
VQTAGEQVAD RRNCIPCPYI GDPCIVRYRE DGHYYRALIT NICEDYLVSV
1610 1620 1630 1640 1650
RLVDFGNIED CVDPKALWAI PSELLSVPMQ AFPCCLSGFN ISEGLCSQEG
1660 1670 1680 1690 1700
NDYFYEIITE DVLEITILEI RRDVCDIPLA IVDLKSKGKS INEKMEKYSK
1710 1720 1730 1740 1750
TGIKSALPYE NIDSEIKQTL GSYNLDVGLK KLSNKAVQNK IYMEQQTDEL
1760 1770 1780 1790 1800
AEITEKDVNI IGTKPSNFRD PKTDNICEGF ENPCKDKIDT EELEGELECH
1810 1820 1830 1840 1850
LVDKAEFDDK YLITGFNTLL PHANETKEIL ELNSLEVPLS PDDESKEFLE
1860 1870 1880 1890 1900
LESIELQNSL VVDEEKGELS PVPPNVPLSQ ECVTKGAMEL FTLQLPLSCE
1910 1920 1930 1940 1950
AEKQPELELP TAQLPLDDKM DPLSLGVSQK AQESMCTEDM RKSSCVESFD
1960 1970 1980 1990 2000
DQRRMSLHLH GADCDPKTQN EMNICEEEFV EYKNRDAISA LMPLFSEEES
2010 2020 2030 2040 2050
SDGSKHNNGL PDHISAQLQN TYTLKAFTVG SKCVVWSSLR NTWSKCEILE
2060 2070 2080 2090
TAEEGTRVLN LSNGMEEIVN PENVWNGIPK LDKSPPEKRG LEVMEI
Length:2,096
Mass (Da):236,517
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19FED65D6FE68E44
GO
Isoform 2 (identifier: O60522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2058-2087: Missing.

Note: No experimental confirmation available.
Show »
Length:2,066
Mass (Da):233,202
Checksum:iF2ECB829FF541756
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y590H0Y590_HUMAN
Tudor domain-containing protein 6
TDRD6
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC18034 differs from that shown. Reason: Frameshift at position 1994.Curated
The sequence CAI45997 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1273E → K in AAC18034 (PubMed:9610721).Curated1
Sequence conflicti1455Q → R in CAI45997 (PubMed:17974005).Curated1
Sequence conflicti1955M → V in CAI45997 (PubMed:17974005).Curated1
Sequence conflicti2016A → D in AAC18034 (PubMed:9610721).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029050192R → Q. Corresponds to variant dbSNP:rs7750596Ensembl.1
Natural variantiVAR_029051398T → A. Corresponds to variant dbSNP:rs3799277Ensembl.1
Natural variantiVAR_052423795I → M. Corresponds to variant dbSNP:rs9463234Ensembl.1
Natural variantiVAR_0290521014Q → E1 PublicationCorresponds to variant dbSNP:rs9381472Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0448012058 – 2087Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL591242 Genomic DNA No translation available.
AK125838 mRNA Translation: BAG54254.1
AK131455 mRNA No translation available.
BX648686 mRNA Translation: CAI45997.1 Different initiation.
AF039442 mRNA Translation: AAC18034.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34470.1 [O60522-1]
CCDS55017.1 [O60522-2]

NCBI Reference Sequences

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RefSeqi
NP_001010870.1, NM_001010870.2 [O60522-1]
NP_001161831.1, NM_001168359.1 [O60522-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316081; ENSP00000346065; ENSG00000180113 [O60522-1]
ENST00000544460; ENSP00000443299; ENSG00000180113 [O60522-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
221400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221400

UCSC genome browser

More...
UCSCi
uc003oyj.4 human [O60522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591242 Genomic DNA No translation available.
AK125838 mRNA Translation: BAG54254.1
AK131455 mRNA No translation available.
BX648686 mRNA Translation: CAI45997.1 Different initiation.
AF039442 mRNA Translation: AAC18034.1 Frameshift.
CCDSiCCDS34470.1 [O60522-1]
CCDS55017.1 [O60522-2]
RefSeqiNP_001010870.1, NM_001010870.2 [O60522-1]
NP_001161831.1, NM_001168359.1 [O60522-2]

3D structure databases

SMRiO60522
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128720, 2 interactors
IntActiO60522, 1 interactor
STRINGi9606.ENSP00000346065

PTM databases

iPTMnetiO60522
PhosphoSitePlusiO60522
SwissPalmiO60522

Polymorphism and mutation databases

BioMutaiTDRD6

Proteomic databases

jPOSTiO60522
MaxQBiO60522
PaxDbiO60522
PeptideAtlasiO60522
PRIDEiO60522
ProteomicsDBi49457

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316081; ENSP00000346065; ENSG00000180113 [O60522-1]
ENST00000544460; ENSP00000443299; ENSG00000180113 [O60522-2]
GeneIDi221400
KEGGihsa:221400
UCSCiuc003oyj.4 human [O60522-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221400
DisGeNETi221400

GeneCards: human genes, protein and diseases

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GeneCardsi
TDRD6

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0025021
HGNCiHGNC:21339 TDRD6
MIMi611200 gene
neXtProtiNX_O60522
OpenTargetsiENSG00000180113
PharmGKBiPA134945900

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2039 Eukaryota
ENOG4110W7C LUCA
GeneTreeiENSGT00940000159049
HOGENOMiHOG000154540
InParanoidiO60522
KOiK18405
OMAiTHVDDPW
OrthoDBi496838at2759
PhylomeDBiO60522

Enzyme and pathway databases

ReactomeiR-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
221400

Protein Ontology

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PROi
PR:O60522

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000180113 Expressed in 149 organ(s), highest expression level in testis
ExpressionAtlasiO60522 baseline and differential
GenevisibleiO60522 HS

Family and domain databases

Gene3Di2.40.50.90, 3 hits
InterProiView protein in InterPro
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor
PfamiView protein in Pfam
PF00567 TUDOR, 7 hits
SMARTiView protein in SMART
SM00333 TUDOR, 8 hits
PROSITEiView protein in PROSITE
PS50304 TUDOR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60522
Secondary accession number(s): B3KWU2
, F5H5M3, Q5HYB1, Q5VTS4, Q6ZMX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: November 28, 2006
Last modified: May 8, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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