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Protein

Eukaryotic translation initiation factor 4E-binding protein 3

Gene

EIF4EBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.By similarity

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: GO_Central
  • translation repressor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionProtein synthesis inhibitor
Biological processTranslation regulation

Enzyme and pathway databases

SIGNORiO60516

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E-binding protein 3
Short name:
4E-BP3
Short name:
eIF4E-binding protein 3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000243056.1
HGNCiHGNC:3290 EIF4EBP3
MIMi603483 gene
neXtProtiNX_O60516

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40Y → A: Loss of interaction with EIF4E. 1 Publication1
Mutagenesisi45L → A: Loss of interaction with EIF4E. 1 Publication1

Organism-specific databases

DisGeNETi8637
OpenTargetsiENSG00000243056
PharmGKBiPA27718

Polymorphism and mutation databases

BioMutaiEIF4EBP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001905181 – 100Eukaryotic translation initiation factor 4E-binding protein 3Add BLAST100

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60516
PaxDbiO60516
PeptideAtlasiO60516
PRIDEiO60516
ProteomicsDBi49454

PTM databases

iPTMnetiO60516
PhosphoSitePlusiO60516

Expressioni

Tissue specificityi

Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.1 Publication

Gene expression databases

BgeeiENSG00000243056 Expressed in 89 organ(s), highest expression level in body of stomach
GenevisibleiO60516 HS

Organism-specific databases

HPAiHPA045537

Interactioni

Subunit structurei

EIF4EBP3 interacts with EIF4E.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114190, 8 interactors
ELMiO60516
IntActiO60516, 5 interactors
MINTiO60516
STRINGi9606.ENSP00000308472

Structurei

3D structure databases

ProteinModelPortaliO60516
SMRiO60516
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 46YXXXXLphi motif1 Publication7
Motifi96 – 100TOS motifBy similarity5

Sequence similaritiesi

Belongs to the eIF4E-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410J2Z0 Eukaryota
ENOG4112779 LUCA
GeneTreeiENSGT00390000013843
HOGENOMiHOG000231190
HOVERGENiHBG050425
InParanoidiO60516
KOiK18645
OMAiSQLPDCY
OrthoDBiEOG091G0ZHJ
PhylomeDBiO60516
TreeFamiTF101530

Family and domain databases

InterProiView protein in InterPro
IPR008606 EIF4EBP
PfamiView protein in Pfam
PF05456 eIF_4EBP, 1 hit

Sequencei

Sequence statusi: Complete.

O60516-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN
60 70 80 90 100
SPIARTPPCC LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI
Length:100
Mass (Da):10,873
Last modified:August 1, 1998 - v1
Checksum:iFD29A7F3829E546E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038869 mRNA Translation: AAC39761.1
BC010881 mRNA Translation: AAH10881.1
BC069293 mRNA Translation: AAH69293.1
BC073751 mRNA Translation: AAH73751.1
CCDSiCCDS4226.1
RefSeqiNP_003723.1, NM_003732.2
UniGeneiHs.594084

Genome annotation databases

EnsembliENST00000310331; ENSP00000308472; ENSG00000243056
GeneIDi8637
KEGGihsa:8637
UCSCiuc003lfy.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038869 mRNA Translation: AAC39761.1
BC010881 mRNA Translation: AAH10881.1
BC069293 mRNA Translation: AAH69293.1
BC073751 mRNA Translation: AAH73751.1
CCDSiCCDS4226.1
RefSeqiNP_003723.1, NM_003732.2
UniGeneiHs.594084

3D structure databases

ProteinModelPortaliO60516
SMRiO60516
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114190, 8 interactors
ELMiO60516
IntActiO60516, 5 interactors
MINTiO60516
STRINGi9606.ENSP00000308472

PTM databases

iPTMnetiO60516
PhosphoSitePlusiO60516

Polymorphism and mutation databases

BioMutaiEIF4EBP3

Proteomic databases

EPDiO60516
PaxDbiO60516
PeptideAtlasiO60516
PRIDEiO60516
ProteomicsDBi49454

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310331; ENSP00000308472; ENSG00000243056
GeneIDi8637
KEGGihsa:8637
UCSCiuc003lfy.1 human

Organism-specific databases

CTDi8637
DisGeNETi8637
EuPathDBiHostDB:ENSG00000243056.1
GeneCardsiEIF4EBP3
HGNCiHGNC:3290 EIF4EBP3
HPAiHPA045537
MIMi603483 gene
neXtProtiNX_O60516
OpenTargetsiENSG00000243056
PharmGKBiPA27718
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2Z0 Eukaryota
ENOG4112779 LUCA
GeneTreeiENSGT00390000013843
HOGENOMiHOG000231190
HOVERGENiHBG050425
InParanoidiO60516
KOiK18645
OMAiSQLPDCY
OrthoDBiEOG091G0ZHJ
PhylomeDBiO60516
TreeFamiTF101530

Enzyme and pathway databases

SIGNORiO60516

Miscellaneous databases

GeneWikiiEIF4EBP3
GenomeRNAii8637
PROiPR:O60516
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243056 Expressed in 89 organ(s), highest expression level in body of stomach
GenevisibleiO60516 HS

Family and domain databases

InterProiView protein in InterPro
IPR008606 EIF4EBP
PfamiView protein in Pfam
PF05456 eIF_4EBP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei4EBP3_HUMAN
AccessioniPrimary (citable) accession number: O60516
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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