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Entry version 183 (02 Dec 2020)
Sequence version 2 (21 Jun 2005)
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Protein

Beta-1,4-galactosyltransferase 3

Gene

B4GALT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=63 µM for GlcNAc-B-S-pNP1 Publication
  2. KM=0.084 mM for UDP-galactose1 Publication
  3. KM=0.58 mM for benzyl-beta-D-GlcNAc1 Publication
  4. KM=13.1 mM for D-GlcNAc1 Publication
  1. Vmax=64.35 pmol/min/mg enzyme towards UDP-galactose1 Publication
  2. Vmax=66.25 pmol/min/mg enzyme towards for benzyl-beta-D-GlcNAc1 Publication
  3. Vmax=60.85 pmol/min/mg enzyme towards D-GlcNAc1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.2 Publications
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi197ManganeseBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei226UDP-alpha-D-galactoseBy similarity1
Binding sitei258UDP-alpha-D-galactoseBy similarity1
Metal bindingi291Manganese; via tele nitrogenBy similarity1
Binding sitei303N-acetyl-D-glucosamineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS08336-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O60512

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022854, Keratan sulfate biosynthesis
R-HSA-975577, N-Glycan antennae elongation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT7, Glycosyltransferase Family 7

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000790

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-1,4-galactosyltransferase 3Curated (EC:2.4.1.-1 Publication)
Short name:
Beta-1,4-GalTase 31 Publication
Short name:
Beta4Gal-T3
Short name:
b4Gal-T31 Publication
Alternative name(s):
Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase1 Publication (EC:2.4.1.381 Publication)
N-acetyllactosamine synthase1 Publication (EC:2.4.1.901 Publication)
Nal synthase
Neolactotriaosylceramide beta-1,4-galactosyltransferase1 Publication (EC:2.4.1.2751 Publication)
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:B4GALT3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000158850.14

Human Gene Nomenclature Database

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HGNCi
HGNC:926, B4GALT3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604014, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60512

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini32 – 393LumenalSequence analysisAdd BLAST362

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8703

Open Targets

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OpenTargetsi
ENSG00000158850

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25225

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60512, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
B4GALT3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000805371 – 393Beta-1,4-galactosyltransferase 3Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi77 ↔ 119By similarity
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi190 ↔ 209By similarity
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60512

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60512

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O60512

MaxQB - The MaxQuant DataBase

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MaxQBi
O60512

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60512

PeptideAtlas

More...
PeptideAtlasi
O60512

PRoteomics IDEntifications database

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PRIDEi
O60512

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
49451 [O60512-1]
49452 [O60512-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1032, 6 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
O60512, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60512

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60512

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60512

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in various tissues. Highest expression in placenta, prostate, testis, ovary, intestine and muscle, and in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000158850, Expressed in granulocyte and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60512, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60512, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000158850, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114246, 62 interactors

Protein interaction database and analysis system

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IntActi
O60512, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480428

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O60512, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60512

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni130 – 134UDP-alpha-D-galactose bindingBy similarity5
Regioni169 – 171UDP-alpha-D-galactose bindingBy similarity3
Regioni196 – 197UDP-alpha-D-galactose bindingBy similarity2
Regioni260 – 263N-acetyl-D-glucosamine bindingBy similarity4
Regioni291 – 293UDP-alpha-D-galactose bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 7 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3916, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158549

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044391_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60512

Identification of Orthologs from Complete Genome Data

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OMAi
NIGEDPH

Database of Orthologous Groups

More...
OrthoDBi
1201618at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60512

TreeFam database of animal gene trees

More...
TreeFami
TF312834

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003859, Galactosyl_T
IPR027791, Galactosyl_T_C
IPR027995, Galactosyl_T_N
IPR029044, Nucleotide-diphossugar_trans

The PANTHER Classification System

More...
PANTHERi
PTHR19300, PTHR19300, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02709, Glyco_transf_7C, 1 hit
PF13733, Glyco_transf_7N, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02050, B14GALTRFASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60512-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRRLLERPC TLALLVGSQL AVMMYLSLGG FRSLSALFGR DQGPTFDYSH
60 70 80 90 100
PRDVYSNLSH LPGAPGGPPA PQGLPYCPER SPLLVGPVSV SFSPVPSLAE
110 120 130 140 150
IVERNPRVEP GGRYRPAGCE PRSRTAIIVP HRAREHHLRL LLYHLHPFLQ
160 170 180 190 200
RQQLAYGIYV IHQAGNGTFN RAKLLNVGVR EALRDEEWDC LFLHDVDLLP
210 220 230 240 250
ENDHNLYVCD PRGPRHVAVA MNKFGYSLPY PQYFGGVSAL TPDQYLKMNG
260 270 280 290 300
FPNEYWGWGG EDDDIATRVR LAGMKISRPP TSVGHYKMVK HRGDKGNEEN
310 320 330 340 350
PHRFDLLVRT QNSWTQDGMN SLTYQLLARE LGPLYTNITA DIGTDPRGPR
360 370 380 390
APSGPRYPPG SSQAFRQEML QRRPPARPGP LSTANHTALR GSH
Length:393
Mass (Da):43,928
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA0BF955F95ED1F4
GO
Isoform 2 (identifier: O60512-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-145: PAGCEPRSRTAIIVPHRAREHHLRLLLYHL → PAALPPAPLLAAPAACLWHLCHPPGWKWNI
     146-393: Missing.

Show »
Length:145
Mass (Da):15,654
Checksum:i4231F9B50756A99C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64A → R in AAC39734 (PubMed:9597550).Curated1
Sequence conflicti112G → A in AAC39734 (PubMed:9597550).Curated1
Sequence conflicti223K → S in AAC39734 (PubMed:9597550).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014106116 – 145PAGCE…LLYHL → PAALPPAPLLAAPAACLWHL CHPPGWKWNI in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_014107146 – 393Missing in isoform 2. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y12509 mRNA Translation: CAA73111.1
AF038661 mRNA Translation: AAC39734.1
AB024435 mRNA Translation: BAA75820.1
AL590714 Genomic DNA No translation available.
AK023311 mRNA Translation: BAB14520.1
CH471121 Genomic DNA Translation: EAW52628.1
CH471121 Genomic DNA Translation: EAW52629.1
CH471121 Genomic DNA Translation: EAW52630.1
CH471121 Genomic DNA Translation: EAW52631.1
CH471121 Genomic DNA Translation: EAW52632.1
BC000276 mRNA Translation: AAH00276.1
BC006099 mRNA Translation: AAH06099.1
BC009985 mRNA Translation: AAH09985.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1222.1 [O60512-1]

NCBI Reference Sequences

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RefSeqi
NP_001186802.1, NM_001199873.1 [O60512-1]
NP_001186803.1, NM_001199874.1 [O60512-1]
NP_003770.1, NM_003779.3 [O60512-1]
XP_005245623.1, XM_005245566.1 [O60512-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319769; ENSP00000320965; ENSG00000158850 [O60512-1]
ENST00000367998; ENSP00000356977; ENSG00000158850 [O60512-1]
ENST00000622395; ENSP00000480428; ENSG00000158850 [O60512-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8703

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8703

UCSC genome browser

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UCSCi
uc001fyq.3, human [O60512-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - GTase

Beta-1,4-galactosyltransferase 3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12509 mRNA Translation: CAA73111.1
AF038661 mRNA Translation: AAC39734.1
AB024435 mRNA Translation: BAA75820.1
AL590714 Genomic DNA No translation available.
AK023311 mRNA Translation: BAB14520.1
CH471121 Genomic DNA Translation: EAW52628.1
CH471121 Genomic DNA Translation: EAW52629.1
CH471121 Genomic DNA Translation: EAW52630.1
CH471121 Genomic DNA Translation: EAW52631.1
CH471121 Genomic DNA Translation: EAW52632.1
BC000276 mRNA Translation: AAH00276.1
BC006099 mRNA Translation: AAH06099.1
BC009985 mRNA Translation: AAH09985.1
CCDSiCCDS1222.1 [O60512-1]
RefSeqiNP_001186802.1, NM_001199873.1 [O60512-1]
NP_001186803.1, NM_001199874.1 [O60512-1]
NP_003770.1, NM_003779.3 [O60512-1]
XP_005245623.1, XM_005245566.1 [O60512-1]

3D structure databases

SMRiO60512
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114246, 62 interactors
IntActiO60512, 24 interactors
STRINGi9606.ENSP00000480428

Chemistry databases

SwissLipidsiSLP:000000790

Protein family/group databases

CAZyiGT7, Glycosyltransferase Family 7

PTM databases

GlyConnecti1032, 6 N-Linked glycans (2 sites)
GlyGeniO60512, 5 sites
iPTMnetiO60512
PhosphoSitePlusiO60512
SwissPalmiO60512

Polymorphism and mutation databases

BioMutaiB4GALT3

Proteomic databases

EPDiO60512
jPOSTiO60512
MassIVEiO60512
MaxQBiO60512
PaxDbiO60512
PeptideAtlasiO60512
PRIDEiO60512
ProteomicsDBi49451 [O60512-1]
49452 [O60512-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2534, 206 antibodies

The DNASU plasmid repository

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DNASUi
8703

Genome annotation databases

EnsembliENST00000319769; ENSP00000320965; ENSG00000158850 [O60512-1]
ENST00000367998; ENSP00000356977; ENSG00000158850 [O60512-1]
ENST00000622395; ENSP00000480428; ENSG00000158850 [O60512-1]
GeneIDi8703
KEGGihsa:8703
UCSCiuc001fyq.3, human [O60512-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8703
DisGeNETi8703
EuPathDBiHostDB:ENSG00000158850.14

GeneCards: human genes, protein and diseases

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GeneCardsi
B4GALT3
HGNCiHGNC:926, B4GALT3
HPAiENSG00000158850, Low tissue specificity
MIMi604014, gene
neXtProtiNX_O60512
OpenTargetsiENSG00000158850
PharmGKBiPA25225

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3916, Eukaryota
GeneTreeiENSGT00940000158549
HOGENOMiCLU_044391_1_2_1
InParanoidiO60512
OMAiNIGEDPH
OrthoDBi1201618at2759
PhylomeDBiO60512
TreeFamiTF312834

Enzyme and pathway databases

UniPathwayiUPA00378
BioCyciMetaCyc:HS08336-MONOMER
PathwayCommonsiO60512
ReactomeiR-HSA-2022854, Keratan sulfate biosynthesis
R-HSA-975577, N-Glycan antennae elongation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8703, 17 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
B4GALT3, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
B4GALT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8703
PharosiO60512, Tbio

Protein Ontology

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PROi
PR:O60512
RNActiO60512, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158850, Expressed in granulocyte and 233 other tissues
ExpressionAtlasiO60512, baseline and differential
GenevisibleiO60512, HS

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR003859, Galactosyl_T
IPR027791, Galactosyl_T_C
IPR027995, Galactosyl_T_N
IPR029044, Nucleotide-diphossugar_trans
PANTHERiPTHR19300, PTHR19300, 1 hit
PfamiView protein in Pfam
PF02709, Glyco_transf_7C, 1 hit
PF13733, Glyco_transf_7N, 1 hit
PRINTSiPR02050, B14GALTRFASE
SUPFAMiSSF53448, SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4GT3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60512
Secondary accession number(s): D3DVG3
, O60910, Q9BPZ4, Q9H8T2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 21, 2005
Last modified: December 2, 2020
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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