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UniProtKB - O60512 (B4GT3_HUMAN)

Protein

Beta-1,4-galactosyltransferase 3

Gene

B4GALT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=63 µM for GlcNAc-B-S-pNP1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi197ManganeseBy similarity1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei226UDP-alpha-D-galactoseBy similarity1
    Binding sitei258UDP-alpha-D-galactoseBy similarity1
    Metal bindingi291Manganese; via tele nitrogenBy similarity1
    Binding sitei303N-acetyl-D-glucosamineBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    View the complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    LigandManganese, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS08336-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2022854 Keratan sulfate biosynthesis
    R-HSA-975577 N-Glycan antennae elongation

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi
    UPA00378

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...    CAZyi    		GT7 Glycosyltransferase Family 7

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000000790

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Beta-1,4-galactosyltransferase 3 (EC:2.4.1.-)
    Short name:
    Beta-1,4-GalTase 3
    Short name:
    Beta4Gal-T3
    Short name:
    b4Gal-T3
    Alternative name(s):
    Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC:2.4.1.38)
    N-acetyllactosamine synthase (EC:2.4.1.90)
    Nal synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:B4GALT3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000158850.14

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:926 B4GALT3

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		604014 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_O60512

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini32 – 393LumenalSequence analysisAdd BLAST362

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		8703

    Open Targets

    More...    OpenTargetsi    		ENSG00000158850

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA25225

    Chemistry databases

    Drug and drug target database

    More...    DrugBanki    		DB00141 N-Acetyl-D-glucosamine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		B4GALT3

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000805371 – 393Beta-1,4-galactosyltransferase 3Add BLAST393

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi77 ↔ 119By similarity
    Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi190 ↔ 209By similarity
    Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		O60512

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		O60512

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		O60512

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		O60512

    PeptideAtlas

    More...    PeptideAtlasi    		O60512

    PRoteomics IDEntifications database

    More...    PRIDEi    		O60512

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		49451
    49452 [O60512-2]

    PTM databases

    GlyConnect protein glycosylation platform

    More...    GlyConnecti    		1032

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		O60512

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		O60512

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Found in various tissues. Highest expression in placenta, prostate, testis, ovary, intestine and muscle, and in fetal brain.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000158850 Expressed in 220 organ(s), highest expression level in oocyte

    CleanEx database of gene expression profiles

    More...    CleanExi    		HS_B4GALT3

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		O60512 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA010793

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		114246, 35 interactors

    Protein interaction database and analysis system

    More...    IntActi    		O60512, 6 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000320965

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...    ProteinModelPortali    		O60512

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		O60512

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni130 – 134UDP-alpha-D-galactose bindingBy similarity5
    Regioni169 – 171UDP-alpha-D-galactose bindingBy similarity3
    Regioni196 – 197UDP-alpha-D-galactose bindingBy similarity2
    Regioni260 – 263N-acetyl-D-glucosamine bindingBy similarity4
    Regioni291 – 293UDP-alpha-D-galactose bindingBy similarity3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 7 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3916 Eukaryota
    ENOG410ZYYA LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000158549

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000231027

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...    HOVERGENi    		HBG058334

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		O60512

    KEGG Orthology (KO)

    More...    KOi    		K07968

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		VAIGHYK

    Database of Orthologous Groups

    More...    OrthoDBi    		1201618at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		O60512

    TreeFam database of animal gene trees

    More...    TreeFami    		TF312834

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.90.550.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR003859 Galactosyl_T
    IPR027791 Galactosyl_T_C
    IPR027995 Galactosyl_T_N
    IPR029044 Nucleotide-diphossugar_trans

    The PANTHER Classification System

    More...    PANTHERi    		PTHR19300 PTHR19300, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF02709 Glyco_transf_7C, 1 hit
    PF13733 Glyco_transf_7N, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR02050 B14GALTRFASE

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF53448 SSF53448, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: O60512-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MLRRLLERPC TLALLVGSQL AVMMYLSLGG FRSLSALFGR DQGPTFDYSH 
            60         70         80         90        100
    PRDVYSNLSH LPGAPGGPPA PQGLPYCPER SPLLVGPVSV SFSPVPSLAE 
           110        120        130        140        150
    IVERNPRVEP GGRYRPAGCE PRSRTAIIVP HRAREHHLRL LLYHLHPFLQ 
           160        170        180        190        200
    RQQLAYGIYV IHQAGNGTFN RAKLLNVGVR EALRDEEWDC LFLHDVDLLP 
           210        220        230        240        250
    ENDHNLYVCD PRGPRHVAVA MNKFGYSLPY PQYFGGVSAL TPDQYLKMNG 
           260        270        280        290        300
    FPNEYWGWGG EDDDIATRVR LAGMKISRPP TSVGHYKMVK HRGDKGNEEN 
           310        320        330        340        350
    PHRFDLLVRT QNSWTQDGMN SLTYQLLARE LGPLYTNITA DIGTDPRGPR 
           360        370        380        390 
    APSGPRYPPG SSQAFRQEML QRRPPARPGP LSTANHTALR GSH
    Length:393
    Mass (Da):43,928
    Last modified:June 21, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA0BF955F95ED1F4
    GO
    Isoform 2 (identifier: O60512-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         116-145: PAGCEPRSRTAIIVPHRAREHHLRLLLYHL → PAALPPAPLLAAPAACLWHLCHPPGWKWNI
         146-393: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:145
    Mass (Da):15,654
    Checksum:i4231F9B50756A99C
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64A → R in AAC39734 (PubMed:9597550).Curated1
    Sequence conflicti112G → A in AAC39734 (PubMed:9597550).Curated1
    Sequence conflicti223K → S in AAC39734 (PubMed:9597550).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014106116 – 145PAGCE…LLYHL → PAALPPAPLLAAPAACLWHL CHPPGWKWNI in isoform 2. 1 PublicationAdd BLAST30
    Alternative sequenceiVSP_014107146 – 393Missing in isoform 2. 1 PublicationAdd BLAST248

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		Y12509 mRNA Translation: CAA73111.1
    AF038661 mRNA Translation: AAC39734.1
    AB024435 mRNA Translation: BAA75820.1
    AL590714 Genomic DNA No translation available.
    AK023311 mRNA Translation: BAB14520.1
    CH471121 Genomic DNA Translation: EAW52628.1
    CH471121 Genomic DNA Translation: EAW52629.1
    CH471121 Genomic DNA Translation: EAW52630.1
    CH471121 Genomic DNA Translation: EAW52631.1
    CH471121 Genomic DNA Translation: EAW52632.1
    BC000276 mRNA Translation: AAH00276.1
    BC006099 mRNA Translation: AAH06099.1
    BC009985 mRNA Translation: AAH09985.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS1222.1 [O60512-1]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001186802.1, NM_001199873.1 [O60512-1]
    NP_001186803.1, NM_001199874.1 [O60512-1]
    NP_003770.1, NM_003779.3 [O60512-1]
    XP_005245623.1, XM_005245566.1 [O60512-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...    UniGenei    		Hs.321231
    Hs.741821

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000319769; ENSP00000320965; ENSG00000158850 [O60512-1]
    ENST00000367998; ENSP00000356977; ENSG00000158850 [O60512-1]
    ENST00000622395; ENSP00000480428; ENSG00000158850 [O60512-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		8703

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:8703

    UCSC genome browser

    More...    UCSCi    		uc001fyq.3 human [O60512-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Functional Glycomics Gateway - GTase

    Beta-1,4-galactosyltransferase 3

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		Y12509 mRNA Translation: CAA73111.1
    AF038661 mRNA Translation: AAC39734.1
    AB024435 mRNA Translation: BAA75820.1
    AL590714 Genomic DNA No translation available.
    AK023311 mRNA Translation: BAB14520.1
    CH471121 Genomic DNA Translation: EAW52628.1
    CH471121 Genomic DNA Translation: EAW52629.1
    CH471121 Genomic DNA Translation: EAW52630.1
    CH471121 Genomic DNA Translation: EAW52631.1
    CH471121 Genomic DNA Translation: EAW52632.1
    BC000276 mRNA Translation: AAH00276.1
    BC006099 mRNA Translation: AAH06099.1
    BC009985 mRNA Translation: AAH09985.1
    CCDSiCCDS1222.1 [O60512-1]
    RefSeqiNP_001186802.1, NM_001199873.1 [O60512-1]
    NP_001186803.1, NM_001199874.1 [O60512-1]
    NP_003770.1, NM_003779.3 [O60512-1]
    XP_005245623.1, XM_005245566.1 [O60512-1]
    UniGeneiHs.321231
    Hs.741821

    3D structure databases

    ProteinModelPortaliO60512
    SMRiO60512
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi114246, 35 interactors
    IntActiO60512, 6 interactors
    STRINGi9606.ENSP00000320965

    Chemistry databases

    DrugBankiDB00141 N-Acetyl-D-glucosamine
    SwissLipidsiSLP:000000790

    Protein family/group databases

    CAZyiGT7 Glycosyltransferase Family 7

    PTM databases

    GlyConnecti1032
    iPTMnetiO60512
    PhosphoSitePlusiO60512

    Polymorphism and mutation databases

    BioMutaiB4GALT3

    Proteomic databases

    EPDiO60512
    jPOSTiO60512
    MaxQBiO60512
    PaxDbiO60512
    PeptideAtlasiO60512
    PRIDEiO60512
    ProteomicsDBi49451
    49452 [O60512-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...    DNASUi    		8703
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000319769; ENSP00000320965; ENSG00000158850 [O60512-1]
    ENST00000367998; ENSP00000356977; ENSG00000158850 [O60512-1]
    ENST00000622395; ENSP00000480428; ENSG00000158850 [O60512-1]
    GeneIDi8703
    KEGGihsa:8703
    UCSCiuc001fyq.3 human [O60512-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		8703
    DisGeNETi8703
    EuPathDBiHostDB:ENSG00000158850.14

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		B4GALT3

    H-Invitational Database, human transcriptome db

    More...    H-InvDBi    		HIX0159958
    HGNCiHGNC:926 B4GALT3
    HPAiHPA010793
    MIMi604014 gene
    neXtProtiNX_O60512
    OpenTargetsiENSG00000158850
    PharmGKBiPA25225

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG3916 Eukaryota
    ENOG410ZYYA LUCA
    GeneTreeiENSGT00940000158549
    HOGENOMiHOG000231027
    HOVERGENiHBG058334
    InParanoidiO60512
    KOiK07968
    OMAiVAIGHYK
    OrthoDBi1201618at2759
    PhylomeDBiO60512
    TreeFamiTF312834

    Enzyme and pathway databases

    UniPathwayi
    UPA00378

    BioCyciMetaCyc:HS08336-MONOMER
    ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
    R-HSA-975577 N-Glycan antennae elongation

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		B4GALT3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		8703

    Protein Ontology

    More...    PROi    		PR:O60512

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000158850 Expressed in 220 organ(s), highest expression level in oocyte
    CleanExiHS_B4GALT3
    GenevisibleiO60512 HS

    Family and domain databases

    Gene3Di3.90.550.10, 1 hit
    InterProiView protein in InterPro
    IPR003859 Galactosyl_T
    IPR027791 Galactosyl_T_C
    IPR027995 Galactosyl_T_N
    IPR029044 Nucleotide-diphossugar_trans
    PANTHERiPTHR19300 PTHR19300, 1 hit
    PfamiView protein in Pfam
    PF02709 Glyco_transf_7C, 1 hit
    PF13733 Glyco_transf_7N, 1 hit
    PRINTSiPR02050 B14GALTRFASE
    SUPFAMiSSF53448 SSF53448, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4GT3_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60512
    Secondary accession number(s): D3DVG3
    , O60910, Q9BPZ4, Q9H8T2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: June 21, 2005
    Last modified: January 16, 2019
    This is version 170 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
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