B4GALT3

Functionⁱ

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Catalytic activityⁱ

UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.

UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.

Cofactorⁱ

Mn²⁺By similarity

Kineticsⁱ

K_M=
63 µM for GlcNAc-B-S-pNP
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells."
  Guo S., Sato T., Shirane K., Furukawa K.
  Glycobiology 11:813-820(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), BIOPHYSICOCHEMICAL PROPERTIES.

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	197	ManganeseBy similarity	1
Binding siteⁱ	226	UDP-alpha-D-galactoseBy similarity	1
Binding siteⁱ	258	UDP-alpha-D-galactoseBy similarity	1
Metal bindingⁱ	291	Manganese; via tele nitrogenBy similarity	1
Binding siteⁱ	303	N-acetyl-D-glucosamineBy similarity	1

GO - Molecular functionⁱ

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Source: Reactome
galactosyltransferase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 9405390
metal ion binding Source: UniProtKB-KW
N-acetyllactosamine synthase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
galactosylceramide biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 9405390
keratan sulfate biosynthetic process Source: Reactome
protein glycosylation Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS08336-MONOMER
Reactomeⁱ	R-HSA-2022854 Keratan sulfate biosynthesis R-HSA-975577 N-Glycan antennae elongation
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT7 Glycosyltransferase Family 7

CAZyⁱ

GT7 Glycosyltransferase Family 7

Chemistry databases

SwissLipidsⁱ	SLP:000000790

SwissLipidsⁱ

SLP:000000790

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-1,4-galactosyltransferase 3 (EC:2.4.1.-) Short name: Beta-1,4-GalTase 3 Short name: Beta4Gal-T3 Short name: b4Gal-T3 Alternative name(s): UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3 Including the following 3 domains: N-acetyllactosamine synthase (EC:2.4.1.90) Alternative name(s): Nal synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC:2.4.1.38) Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC:2.4.1.-)
Gene namesⁱ	Name:B4GALT3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158850.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:926 B4GALT3
MIMⁱ	604014 gene
neXtProtⁱ	NX_O60512

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 10	CytoplasmicSequence analysis	10
Transmembraneⁱ	11 – 31	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	32 – 393	LumenalSequence analysisAdd BLAST	362

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8703
Open Targets More...OpenTargetsⁱ	ENSG00000158850
PharmGKBⁱ	PA25225

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00141 N-Acetyl-D-glucosamine

DrugBankⁱ

DB00141 N-Acetyl-D-glucosamine

Polymorphism and mutation databases

BioMutaⁱ	B4GALT3

BioMutaⁱ

B4GALT3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080537	1 – 393	Beta-1,4-galactosyltransferase 3Add BLAST		393

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	57	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	77 ↔ 119	By similarity
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	190 ↔ 209	By similarity
Glycosylationⁱ	337	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	385	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	O60512
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60512
PaxDbⁱ	O60512
PeptideAtlas More...PeptideAtlasⁱ	O60512
PRIDEⁱ	O60512
ProteomicsDBⁱ	49451 49452 [O60512-2]

PTM databases

GlyConnectⁱ	1032
iPTMnetⁱ	O60512
PhosphoSitePlusⁱ	O60512

Expressionⁱ

Tissue specificityⁱ

Found in various tissues. Highest expression in placenta, prostate, testis, ovary, intestine and muscle, and in fetal brain.

Gene expression databases

Bgeeⁱ	ENSG00000158850 Expressed in 220 organ(s), highest expression level in oocyte
CleanExⁱ	HS_B4GALT3
Genevisibleⁱ	O60512 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010793

HPAⁱ

HPA010793

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114246, 35 interactors
IntActⁱ	O60512, 6 interactors
STRINGⁱ	9606.ENSP00000320965

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60512
SMRⁱ	O60512
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	130 – 134	UDP-alpha-D-galactose bindingBy similarity	5
Regionⁱ	169 – 171	UDP-alpha-D-galactose bindingBy similarity	3
Regionⁱ	196 – 197	UDP-alpha-D-galactose bindingBy similarity	2
Regionⁱ	260 – 263	N-acetyl-D-glucosamine bindingBy similarity	4
Regionⁱ	291 – 293	UDP-alpha-D-galactose bindingBy similarity	3

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 7 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3916 Eukaryota ENOG410ZYYA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119140
HOGENOMⁱ	HOG000231027
HOVERGENⁱ	HBG058334
InParanoidⁱ	O60512
KEGG Orthology (KO) More...KOⁱ	K07968
OMAⁱ	VAIGHYK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P66
PhylomeDBⁱ	O60512
TreeFamⁱ	TF312834

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR003859 Galactosyl_T IPR027791 Galactosyl_T_C IPR027995 Galactosyl_T_N IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR19300 PTHR19300, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02709 Glyco_transf_7C, 1 hit PF13733 Glyco_transf_7N, 1 hit
PRINTSⁱ	PR02050 B14GALTRFASE
SUPFAMⁱ	SSF53448 SSF53448, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O60512-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRRLLERPC TLALLVGSQL AVMMYLSLGG FRSLSALFGR DQGPTFDYSH 
        60         70         80         90        100
PRDVYSNLSH LPGAPGGPPA PQGLPYCPER SPLLVGPVSV SFSPVPSLAE 
       110        120        130        140        150
IVERNPRVEP GGRYRPAGCE PRSRTAIIVP HRAREHHLRL LLYHLHPFLQ 
       160        170        180        190        200
RQQLAYGIYV IHQAGNGTFN RAKLLNVGVR EALRDEEWDC LFLHDVDLLP 
       210        220        230        240        250
ENDHNLYVCD PRGPRHVAVA MNKFGYSLPY PQYFGGVSAL TPDQYLKMNG 
       260        270        280        290        300
FPNEYWGWGG EDDDIATRVR LAGMKISRPP TSVGHYKMVK HRGDKGNEEN 
       310        320        330        340        350
PHRFDLLVRT QNSWTQDGMN SLTYQLLARE LGPLYTNITA DIGTDPRGPR 
       360        370        380        390 
APSGPRYPPG SSQAFRQEML QRRPPARPGP LSTANHTALR GSH

Length:393

Mass (Da):43,928

Last modified:June 21, 2005 - v2

Checksum:ⁱCA0BF955F95ED1F4

GO

Isoform 2 (identifier: O60512-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
116-145: PAGCEPRSRTAIIVPHRAREHHLRLLLYHL → PAALPPAPLLAAPAACLWHLCHPPGWKWNI
146-393: Missing.

« Hide

        10         20         30         40         50
MLRRLLERPC TLALLVGSQL AVMMYLSLGG FRSLSALFGR DQGPTFDYSH 
        60         70         80         90        100
PRDVYSNLSH LPGAPGGPPA PQGLPYCPER SPLLVGPVSV SFSPVPSLAE 
       110        120        130        140 
IVERNPRVEP GGRYRPAALP PAPLLAAPAA CLWHLCHPPG WKWNI

Note: No experimental confirmation available.

Show »

Length:145

Mass (Da):15,654

Checksum:ⁱ4231F9B50756A99C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	64	A → R in AAC39734 (PubMed:9597550).Curated	1
Sequence conflictⁱ	112	G → A in AAC39734 (PubMed:9597550).Curated	1
Sequence conflictⁱ	223	K → S in AAC39734 (PubMed:9597550).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_014106	116 – 145	PAGCE…LLYHL → PAALPPAPLLAAPAACLWHL CHPPGWKWNI in isoform 2. 1 PublicationAdd BLAST		30
Alternative sequenceⁱVSP_014107	146 – 393	Missing in isoform 2. 1 PublicationAdd BLAST		248

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y12509 mRNA Translation: CAA73111.1 AF038661 mRNA Translation: AAC39734.1 AB024435 mRNA Translation: BAA75820.1 AL590714 Genomic DNA No translation available. AK023311 mRNA Translation: BAB14520.1 CH471121 Genomic DNA Translation: EAW52628.1 CH471121 Genomic DNA Translation: EAW52629.1 CH471121 Genomic DNA Translation: EAW52630.1 CH471121 Genomic DNA Translation: EAW52631.1 CH471121 Genomic DNA Translation: EAW52632.1 BC000276 mRNA Translation: AAH00276.1 BC006099 mRNA Translation: AAH06099.1 BC009985 mRNA Translation: AAH09985.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1222.1 [O60512-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001186802.1, NM_001199873.1 [O60512-1] NP_001186803.1, NM_001199874.1 [O60512-1] NP_003770.1, NM_003779.3 [O60512-1] XP_005245623.1, XM_005245566.1 [O60512-1]
UniGeneⁱ	Hs.321231 Hs.741821

Genome annotation databases

Ensemblⁱ	ENST00000319769; ENSP00000320965; ENSG00000158850 [O60512-1] ENST00000367998; ENSP00000356977; ENSG00000158850 [O60512-1] ENST00000622395; ENSP00000480428; ENSG00000158850 [O60512-1]
GeneIDⁱ	8703
KEGGⁱ	hsa:8703
UCSC genome browser More...UCSCⁱ	uc001fyq.3 human [O60512-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60512	Beta-1,4-galactosyltransferase 3		BOVIN		396	UniRef90_O60512
Beta-1,4-galactosyltransferase 3		CRIGR		395
Beta-1,4-galactosyltransferase 3		MOUSE		395
Beta-1,4-galactosyltransferase 3		RAT		395
Beta-1,4-galactosyltransferase 3		PONAB		393
+101

Protein	Similar proteins		Species	Score	Length	Source
O60512	Beta-1,4-galactosyltransferase 3		BOVIN		396	UniRef50_O60512
Beta-1,4-galactosyltransferase 3		RAT		395
Beta-1,4-galactosyltransferase 3		MOUSE		395
Beta-1,4-galactosyltransferase 3		CRIGR		395
Beta-1,4-galactosyltransferase 3		PONAB		393
+129
O60512-2	Beta-1,4-galactosyltransferase 3 (Fragment)		MOUSE		139	UniRef50_O60512-2
UPI0004D0A0EC		GALVR		166

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - GTase

Beta-1,4-galactosyltransferase 3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y12509 mRNA Translation: CAA73111.1 AF038661 mRNA Translation: AAC39734.1 AB024435 mRNA Translation: BAA75820.1 AL590714 Genomic DNA No translation available. AK023311 mRNA Translation: BAB14520.1 CH471121 Genomic DNA Translation: EAW52628.1 CH471121 Genomic DNA Translation: EAW52629.1 CH471121 Genomic DNA Translation: EAW52630.1 CH471121 Genomic DNA Translation: EAW52631.1 CH471121 Genomic DNA Translation: EAW52632.1 BC000276 mRNA Translation: AAH00276.1 BC006099 mRNA Translation: AAH06099.1 BC009985 mRNA Translation: AAH09985.1
CCDSⁱ	CCDS1222.1 [O60512-1]
RefSeqⁱ	NP_001186802.1, NM_001199873.1 [O60512-1] NP_001186803.1, NM_001199874.1 [O60512-1] NP_003770.1, NM_003779.3 [O60512-1] XP_005245623.1, XM_005245566.1 [O60512-1]
UniGeneⁱ	Hs.321231 Hs.741821

3D structure databases

ProteinModelPortalⁱ	O60512
SMRⁱ	O60512
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114246, 35 interactors
IntActⁱ	O60512, 6 interactors
STRINGⁱ	9606.ENSP00000320965

Chemistry databases

DrugBankⁱ	DB00141 N-Acetyl-D-glucosamine
SwissLipidsⁱ	SLP:000000790

Protein family/group databases

CAZyⁱ	GT7 Glycosyltransferase Family 7

CAZyⁱ

GT7 Glycosyltransferase Family 7

PTM databases

GlyConnectⁱ	1032
iPTMnetⁱ	O60512
PhosphoSitePlusⁱ	O60512

Polymorphism and mutation databases

BioMutaⁱ	B4GALT3

BioMutaⁱ

B4GALT3

Proteomic databases

EPDⁱ	O60512
MaxQBⁱ	O60512
PaxDbⁱ	O60512
PeptideAtlasⁱ	O60512
PRIDEⁱ	O60512
ProteomicsDBⁱ	49451 49452 [O60512-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8703
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000319769; ENSP00000320965; ENSG00000158850 [O60512-1] ENST00000367998; ENSP00000356977; ENSG00000158850 [O60512-1] ENST00000622395; ENSP00000480428; ENSG00000158850 [O60512-1]
GeneIDⁱ	8703
KEGGⁱ	hsa:8703
UCSCⁱ	uc001fyq.3 human [O60512-1]

Organism-specific databases

CTDⁱ	8703
DisGeNETⁱ	8703
EuPathDBⁱ	HostDB:ENSG00000158850.14
GeneCardsⁱ	B4GALT3
H-InvDBⁱ	HIX0159958
HGNCⁱ	HGNC:926 B4GALT3
HPAⁱ	HPA010793
MIMⁱ	604014 gene
neXtProtⁱ	NX_O60512
OpenTargetsⁱ	ENSG00000158850
PharmGKBⁱ	PA25225
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3916 Eukaryota ENOG410ZYYA LUCA
GeneTreeⁱ	ENSGT00760000119140
HOGENOMⁱ	HOG000231027
HOVERGENⁱ	HBG058334
InParanoidⁱ	O60512
KOⁱ	K07968
OMAⁱ	VAIGHYK
OrthoDBⁱ	EOG091G0P66
PhylomeDBⁱ	O60512
TreeFamⁱ	TF312834

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
BioCycⁱ	MetaCyc:HS08336-MONOMER
Reactomeⁱ	R-HSA-2022854 Keratan sulfate biosynthesis R-HSA-975577 N-Glycan antennae elongation

Miscellaneous databases

GeneWikiⁱ	B4GALT3
GenomeRNAiⁱ	8703
Protein Ontology More...PROⁱ	PR:O60512
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158850 Expressed in 220 organ(s), highest expression level in oocyte
CleanExⁱ	HS_B4GALT3
Genevisibleⁱ	O60512 HS

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR003859 Galactosyl_T IPR027791 Galactosyl_T_C IPR027995 Galactosyl_T_N IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR19300 PTHR19300, 1 hit
Pfamⁱ	View protein in Pfam PF02709 Glyco_transf_7C, 1 hit PF13733 Glyco_transf_7N, 1 hit
PRINTSⁱ	PR02050 B14GALTRFASE
SUPFAMⁱ	SSF53448 SSF53448, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B4GT3_HUMAN
Accessionⁱ	O60512Primary (citable) accession number: O60512 Secondary accession number(s): D3DVG3 , O60910, Q9BPZ4, Q9H8T2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	June 21, 2005
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O60512 (B4GT3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Beta-1,4-galactosyltransferase 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Cytosol

Extracellular region or secreted

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Your basket is currently empty. ⁱ

Functionⁱ

Kineticsⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ