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Protein

Pre-mRNA-processing factor 17

Gene

CDC40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
SignaLinkiO60508

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 17
Alternative name(s):
Cell division cycle 40 homolog
EH-binding protein 3
Short name:
Ehb3
PRP17 homolog
Short name:
hPRP17
Gene namesi
Name:CDC40
Synonyms:EHB3, PRP17, PRPF17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000168438.14
HGNCiHGNC:17350 CDC40
MIMi605585 gene
neXtProtiNX_O60508

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi51362
OpenTargetsiENSG00000168438
PharmGKBiPA134891332

Polymorphism and mutation databases

BioMutaiCDC40

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511421 – 579Pre-mRNA-processing factor 17Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60508
MaxQBiO60508
PaxDbiO60508
PeptideAtlasiO60508
PRIDEiO60508
ProteomicsDBi49450

PTM databases

iPTMnetiO60508
PhosphoSitePlusiO60508

Miscellaneous databases

PMAP-CutDBiO60508

Expressioni

Gene expression databases

BgeeiENSG00000168438 Expressed in 236 organ(s), highest expression level in frontal cortex
CleanExiHS_CDC40
ExpressionAtlasiO60508 baseline and differential
GenevisibleiO60508 HS

Organism-specific databases

HPAiHPA046620

Interactioni

Subunit structurei

Identified in the spliceosome C complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRPF19Q9UMS42EBI-2557812,EBI-395746

Protein-protein interaction databases

BioGridi119497, 62 interactors
CORUMiO60508
IntActiO60508, 8 interactors
MINTiO60508
STRINGi9606.ENSP00000304370

Structurei

3D structure databases

ProteinModelPortaliO60508
SMRiO60508
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati286 – 326WD 1Add BLAST41
Repeati330 – 369WD 2Add BLAST40
Repeati371 – 413WD 3Add BLAST43
Repeati416 – 455WD 4Add BLAST40
Repeati459 – 498WD 5Add BLAST40
Repeati504 – 545WD 6Add BLAST42
Repeati548 – 578WD 7Add BLAST31

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0282 Eukaryota
ENOG410XP87 LUCA
GeneTreeiENSGT00530000063583
HOGENOMiHOG000214672
HOVERGENiHBG053695
InParanoidiO60508
KOiK12816
OMAiSGGYVCF
OrthoDBiEOG091G03TK
PhylomeDBiO60508
TreeFamiTF101064

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR032847 PRPF17
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR43979 PTHR43979, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAIAALAA SYGSGSGSES DSDSESSRCP LPAADSLMHL TKSPSSKPSL
60 70 80 90 100
AVAVDSAPEV AVKEDLETGV HLDPAVKEVQ YNPTYETMFA PEFGPENPFR
110 120 130 140 150
TQQMAAPRNM LSGYAEPAHI NDFMFEQQRR TFATYGYALD PSLDNHQVSA
160 170 180 190 200
KYIGSVEEAE KNQGLTVFET GQKKTEKRKK FKENDASNID GFLGPWAKYV
210 220 230 240 250
DEKDVAKPSE EEQKELDEIT AKRQKKGKQE EEKPGEEKTI LHVKEMYDYQ
260 270 280 290 300
GRSYLHIPQD VGVNLRSTMP PEKCYLPKKQ IHVWSGHTKG VSAVRLFPLS
310 320 330 340 350
GHLLLSCSMD CKIKLWEVYG ERRCLRTFIG HSKAVRDICF NTAGTQFLSA
360 370 380 390 400
AYDRYLKLWD TETGQCISRF TNRKVPYCVK FNPDEDKQNL FVAGMSDKKI
410 420 430 440 450
VQWDIRSGEI VQEYDRHLGA VNTIVFVDEN RRFVSTSDDK SLRVWEWDIP
460 470 480 490 500
VDFKYIAEPS MHSMPAVTLS PNGKWLACQS MDNQILIFGA QNRFRLNKKK
510 520 530 540 550
IFKGHMVAGY ACQVDFSPDM SYVISGDGNG KLNIWDWKTT KLYSRFKAHD
560 570
KVCIGAVWHP HETSKVITCG WDGLIKLWD
Length:579
Mass (Da):65,521
Last modified:August 1, 1998 - v1
Checksum:i1DE2BAA6F03FF16D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SRN1Q5SRN1_HUMAN
Pre-mRNA-processing factor 17
CDC40
539Annotation score:

Sequence cautioni

The sequence AAC25166 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → V in AAD01552 (PubMed:9303539).Curated1
Sequence conflicti31L → P in AAC25166 (PubMed:9769104).Curated1
Sequence conflicti210E → R in AAC25166 (PubMed:9769104).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038392 mRNA Translation: AAC39730.1
AL671518 Genomic DNA No translation available.
AK314601 mRNA Translation: BAG37172.1
BC117145 mRNA Translation: AAI17146.1
BC126114 mRNA Translation: AAI26115.1
AF061241 mRNA Translation: AAC25166.1 Different initiation.
AF015044 mRNA Translation: AAD01552.1
CCDSiCCDS5081.1
RefSeqiNP_056975.1, NM_015891.2
UniGeneiHs.428147

Genome annotation databases

EnsembliENST00000307731; ENSP00000304370; ENSG00000168438
ENST00000368932; ENSP00000357928; ENSG00000168438
GeneIDi51362
KEGGihsa:51362
UCSCiuc003pua.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038392 mRNA Translation: AAC39730.1
AL671518 Genomic DNA No translation available.
AK314601 mRNA Translation: BAG37172.1
BC117145 mRNA Translation: AAI17146.1
BC126114 mRNA Translation: AAI26115.1
AF061241 mRNA Translation: AAC25166.1 Different initiation.
AF015044 mRNA Translation: AAD01552.1
CCDSiCCDS5081.1
RefSeqiNP_056975.1, NM_015891.2
UniGeneiHs.428147

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MQFelectron microscopy5.90E1-579[»]
5XJCelectron microscopy3.60W1-579[»]
5YZGelectron microscopy4.10W1-579[»]
5Z56electron microscopy5.10W1-579[»]
5Z57electron microscopy6.50W1-579[»]
6FF4electron microscopy16.00E1-579[»]
ProteinModelPortaliO60508
SMRiO60508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119497, 62 interactors
CORUMiO60508
IntActiO60508, 8 interactors
MINTiO60508
STRINGi9606.ENSP00000304370

PTM databases

iPTMnetiO60508
PhosphoSitePlusiO60508

Polymorphism and mutation databases

BioMutaiCDC40

Proteomic databases

EPDiO60508
MaxQBiO60508
PaxDbiO60508
PeptideAtlasiO60508
PRIDEiO60508
ProteomicsDBi49450

Protocols and materials databases

DNASUi51362
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307731; ENSP00000304370; ENSG00000168438
ENST00000368932; ENSP00000357928; ENSG00000168438
GeneIDi51362
KEGGihsa:51362
UCSCiuc003pua.4 human

Organism-specific databases

CTDi51362
DisGeNETi51362
EuPathDBiHostDB:ENSG00000168438.14
GeneCardsiCDC40
HGNCiHGNC:17350 CDC40
HPAiHPA046620
MIMi605585 gene
neXtProtiNX_O60508
OpenTargetsiENSG00000168438
PharmGKBiPA134891332
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0282 Eukaryota
ENOG410XP87 LUCA
GeneTreeiENSGT00530000063583
HOGENOMiHOG000214672
HOVERGENiHBG053695
InParanoidiO60508
KOiK12816
OMAiSGGYVCF
OrthoDBiEOG091G03TK
PhylomeDBiO60508
TreeFamiTF101064

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
SignaLinkiO60508

Miscellaneous databases

GeneWikiiCDC40
GenomeRNAii51362
PMAP-CutDBiO60508
PROiPR:O60508
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168438 Expressed in 236 organ(s), highest expression level in frontal cortex
CleanExiHS_CDC40
ExpressionAtlasiO60508 baseline and differential
GenevisibleiO60508 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR032847 PRPF17
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR43979 PTHR43979, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRP17_HUMAN
AccessioniPrimary (citable) accession number: O60508
Secondary accession number(s): B2RBC5
, O75471, Q5SRN0, Q9UPG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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