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Protein

Heterogeneous nuclear ribonucleoprotein Q

Gene

SYNCRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA 5'-UTR binding Source: GO_Central
  • mRNA binding Source: GO_Central
  • poly(A) binding Source: Ensembl
  • RNA binding Source: UniProtKB

GO - Biological processi

  • cellular response to interferon-gamma Source: UniProtKB
  • CRD-mediated mRNA stabilization Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of translation Source: UniProtKB
  • osteoblast differentiation Source: UniProtKB
  • RNA processing Source: ProtInc
  • RNA splicing Source: ProtInc
  • viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processHost-virus interaction, mRNA processing, mRNA splicing, Translation regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60506

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein Q
Short name:
hnRNP Q
Alternative name(s):
Glycine- and tyrosine-rich RNA-binding protein
Short name:
GRY-RBP
NS1-associated protein 1
Synaptotagmin-binding, cytoplasmic RNA-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNCRIP
Synonyms:HNRPQ, NSAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000135316.17

Human Gene Nomenclature Database

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HGNCi
HGNC:16918 SYNCRIP

neXtProt; the human protein knowledge platform

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neXtProti
NX_O60506

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10492

Open Targets

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OpenTargetsi
ENSG00000135316

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134985065

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYNCRIP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818672 – 623Heterogeneous nuclear ribonucleoprotein QAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei159PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei221N6-acetyllysineCombined sources1
Modified residuei363N6-acetyllysineCombined sources1
Modified residuei373Phosphotyrosine1 Publication1
Modified residuei444Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei444Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei496Omega-N-methylarginine; by PRMT11 Publication1
Modified residuei510Asymmetric dimethylarginine; by PRMT11 Publication1
Modified residuei518Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei518Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei526Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei526Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei536Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei536Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei539Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei539Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei587PhosphoserineCombined sources1
Cross-linki607Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60506

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60506

MaxQB - The MaxQuant DataBase

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MaxQBi
O60506

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60506

PeptideAtlas

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PeptideAtlasi
O60506

PRoteomics IDEntifications database

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PRIDEi
O60506

ProteomicsDB human proteome resource

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ProteomicsDBi
49444
49445 [O60506-2]
49446 [O60506-3]
49447 [O60506-4]
49448 [O60506-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60506

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60506

SwissPalm database of S-palmitoylation events

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SwissPalmi
O60506

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135316 Expressed in 234 organ(s), highest expression level in tendon

CleanEx database of gene expression profiles

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CleanExi
HS_SYNCRIP

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60506 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60506 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010895
HPA041275

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 is a component of the APOB mRNA editosome complex and interacts with APOBEC1 and A1CF (APOBEC1 complementation factor). Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR, HNRPD and SYNCRIP. Isoform 3 interacts with HNRPR. Interacts with POLR2A hyperphosphorylated C-terminal domain. Isoform 1, isoform 2 and isoform 3 interact with SMN. Isoform 3 interacts through its C-terminal domain with SYT7, SYT8 and SYT9 (By similarity). The non-phosphorylated and phosphorylated forms are colocalized with PAIP1 in polysomes (By similarity). Interacts with HABP4 (PubMed:19523114). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Identified in the spliceosome C complex. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with GTPBP1. Component of the GAIT complex; in humans the complex assembly seems to be a two-step process in which EPRS first associates with SYNCRIP to form a pre-GAIT complex which is deficient in GAIT element binding.By similarity13 Publications
(Microbial infection) Interacts with minute virus of mice (MVM) NS1 protein.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115755, 399 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1076 mCRD-poly(A)-bridging complex
CPX-1080 CRD-mediated mRNA stability complex
CPX-1097 C-to-U editosome complex [O60506-1]

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O60506

Database of interacting proteins

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DIPi
DIP-35540N

Protein interaction database and analysis system

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IntActi
O60506, 165 interactors

Molecular INTeraction database

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MINTi
O60506

STRING: functional protein association networks

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STRINGi
9606.ENSP00000358635

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1623
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGUNMR-A334-423[»]
2MXTNMR-A24-107[»]
2NBBNMR-A24-140[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60506

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60506

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O60506

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini162 – 241RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini243 – 325RRM 2PROSITE-ProRule annotationAdd BLAST83
Domaini338 – 408RRM 3PROSITE-ProRule annotationAdd BLAST71
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati448 – 4501-13
Repeati451 – 4531-23
Repeati460 – 4642-15
Repeati469 – 4722-24
Repeati478 – 4801-33
Repeati485 – 4882-34
Repeati498 – 5001-43
Repeati526 – 5281-53
Repeati539 – 5411-63
Repeati554 – 5561-73
Repeati557 – 5591-83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni400 – 561Interaction with APOBEC1Add BLAST162
Regioni448 – 5598 X 3 AA repeats of R-G-GAdd BLAST112
Regioni460 – 4883 X 4 AA repeats of Y-Y-G-YAdd BLAST29
Regioni518 – 549Interaction with SMN1 PublicationAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi564 – 578Bipartite nuclear localization signalSequence analysisAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi431 – 434Poly-Tyr4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The domain containing eight Arg-Gly-Gly repeats (RGG/RXR-box) may be involved in RNA-binding and protein-protein interactions. It is methylated by PRMT1, and essential for nuclear localization.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0117 Eukaryota
ENOG410XTJ5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153511

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051917

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60506

KEGG Orthology (KO)

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KOi
K13160

Identification of Orthologs from Complete Genome Data

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OMAi
RAGYAQR

Database of Orthologous Groups

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OrthoDBi
1384330at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60506

TreeFam database of animal gene trees

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TreeFami
TF314932

Family and domain databases

Conserved Domains Database

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CDDi
cd12483 RRM1_hnRNPQ, 1 hit
cd12489 RRM2_hnRNPQ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR034544 hnRNPQ_RRM1
IPR034548 hnRNPQ_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928 SSF54928, 3 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01648 hnRNP-R-Q, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60506-1) [UniParc]FASTAAdd to basket
Also known as: hnRNP Q3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATEHVNGNG TEEPMDTTSA VIHSENFQTL LDAGLPQKVA EKLDEIYVAG
60 70 80 90 100
LVAHSDLDER AIEALKEFNE DGALAVLQQF KDSDLSHVQN KSAFLCGVMK
110 120 130 140 150
TYRQREKQGT KVADSSKGPD EAKIKALLER TGYTLDVTTG QRKYGGPPPD
160 170 180 190 200
SVYSGQQPSV GTEIFVGKIP RDLFEDELVP LFEKAGPIWD LRLMMDPLTG
210 220 230 240 250
LNRGYAFVTF CTKEAAQEAV KLYNNHEIRS GKHIGVCISV ANNRLFVGSI
260 270 280 290 300
PKSKTKEQIL EEFSKVTEGL TDVILYHQPD DKKKNRGFCF LEYEDHKTAA
310 320 330 340 350
QARRRLMSGK VKVWGNVGTV EWADPIEDPD PEVMAKVKVL FVRNLANTVT
360 370 380 390 400
EEILEKAFSQ FGKLERVKKL KDYAFIHFDE RDGAVKAMEE MNGKDLEGEN
410 420 430 440 450
IEIVFAKPPD QKRKERKAQR QAAKNQMYDD YYYYGPPHMP PPTRGRGRGG
460 470 480 490 500
RGGYGYPPDY YGYEDYYDYY GYDYHNYRGG YEDPYYGYED FQVGARGRGG
510 520 530 540 550
RGARGAAPSR GRGAAPPRGR AGYSQRGGPG SARGVRGARG GAQQQRGRGV
560 570 580 590 600
RGARGGRGGN VGGKRKADGY NQPDSKRRQT NNQNWGSQPI AQQPLQGGDH
610 620
SGNYGYKSEN QEFYQDTFGQ QWK
Length:623
Mass (Da):69,603
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0669FA604E8FBBDF
GO
Isoform 2 (identifier: O60506-2) [UniParc]FASTAAdd to basket
Also known as: hnRNP Q2

The sequence of this isoform differs from the canonical sequence as follows:
     302-336: Missing.

Note: May be due to a competing donor splice site.
Show »
Length:588
Mass (Da):65,682
Checksum:i907A3EFBF5502D3F
GO
Isoform 3 (identifier: O60506-3) [UniParc]FASTAAdd to basket
Also known as: hnRNP Q1

The sequence of this isoform differs from the canonical sequence as follows:
     550-623: VRGARGGRGG...YQDTFGQQWK → QGKGVEAGPDLLQ

Note: May be due to a competing donor splice site and to an exon inclusion.
Show »
Length:562
Mass (Da):62,656
Checksum:i32F5C37178197E45
GO
Isoform 4 (identifier: O60506-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-336: Missing.
     550-623: VRGARGGRGG...YQDTFGQQWK → QGKGVEAGPDLLQ

Note: May be due to a competing donor splice site and to an exon inclusion. No experimental confirmation available.
Show »
Length:527
Mass (Da):58,736
Checksum:iC17388F6F991A127
GO
Isoform 5 (identifier: O60506-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.
     153-163: YSGQQPSVGTE → MEDHLQIPFIQ
     550-623: VRGARGGRGG...YQDTFGQQWK → QGKGVEAGPDLLQ

Note: May be due to a competing donor splice site and to an exon inclusion.
Show »
Length:410
Mass (Da):46,328
Checksum:i4F1AD0FE9570F7BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z645B7Z645_HUMAN
Synaptotagmin binding, cytoplasmic ...
SYNCRIP hCG_401112
464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UXX1F6UXX1_HUMAN
Heterogeneous nuclear ribonucleopro...
SYNCRIP
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15575 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 413.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti265K → Q in AAD38198 (PubMed:9847309).Curated1
Sequence conflicti287G → S (Ref. 2) Curated1
Sequence conflicti287G → S (PubMed:11574476).Curated1
Sequence conflicti288F → S in AAH40844 (PubMed:15489334).Curated1
Isoform 3 (identifier: O60506-3)
Sequence conflicti550 – 551QG → V in AAK59705 (PubMed:14574404).2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0095811 – 152Missing in isoform 5. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_009582153 – 163YSGQQPSVGTE → MEDHLQIPFIQ in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_009583302 – 336Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_009584550 – 623VRGAR…GQQWK → QGKGVEAGPDLLQ in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST74

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF155568 mRNA Translation: AAD38198.1
AF037448 mRNA Translation: AAC12926.1
AY034481 mRNA Translation: AAK59703.1
AY034482 mRNA Translation: AAK59704.1
AY034483 mRNA Translation: AAK59705.1
AK222776 mRNA Translation: BAD96496.1
AL136082 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48625.1
CH471051 Genomic DNA Translation: EAW48626.1
CH471051 Genomic DNA Translation: EAW48629.1
CH471051 Genomic DNA Translation: EAW48630.1
BC015575 mRNA Translation: AAH15575.1 Sequence problems.
BC032643 mRNA Translation: AAH32643.1
BC040844 mRNA Translation: AAH40844.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5005.1 [O60506-1]
CCDS55041.1 [O60506-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001153145.1, NM_001159673.1
NP_001153146.1, NM_001159674.1 [O60506-4]
NP_001153147.1, NM_001159675.1 [O60506-2]
NP_001153148.1, NM_001159676.1
NP_001153149.1, NM_001159677.1 [O60506-3]
NP_001240700.1, NM_001253771.1 [O60506-5]
NP_006363.4, NM_006372.4 [O60506-1]
XP_005248694.1, XM_005248637.2 [O60506-1]
XP_016865667.1, XM_017010178.1 [O60506-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.571177

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355238; ENSP00000347380; ENSG00000135316 [O60506-3]
ENST00000369622; ENSP00000358635; ENSG00000135316 [O60506-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10492

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10492

UCSC genome browser

More...
UCSCi
uc003pkv.4 human [O60506-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155568 mRNA Translation: AAD38198.1
AF037448 mRNA Translation: AAC12926.1
AY034481 mRNA Translation: AAK59703.1
AY034482 mRNA Translation: AAK59704.1
AY034483 mRNA Translation: AAK59705.1
AK222776 mRNA Translation: BAD96496.1
AL136082 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48625.1
CH471051 Genomic DNA Translation: EAW48626.1
CH471051 Genomic DNA Translation: EAW48629.1
CH471051 Genomic DNA Translation: EAW48630.1
BC015575 mRNA Translation: AAH15575.1 Sequence problems.
BC032643 mRNA Translation: AAH32643.1
BC040844 mRNA Translation: AAH40844.1
CCDSiCCDS5005.1 [O60506-1]
CCDS55041.1 [O60506-3]
RefSeqiNP_001153145.1, NM_001159673.1
NP_001153146.1, NM_001159674.1 [O60506-4]
NP_001153147.1, NM_001159675.1 [O60506-2]
NP_001153148.1, NM_001159676.1
NP_001153149.1, NM_001159677.1 [O60506-3]
NP_001240700.1, NM_001253771.1 [O60506-5]
NP_006363.4, NM_006372.4 [O60506-1]
XP_005248694.1, XM_005248637.2 [O60506-1]
XP_016865667.1, XM_017010178.1 [O60506-3]
UniGeneiHs.571177

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGUNMR-A334-423[»]
2MXTNMR-A24-107[»]
2NBBNMR-A24-140[»]
ProteinModelPortaliO60506
SMRiO60506
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115755, 399 interactors
ComplexPortaliCPX-1076 mCRD-poly(A)-bridging complex
CPX-1080 CRD-mediated mRNA stability complex
CPX-1097 C-to-U editosome complex [O60506-1]
CORUMiO60506
DIPiDIP-35540N
IntActiO60506, 165 interactors
MINTiO60506
STRINGi9606.ENSP00000358635

PTM databases

iPTMnetiO60506
PhosphoSitePlusiO60506
SwissPalmiO60506

Polymorphism and mutation databases

BioMutaiSYNCRIP

Proteomic databases

EPDiO60506
jPOSTiO60506
MaxQBiO60506
PaxDbiO60506
PeptideAtlasiO60506
PRIDEiO60506
ProteomicsDBi49444
49445 [O60506-2]
49446 [O60506-3]
49447 [O60506-4]
49448 [O60506-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10492
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355238; ENSP00000347380; ENSG00000135316 [O60506-3]
ENST00000369622; ENSP00000358635; ENSG00000135316 [O60506-1]
GeneIDi10492
KEGGihsa:10492
UCSCiuc003pkv.4 human [O60506-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10492
DisGeNETi10492
EuPathDBiHostDB:ENSG00000135316.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SYNCRIP
HGNCiHGNC:16918 SYNCRIP
HPAiCAB010895
HPA041275
neXtProtiNX_O60506
OpenTargetsiENSG00000135316
PharmGKBiPA134985065

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0117 Eukaryota
ENOG410XTJ5 LUCA
GeneTreeiENSGT00940000153511
HOVERGENiHBG051917
InParanoidiO60506
KOiK13160
OMAiRAGYAQR
OrthoDBi1384330at2759
PhylomeDBiO60506
TreeFamiTF314932

Enzyme and pathway databases

SIGNORiO60506

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SYNCRIP human
EvolutionaryTraceiO60506

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SYNCRIP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10492

Protein Ontology

More...
PROi
PR:O60506

Gene expression databases

BgeeiENSG00000135316 Expressed in 234 organ(s), highest expression level in tendon
CleanExiHS_SYNCRIP
ExpressionAtlasiO60506 baseline and differential
GenevisibleiO60506 HS

Family and domain databases

CDDicd12483 RRM1_hnRNPQ, 1 hit
cd12489 RRM2_hnRNPQ, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR034544 hnRNPQ_RRM1
IPR034548 hnRNPQ_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRPQ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60506
Secondary accession number(s): E1P501
, E1P502, Q53H05, Q5TCG2, Q5TCG3, Q8IW78, Q8N599, Q96LC1, Q96LC2, Q9Y583
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 7, 2006
Last modified: January 16, 2019
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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