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Entry version 169 (13 Feb 2019)
Sequence version 4 (13 Dec 2002)
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Protein

Adenylate cyclase type 9

Gene

ADCY9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation (PubMed:9628827). Activity is down-regulated by calcium/calcineurin (PubMed:10987815).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi399Magnesium 1; catalyticPROSITE-ProRule annotation1
Metal bindingi399Magnesium 2; catalyticPROSITE-ProRule annotation1
Metal bindingi400Magnesium 2; via carbonyl oxygen; catalyticPROSITE-ProRule annotation1
Metal bindingi443Magnesium 1; catalyticPROSITE-ProRule annotation1
Metal bindingi443Magnesium 2; catalyticPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei487ATPBy similarity1
Binding sitei1108ATPBy similarity1
Binding sitei1232ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi399 – 404ATPBy similarity6
Nucleotide bindingi441 – 443ATPBy similarity3
Nucleotide bindingi1185 – 1187ATPBy similarity3
Nucleotide bindingi1192 – 1196ATPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adenylate cyclase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-163615 PKA activation
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-170660 Adenylate cyclase activating pathway
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5610787 Hedgehog 'off' state

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60503

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylate cyclase type 91 Publication (EC:4.6.1.14 Publications)
Alternative name(s):
ATP pyrophosphate-lyase 9
Adenylate cyclase type IX1 Publication
Short name:
ACIX1 Publication
Adenylyl cyclase 9
Short name:
AC91 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADCY9
Synonyms:KIAA0520
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162104.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:240 ADCY9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603302 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60503

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 117CytoplasmicSequence analysisAdd BLAST117
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 141ExtracellularSequence analysis3
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 171CytoplasmicSequence analysis9
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 215ExtracellularSequence analysisAdd BLAST23
Transmembranei216 – 235HelicalSequence analysisAdd BLAST20
Topological domaini236 – 241CytoplasmicSequence analysis6
Transmembranei242 – 259HelicalSequence analysisAdd BLAST18
Topological domaini260 – 280ExtracellularSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 786CytoplasmicSequence analysisAdd BLAST485
Transmembranei787 – 807HelicalSequence analysisAdd BLAST21
Topological domaini808 – 818ExtracellularSequence analysisAdd BLAST11
Transmembranei819 – 839HelicalSequence analysisAdd BLAST21
Topological domaini840 – 867CytoplasmicSequence analysisAdd BLAST28
Transmembranei868 – 888HelicalSequence analysisAdd BLAST21
Topological domaini889 – 891ExtracellularSequence analysis3
Transmembranei892 – 912HelicalSequence analysisAdd BLAST21
Topological domaini913 – 920CytoplasmicSequence analysis8
Transmembranei921 – 941HelicalSequence analysisAdd BLAST21
Topological domaini942 – 975ExtracellularSequence analysisAdd BLAST34
Transmembranei976 – 996HelicalSequence analysisAdd BLAST21
Topological domaini997 – 1353CytoplasmicSequence analysisAdd BLAST357

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
115

Open Targets

More...
OpenTargetsi
ENSG00000162104

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2655

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADCY9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001957081 – 1353Adenylate cyclase type 9Add BLAST1353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei610PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Modified residuei691PhosphoserineBy similarity1
Modified residuei706PhosphoserineCombined sources1
Glycosylationi955N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi964N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1295PhosphoserineBy similarity1
Modified residuei1307PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60503

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60503

MaxQB - The MaxQuant DataBase

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MaxQBi
O60503

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60503

PeptideAtlas

More...
PeptideAtlasi
O60503

PRoteomics IDEntifications database

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PRIDEi
O60503

ProteomicsDB human proteome resource

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ProteomicsDBi
49441

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60503

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60503

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162104 Expressed in 237 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60503 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60503 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041328
HPA044225

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106628, 43 interactors

Protein interaction database and analysis system

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IntActi
O60503, 5 interactors

Molecular INTeraction database

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MINTi
O60503

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294016

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60503

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60503

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini394 – 521Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST128
Domaini1058 – 1198Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST141

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3618 Eukaryota
COG2114 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155577

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050459

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60503

KEGG Orthology (KO)

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KOi
K08049

Identification of Orthologs from Complete Genome Data

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OMAi
FETNIHF

Database of Orthologous Groups

More...
OrthoDBi
430975at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60503

TreeFam database of animal gene trees

More...
TreeFami
TF313845

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.1230, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211 Guanylate_cyc, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044 CYCc, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55073 SSF55073, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O60503-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN SHPKHCKYSI
60 70 80 90 100
SSSCSSSGDS GGVPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSVNL
110 120 130 140 150
EEACLERCFP QTQRRFRYAL FYIGFACLLW SIYFAVHMRS RLIVMVAPAL
160 170 180 190 200
CFLLVCVGFF LFTFTKLYAR HYAWTSLALT LLVFALTLAA QFQVLTPVSG
210 220 230 240 250
RGDSSNLTAT ARPTDTCLSQ VGSFSMCIEV LFLLYTVMHL PLYLSLCLGV
260 270 280 290 300
AYSVLFETFG YHFRDEACFP SPGAGALHWE LLSRGLLHGC IHAIGVHLFV
310 320 330 340 350
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG
360 370 380 390 400
DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI
410 420 430 440 450
VGFTKMSANK SAHALVGLLN DLFGRFDRLC EETKCEKIST LGDCYYCVAG
460 470 480 490 500
CPEPRADHAY CCIEMGLGMI KAIEQFCQEK KEMVNMRVGV HTGTVLCGIL
510 520 530 540 550
GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGKV
560 570 580 590 600
IERLGQSVVA DQLKGLKTYL ISGQRAKESR CSCAEALLSG FEVIDGSQVS
610 620 630 640 650
SGPRGQGTAS SGNVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGAP
660 670 680 690 700
QNGCQDEHKN STKASGGPNP KTQNGLLSPP QEEKLTNSQT SLCEILQEKG
710 720 730 740 750
RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF
760 770 780 790 800
SLNFLDQELE RSYRTSYQEE VIKNSPVKTF ASPTFSSLLD VFLSTTVFLT
810 820 830 840 850
LSTTCFLKYE AATVPPPPAA LAVFSAALLL EVLSLAVSIR MVFFLEDVMA
860 870 880 890 900
CTKRLLEWIA GWLPRHCIGA ILVSLPALAV YSHVTSEYET NIHFPVFTGS
910 920 930 940 950
AALIAVVHYC NFCQLSSWMR SSLATVVGAG PLLLLYVSLC PDSSVLTSPL
960 970 980 990 1000
DAVQNFSSER NPCNSSVPRD LRRPASLIGQ EVVLVFFLLL LLVWFLNREF
1010 1020 1030 1040 1050
EVSYRLHYHG DVEADLHRTK IQSMRDQADW LLRNIIPYHV AEQLKVSQTY
1060 1070 1080 1090 1100
SKNHDSGGVI FASIVNFSEF YEENYEGGKE CYRVLNELIG DFDELLSKPD
1110 1120 1130 1140 1150
YSSIEKIKTI GATYMAASGL NTAQAQDGSH PQEHLQILFE FAKEMMRVVD
1160 1170 1180 1190 1200
DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT
1210 1220 1230 1240 1250
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDHRV
1260 1270 1280 1290 1300
IPQHQLSISP DIRVQVDGSI GRSPTDEIAN LVPSVQYVDK TSLGSDSSTQ
1310 1320 1330 1340 1350
AKDAHLSPKR PWKEPVKAEE RGRFGKAIEK DDCDETGIEE ANELTKLNVS

KSV
Length:1,353
Mass (Da):150,701
Last modified:December 13, 2002 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CBF051EA49B5B7B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3NI20I3NI20_HUMAN
Adenylate cyclase type 9
ADCY9
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L342I3L342_HUMAN
Adenylate cyclase type 9
ADCY9
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L300I3L300_HUMAN
Adenylate cyclase type 9
ADCY9
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC24201 differs from that shown. Reason: Frameshift at position 1252.Curated
The sequence BAA25446 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti493G → R in CAB65084 (PubMed:10987815).Curated1
Sequence conflicti884V → A in CAB65084 (PubMed:10987815).Curated1
Sequence conflicti1308P → R in CAB65084 (PubMed:10987815).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023750772I → M Common polymorphism; found in 37.5% of the Asian population, in 30% of the Caucasian population and in 16.3% of the African-American population; reduced adenylyl cyclase activity in response to stimulation of the beta-adregnergic receptor by Mn(2+) agonists isoproteronol and NaF; increased albuterol-stimulated adenylyl cyclase activity in the presence of corticosteroid. 2 PublicationsCorresponds to variant dbSNP:rs2230739Ensembl.1
Natural variantiVAR_0708871154N → S3 PublicationsCorresponds to variant dbSNP:rs61731445Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF036927 mRNA Translation: AAC24201.1 Frameshift.
DQ008441 mRNA Translation: AAY27880.1
DQ005545 mRNA Translation: AAY21237.1
AJ133123 mRNA Translation: CAB65084.1
AY028959
, AY028949, AY028950, AY028951, AY028952, AY028953, AY028954, AY028955, AY028956, AY028957 Genomic DNA Translation: AAK29464.1
AB011092 mRNA Translation: BAA25446.3 Different initiation.
CH471112 Genomic DNA Translation: EAW85331.1
CH471112 Genomic DNA Translation: EAW85332.1
BC136657 mRNA Translation: AAI36658.1
BC136658 mRNA Translation: AAI36659.1
BC151207 mRNA Translation: AAI51208.1
BC151229 mRNA Translation: AAI51230.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32382.1

NCBI Reference Sequences

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RefSeqi
NP_001107.2, NM_001116.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.391860
Hs.610484

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000294016; ENSP00000294016; ENSG00000162104

Database of genes from NCBI RefSeq genomes

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GeneIDi
115

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:115

UCSC genome browser

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UCSCi
uc002cvx.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036927 mRNA Translation: AAC24201.1 Frameshift.
DQ008441 mRNA Translation: AAY27880.1
DQ005545 mRNA Translation: AAY21237.1
AJ133123 mRNA Translation: CAB65084.1
AY028959
, AY028949, AY028950, AY028951, AY028952, AY028953, AY028954, AY028955, AY028956, AY028957 Genomic DNA Translation: AAK29464.1
AB011092 mRNA Translation: BAA25446.3 Different initiation.
CH471112 Genomic DNA Translation: EAW85331.1
CH471112 Genomic DNA Translation: EAW85332.1
BC136657 mRNA Translation: AAI36658.1
BC136658 mRNA Translation: AAI36659.1
BC151207 mRNA Translation: AAI51208.1
BC151229 mRNA Translation: AAI51230.1
CCDSiCCDS32382.1
RefSeqiNP_001107.2, NM_001116.3
UniGeneiHs.391860
Hs.610484

3D structure databases

ProteinModelPortaliO60503
SMRiO60503
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106628, 43 interactors
IntActiO60503, 5 interactors
MINTiO60503
STRINGi9606.ENSP00000294016

Chemistry databases

ChEMBLiCHEMBL2655

PTM databases

iPTMnetiO60503
PhosphoSitePlusiO60503

Polymorphism and mutation databases

BioMutaiADCY9

Proteomic databases

EPDiO60503
jPOSTiO60503
MaxQBiO60503
PaxDbiO60503
PeptideAtlasiO60503
PRIDEiO60503
ProteomicsDBi49441

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294016; ENSP00000294016; ENSG00000162104
GeneIDi115
KEGGihsa:115
UCSCiuc002cvx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
115
DisGeNETi115
EuPathDBiHostDB:ENSG00000162104.9

GeneCards: human genes, protein and diseases

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GeneCardsi
ADCY9
HGNCiHGNC:240 ADCY9
HPAiHPA041328
HPA044225
MIMi603302 gene
neXtProtiNX_O60503
OpenTargetsiENSG00000162104
PharmGKBiPA30

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3618 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00940000155577
HOVERGENiHBG050459
InParanoidiO60503
KOiK08049
OMAiFETNIHF
OrthoDBi430975at2759
PhylomeDBiO60503
TreeFamiTF313845

Enzyme and pathway databases

ReactomeiR-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-163615 PKA activation
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-170660 Adenylate cyclase activating pathway
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5610787 Hedgehog 'off' state
SIGNORiO60503

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADCY9 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ADCY9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
115

Protein Ontology

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PROi
PR:O60503

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162104 Expressed in 237 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiO60503 baseline and differential
GenevisibleiO60503 HS

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADCY9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60503
Secondary accession number(s): A7E2V5
, A7E2X2, D3DUD1, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 13, 2002
Last modified: February 13, 2019
This is version 169 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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