UniProtKB - O60502 (OGA_HUMAN)
Protein
Protein O-GlcNAcase
Gene
OGA
Organism
Homo sapiens (Human)
Status
Functioni
Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).5 Publications
Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.1 Publication
Caution
The mouse and rat orthologs were initially identified as bi-functional proteins containing an N-terminal domain with O-GlcNAcase activity and a C-terminal domain with histone acetyltransferase activity. The histone acetyltransferase activity was detected only when the protein was expressed in mammalian cells, but not when expressed in bacterial cells, suggesting that the histone acetyltransferase activity might be due to the presence of a contaminant. Comparison of the human protein with a bacterial putative acetyltransferase (AC Q2CEE2) shows that the residues important for acetyl-CoA binding are not conserved, and that the residues proposed to be important for histone acetyltransferase activity are not in a position where they could participate in catalysis. Characterization of the human protein shows that it does not bind acetyl-CoA and therefore cannot have acetyltransferase activity.1 Publication1 Publication
Catalytic activityi
- 3-O-(N-acetyl-β-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine1 Publication5 PublicationsEC:3.2.1.1691 Publication5 Publications
- 3-O-(N-acetyl-β-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine1 Publication5 PublicationsEC:3.2.1.1691 Publication5 Publications
Activity regulationi
Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.1 Publication
Kineticsi
- KM=1.1 mM for pNP-GlcNAc1 Publication
- Vmax=652 µmol/min/mg enzyme with pNP-GLcNAc as substrate1 Publication
pH dependencei
Optimum pH is 5.7-7.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 67 | Substrate; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 98 | SubstrateBy similarity | 1 | |
Binding sitei | 174 | SubstrateBy similarity | 1 | |
Active sitei | 175 | Proton donor1 Publication | 1 | |
Binding sitei | 219 | SubstrateBy similarity | 1 | |
Binding sitei | 285 | SubstrateBy similarity | 1 | |
Binding sitei | 313 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity Source: UniProtKB-EC
- [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity Source: UniProtKB-EC
- [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity Source: UniProtKB-EC
- beta-N-acetylglucosaminidase activity Source: UniProtKB
- hyalurononglucosaminidase activity Source: ProtInc
GO - Biological processi
- glycoprotein catabolic process Source: ProtInc
- glycoprotein metabolic process Source: GO_Central
- N-acetylglucosamine metabolic process Source: UniProtKB
- protein deglycosylation Source: UniProtKB
- protein O-linked glycosylation Source: ParkinsonsUK-UCL
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Host-virus interaction |
Enzyme and pathway databases
BioCyci | MetaCyc:HS03036-MONOMER |
BRENDAi | 3.2.1.35, 2681 |
PathwayCommonsi | O60502 |
Protein family/group databases
CAZyi | GH84, Glycoside Hydrolase Family 84 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein O-GlcNAcase2 PublicationsCurated (EC:3.2.1.1691 Publication5 Publications)Short name: OGA1 Publication Alternative name(s): Beta-N-acetylglucosaminidase1 Publication Beta-N-acetylhexosaminidase Beta-hexosaminidase Meningioma-expressed antigen 51 Publication N-acetyl-beta-D-glucosaminidase N-acetyl-beta-glucosaminidase Nuclear cytoplasmic O-GlcNAcase and acetyltransferase Short name: NCOAT |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7056, OGA |
MIMi | 604039, gene |
neXtProti | NX_O60502 |
VEuPathDBi | HostDB:ENSG00000198408.13 |
Subcellular locationi
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 69 | Y → K or Q: Strongly reduces affinity for glycopeptide substrates. Nearly abolishes enzyme activity. 2 Publications | 1 | |
Mutagenesisi | 69 | Y → S: Strongly reduces affinity for glycopeptide substrates. Nearly abolishes enzyme activity. 2 Publications | 1 | |
Mutagenesisi | 174 | D → A: Nearly abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 175 | D → A: Nearly abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 175 | D → N: Nearly abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 255 | V → G or T: Nearly abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 286 | Y → S: Nearly abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 287 | D → A: Nearly abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 413 | D → A: Abrogates cleavage by caspase-3. 1 Publication | 1 | |
Mutagenesisi | 679 | W → N: Nearly abolishes enzyme activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 10724 |
OpenTargetsi | ENSG00000198408 |
PharmGKBi | PA30787 |
Miscellaneous databases
Pharosi | O60502, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5921 |
DrugBanki | DB00428, Streptozocin |
GuidetoPHARMACOLOGYi | 3101 |
Genetic variation databases
BioMutai | MGEA5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252118 | 1 – 916 | Protein O-GlcNAcaseAdd BLAST | 916 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 364 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 413 – 414 | Cleavage; by caspase-31 Publication | 2 |
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-1223 |
EPDi | O60502 |
jPOSTi | O60502 |
MassIVEi | O60502 |
MaxQBi | O60502 |
PaxDbi | O60502 |
PeptideAtlasi | O60502 |
PRIDEi | O60502 |
ProteomicsDBi | 20314 49438 [O60502-1] 49439 [O60502-2] 49440 [O60502-3] |
PTM databases
GlyGeni | O60502, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O60502 |
MetOSitei | O60502 |
PhosphoSitePlusi | O60502 |
SwissPalmi | O60502 |
Expressioni
Tissue specificityi
Ubiquitous. Shows highest expression in the brain, placenta and pancreas.2 Publications
Gene expression databases
Bgeei | ENSG00000198408, Expressed in forebrain and 244 other tissues |
ExpressionAtlasi | O60502, baseline and differential |
Genevisiblei | O60502, HS |
Organism-specific databases
HPAi | ENSG00000198408, Low tissue specificity |
Interactioni
Subunit structurei
(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction increases Tax interacting partner CREB1 O-GlcNAcylation.
1 PublicationProtein-protein interaction databases
BioGRIDi | 115948, 44 interactors |
IntActi | O60502, 34 interactors |
MINTi | O60502 |
STRINGi | 9606.ENSP00000354850 |
Chemistry databases
BindingDBi | O60502 |
Miscellaneous databases
RNActi | O60502, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O60502 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 278 – 280 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 84 family.Curated
Phylogenomic databases
eggNOGi | KOG3698, Eukaryota |
GeneTreei | ENSGT00390000007726 |
HOGENOMi | CLU_009837_1_0_1 |
InParanoidi | O60502 |
OMAi | QFGCEAY |
OrthoDBi | 159999at2759 |
PhylomeDBi | O60502 |
TreeFami | TF313732 |
Family and domain databases
DisProti | DP02479 |
IDEALi | IID00643 |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR011496, Beta-N-acetylglucosaminidase IPR017853, Glycoside_hydrolase_SF |
Pfami | View protein in Pfam PF07555, NAGidase, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF55729, SSF55729, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O60502-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVQKESQATL EERESELSSN PAASAGASLE PPAAPAPGED NPAGAGGAAV
60 70 80 90 100
AGAAGGARRF LCGVVEGFYG RPWVMEQRKE LFRRLQKWEL NTYLYAPKDD
110 120 130 140 150
YKHRMFWREM YSVEEAEQLM TLISAAREYE IEFIYAISPG LDITFSNPKE
160 170 180 190 200
VSTLKRKLDQ VSQFGCRSFA LLFDDIDHNM CAADKEVFSS FAHAQVSITN
210 220 230 240 250
EIYQYLGEPE TFLFCPTEYC GTFCYPNVSQ SPYLRTVGEK LLPGIEVLWT
260 270 280 290 300
GPKVVSKEIP VESIEEVSKI IKRAPVIWDN IHANDYDQKR LFLGPYKGRS
310 320 330 340 350
TELIPRLKGV LTNPNCEFEA NYVAIHTLAT WYKSNMNGVR KDVVMTDSED
360 370 380 390 400
STVSIQIKLE NEGSDEDIET DVLYSPQMAL KLALTEWLQE FGVPHQYSSR
410 420 430 440 450
QVAHSGAKAS VVDGTPLVAA PSLNATTVVT TVYQEPIMSQ GAALSGEPTT
460 470 480 490 500
LTKEEEKKQP DEEPMDMVVE KQEETDHKND NQILSEIVEA KMAEELKPMD
510 520 530 540 550
TDKESIAESK SPEMSMQEDC ISDIAPMQTD EQTNKEQFVP GPNEKPLYTA
560 570 580 590 600
EPVTLEDLQL LADLFYLPYE HGPKGAQMLR EFQWLRANSS VVSVNCKGKD
610 620 630 640 650
SEKIEEWRSR AAKFEEMCGL VMGMFTRLSN CANRTILYDM YSYVWDIKSI
660 670 680 690 700
MSMVKSFVQW LGCRSHSSAQ FLIGDQEPWA FRGGLAGEFQ RLLPIDGAND
710 720 730 740 750
LFFQPPPLTP TSKVYTIRPY FPKDEASVYK ICREMYDDGV GLPFQSQPDL
760 770 780 790 800
IGDKLVGGLL SLSLDYCFVL EDEDGICGYA LGTVDVTPFI KKCKISWIPF
810 820 830 840 850
MQEKYTKPNG DKELSEAEKI MLSFHEEQEV LPETFLANFP SLIKMDIHKK
860 870 880 890 900
VTDPSVAKSM MACLLSSLKA NGSRGAFCEV RPDDKRILEF YSKLGCFEIA
910
KMEGFPKDVV ILGRSL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C3X0 | H7C3X0_HUMAN | Protein O-GlcNAcase | OGA | 256 | Annotation score: |
Sequence cautioni
The sequence AAH47877 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA31654 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027761 | 46 | G → E. Corresponds to variant dbSNP:rs3740421Ensembl. | 1 | |
Natural variantiVAR_027762 | 602 | E → K1 PublicationCorresponds to variant dbSNP:rs17853930Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020866 | 346 – 398 | Missing in isoform 2 and isoform 4. CuratedAdd BLAST | 53 | |
Alternative sequenceiVSP_020867 | 663 – 677 | CRSHS…IGDQE → RCTRNNLFSSNILSL in isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_020868 | 678 – 916 | Missing in isoform 3. 1 PublicationAdd BLAST | 239 | |
Alternative sequenceiVSP_020869 | 691 – 704 | Missing in isoform 2. CuratedAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036144 mRNA Translation: AAD05385.2 AF307332 mRNA Translation: AAG21428.1 AB014579 mRNA Translation: BAA31654.2 Different initiation. AC010789 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49744.1 CH471066 Genomic DNA Translation: EAW49741.1 CH471066 Genomic DNA Translation: EAW49742.1 BC001343 mRNA Translation: AAH01343.1 BC039583 mRNA Translation: AAH39583.2 BC047877 mRNA Translation: AAH47877.1 Sequence problems. |
CCDSi | CCDS44471.1 [O60502-4] CCDS7520.1 [O60502-1] |
PIRi | T00360 |
RefSeqi | NP_001135906.1, NM_001142434.1 [O60502-4] NP_036347.1, NM_012215.3 [O60502-1] |
Genome annotation databases
Ensembli | ENST00000357797; ENSP00000350445; ENSG00000198408 [O60502-2] ENST00000361464; ENSP00000354850; ENSG00000198408 [O60502-1] ENST00000370094; ENSP00000359112; ENSG00000198408 [O60502-3] ENST00000439817; ENSP00000409973; ENSG00000198408 [O60502-4] |
GeneIDi | 10724 |
KEGGi | hsa:10724 |
UCSCi | uc001ktv.3, human [O60502-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036144 mRNA Translation: AAD05385.2 AF307332 mRNA Translation: AAG21428.1 AB014579 mRNA Translation: BAA31654.2 Different initiation. AC010789 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49744.1 CH471066 Genomic DNA Translation: EAW49741.1 CH471066 Genomic DNA Translation: EAW49742.1 BC001343 mRNA Translation: AAH01343.1 BC039583 mRNA Translation: AAH39583.2 BC047877 mRNA Translation: AAH47877.1 Sequence problems. |
CCDSi | CCDS44471.1 [O60502-4] CCDS7520.1 [O60502-1] |
PIRi | T00360 |
RefSeqi | NP_001135906.1, NM_001142434.1 [O60502-4] NP_036347.1, NM_012215.3 [O60502-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YDQ | X-ray | 2.60 | T | 402-408 | [»] | |
5M7R | X-ray | 2.35 | A/B | 1-916 | [»] | |
5M7S | X-ray | 2.40 | A/B | 1-916 | [»] | |
5M7T | X-ray | 2.60 | A/B | 1-916 | [»] | |
5M7U | X-ray | 2.30 | A/B | 1-916 | [»] | |
5TKE | X-ray | 2.48 | A/B | 60-400 | [»] | |
A/B | 553-704 | [»] | ||||
5UHK | X-ray | 2.97 | A/C | 56-400 | [»] | |
B/D | 544-705 | [»] | ||||
5UHL | X-ray | 3.14 | A/C | 56-400 | [»] | |
B/D | 544-705 | [»] | ||||
5UHO | X-ray | 3.21 | A/C | 56-400 | [»] | |
B/D | 544-705 | [»] | ||||
5UHP | X-ray | 2.79 | A/B/C/D | 14-400 | [»] | |
E/F/G/H | 554-705 | [»] | ||||
5UN8 | X-ray | 2.13 | A/B/C/D | 60-400 | [»] | |
A/B/C/D | 553-704 | [»] | ||||
5UN9 | X-ray | 2.50 | A/B | 60-400 | [»] | |
A/B | 553-704 | [»] | ||||
5VVO | X-ray | 2.60 | A/B | 60-400 | [»] | |
A/B | 553-704 | [»] | ||||
5VVT | X-ray | 2.80 | A/C | 60-400 | [»] | |
A/C | 553-704 | [»] | ||||
5VVU | X-ray | 2.70 | A/C | 60-400 | [»] | |
A/C | 553-704 | [»] | ||||
5VVV | X-ray | 2.80 | A/C | 60-400 | [»] | |
A/C | 553-704 | [»] | ||||
5VVX | X-ray | 2.90 | A/C | 60-400 | [»] | |
A/C | 553-704 | [»] | ||||
6HKI | X-ray | 3.30 | A/B | 1-916 | [»] | |
6PM9 | X-ray | 2.86 | A/B/C/D | 14-400 | [»] | |
E/F/G/H | 553-705 | [»] | ||||
SMRi | O60502 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115948, 44 interactors |
IntActi | O60502, 34 interactors |
MINTi | O60502 |
STRINGi | 9606.ENSP00000354850 |
Chemistry databases
BindingDBi | O60502 |
ChEMBLi | CHEMBL5921 |
DrugBanki | DB00428, Streptozocin |
GuidetoPHARMACOLOGYi | 3101 |
Protein family/group databases
CAZyi | GH84, Glycoside Hydrolase Family 84 |
PTM databases
GlyGeni | O60502, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O60502 |
MetOSitei | O60502 |
PhosphoSitePlusi | O60502 |
SwissPalmi | O60502 |
Genetic variation databases
BioMutai | MGEA5 |
Proteomic databases
CPTACi | CPTAC-1223 |
EPDi | O60502 |
jPOSTi | O60502 |
MassIVEi | O60502 |
MaxQBi | O60502 |
PaxDbi | O60502 |
PeptideAtlasi | O60502 |
PRIDEi | O60502 |
ProteomicsDBi | 20314 49438 [O60502-1] 49439 [O60502-2] 49440 [O60502-3] |
Protocols and materials databases
Antibodypediai | 31340, 166 antibodies |
DNASUi | 10724 |
Genome annotation databases
Ensembli | ENST00000357797; ENSP00000350445; ENSG00000198408 [O60502-2] ENST00000361464; ENSP00000354850; ENSG00000198408 [O60502-1] ENST00000370094; ENSP00000359112; ENSG00000198408 [O60502-3] ENST00000439817; ENSP00000409973; ENSG00000198408 [O60502-4] |
GeneIDi | 10724 |
KEGGi | hsa:10724 |
UCSCi | uc001ktv.3, human [O60502-1] |
Organism-specific databases
CTDi | 10724 |
DisGeNETi | 10724 |
GeneCardsi | OGA |
HGNCi | HGNC:7056, OGA |
HPAi | ENSG00000198408, Low tissue specificity |
MIMi | 604039, gene |
neXtProti | NX_O60502 |
OpenTargetsi | ENSG00000198408 |
PharmGKBi | PA30787 |
VEuPathDBi | HostDB:ENSG00000198408.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3698, Eukaryota |
GeneTreei | ENSGT00390000007726 |
HOGENOMi | CLU_009837_1_0_1 |
InParanoidi | O60502 |
OMAi | QFGCEAY |
OrthoDBi | 159999at2759 |
PhylomeDBi | O60502 |
TreeFami | TF313732 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS03036-MONOMER |
BRENDAi | 3.2.1.35, 2681 |
PathwayCommonsi | O60502 |
Miscellaneous databases
BioGRID-ORCSi | 10724, 97 hits in 881 CRISPR screens |
ChiTaRSi | MGEA5, human |
GeneWikii | MGEA5 |
GenomeRNAii | 10724 |
Pharosi | O60502, Tchem |
PROi | PR:O60502 |
RNActi | O60502, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198408, Expressed in forebrain and 244 other tissues |
ExpressionAtlasi | O60502, baseline and differential |
Genevisiblei | O60502, HS |
Family and domain databases
DisProti | DP02479 |
IDEALi | IID00643 |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR011496, Beta-N-acetylglucosaminidase IPR017853, Glycoside_hydrolase_SF |
Pfami | View protein in Pfam PF07555, NAGidase, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF55729, SSF55729, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OGA_HUMAN | |
Accessioni | O60502Primary (citable) accession number: O60502 Secondary accession number(s): B7WPB9 Q9HAR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families