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UniProtKB - O60502 (OGA_HUMAN)

Entry version 171 (29 Sep 2021)
Sequence version 2 (01 Mar 2001)
Previous versions | rss
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Protein

Protein O-GlcNAcase

Gene

OGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210).

Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).

5 Publications

Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

1 Publication

Caution

The mouse and rat orthologs were initially identified as bi-functional proteins containing an N-terminal domain with O-GlcNAcase activity and a C-terminal domain with histone acetyltransferase activity. The histone acetyltransferase activity was detected only when the protein was expressed in mammalian cells, but not when expressed in bacterial cells, suggesting that the histone acetyltransferase activity might be due to the presence of a contaminant. Comparison of the human protein with a bacterial putative acetyltransferase (AC Q2CEE2) shows that the residues important for acetyl-CoA binding are not conserved, and that the residues proposed to be important for histone acetyltransferase activity are not in a position where they could participate in catalysis. Characterization of the human protein shows that it does not bind acetyl-CoA and therefore cannot have acetyltransferase activity.1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.1 mM for pNP-GlcNAc1 Publication
  1. Vmax=652 µmol/min/mg enzyme with pNP-GLcNAc as substrate1 Publication

pH dependencei

Optimum pH is 5.7-7.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei67Substrate; via carbonyl oxygenBy similarity1
Binding sitei98SubstrateBy similarity1
Binding sitei174SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei175Proton donor1 Publication1
Binding sitei219SubstrateBy similarity1
Binding sitei285SubstrateBy similarity1
Binding sitei313SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processHost-virus interaction

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS03036-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.169, 2681
3.2.1.35, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60502

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH84, Glycoside Hydrolase Family 84

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein O-GlcNAcase2 PublicationsCurated (EC:3.2.1.1691 Publication5 Publications)
Short name:
OGA1 Publication
Alternative name(s):
Beta-N-acetylglucosaminidase1 Publication
Beta-N-acetylhexosaminidase
Beta-hexosaminidase
Meningioma-expressed antigen 51 Publication
N-acetyl-beta-D-glucosaminidase
N-acetyl-beta-glucosaminidase
Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
Short name:
NCOAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OGAImported
Synonyms:HEXC, KIAA0679, MEA5, MGEA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7056, OGA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604039, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60502

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198408

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69Y → K or Q: Strongly reduces affinity for glycopeptide substrates. Nearly abolishes enzyme activity. 2 Publications1
Mutagenesisi69Y → S: Strongly reduces affinity for glycopeptide substrates. Nearly abolishes enzyme activity. 2 Publications1
Mutagenesisi174D → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi175D → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi175D → N: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi255V → G or T: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi286Y → S: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi287D → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi413D → A: Abrogates cleavage by caspase-3. 1 Publication1
Mutagenesisi679W → N: Nearly abolishes enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10724

Open Targets

More...OpenTargetsi		ENSG00000198408

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30787

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60502, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5921

Drug and drug target database

More...DrugBanki		DB00428, Streptozocin

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		3101

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MGEA5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002521181 – 916Protein O-GlcNAcaseAdd BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei364PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei413 – 414Cleavage; by caspase-31 Publication2

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1223

Encyclopedia of Proteome Dynamics

More...EPDi		O60502

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60502

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60502

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60502

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60502

PeptideAtlas

More...PeptideAtlasi		O60502

PRoteomics IDEntifications database

More...PRIDEi		O60502

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20314
49438 [O60502-1]
49439 [O60502-2]
49440 [O60502-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O60502, 5 sites, 2 O-linked glycans (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60502

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O60502

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60502

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O60502

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Shows highest expression in the brain, placenta and pancreas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198408, Expressed in forebrain and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60502, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60502, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198408, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:11788610).

Interacts with CLOCK (By similarity).

By similarity1 Publication

(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction increases Tax interacting partner CREB1 O-GlcNAcylation.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115948, 49 interactors

Protein interaction database and analysis system

More...IntActi		O60502, 35 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354850

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O60502

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60502, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1916
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60502

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 48DisorderedSequence analysisAdd BLAST48
Regioni278 – 280Substrate bindingBy similarity3
Regioni441 – 465DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi450 – 465Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 84 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3698, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007726

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009837_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60502

Identification of Orthologs from Complete Genome Data

More...OMAi		ICTRTYL

Database of Orthologous Groups

More...OrthoDBi		159999at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60502

TreeFam database of animal gene trees

More...TreeFami		TF313732

Family and domain databases

Database of protein disorder

More...DisProti		DP02479

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00643

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR011496, Beta-N-acetylglucosaminidase
IPR017853, Glycoside_hydrolase_SF

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07555, NAGidase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51445, SSF51445, 1 hit
SSF55729, SSF55729, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O60502-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQKESQATL EERESELSSN PAASAGASLE PPAAPAPGED NPAGAGGAAV 
        60         70         80         90        100
AGAAGGARRF LCGVVEGFYG RPWVMEQRKE LFRRLQKWEL NTYLYAPKDD 
       110        120        130        140        150
YKHRMFWREM YSVEEAEQLM TLISAAREYE IEFIYAISPG LDITFSNPKE 
       160        170        180        190        200
VSTLKRKLDQ VSQFGCRSFA LLFDDIDHNM CAADKEVFSS FAHAQVSITN 
       210        220        230        240        250
EIYQYLGEPE TFLFCPTEYC GTFCYPNVSQ SPYLRTVGEK LLPGIEVLWT 
       260        270        280        290        300
GPKVVSKEIP VESIEEVSKI IKRAPVIWDN IHANDYDQKR LFLGPYKGRS 
       310        320        330        340        350
TELIPRLKGV LTNPNCEFEA NYVAIHTLAT WYKSNMNGVR KDVVMTDSED 
       360        370        380        390        400
STVSIQIKLE NEGSDEDIET DVLYSPQMAL KLALTEWLQE FGVPHQYSSR 
       410        420        430        440        450
QVAHSGAKAS VVDGTPLVAA PSLNATTVVT TVYQEPIMSQ GAALSGEPTT 
       460        470        480        490        500
LTKEEEKKQP DEEPMDMVVE KQEETDHKND NQILSEIVEA KMAEELKPMD 
       510        520        530        540        550
TDKESIAESK SPEMSMQEDC ISDIAPMQTD EQTNKEQFVP GPNEKPLYTA 
       560        570        580        590        600
EPVTLEDLQL LADLFYLPYE HGPKGAQMLR EFQWLRANSS VVSVNCKGKD 
       610        620        630        640        650
SEKIEEWRSR AAKFEEMCGL VMGMFTRLSN CANRTILYDM YSYVWDIKSI 
       660        670        680        690        700
MSMVKSFVQW LGCRSHSSAQ FLIGDQEPWA FRGGLAGEFQ RLLPIDGAND 
       710        720        730        740        750
LFFQPPPLTP TSKVYTIRPY FPKDEASVYK ICREMYDDGV GLPFQSQPDL 
       760        770        780        790        800
IGDKLVGGLL SLSLDYCFVL EDEDGICGYA LGTVDVTPFI KKCKISWIPF 
       810        820        830        840        850
MQEKYTKPNG DKELSEAEKI MLSFHEEQEV LPETFLANFP SLIKMDIHKK 
       860        870        880        890        900
VTDPSVAKSM MACLLSSLKA NGSRGAFCEV RPDDKRILEF YSKLGCFEIA 
       910 
KMEGFPKDVV ILGRSL
Length:916
Mass (Da):102,915
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01F8A64A9B1475C6
GO
Isoform 2 (identifier: O60502-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-398: Missing.
     691-704: Missing.

Show »
Length:849
Mass (Da):95,331
Checksum:iA65EFD64BE0AD17C
GO
Isoform 3 (identifier: O60502-3) [UniParc]FASTAAdd to basket
Also known as: MGEA5s

The sequence of this isoform differs from the canonical sequence as follows:
     663-677: CRSHSSAQFLIGDQE → RCTRNNLFSSNILSL
     678-916: Missing.

Show »
Length:677
Mass (Da):76,193
Checksum:iBF83DEF3ABDE4AA8
GO
Isoform 4 (identifier: O60502-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-398: Missing.

Show »
Length:863
Mass (Da):96,932
Checksum:iD6AB77EE6830F570
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3X0H7C3X0_HUMAN
Protein O-GlcNAcase
OGA
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH47877 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA31654 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02776146G → E. Corresponds to variant dbSNP:rs3740421Ensembl.1
Natural variantiVAR_027762602E → K1 PublicationCorresponds to variant dbSNP:rs17853930Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020866346 – 398Missing in isoform 2 and isoform 4. CuratedAdd BLAST53
Alternative sequenceiVSP_020867663 – 677CRSHS…IGDQE → RCTRNNLFSSNILSL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_020868678 – 916Missing in isoform 3. 1 PublicationAdd BLAST239
Alternative sequenceiVSP_020869691 – 704Missing in isoform 2. CuratedAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF036144 mRNA Translation: AAD05385.2
AF307332 mRNA Translation: AAG21428.1
AB014579 mRNA Translation: BAA31654.2 Different initiation.
AC010789 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49744.1
CH471066 Genomic DNA Translation: EAW49741.1
CH471066 Genomic DNA Translation: EAW49742.1
BC001343 mRNA Translation: AAH01343.1
BC039583 mRNA Translation: AAH39583.2
BC047877 mRNA Translation: AAH47877.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44471.1 [O60502-4]
CCDS7520.1 [O60502-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T00360

NCBI Reference Sequences

More...RefSeqi		NP_001135906.1, NM_001142434.1 [O60502-4]
NP_036347.1, NM_012215.3 [O60502-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357797; ENSP00000350445; ENSG00000198408 [O60502-2]
ENST00000361464; ENSP00000354850; ENSG00000198408 [O60502-1]
ENST00000370094; ENSP00000359112; ENSG00000198408 [O60502-3]
ENST00000439817; ENSP00000409973; ENSG00000198408 [O60502-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10724

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10724

UCSC genome browser

More...UCSCi		uc001ktv.3, human [O60502-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036144 mRNA Translation: AAD05385.2
AF307332 mRNA Translation: AAG21428.1
AB014579 mRNA Translation: BAA31654.2 Different initiation.
AC010789 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49744.1
CH471066 Genomic DNA Translation: EAW49741.1
CH471066 Genomic DNA Translation: EAW49742.1
BC001343 mRNA Translation: AAH01343.1
BC039583 mRNA Translation: AAH39583.2
BC047877 mRNA Translation: AAH47877.1 Sequence problems.
CCDSiCCDS44471.1 [O60502-4]
CCDS7520.1 [O60502-1]
PIRiT00360
RefSeqiNP_001135906.1, NM_001142434.1 [O60502-4]
NP_036347.1, NM_012215.3 [O60502-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YDQX-ray2.60T402-408[»]
5M7RX-ray2.35A/B1-916[»]
5M7SX-ray2.40A/B1-916[»]
5M7TX-ray2.60A/B1-916[»]
5M7UX-ray2.30A/B1-916[»]
5TKEX-ray2.48A/B60-400[»]
A/B553-704[»]
5UHKX-ray2.97A/C56-400[»]
B/D544-705[»]
5UHLX-ray3.14A/C56-400[»]
B/D544-705[»]
5UHOX-ray3.21A/C56-400[»]
B/D544-705[»]
5UHPX-ray2.79A/B/C/D14-400[»]
E/F/G/H554-705[»]
5UN8X-ray2.13A/B/C/D60-400[»]
A/B/C/D553-704[»]
5UN9X-ray2.50A/B60-400[»]
A/B553-704[»]
5VVOX-ray2.60A/B60-400[»]
A/B553-704[»]
5VVTX-ray2.80A/C60-400[»]
A/C553-704[»]
5VVUX-ray2.70A/C60-400[»]
A/C553-704[»]
5VVVX-ray2.80A/C60-400[»]
A/C553-704[»]
5VVXX-ray2.90A/C60-400[»]
A/C553-704[»]
6HKIX-ray3.30A/B1-916[»]
6PM9X-ray2.86A/B/C/D14-400[»]
E/F/G/H553-705[»]
SMRiO60502
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115948, 49 interactors
IntActiO60502, 35 interactors
STRINGi9606.ENSP00000354850

Chemistry databases

BindingDBiO60502
ChEMBLiCHEMBL5921
DrugBankiDB00428, Streptozocin
GuidetoPHARMACOLOGYi3101

Protein family/group databases

CAZyiGH84, Glycoside Hydrolase Family 84

PTM databases

GlyGeniO60502, 5 sites, 2 O-linked glycans (5 sites)
iPTMnetiO60502
MetOSiteiO60502
PhosphoSitePlusiO60502
SwissPalmiO60502

Genetic variation databases

BioMutaiMGEA5

Proteomic databases

CPTACiCPTAC-1223
EPDiO60502
jPOSTiO60502
MassIVEiO60502
MaxQBiO60502
PaxDbiO60502
PeptideAtlasiO60502
PRIDEiO60502
ProteomicsDBi20314
49438 [O60502-1]
49439 [O60502-2]
49440 [O60502-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31340, 182 antibodies

The DNASU plasmid repository

More...DNASUi		10724

Genome annotation databases

EnsembliENST00000357797; ENSP00000350445; ENSG00000198408 [O60502-2]
ENST00000361464; ENSP00000354850; ENSG00000198408 [O60502-1]
ENST00000370094; ENSP00000359112; ENSG00000198408 [O60502-3]
ENST00000439817; ENSP00000409973; ENSG00000198408 [O60502-4]
GeneIDi10724
KEGGihsa:10724
UCSCiuc001ktv.3, human [O60502-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10724
DisGeNETi10724

GeneCards: human genes, protein and diseases

More...GeneCardsi		OGA
HGNCiHGNC:7056, OGA
HPAiENSG00000198408, Low tissue specificity
MIMi604039, gene
neXtProtiNX_O60502
OpenTargetsiENSG00000198408
PharmGKBiPA30787
VEuPathDBiHostDB:ENSG00000198408

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3698, Eukaryota
GeneTreeiENSGT00390000007726
HOGENOMiCLU_009837_1_0_1
InParanoidiO60502
OMAiICTRTYL
OrthoDBi159999at2759
PhylomeDBiO60502
TreeFamiTF313732

Enzyme and pathway databases

BioCyciMetaCyc:HS03036-MONOMER
BRENDAi3.2.1.169, 2681
3.2.1.35, 2681
PathwayCommonsiO60502

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10724, 103 hits in 1028 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MGEA5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MGEA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10724
PharosiO60502, Tchem

Protein Ontology

More...PROi		PR:O60502
RNActiO60502, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198408, Expressed in forebrain and 244 other tissues
ExpressionAtlasiO60502, baseline and differential
GenevisibleiO60502, HS

Family and domain databases

DisProtiDP02479
IDEALiIID00643
InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR011496, Beta-N-acetylglucosaminidase
IPR017853, Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF07555, NAGidase, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit
SSF55729, SSF55729, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOGA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60502
Secondary accession number(s): B7WPB9
, D3DR79, E9PGF9, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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