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Protein

Protein O-GlcNAcase

Gene

OGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).5 Publications
Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.1 Publication

Caution

The mouse and rat orthologs were initially identified as bi-functional proteins containing an N-terminal domain with O-GlcNAcase activity and a C-terminal domain with histone acetyltransferase activity. The histone acetyltransferase activity was detected only when the protein was expressed in mammalian cells, but not when expressed in bacterial cells, suggesting that the histone acetyltransferase activity might be due to the presence of a contaminant. Comparison of the human protein with a bacterial putative acetyltransferase (AC Q2CEE2) shows that the residues important for acetyl-CoA binding are not conserved, and that the residues proposed to be important for histone acetyltransferase activity are not in a position where they could participate in catalysis. Characterization of the human protein shows that it does not bind acetyl-CoA and therefore cannot have acetyltransferase activity.1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.1 mM for pNP-GlcNAc1 Publication
  1. Vmax=652 µmol/min/mg enzyme with pNP-GLcNAc as substrate1 Publication

pH dependencei

Optimum pH is 5.7-7.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei67Substrate; via carbonyl oxygenBy similarity1
Binding sitei98SubstrateBy similarity1
Binding sitei174SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei175Proton donor1 Publication1
Binding sitei219SubstrateBy similarity1
Binding sitei285SubstrateBy similarity1
Binding sitei313SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • glycoprotein catabolic process Source: ProtInc
  • glycoprotein metabolic process Source: GO_Central
  • N-acetylglucosamine metabolic process Source: UniProtKB
  • protein deglycosylation Source: UniProtKB
  • protein O-linked glycosylation Source: ParkinsonsUK-UCL
  • viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processHost-virus interaction

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03036-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.2.1.35 2681

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH84 Glycoside Hydrolase Family 84

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein O-GlcNAcase2 PublicationsCurated (EC:3.2.1.1691 Publication5 Publications)
Short name:
OGA1 Publication
Alternative name(s):
Beta-N-acetylglucosaminidase1 Publication
Beta-N-acetylhexosaminidase
Beta-hexosaminidase
Meningioma-expressed antigen 51 Publication
N-acetyl-beta-D-glucosaminidase
N-acetyl-beta-glucosaminidase
Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
Short name:
NCOAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OGAImported
Synonyms:HEXC, KIAA0679, MEA5, MGEA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198408.13

Human Gene Nomenclature Database

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HGNCi
HGNC:7056 OGA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604039 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O60502

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69Y → K or Q: Strongly reduces affinity for glycopeptide substrates. Nearly abolishes enzyme activity. 2 Publications1
Mutagenesisi69Y → S: Strongly reduces affinity for glycopeptide substrates. Nearly abolishes enzyme activity. 2 Publications1
Mutagenesisi174D → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi175D → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi175D → N: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi255V → G or T: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi286Y → S: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi287D → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi413D → A: Abrogates cleavage by caspase-3. 1 Publication1
Mutagenesisi679W → N: Nearly abolishes enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10724

Open Targets

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OpenTargetsi
ENSG00000198408

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30787

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5921

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MGEA5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002521181 – 916Protein O-GlcNAcaseAdd BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei364PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei413 – 414Cleavage; by caspase-31 Publication2

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60502

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60502

MaxQB - The MaxQuant DataBase

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MaxQBi
O60502

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60502

PeptideAtlas

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PeptideAtlasi
O60502

PRoteomics IDEntifications database

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PRIDEi
O60502

ProteomicsDB human proteome resource

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ProteomicsDBi
49438
49439 [O60502-2]
49440 [O60502-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60502

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60502

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
O60502

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Shows highest expression in the brain, placenta and pancreas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198408 Expressed in 233 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

More...
CleanExi
HS_MGEA5

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60502 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60502 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036141
HPA076501

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).By similarity1 Publication
(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction increases Tax interacting partner CREB1 O-GlcNAcylation.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115948, 38 interactors

Protein interaction database and analysis system

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IntActi
O60502, 23 interactors

Molecular INTeraction database

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MINTi
O60502

STRING: functional protein association networks

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STRINGi
9606.ENSP00000354850

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60502

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1916
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YDQX-ray2.60T402-408[»]
5M7RX-ray2.35A/B1-916[»]
5M7SX-ray2.40A/B1-916[»]
5M7TX-ray2.60A/B1-916[»]
5M7UX-ray2.30A/B1-916[»]
5TKEX-ray2.48A/B60-400[»]
A/B553-704[»]
5UHKX-ray2.97A/C56-400[»]
B/D544-705[»]
5UHLX-ray3.14A/C56-400[»]
B/D544-705[»]
5UHOX-ray3.21A/C56-400[»]
B/D544-705[»]
5UHPX-ray2.79A/B/C/D14-400[»]
E/F/G/H554-705[»]
5UN8X-ray2.13A/B/C/D60-400[»]
A/B/C/D553-704[»]
5UN9X-ray2.50A/B60-400[»]
A/B553-704[»]
5VVOX-ray2.60A/B60-400[»]
A/B553-704[»]
5VVTX-ray2.80A/C60-400[»]
A/C553-704[»]
5VVUX-ray2.70A/C60-400[»]
A/C553-704[»]
5VVVX-ray2.80A/C60-400[»]
A/C553-704[»]
5VVXX-ray2.90A/C60-400[»]
A/C553-704[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60502

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60502

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni278 – 280Substrate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 84 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3698 Eukaryota
ENOG410XPBQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007726

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053044

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60502

KEGG Orthology (KO)

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KOi
K15719

Identification of Orthologs from Complete Genome Data

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OMAi
QFGCEAY

Database of Orthologous Groups

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OrthoDBi
969618at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60502

TreeFam database of animal gene trees

More...
TreeFami
TF313732

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR011496 Beta-N-acetylglucosaminidase
IPR017853 Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07555 NAGidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 1 hit
SSF55729 SSF55729, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O60502-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQKESQATL EERESELSSN PAASAGASLE PPAAPAPGED NPAGAGGAAV
60 70 80 90 100
AGAAGGARRF LCGVVEGFYG RPWVMEQRKE LFRRLQKWEL NTYLYAPKDD
110 120 130 140 150
YKHRMFWREM YSVEEAEQLM TLISAAREYE IEFIYAISPG LDITFSNPKE
160 170 180 190 200
VSTLKRKLDQ VSQFGCRSFA LLFDDIDHNM CAADKEVFSS FAHAQVSITN
210 220 230 240 250
EIYQYLGEPE TFLFCPTEYC GTFCYPNVSQ SPYLRTVGEK LLPGIEVLWT
260 270 280 290 300
GPKVVSKEIP VESIEEVSKI IKRAPVIWDN IHANDYDQKR LFLGPYKGRS
310 320 330 340 350
TELIPRLKGV LTNPNCEFEA NYVAIHTLAT WYKSNMNGVR KDVVMTDSED
360 370 380 390 400
STVSIQIKLE NEGSDEDIET DVLYSPQMAL KLALTEWLQE FGVPHQYSSR
410 420 430 440 450
QVAHSGAKAS VVDGTPLVAA PSLNATTVVT TVYQEPIMSQ GAALSGEPTT
460 470 480 490 500
LTKEEEKKQP DEEPMDMVVE KQEETDHKND NQILSEIVEA KMAEELKPMD
510 520 530 540 550
TDKESIAESK SPEMSMQEDC ISDIAPMQTD EQTNKEQFVP GPNEKPLYTA
560 570 580 590 600
EPVTLEDLQL LADLFYLPYE HGPKGAQMLR EFQWLRANSS VVSVNCKGKD
610 620 630 640 650
SEKIEEWRSR AAKFEEMCGL VMGMFTRLSN CANRTILYDM YSYVWDIKSI
660 670 680 690 700
MSMVKSFVQW LGCRSHSSAQ FLIGDQEPWA FRGGLAGEFQ RLLPIDGAND
710 720 730 740 750
LFFQPPPLTP TSKVYTIRPY FPKDEASVYK ICREMYDDGV GLPFQSQPDL
760 770 780 790 800
IGDKLVGGLL SLSLDYCFVL EDEDGICGYA LGTVDVTPFI KKCKISWIPF
810 820 830 840 850
MQEKYTKPNG DKELSEAEKI MLSFHEEQEV LPETFLANFP SLIKMDIHKK
860 870 880 890 900
VTDPSVAKSM MACLLSSLKA NGSRGAFCEV RPDDKRILEF YSKLGCFEIA
910
KMEGFPKDVV ILGRSL
Length:916
Mass (Da):102,915
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01F8A64A9B1475C6
GO
Isoform 2 (identifier: O60502-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-398: Missing.
     691-704: Missing.

Show »
Length:849
Mass (Da):95,331
Checksum:iA65EFD64BE0AD17C
GO
Isoform 3 (identifier: O60502-3) [UniParc]FASTAAdd to basket
Also known as: MGEA5s

The sequence of this isoform differs from the canonical sequence as follows:
     663-677: CRSHSSAQFLIGDQE → RCTRNNLFSSNILSL
     678-916: Missing.

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Length:677
Mass (Da):76,193
Checksum:iBF83DEF3ABDE4AA8
GO
Isoform 4 (identifier: O60502-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-398: Missing.

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Length:863
Mass (Da):96,932
Checksum:iD6AB77EE6830F570
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3X0H7C3X0_HUMAN
Protein O-GlcNAcase
OGA
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH47877 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA31654 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02776146G → E. Corresponds to variant dbSNP:rs3740421Ensembl.1
Natural variantiVAR_027762602E → K1 PublicationCorresponds to variant dbSNP:rs17853930Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020866346 – 398Missing in isoform 2 and isoform 4. CuratedAdd BLAST53
Alternative sequenceiVSP_020867663 – 677CRSHS…IGDQE → RCTRNNLFSSNILSL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_020868678 – 916Missing in isoform 3. 1 PublicationAdd BLAST239
Alternative sequenceiVSP_020869691 – 704Missing in isoform 2. CuratedAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF036144 mRNA Translation: AAD05385.2
AF307332 mRNA Translation: AAG21428.1
AB014579 mRNA Translation: BAA31654.2 Different initiation.
AC010789 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49744.1
CH471066 Genomic DNA Translation: EAW49741.1
CH471066 Genomic DNA Translation: EAW49742.1
BC001343 mRNA Translation: AAH01343.1
BC039583 mRNA Translation: AAH39583.2
BC047877 mRNA Translation: AAH47877.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS44471.1 [O60502-4]
CCDS7520.1 [O60502-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00360

NCBI Reference Sequences

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RefSeqi
NP_001135906.1, NM_001142434.1 [O60502-4]
NP_036347.1, NM_012215.3 [O60502-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.500842

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000357797; ENSP00000350445; ENSG00000198408 [O60502-2]
ENST00000361464; ENSP00000354850; ENSG00000198408 [O60502-1]
ENST00000370094; ENSP00000359112; ENSG00000198408 [O60502-3]
ENST00000439817; ENSP00000409973; ENSG00000198408 [O60502-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10724

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10724

UCSC genome browser

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UCSCi
uc001ktv.3 human [O60502-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036144 mRNA Translation: AAD05385.2
AF307332 mRNA Translation: AAG21428.1
AB014579 mRNA Translation: BAA31654.2 Different initiation.
AC010789 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49744.1
CH471066 Genomic DNA Translation: EAW49741.1
CH471066 Genomic DNA Translation: EAW49742.1
BC001343 mRNA Translation: AAH01343.1
BC039583 mRNA Translation: AAH39583.2
BC047877 mRNA Translation: AAH47877.1 Sequence problems.
CCDSiCCDS44471.1 [O60502-4]
CCDS7520.1 [O60502-1]
PIRiT00360
RefSeqiNP_001135906.1, NM_001142434.1 [O60502-4]
NP_036347.1, NM_012215.3 [O60502-1]
UniGeneiHs.500842

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YDQX-ray2.60T402-408[»]
5M7RX-ray2.35A/B1-916[»]
5M7SX-ray2.40A/B1-916[»]
5M7TX-ray2.60A/B1-916[»]
5M7UX-ray2.30A/B1-916[»]
5TKEX-ray2.48A/B60-400[»]
A/B553-704[»]
5UHKX-ray2.97A/C56-400[»]
B/D544-705[»]
5UHLX-ray3.14A/C56-400[»]
B/D544-705[»]
5UHOX-ray3.21A/C56-400[»]
B/D544-705[»]
5UHPX-ray2.79A/B/C/D14-400[»]
E/F/G/H554-705[»]
5UN8X-ray2.13A/B/C/D60-400[»]
A/B/C/D553-704[»]
5UN9X-ray2.50A/B60-400[»]
A/B553-704[»]
5VVOX-ray2.60A/B60-400[»]
A/B553-704[»]
5VVTX-ray2.80A/C60-400[»]
A/C553-704[»]
5VVUX-ray2.70A/C60-400[»]
A/C553-704[»]
5VVVX-ray2.80A/C60-400[»]
A/C553-704[»]
5VVXX-ray2.90A/C60-400[»]
A/C553-704[»]
ProteinModelPortaliO60502
SMRiO60502
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115948, 38 interactors
IntActiO60502, 23 interactors
MINTiO60502
STRINGi9606.ENSP00000354850

Chemistry databases

BindingDBiO60502
ChEMBLiCHEMBL5921

Protein family/group databases

CAZyiGH84 Glycoside Hydrolase Family 84

PTM databases

iPTMnetiO60502
PhosphoSitePlusiO60502

Polymorphism and mutation databases

BioMutaiMGEA5

Proteomic databases

EPDiO60502
jPOSTiO60502
MaxQBiO60502
PaxDbiO60502
PeptideAtlasiO60502
PRIDEiO60502
ProteomicsDBi49438
49439 [O60502-2]
49440 [O60502-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10724
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357797; ENSP00000350445; ENSG00000198408 [O60502-2]
ENST00000361464; ENSP00000354850; ENSG00000198408 [O60502-1]
ENST00000370094; ENSP00000359112; ENSG00000198408 [O60502-3]
ENST00000439817; ENSP00000409973; ENSG00000198408 [O60502-4]
GeneIDi10724
KEGGihsa:10724
UCSCiuc001ktv.3 human [O60502-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10724
DisGeNETi10724
EuPathDBiHostDB:ENSG00000198408.13

GeneCards: human genes, protein and diseases

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GeneCardsi
OGA
HGNCiHGNC:7056 OGA
HPAiHPA036141
HPA076501
MIMi604039 gene
neXtProtiNX_O60502
OpenTargetsiENSG00000198408
PharmGKBiPA30787

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3698 Eukaryota
ENOG410XPBQ LUCA
GeneTreeiENSGT00390000007726
HOVERGENiHBG053044
InParanoidiO60502
KOiK15719
OMAiQFGCEAY
OrthoDBi969618at2759
PhylomeDBiO60502
TreeFamiTF313732

Enzyme and pathway databases

BioCyciMetaCyc:HS03036-MONOMER
BRENDAi3.2.1.35 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MGEA5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MGEA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10724
PMAP-CutDBiO60502

Protein Ontology

More...
PROi
PR:O60502

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198408 Expressed in 233 organ(s), highest expression level in forebrain
CleanExiHS_MGEA5
ExpressionAtlasiO60502 baseline and differential
GenevisibleiO60502 HS

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR011496 Beta-N-acetylglucosaminidase
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF07555 NAGidase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF55729 SSF55729, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOGA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60502
Secondary accession number(s): B7WPB9
, D3DR79, E9PGF9, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: January 16, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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