UniProtKB - O60499 (STX10_HUMAN)
Protein
Syntaxin-10
Gene
STX10
Organism
Homo sapiens (Human)
Status
Functioni
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: UniProtKB
GO - Biological processi
- Golgi vesicle transport Source: InterPro
- intracellular protein transport Source: GO_Central
- regulation of protein localization Source: UniProtKB
- retrograde transport, endosome to Golgi Source: UniProtKB
- vesicle docking Source: GO_Central
- vesicle fusion Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O60499 |
Reactomei | R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
SIGNORi | O60499 |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-10Short name: Syn10 |
Gene namesi | Name:STX10 Synonyms:SYN10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11428, STX10 |
MIMi | 603765, gene |
neXtProti | NX_O60499 |
VEuPathDBi | HostDB:ENSG00000104915.14 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane Curated; Single-pass type IV membrane protein Curated
Cytosol
- cytosol Source: GOC
Golgi apparatus
- trans-Golgi network Source: UniProtKB
- trans-Golgi network membrane Source: Reactome
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: GO_Central
- integral component of synaptic vesicle membrane Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB
- SNARE complex Source: GO_Central
- synaptic vesicle Source: GO_Central
- vesicle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 228 | CytoplasmicSequence analysisAdd BLAST | 227 | |
Transmembranei | 229 – 249 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8677 |
OpenTargetsi | ENSG00000104915 |
PharmGKBi | PA36228 |
Miscellaneous databases
Pharosi | O60499, Tbio |
Genetic variation databases
BioMutai | STX10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000210220 | 2 – 249 | Syntaxin-10Add BLAST | 248 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 108 | PhosphoserineCombined sources | 1 | |
Modified residuei | 110 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 134 | PhosphoserineCombined sources | 1 | |
Modified residuei | 140 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O60499 |
jPOSTi | O60499 |
MassIVEi | O60499 |
MaxQBi | O60499 |
PaxDbi | O60499 |
PeptideAtlasi | O60499 |
PRIDEi | O60499 |
ProteomicsDBi | 49434 [O60499-1] 49435 [O60499-2] |
TopDownProteomicsi | O60499-1 [O60499-1] |
PTM databases
iPTMneti | O60499 |
MetOSitei | O60499 |
PhosphoSitePlusi | O60499 |
SwissPalmi | O60499 |
Expressioni
Tissue specificityi
Expressed at high levels in heart, skeletal muscle and pancreas.
Gene expression databases
Bgeei | ENSG00000104915, Expressed in blood and 232 other tissues |
ExpressionAtlasi | O60499, baseline and differential |
Genevisiblei | O60499, HS |
Organism-specific databases
HPAi | ENSG00000104915, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with VPS52.
1 PublicationBinary interactionsi
Hide detailsIsoform 1 [O60499-1]
With | #Exp. | IntAct |
---|---|---|
VPS51 - isoform 1 [Q9UID3-1] | 5 | EBI-16067850,EBI-16067837 |
Isoform 2 [O60499-2]
GO - Molecular functioni
- SNARE binding Source: GO_Central
- syntaxin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114225, 46 interactors |
DIPi | DIP-60563N |
IntActi | O60499, 31 interactors |
MINTi | O60499 |
STRINGi | 9606.ENSP00000466298 |
Miscellaneous databases
RNActi | O60499, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O60499 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 157 – 219 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 41 – 69 | Sequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the syntaxin family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3202, Eukaryota |
GeneTreei | ENSGT00940000163101 |
HOGENOMi | CLU_061883_1_0_1 |
InParanoidi | O60499 |
OMAi | DMKDHMV |
OrthoDBi | 1563292at2759 |
PhylomeDBi | O60499 |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR015260, Syntaxin-6_N IPR006012, Syntaxin/epimorphin_CS IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF09177, Syntaxin-6_N, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O60499-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLEDPFFVV RGEVQKAVNT ARGLYQRWCE LLQESAAVGR EELDWTTNEL
60 70 80 90 100
RNGLRSIEWD LEDLEETIGI VEANPGKFKL PAGDLQERKV FVERMREAVQ
110 120 130 140 150
EMKDHMVSPT AVAFLERNNR EILAGKPAAQ KSPSDLLDAS AVSATSRYIE
160 170 180 190 200
EQQATQQLIM DEQDQQLEMV SGSIQVLKHM SGRVGEELDE QGIMLDAFAQ
210 220 230 240
EMDHTQSRMD GVLRKLAKVS HMTSDRRQWC AIAVLVGVLL LVLILLFSL
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5U8S2 | Q5U8S2_HUMAN | Syntaxin-10 | STX10 | 246 | Annotation score: | ||
K7ELY2 | K7ELY2_HUMAN | Syntaxin-10 | STX10 | 201 | Annotation score: | ||
K7EIY4 | K7EIY4_HUMAN | Syntaxin-10 | STX10 | 228 | Annotation score: | ||
X6R2W0 | X6R2W0_HUMAN | Syntaxin-10 | STX10 | 220 | Annotation score: | ||
K7EPP9 | K7EPP9_HUMAN | Syntaxin-10 | STX10 | 122 | Annotation score: | ||
K7EQ84 | K7EQ84_HUMAN | Syntaxin-10 | STX10 | 97 | Annotation score: | ||
K7EK75 | K7EK75_HUMAN | Syntaxin-10 | STX10 | 113 | Annotation score: | ||
F6RTM7 | F6RTM7_HUMAN | Syntaxin-10 | STX10 | 73 | Annotation score: | ||
K7EJ05 | K7EJ05_HUMAN | Syntaxin-10 | STX10 | 58 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006347 | 76 – 124 | Missing in isoform 2. 1 PublicationAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035531 mRNA Translation: AAC05087.1 CR457110 mRNA Translation: CAG33391.1 AC011446 Genomic DNA No translation available. BC017237 mRNA Translation: AAH17237.1 |
CCDSi | CCDS32922.1 [O60499-1] CCDS62571.1 [O60499-2] |
PIRi | JC5922 |
RefSeqi | NP_001258540.1, NM_001271611.1 [O60499-2] NP_003756.1, NM_003765.2 [O60499-1] |
Genome annotation databases
Ensembli | ENST00000343587; ENSP00000339350; ENSG00000104915 [O60499-2] ENST00000587230; ENSP00000466298; ENSG00000104915 [O60499-1] |
GeneIDi | 8677 |
KEGGi | hsa:8677 |
UCSCi | uc021upq.3, human [O60499-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035531 mRNA Translation: AAC05087.1 CR457110 mRNA Translation: CAG33391.1 AC011446 Genomic DNA No translation available. BC017237 mRNA Translation: AAH17237.1 |
CCDSi | CCDS32922.1 [O60499-1] CCDS62571.1 [O60499-2] |
PIRi | JC5922 |
RefSeqi | NP_001258540.1, NM_001271611.1 [O60499-2] NP_003756.1, NM_003765.2 [O60499-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4DND | X-ray | 1.40 | A | 1-108 | [»] | |
SMRi | O60499 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114225, 46 interactors |
DIPi | DIP-60563N |
IntActi | O60499, 31 interactors |
MINTi | O60499 |
STRINGi | 9606.ENSP00000466298 |
PTM databases
iPTMneti | O60499 |
MetOSitei | O60499 |
PhosphoSitePlusi | O60499 |
SwissPalmi | O60499 |
Genetic variation databases
BioMutai | STX10 |
Proteomic databases
EPDi | O60499 |
jPOSTi | O60499 |
MassIVEi | O60499 |
MaxQBi | O60499 |
PaxDbi | O60499 |
PeptideAtlasi | O60499 |
PRIDEi | O60499 |
ProteomicsDBi | 49434 [O60499-1] 49435 [O60499-2] |
TopDownProteomicsi | O60499-1 [O60499-1] |
Protocols and materials databases
Antibodypediai | 43275, 143 antibodies |
Genome annotation databases
Ensembli | ENST00000343587; ENSP00000339350; ENSG00000104915 [O60499-2] ENST00000587230; ENSP00000466298; ENSG00000104915 [O60499-1] |
GeneIDi | 8677 |
KEGGi | hsa:8677 |
UCSCi | uc021upq.3, human [O60499-1] |
Organism-specific databases
CTDi | 8677 |
DisGeNETi | 8677 |
GeneCardsi | STX10 |
HGNCi | HGNC:11428, STX10 |
HPAi | ENSG00000104915, Low tissue specificity |
MIMi | 603765, gene |
neXtProti | NX_O60499 |
OpenTargetsi | ENSG00000104915 |
PharmGKBi | PA36228 |
VEuPathDBi | HostDB:ENSG00000104915.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3202, Eukaryota |
GeneTreei | ENSGT00940000163101 |
HOGENOMi | CLU_061883_1_0_1 |
InParanoidi | O60499 |
OMAi | DMKDHMV |
OrthoDBi | 1563292at2759 |
PhylomeDBi | O60499 |
Enzyme and pathway databases
PathwayCommonsi | O60499 |
Reactomei | R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
SIGNORi | O60499 |
Miscellaneous databases
BioGRID-ORCSi | 8677, 11 hits in 874 CRISPR screens |
ChiTaRSi | STX10, human |
GeneWikii | STX10 |
GenomeRNAii | 8677 |
Pharosi | O60499, Tbio |
PROi | PR:O60499 |
RNActi | O60499, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104915, Expressed in blood and 232 other tissues |
ExpressionAtlasi | O60499, baseline and differential |
Genevisiblei | O60499, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR015260, Syntaxin-6_N IPR006012, Syntaxin/epimorphin_CS IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF09177, Syntaxin-6_N, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX10_HUMAN | |
Accessioni | O60499Primary (citable) accession number: O60499 Secondary accession number(s): A6NC41, Q6IAP4, Q96AE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families