UniProtKB - O60486 (PLXC1_HUMAN)
Protein
Plexin-C1
Gene
PLXNC1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).By similarity1 Publication
GO - Molecular functioni
- semaphorin receptor activity Source: GO_Central
- signaling receptor binding Source: ProtInc
GO - Biological processi
- cell adhesion Source: ProtInc
- negative regulation of cell adhesion Source: GO_Central
- positive regulation of axonogenesis Source: GO_Central
- regulation of cell migration Source: GO_Central
- regulation of cell shape Source: GO_Central
- regulation of GTPase activity Source: GO_Central
- semaphorin-plexin signaling pathway involved in axon guidance Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O60486 |
Reactomei | R-HSA-416700, Other semaphorin interactions |
SIGNORi | O60486 |
Names & Taxonomyi
Protein namesi | Recommended name: Plexin-C1Alternative name(s): Virus-encoded semaphorin protein receptor CD_antigen: CD232 |
Gene namesi | Name:PLXNC1 Synonyms:VESPR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9106, PLXNC1 |
MIMi | 604259, gene |
neXtProti | NX_O60486 |
VEuPathDBi | HostDB:ENSG00000136040.8 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- membrane Source: UniProtKB
- semaphorin receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 35 – 944 | ExtracellularSequence analysisAdd BLAST | 910 | |
Transmembranei | 945 – 965 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 966 – 1568 | CytoplasmicSequence analysisAdd BLAST | 603 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10154 |
OpenTargetsi | ENSG00000136040 |
PharmGKBi | PA33432 |
Miscellaneous databases
Pharosi | O60486, Tbio |
Genetic variation databases
BioMutai | PLXNC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_0000232749 | 35 – 1568 | Plexin-C1Add BLAST | 1534 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 64 ↔ 87 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 86 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 141 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 149 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 156 ↔ 194 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 226 ↔ 354 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 241 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 252 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 283 ↔ 329 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 386 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 407 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 455 ↔ 472 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 461 ↔ 506 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 464 ↔ 481 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 475 ↔ 487 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 548 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 582 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 653 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 692 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 771 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 796 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 821 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 871 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 890 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 978 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
N-glycosylated.2 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | O60486 |
jPOSTi | O60486 |
MassIVEi | O60486 |
MaxQBi | O60486 |
PaxDbi | O60486 |
PeptideAtlasi | O60486 |
PRIDEi | O60486 |
ProteomicsDBi | 49424 |
PTM databases
GlyConnecti | 725, 8 N-Linked glycans (5 sites) |
GlyGeni | O60486, 21 sites, 7 N-linked glycans (5 sites) |
iPTMneti | O60486 |
PhosphoSitePlusi | O60486 |
Expressioni
Tissue specificityi
Detected in heart, brain, lung, spleen and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000136040, Expressed in blood and 229 other tissues |
ExpressionAtlasi | O60486, baseline and differential |
Genevisiblei | O60486, HS |
Organism-specific databases
HPAi | ENSG00000136040, Tissue enhanced (lymphoid tissue, retina) |
Interactioni
Subunit structurei
Monomer. Homodimer.
Interacts with SEMA7A.
2 PublicationsBinary interactionsi
Hide detailsO60486
With | #Exp. | IntAct |
---|---|---|
SEMA7A [O75326] | 4 | EBI-2927384,EBI-1753538 |
EVM139 [Q8JL80] from Ectromelia virus (strain Moscow). | 3 | EBI-2927384,EBI-2927425 |
GO - Molecular functioni
- signaling receptor binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 115456, 1 interactor |
CORUMi | O60486 |
IntActi | O60486, 3 interactors |
MINTi | O60486 |
STRINGi | 9606.ENSP00000258526 |
Miscellaneous databases
RNActi | O60486, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O60486 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60486 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 452 | SemaPROSITE-ProRule annotationAdd BLAST | 418 |
Sequence similaritiesi
Belongs to the plexin family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3610, Eukaryota |
GeneTreei | ENSGT01020000230384 |
HOGENOMi | CLU_004205_0_0_1 |
InParanoidi | O60486 |
OMAi | LFHGENK |
OrthoDBi | 90434at2759 |
PhylomeDBi | O60486 |
TreeFami | TF312962 |
Family and domain databases
CDDi | cd11246, Sema_plexin_C1, 1 hit |
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR002909, IPT_dom IPR031148, Plexin IPR041853, Plexin-C1_Sema IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR002165, Plexin_repeat IPR016201, PSI IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01437, PSI, 1 hit PF01833, TIG, 2 hits |
SMARTi | View protein in SMART SM00429, IPT, 2 hits SM00423, PSI, 2 hits SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
O60486-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA
60 70 80 90 100
ASQEDGVFVA SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR
110 120 130 140 150
PGSSFSKLLL PYREGAAGLG GLLLTGWTFD RGACEVRPLG NLSRNSLRNG
160 170 180 190 200
TEVVSCHPQG STAGVVYRAG RNNRWYLAVA ATYVLPEPET ASRCNPAASD
210 220 230 240 250
HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW NGSIYFPYYP
260 270 280 290 300
YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV
310 320 330 340 350
EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA
360 370 380 390 400
ESHCKEGDQP ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL
410 420 430 440 450
KVILGENLTS NCPEVIYEIK EETPVFYKLV PDPVKNIYIY LTAGKEVRRI
460 470 480 490 500
RVANCNKHKS CSECLTATDP HCGWCHSLQR CTFQGDCVHS ENLENWLDIS
510 520 530 540 550
SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD SSRELCQNKS
560 570 580 590 600
QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA
610 620 630 640 650
CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN
660 670 680 690 700
KGNRTNQALQ VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT
710 720 730 740 750
STCDKDVIQV SHVLNDTHMK FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY
760 770 780 790 800
IALPHCSLIF PATTWISGGQ NITMMGRNFD VIDNLIISHE LKGNINVSEY
810 820 830 840 850
CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY REDPRFTGYR
860 870 880 890 900
VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ
910 920 930 940 950
DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV
960 970 980 990 1000
LPVLLVIVIF AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ
1010 1020 1030 1040 1050
MDKLDVVDSF GTVPFLDYKH FALRTFFPES GGFTHIFTED MHNRDANDKN
1060 1070 1080 1090 1100
ESLTALDALI CNKSFLVTVI HTLEKQKNFS VKDRCLFASF LTIALQTKLV
1110 1120 1130 1140 1150
YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW MSVCLSGFLR
1160 1170 1180 1190 1200
ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA
1210 1220 1230 1240 1250
LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG
1260 1270 1280 1290 1300
LQLNEIGLEL QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI
1310 1320 1330 1340 1350
KVFKKIANFT SDVEYSDDHC HLILPDSEAF QDVQGKRHRG KHKFKVKEMY
1360 1370 1380 1390 1400
LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA PFAIKYFFDF LDAQAENKKI
1410 1420 1430 1440 1450
TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG CLSVIAQAFM
1460 1470 1480 1490 1500
DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM
1510 1520 1530 1540 1550
EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK
1560
QLLHVKVLFD EKKKCKWM
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VUW4 | F8VUW4_HUMAN | Plexin-C1 | PLXNC1 | 109 | Annotation score: | ||
B4DHQ7 | B4DHQ7_HUMAN | Plexin-C1 | PLXNC1 | 615 | Annotation score: | ||
F8W095 | F8W095_HUMAN | Plexin-C1 | PLXNC1 | 103 | Annotation score: | ||
F8W1K6 | F8W1K6_HUMAN | Plexin-C1 | PLXNC1 | 416 | Annotation score: | ||
F5H3A2 | F5H3A2_HUMAN | Plexin-C1 | PLXNC1 | 307 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 671 | K → R in BAD92171 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050602 | 1499 | E → K. Corresponds to variant dbSNP:rs11107500Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF030339 mRNA Translation: AAC18823.1 AB208934 mRNA Translation: BAD92171.1 |
CCDSi | CCDS9049.1 |
PIRi | T09074 |
RefSeqi | NP_005752.1, NM_005761.2 |
Genome annotation databases
Ensembli | ENST00000258526; ENSP00000258526; ENSG00000136040 |
GeneIDi | 10154 |
KEGGi | hsa:10154 |
UCSCi | uc001tdc.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF030339 mRNA Translation: AAC18823.1 AB208934 mRNA Translation: BAD92171.1 |
CCDSi | CCDS9049.1 |
PIRi | T09074 |
RefSeqi | NP_005752.1, NM_005761.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KUZ | X-ray | 2.30 | A/B | 1198-1305 | [»] | |
3NVN | X-ray | 2.26 | B | 35-507 | [»] | |
3NVQ | X-ray | 2.40 | B/F | 35-507 | [»] | |
6VXK | electron microscopy | 3.10 | B/D | 35-1568 | [»] | |
SMRi | O60486 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115456, 1 interactor |
CORUMi | O60486 |
IntActi | O60486, 3 interactors |
MINTi | O60486 |
STRINGi | 9606.ENSP00000258526 |
PTM databases
GlyConnecti | 725, 8 N-Linked glycans (5 sites) |
GlyGeni | O60486, 21 sites, 7 N-linked glycans (5 sites) |
iPTMneti | O60486 |
PhosphoSitePlusi | O60486 |
Genetic variation databases
BioMutai | PLXNC1 |
Proteomic databases
EPDi | O60486 |
jPOSTi | O60486 |
MassIVEi | O60486 |
MaxQBi | O60486 |
PaxDbi | O60486 |
PeptideAtlasi | O60486 |
PRIDEi | O60486 |
ProteomicsDBi | 49424 |
Protocols and materials databases
Antibodypediai | 30073, 117 antibodies |
DNASUi | 10154 |
Genome annotation databases
Ensembli | ENST00000258526; ENSP00000258526; ENSG00000136040 |
GeneIDi | 10154 |
KEGGi | hsa:10154 |
UCSCi | uc001tdc.3, human |
Organism-specific databases
CTDi | 10154 |
DisGeNETi | 10154 |
GeneCardsi | PLXNC1 |
HGNCi | HGNC:9106, PLXNC1 |
HPAi | ENSG00000136040, Tissue enhanced (lymphoid tissue, retina) |
MIMi | 604259, gene |
neXtProti | NX_O60486 |
OpenTargetsi | ENSG00000136040 |
PharmGKBi | PA33432 |
VEuPathDBi | HostDB:ENSG00000136040.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3610, Eukaryota |
GeneTreei | ENSGT01020000230384 |
HOGENOMi | CLU_004205_0_0_1 |
InParanoidi | O60486 |
OMAi | LFHGENK |
OrthoDBi | 90434at2759 |
PhylomeDBi | O60486 |
TreeFami | TF312962 |
Enzyme and pathway databases
PathwayCommonsi | O60486 |
Reactomei | R-HSA-416700, Other semaphorin interactions |
SIGNORi | O60486 |
Miscellaneous databases
BioGRID-ORCSi | 10154, 2 hits in 981 CRISPR screens |
ChiTaRSi | PLXNC1, human |
EvolutionaryTracei | O60486 |
GenomeRNAii | 10154 |
Pharosi | O60486, Tbio |
PROi | PR:O60486 |
RNActi | O60486, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136040, Expressed in blood and 229 other tissues |
ExpressionAtlasi | O60486, baseline and differential |
Genevisiblei | O60486, HS |
Family and domain databases
CDDi | cd11246, Sema_plexin_C1, 1 hit |
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR002909, IPT_dom IPR031148, Plexin IPR041853, Plexin-C1_Sema IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR002165, Plexin_repeat IPR016201, PSI IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01437, PSI, 1 hit PF01833, TIG, 2 hits |
SMARTi | View protein in SMART SM00429, IPT, 2 hits SM00423, PSI, 2 hits SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLXC1_HUMAN | |
Accessioni | O60486Primary (citable) accession number: O60486 Secondary accession number(s): Q59H25 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | August 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families