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UniProtKB - O60486 (PLXC1_HUMAN)

Entry version 164 (25 May 2022)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
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Protein

Plexin-C1

Gene

PLXNC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60486

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-416700, Other semaphorin interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O60486

SIGNOR Signaling Network Open Resource

More...SIGNORi		O60486

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-C1
Alternative name(s):
Virus-encoded semaphorin protein receptor
CD_antigen: CD232
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLXNC1
Synonyms:VESPR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9106, PLXNC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604259, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60486

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000136040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini35 – 944ExtracellularSequence analysisAdd BLAST910
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei945 – 965HelicalSequence analysisAdd BLAST21
Topological domaini966 – 1568CytoplasmicSequence analysisAdd BLAST603

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10154

Open Targets

More...OpenTargetsi		ENSG00000136040

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33432

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60486, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLXNC1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023274935 – 1568Plexin-C1Add BLAST1534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi64 ↔ 87PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi149N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi156 ↔ 194PROSITE-ProRule annotation1 Publication
Disulfide bondi226 ↔ 354PROSITE-ProRule annotation1 Publication
Glycosylationi241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi252N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi283 ↔ 329PROSITE-ProRule annotation1 Publication
Glycosylationi386N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi407N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi455 ↔ 472PROSITE-ProRule annotation1 Publication
Disulfide bondi461 ↔ 506PROSITE-ProRule annotation1 Publication
Disulfide bondi464 ↔ 481PROSITE-ProRule annotation1 Publication
Disulfide bondi475 ↔ 487PROSITE-ProRule annotation1 Publication
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi653N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi692N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi771N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi821N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi871N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei978PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60486

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60486

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60486

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60486

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60486

PeptideAtlas

More...PeptideAtlasi		O60486

PRoteomics IDEntifications database

More...PRIDEi		O60486

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49424

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		725, 8 N-Linked glycans (5 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O60486, 21 sites, 14 N-linked glycans (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60486

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60486

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, brain, lung, spleen and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136040, Expressed in blood and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60486, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60486, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136040, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer.

Interacts with SEMA7A.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115456, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O60486

Protein interaction database and analysis system

More...IntActi		O60486, 3 interactors

Molecular INTeraction database

More...MINTi		O60486

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000258526

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60486, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11568
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O60486

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60486

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O60486

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 452SemaPROSITE-ProRule annotationAdd BLAST418

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3610, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004205_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60486

Identification of Orthologs from Complete Genome Data

More...OMAi		LFHGENK

Database of Orthologous Groups

More...OrthoDBi		90434at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60486

TreeFam database of animal gene trees

More...TreeFami		TF312962

Family and domain databases

Conserved Domains Database

More...CDDi		cd11246, Sema_plexin_C1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.506.10, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR002909, IPT_dom
IPR031148, Plexin
IPR041853, Plexin-C1_Sema
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR22625, PTHR22625, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08337, Plexin_cytopl, 2 hits
PF01437, PSI, 1 hit
PF01833, TIG, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00429, IPT, 2 hits
SM00423, PSI, 2 hits
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O60486-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA 
        60         70         80         90        100
ASQEDGVFVA SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR 
       110        120        130        140        150
PGSSFSKLLL PYREGAAGLG GLLLTGWTFD RGACEVRPLG NLSRNSLRNG 
       160        170        180        190        200
TEVVSCHPQG STAGVVYRAG RNNRWYLAVA ATYVLPEPET ASRCNPAASD 
       210        220        230        240        250
HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW NGSIYFPYYP 
       260        270        280        290        300
YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV 
       310        320        330        340        350
EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA 
       360        370        380        390        400
ESHCKEGDQP ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL 
       410        420        430        440        450
KVILGENLTS NCPEVIYEIK EETPVFYKLV PDPVKNIYIY LTAGKEVRRI 
       460        470        480        490        500
RVANCNKHKS CSECLTATDP HCGWCHSLQR CTFQGDCVHS ENLENWLDIS 
       510        520        530        540        550
SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD SSRELCQNKS 
       560        570        580        590        600
QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA 
       610        620        630        640        650
CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN 
       660        670        680        690        700
KGNRTNQALQ VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT 
       710        720        730        740        750
STCDKDVIQV SHVLNDTHMK FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY 
       760        770        780        790        800
IALPHCSLIF PATTWISGGQ NITMMGRNFD VIDNLIISHE LKGNINVSEY 
       810        820        830        840        850
CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY REDPRFTGYR 
       860        870        880        890        900
VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ 
       910        920        930        940        950
DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV 
       960        970        980        990       1000
LPVLLVIVIF AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ 
      1010       1020       1030       1040       1050
MDKLDVVDSF GTVPFLDYKH FALRTFFPES GGFTHIFTED MHNRDANDKN 
      1060       1070       1080       1090       1100
ESLTALDALI CNKSFLVTVI HTLEKQKNFS VKDRCLFASF LTIALQTKLV 
      1110       1120       1130       1140       1150
YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW MSVCLSGFLR 
      1160       1170       1180       1190       1200
ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA 
      1210       1220       1230       1240       1250
LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG 
      1260       1270       1280       1290       1300
LQLNEIGLEL QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI 
      1310       1320       1330       1340       1350
KVFKKIANFT SDVEYSDDHC HLILPDSEAF QDVQGKRHRG KHKFKVKEMY 
      1360       1370       1380       1390       1400
LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA PFAIKYFFDF LDAQAENKKI 
      1410       1420       1430       1440       1450
TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG CLSVIAQAFM 
      1460       1470       1480       1490       1500
DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM 
      1510       1520       1530       1540       1550
EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK 
      1560 
QLLHVKVLFD EKKKCKWM
Length:1,568
Mass (Da):175,742
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA0CE5519BEF925D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VUW4F8VUW4_HUMAN
Plexin-C1
PLXNC1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1K6F8W1K6_HUMAN
Plexin-C1
PLXNC1
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W095F8W095_HUMAN
Plexin-C1
PLXNC1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DHQ7B4DHQ7_HUMAN
Plexin-C1
PLXNC1
615Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3A2F5H3A2_HUMAN
Plexin-C1
PLXNC1
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti671K → R in BAD92171 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0506021499E → K. Corresponds to variant dbSNP:rs11107500Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF030339 mRNA Translation: AAC18823.1
AB208934 mRNA Translation: BAD92171.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9049.1

Protein sequence database of the Protein Information Resource

More...PIRi		T09074

NCBI Reference Sequences

More...RefSeqi		NP_005752.1, NM_005761.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258526.9; ENSP00000258526.4; ENSG00000136040.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10154

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000258526.9; ENSP00000258526.4; NM_005761.3; NP_005752.1

UCSC genome browser

More...UCSCi		uc001tdc.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030339 mRNA Translation: AAC18823.1
AB208934 mRNA Translation: BAD92171.1
CCDSiCCDS9049.1
PIRiT09074
RefSeqiNP_005752.1, NM_005761.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KUZX-ray2.30A/B1198-1305[»]
3NVNX-ray2.26B35-507[»]
3NVQX-ray2.40B/F35-507[»]
6VXKelectron microscopy3.10B/D35-1568[»]
AlphaFoldDBiO60486
SMRiO60486
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115456, 12 interactors
CORUMiO60486
IntActiO60486, 3 interactors
MINTiO60486
STRINGi9606.ENSP00000258526

PTM databases

GlyConnecti725, 8 N-Linked glycans (5 sites)
GlyGeniO60486, 21 sites, 14 N-linked glycans (5 sites)
iPTMnetiO60486
PhosphoSitePlusiO60486

Genetic variation databases

BioMutaiPLXNC1

Proteomic databases

EPDiO60486
jPOSTiO60486
MassIVEiO60486
MaxQBiO60486
PaxDbiO60486
PeptideAtlasiO60486
PRIDEiO60486
ProteomicsDBi49424

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30073, 121 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		10154

Genome annotation databases

EnsembliENST00000258526.9; ENSP00000258526.4; ENSG00000136040.9
GeneIDi10154
KEGGihsa:10154
MANE-SelectiENST00000258526.9; ENSP00000258526.4; NM_005761.3; NP_005752.1
UCSCiuc001tdc.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10154
DisGeNETi10154

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLXNC1
HGNCiHGNC:9106, PLXNC1
HPAiENSG00000136040, Low tissue specificity
MIMi604259, gene
neXtProtiNX_O60486
OpenTargetsiENSG00000136040
PharmGKBiPA33432
VEuPathDBiHostDB:ENSG00000136040

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3610, Eukaryota
GeneTreeiENSGT01020000230384
HOGENOMiCLU_004205_0_0_1
InParanoidiO60486
OMAiLFHGENK
OrthoDBi90434at2759
PhylomeDBiO60486
TreeFamiTF312962

Enzyme and pathway databases

PathwayCommonsiO60486
ReactomeiR-HSA-416700, Other semaphorin interactions
SignaLinkiO60486
SIGNORiO60486

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10154, 8 hits in 1065 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLXNC1, human
EvolutionaryTraceiO60486

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10154
PharosiO60486, Tbio

Protein Ontology

More...PROi		PR:O60486
RNActiO60486, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136040, Expressed in blood and 230 other tissues
ExpressionAtlasiO60486, baseline and differential
GenevisibleiO60486, HS

Family and domain databases

CDDicd11246, Sema_plexin_C1, 1 hit
Gene3Di1.10.506.10, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR002909, IPT_dom
IPR031148, Plexin
IPR041853, Plexin-C1_Sema
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625, PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337, Plexin_cytopl, 2 hits
PF01437, PSI, 1 hit
PF01833, TIG, 2 hits
SMARTiView protein in SMART
SM00429, IPT, 2 hits
SM00423, PSI, 2 hits
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60486
Secondary accession number(s): Q59H25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 1, 1998
Last modified: May 25, 2022
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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