UniProtKB - O60481 (ZIC3_HUMAN)
Zinc finger protein ZIC 3
ZIC3
Functioni
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 251 – 286 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 295 – 322 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 328 – 352 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 358 – 382 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 388 – 410 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anterior/posterior pattern specification Source: Ensembl
- cell differentiation Source: UniProtKB-KW
- central nervous system development Source: GO_Central
- determination of digestive tract left/right asymmetry Source: BHF-UCL
- determination of left/right asymmetry in nervous system Source: Ensembl
- determination of left/right symmetry Source: BHF-UCL
- determination of liver left/right asymmetry Source: BHF-UCL
- determination of pancreatic left/right asymmetry Source: BHF-UCL
- heart looping Source: BHF-UCL
- lung development Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O60481 |
Reactomei | R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-452723, Transcriptional regulation of pluripotent stem cells |
SignaLinki | O60481 |
SIGNORi | O60481 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein ZIC 3Alternative name(s): Zinc finger protein 203 Zinc finger protein of the cerebellum 3 |
Gene namesi | Name:ZIC3 Synonyms:ZNF203 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12874, ZIC3 |
MIMi | 300265, gene |
neXtProti | NX_O60481 |
VEuPathDBi | HostDB:ENSG00000156925 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Heterotaxy, visceral, 1, X-linked (HTX1)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025632 | 217 | P → A in HTX1 and CHTD1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3; decrease in nuclear localization. 4 PublicationsCorresponds to variant dbSNP:rs104894963EnsemblClinVar. | 1 | |
Natural variantiVAR_025633 | 253 | C → S in HTX1; increases strongly its cytoplasmic localization; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 3 PublicationsCorresponds to variant dbSNP:rs104894961EnsemblClinVar. | 1 | |
Natural variantiVAR_042416 | 255 | W → G in HTX1; decreases protein expression and transcriptional activity and increases its cytoplasmic localization. 2 PublicationsCorresponds to variant dbSNP:rs122463168EnsemblClinVar. | 1 | |
Natural variantiVAR_025634 | 286 | H → R in HTX1; inreases weakly its cytoplasmic localization; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 3 Publications | 1 | |
Natural variantiVAR_007753 | 323 | T → M in HTX1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 2 PublicationsCorresponds to variant dbSNP:rs122462165EnsemblClinVar. | 1 | |
Natural variantiVAR_025635 | 405 | K → E in HTX1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 2 PublicationsCorresponds to variant dbSNP:rs104894962EnsemblClinVar. | 1 |
VACTERL association X-linked with or without hydrocephalus (VACTERLX)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066626 | 46 | A → AAA in VACTERLX. 1 Publication | 1 | |
Natural variantiVAR_071333 | 318 | H → N in VACTERLX; decrease in transcriptional activator activity; significant decrease in nuclear localization. 1 Publication | 1 |
Congenital heart defects, multiple types, 1, X-linked (CHTD1)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071332 | 109 | S → C in CHTD1; does not affect its transcriptional activator activity; decrease in nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs373628598EnsemblClinVar. | 1 | |
Natural variantiVAR_025632 | 217 | P → A in HTX1 and CHTD1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3; decrease in nuclear localization. 4 PublicationsCorresponds to variant dbSNP:rs104894963EnsemblClinVar. | 1 | |
Natural variantiVAR_071334 | 447 | A → G in CHTD1; Increase in transcriptional activator activity; decrease in nuclear localization. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 268 | C → S: Increases weakly its cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 281 | H → R: Increases its cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 304 | R → M: Increases its cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 307 | K → M: Increases its cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 310 | K → M: Increases its cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 312 | K → M: Increases its cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 314 | K → M: Does not increase its cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 320 | R → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-337; A-341; A-346; A-349 and A-350. 1 Publication | 1 | |
Mutagenesisi | 326 | K → M: Does not increase its cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 337 | K → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-341; A-346; A-349 and A-350. 1 Publication | 1 | |
Mutagenesisi | 341 | R → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-346; A-349 and A-350. 1 Publication | 1 | |
Mutagenesisi | 346 | K → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-341; A-349 and A-350. 1 Publication | 1 | |
Mutagenesisi | 349 | K → A: Increases its cytoplasmic localization. Does not interacts with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-341; A-346 and A-350. 1 Publication | 1 | |
Mutagenesisi | 350 | R → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-341; A-346 and A-349. 1 Publication | 1 | |
Mutagenesisi | 356 | K → A: Does not increase its cytoplasmic localization. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, HeterotaxyOrganism-specific databases
DisGeNETi | 7547 |
MalaCardsi | ZIC3 |
MIMi | 306955, phenotype 314390, phenotype |
OpenTargetsi | ENSG00000156925 |
Orphaneti | 216718, Isolated congenitally uncorrected transposition of the great arteries 157769, Situs ambiguus |
PharmGKBi | PA37463 |
Miscellaneous databases
Pharosi | O60481, Tbio |
Genetic variation databases
BioMutai | ZIC3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047250 | 1 – 467 | Zinc finger protein ZIC 3Add BLAST | 467 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 248 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | O60481 |
MassIVEi | O60481 |
MaxQBi | O60481 |
PaxDbi | O60481 |
PeptideAtlasi | O60481 |
PRIDEi | O60481 |
ProteomicsDBi | 49422 [O60481-1] 49423 [O60481-2] |
PTM databases
iPTMneti | O60481 |
PhosphoSitePlusi | O60481 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156925, Expressed in embryo and 71 other tissues |
Genevisiblei | O60481, HS |
Organism-specific databases
HPAi | ENSG00000156925, Tissue enhanced (brain, choroid plexus, retina) |
Interactioni
Subunit structurei
Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity (By similarity).
Interacts with KPNA1 and KPNA6.
Interacts (via C2H2-type domains 3, 4 and 5) with GLI3; the interaction enhances its transcriptional activity.
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 113379, 8 interactors |
IntActi | O60481, 3 interactors |
STRINGi | 9606.ENSP00000287538 |
Miscellaneous databases
RNActi | O60481, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O60481 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60481 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 66 – 107 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 404 – 467 | DisorderedSequence analysisAdd BLAST | 64 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 297 – 322 | Nuclear localization signalAdd BLAST | 26 | |
Motifi | 330 – 352 | Nuclear localization signalAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 85 – 99 | Basic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 413 – 459 | Polar residuesSequence analysisAdd BLAST | 47 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 251 – 286 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 295 – 322 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 328 – 352 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 358 – 382 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 388 – 410 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160788 |
HOGENOMi | CLU_002678_37_1_1 |
InParanoidi | O60481 |
OMAi | PRHHDIG |
OrthoDBi | 768287at2759 |
PhylomeDBi | O60481 |
TreeFami | TF351425 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTMLLDGGPQ FPGLGVGSFG APRHHEMPNR EPAGMGLNPF GDSTHAAAAA
60 70 80 90 100
AAAAAFKLSP AAAHDLSSGQ SSAFTPQGSG YANALGHHHH HHHHHHHTSQ
110 120 130 140 150
VPSYGGAASA AFNSTREFLF RQRSSGLSEA ASGGGQHGLF AGSASSLHAP
160 170 180 190 200
AGIPEPPSYL LFPGLHEQGA GHPSPTGHVD NNQVHLGLRG ELFGRADPYR
210 220 230 240 250
PVASPRTDPY AAGAQFPNYS PMNMNMGVNV AAHHGPGAFF RYMRQPIKQE
260 270 280 290 300
LSCKWIDEAQ LSRPKKSCDR TFSTMHELVT HVTMEHVGGP EQNNHVCYWE
310 320 330 340 350
ECPREGKSFK AKYKLVNHIR VHTGEKPFPC PFPGCGKIFA RSENLKIHKR
360 370 380 390 400
THTGEKPFKC EFEGCDRRFA NSSDRKKHMH VHTSDKPYIC KVCDKSYTHP
410 420 430 440 450
SSLRKHMKVH ESQGSDSSPA ASSGYESSTP PAIASANSKD TTKTPSAVQT
460
STSHNPGLPP NFNEWYV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071330 | 17 | G → C Unknown pathological significance; no effect on its transcriptional activator activity or subcellular localization. 1 PublicationCorresponds to variant dbSNP:rs147232392EnsemblClinVar. | 1 | |
Natural variantiVAR_066626 | 46 | A → AAA in VACTERLX. 1 Publication | 1 | |
Natural variantiVAR_071331 | 53 | A → AA Unknown pathological significance; no effect on its transcriptional activator activity or subcellular localization. 1 Publication | 1 | |
Natural variantiVAR_071332 | 109 | S → C in CHTD1; does not affect its transcriptional activator activity; decrease in nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs373628598EnsemblClinVar. | 1 | |
Natural variantiVAR_025632 | 217 | P → A in HTX1 and CHTD1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3; decrease in nuclear localization. 4 PublicationsCorresponds to variant dbSNP:rs104894963EnsemblClinVar. | 1 | |
Natural variantiVAR_025633 | 253 | C → S in HTX1; increases strongly its cytoplasmic localization; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 3 PublicationsCorresponds to variant dbSNP:rs104894961EnsemblClinVar. | 1 | |
Natural variantiVAR_042416 | 255 | W → G in HTX1; decreases protein expression and transcriptional activity and increases its cytoplasmic localization. 2 PublicationsCorresponds to variant dbSNP:rs122463168EnsemblClinVar. | 1 | |
Natural variantiVAR_025634 | 286 | H → R in HTX1; inreases weakly its cytoplasmic localization; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 3 Publications | 1 | |
Natural variantiVAR_071333 | 318 | H → N in VACTERLX; decrease in transcriptional activator activity; significant decrease in nuclear localization. 1 Publication | 1 | |
Natural variantiVAR_007753 | 323 | T → M in HTX1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 2 PublicationsCorresponds to variant dbSNP:rs122462165EnsemblClinVar. | 1 | |
Natural variantiVAR_025635 | 405 | K → E in HTX1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 2 PublicationsCorresponds to variant dbSNP:rs104894962EnsemblClinVar. | 1 | |
Natural variantiVAR_071334 | 447 | A → G in CHTD1; Increase in transcriptional activator activity; decrease in nuclear localization. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044010 | 409 – 467 | VHESQ…NEWYV → CCPAWYPGQSLIPDEELDTD VGMQQPALHNTTYPKCRVNA EPTVQEMIY in isoform 2. CuratedAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF028706 mRNA Translation: AAC05594.1 EU532020 mRNA Translation: ACB30403.1 AL035443 Genomic DNA No translation available. BC113393 mRNA Translation: AAI13394.1 BC113395 mRNA Translation: AAI13396.1 |
CCDSi | CCDS14663.1 [O60481-1] CCDS83494.1 [O60481-2] |
RefSeqi | NP_001317590.1, NM_001330661.1 [O60481-2] NP_003404.1, NM_003413.3 [O60481-1] |
Genome annotation databases
Ensembli | ENST00000287538; ENSP00000287538; ENSG00000156925 ENST00000370606; ENSP00000359638; ENSG00000156925 [O60481-2] |
GeneIDi | 7547 |
KEGGi | hsa:7547 |
MANE-Selecti | ENST00000287538.10; ENSP00000287538.5; NM_003413.4; NP_003404.1 |
UCSCi | uc004fak.4, human [O60481-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Triplet repeat expansionSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF028706 mRNA Translation: AAC05594.1 EU532020 mRNA Translation: ACB30403.1 AL035443 Genomic DNA No translation available. BC113393 mRNA Translation: AAI13394.1 BC113395 mRNA Translation: AAI13396.1 |
CCDSi | CCDS14663.1 [O60481-1] CCDS83494.1 [O60481-2] |
RefSeqi | NP_001317590.1, NM_001330661.1 [O60481-2] NP_003404.1, NM_003413.3 [O60481-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EJ4 | NMR | - | A | 245-326 | [»] | |
2RPC | NMR | - | A | 245-386 | [»] | |
SMRi | O60481 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113379, 8 interactors |
IntActi | O60481, 3 interactors |
STRINGi | 9606.ENSP00000287538 |
PTM databases
iPTMneti | O60481 |
PhosphoSitePlusi | O60481 |
Genetic variation databases
BioMutai | ZIC3 |
Proteomic databases
jPOSTi | O60481 |
MassIVEi | O60481 |
MaxQBi | O60481 |
PaxDbi | O60481 |
PeptideAtlasi | O60481 |
PRIDEi | O60481 |
ProteomicsDBi | 49422 [O60481-1] 49423 [O60481-2] |
Protocols and materials databases
Antibodypediai | 30470, 277 antibodies from 32 providers |
DNASUi | 7547 |
Genome annotation databases
Ensembli | ENST00000287538; ENSP00000287538; ENSG00000156925 ENST00000370606; ENSP00000359638; ENSG00000156925 [O60481-2] |
GeneIDi | 7547 |
KEGGi | hsa:7547 |
MANE-Selecti | ENST00000287538.10; ENSP00000287538.5; NM_003413.4; NP_003404.1 |
UCSCi | uc004fak.4, human [O60481-1] |
Organism-specific databases
CTDi | 7547 |
DisGeNETi | 7547 |
GeneCardsi | ZIC3 |
HGNCi | HGNC:12874, ZIC3 |
HPAi | ENSG00000156925, Tissue enhanced (brain, choroid plexus, retina) |
MalaCardsi | ZIC3 |
MIMi | 300265, gene 306955, phenotype 314390, phenotype |
neXtProti | NX_O60481 |
OpenTargetsi | ENSG00000156925 |
Orphaneti | 216718, Isolated congenitally uncorrected transposition of the great arteries 157769, Situs ambiguus |
PharmGKBi | PA37463 |
VEuPathDBi | HostDB:ENSG00000156925 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160788 |
HOGENOMi | CLU_002678_37_1_1 |
InParanoidi | O60481 |
OMAi | PRHHDIG |
OrthoDBi | 768287at2759 |
PhylomeDBi | O60481 |
TreeFami | TF351425 |
Enzyme and pathway databases
PathwayCommonsi | O60481 |
Reactomei | R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-452723, Transcriptional regulation of pluripotent stem cells |
SignaLinki | O60481 |
SIGNORi | O60481 |
Miscellaneous databases
BioGRID-ORCSi | 7547, 4 hits in 682 CRISPR screens |
EvolutionaryTracei | O60481 |
GeneWikii | ZIC3 |
GenomeRNAii | 7547 |
Pharosi | O60481, Tbio |
PROi | PR:O60481 |
RNActi | O60481, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156925, Expressed in embryo and 71 other tissues |
Genevisiblei | O60481, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZIC3_HUMAN | |
Accessioni | O60481Primary (citable) accession number: O60481 Secondary accession number(s): B2CNW4, Q14DE5, Q5JY75 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 197 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families