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Protein

BMP/retinoic acid-inducible neural-specific protein 1

Gene

BRINP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.3 Publications

Miscellaneous

Silenced by methylation in 50% of bladder cancer cell lines.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Growth arrest

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.39.17.1 the membrane attack complex/perforin (macpf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 1
Alternative name(s):
Deleted in bladder cancer protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRINP1
Synonyms:DBC1, DBCCR1, FAM5A
ORF Names:IB3089A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000078725.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2687 BRINP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602865 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60477

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1620

Open Targets

More...
OpenTargetsi
ENSG00000078725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27156

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRINP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004576620 – 761BMP/retinoic acid-inducible neural-specific protein 1Add BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi677N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60477

PeptideAtlas

More...
PeptideAtlasi
O60477

PRoteomics IDEntifications database

More...
PRIDEi
O60477

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49417
49418 [O60477-2]
49419 [O60477-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60477

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60477

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000078725 Expressed in 140 organ(s), highest expression level in primary visual cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_DBC1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60477 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038828

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF326Q5BKZ15EBI-3904864,EBI-2560158

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107988, 31 interactors

Protein interaction database and analysis system

More...
IntActi
O60477, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265922

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60477

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 251MACPFAdd BLAST184

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BRINP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF4X Eukaryota
ENOG410XQ74 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158084

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049122

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081412

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60477

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTCVCHT

Database of Orthologous Groups

More...
OrthoDBi
157712at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60477

TreeFam database of animal gene trees

More...
TreeFami
TF331600

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033237 BRINP
IPR020864 MACPF

The PANTHER Classification System

More...
PANTHERi
PTHR15564 PTHR15564, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01823 MACPF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00457 MACPF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60477-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH
60 70 80 90 100
SRSYLSFVER HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE
110 120 130 140 150
FQRSIRLLGR RPTTQQFIDT IIKKYGTHLL ISATLGGEEA LTMYMDKSRL
160 170 180 190 200
DRKSGNATQS VEALHQLASS YFVDRDGTMR RLHEIQISTG AIKVTETRTG
210 220 230 240 250
PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE KFVQSALSYI
260 270 280 290 300
MCNGEGEYLC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ANMAKSWAEA
310 320 330 340 350
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSATE
360 370 380 390 400
AQRQKIQRTA RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN
410 420 430 440 450
GFWGTFLESQ RSCVCHGSTT LCQRPIPCVI GGNNSCAMCS LANISLCGSC
460 470 480 490 500
NKGYKLYRGR CEPQNVDSER SEQFISFETD LDFQDLELKY LLQKMDSRLY
510 520 530 540 550
VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM VIGMSMRICQ
560 570 580 590 600
MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
610 620 630 640 650
TLLLGNRWKT FFETVHIYLR SRTRLPTLLR NETGQGPVDL SDPSKRQFYI
660 670 680 690 700
KISDVQVFGY SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR
710 720 730 740 750
DRINRLAPPV APGKPQLDLF SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL
760
KQSDQMTAKL C
Length:761
Mass (Da):88,760
Last modified:January 24, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16FF47082FD52252
GO
Isoform 2 (identifier: O60477-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-320: DEFKSFMKRLPSN → GRESHSVPLHEWP
     321-761: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):37,168
Checksum:i216A4CB3D764C5C3
GO
Isoform 3 (identifier: O60477-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.

Note: No experimental confirmation available.
Show »
Length:476
Mass (Da):55,671
Checksum:iC27A7EF8373CAA04
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029989347S → R Common polymorphism. 1 Publication1
Natural variantiVAR_029990358R → H Common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs17476783Ensembl.1
Natural variantiVAR_024930437A → T2 PublicationsCorresponds to variant dbSNP:rs1043377Ensembl.1
Natural variantiVAR_036336712P → T in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0170211 – 285Missing in isoform 3. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_017022308 – 320DEFKS…RLPSN → GRESHSVPLHEWP in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_017023321 – 761Missing in isoform 2. 1 PublicationAdd BLAST441

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF027734 mRNA Translation: AAC39691.1
AL138894 Genomic DNA No translation available.
AL353773 Genomic DNA No translation available.
BC021560 mRNA Translation: AAH21560.1
BC065196 mRNA Translation: AAH65196.1
BC071702 mRNA Translation: AAH71702.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6822.1 [O60477-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T09052

NCBI Reference Sequences

More...
RefSeqi
NP_055433.2, NM_014618.2 [O60477-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.532316

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265922; ENSP00000265922; ENSG00000078725 [O60477-1]
ENST00000373964; ENSP00000363075; ENSG00000078725 [O60477-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1620

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1620

UCSC genome browser

More...
UCSCi
uc004bkc.3 human [O60477-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027734 mRNA Translation: AAC39691.1
AL138894 Genomic DNA No translation available.
AL353773 Genomic DNA No translation available.
BC021560 mRNA Translation: AAH21560.1
BC065196 mRNA Translation: AAH65196.1
BC071702 mRNA Translation: AAH71702.1
CCDSiCCDS6822.1 [O60477-1]
PIRiT09052
RefSeqiNP_055433.2, NM_014618.2 [O60477-1]
UniGeneiHs.532316

3D structure databases

ProteinModelPortaliO60477
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107988, 31 interactors
IntActiO60477, 22 interactors
STRINGi9606.ENSP00000265922

Protein family/group databases

TCDBi1.C.39.17.1 the membrane attack complex/perforin (macpf) family

PTM databases

iPTMnetiO60477
PhosphoSitePlusiO60477

Polymorphism and mutation databases

BioMutaiBRINP1

Proteomic databases

PaxDbiO60477
PeptideAtlasiO60477
PRIDEiO60477
ProteomicsDBi49417
49418 [O60477-2]
49419 [O60477-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265922; ENSP00000265922; ENSG00000078725 [O60477-1]
ENST00000373964; ENSP00000363075; ENSG00000078725 [O60477-2]
GeneIDi1620
KEGGihsa:1620
UCSCiuc004bkc.3 human [O60477-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1620
DisGeNETi1620
EuPathDBiHostDB:ENSG00000078725.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BRINP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0034750
HGNCiHGNC:2687 BRINP1
HPAiHPA038828
MIMi602865 gene
neXtProtiNX_O60477
OpenTargetsiENSG00000078725
PharmGKBiPA27156

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF4X Eukaryota
ENOG410XQ74 LUCA
GeneTreeiENSGT00940000158084
HOGENOMiHOG000049122
HOVERGENiHBG081412
InParanoidiO60477
OMAiRTCVCHT
OrthoDBi157712at2759
PhylomeDBiO60477
TreeFamiTF331600

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DBC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1620

Protein Ontology

More...
PROi
PR:O60477

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000078725 Expressed in 140 organ(s), highest expression level in primary visual cortex
CleanExiHS_DBC1
GenevisibleiO60477 HS

Family and domain databases

InterProiView protein in InterPro
IPR033237 BRINP
IPR020864 MACPF
PANTHERiPTHR15564 PTHR15564, 1 hit
PfamiView protein in Pfam
PF01823 MACPF, 1 hit
SMARTiView protein in SMART
SM00457 MACPF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRNP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60477
Secondary accession number(s): Q6IPV6, Q6P1A0, Q8WU22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: January 16, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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