UniProtKB - O60469 (DSCAM_HUMAN)
Down syndrome cell adhesion molecule
DSCAM
Functioni
Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149).
Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity).
In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994).
Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762).
Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994).
Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).
By similarity4 PublicationsGO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
- netrin receptor binding Source: UniProtKB
- protein tyrosine kinase binding Source: Ensembl
GO - Biological processi
- axon guidance Source: UniProtKB
- camera-type eye photoreceptor cell differentiation Source: UniProtKB
- cell adhesion Source: ProtInc
- dendrite morphogenesis Source: Ensembl
- dendrite self-avoidance Source: UniProtKB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- locomotory behavior Source: Ensembl
- negative regulation of cell adhesion Source: UniProtKB
- nervous system development Source: ProtInc
- positive regulation of axon extension involved in axon guidance Source: UniProtKB
- positive regulation of phosphorylation Source: UniProtKB
- post-embryonic retina morphogenesis in camera-type eye Source: Ensembl
- retina layer formation Source: UniProtKB
- synapse assembly Source: UniProtKB
Keywordsi
Biological process | Cell adhesion, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | O60469 |
Reactomei | R-HSA-376172, DSCAM interactions |
SignaLinki | O60469 |
SIGNORi | O60469 |
Names & Taxonomyi
Protein namesi | Recommended name: Down syndrome cell adhesion moleculeAlternative name(s): CHD2 |
Gene namesi | Name:DSCAM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3039, DSCAM |
MIMi | 602523, gene |
neXtProti | NX_O60469 |
VEuPathDBi | HostDB:ENSG00000171587 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- axon By similarity
- dendrite By similarity
- growth cone By similarity
- synapse By similarity
Note: Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: UniProtKB
Other locations
- axon Source: UniProtKB
- dendrite Source: UniProtKB
- growth cone Source: UniProtKB
- membrane Source: ProtInc
- neuronal cell body Source: UniProtKB
- synapse Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 1595 | ExtracellularSequence analysisAdd BLAST | 1578 | |
Transmembranei | 1596 – 1616 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1617 – 2012 | CytoplasmicSequence analysisAdd BLAST | 396 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, Secreted, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 1826 |
OpenTargetsi | ENSG00000171587 |
PharmGKBi | PA27491 |
Miscellaneous databases
Pharosi | O60469, Tbio |
Genetic variation databases
BioMutai | DSCAM |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000014747 | 18 – 2012 | Down syndrome cell adhesion moleculeAdd BLAST | 1995 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 46 ↔ 102 | PROSITE-ProRule annotation | ||
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 145 ↔ 197 | PROSITE-ProRule annotation | ||
Disulfide bondi | 246 ↔ 293 | PROSITE-ProRule annotation | ||
Disulfide bondi | 335 ↔ 385 | PROSITE-ProRule annotation | ||
Disulfide bondi | 428 ↔ 484 | PROSITE-ProRule annotation | ||
Glycosylationi | 470 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 487 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 512 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 525 ↔ 575 | PROSITE-ProRule annotation | ||
Glycosylationi | 556 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 617 ↔ 669 | PROSITE-ProRule annotation | ||
Glycosylationi | 658 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 666 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 710 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 711 ↔ 766 | PROSITE-ProRule annotation | ||
Glycosylationi | 748 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 795 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 809 ↔ 865 | PROSITE-ProRule annotation | ||
Glycosylationi | 924 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1142 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1160 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1250 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1271 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1307 ↔ 1359 | PROSITE-ProRule annotation | ||
Glycosylationi | 1341 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1488 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | O60469 |
jPOSTi | O60469 |
MassIVEi | O60469 |
PaxDbi | O60469 |
PeptideAtlasi | O60469 |
PRIDEi | O60469 |
ProteomicsDBi | 49414 [O60469-1] 49415 [O60469-2] |
PTM databases
GlyGeni | O60469, 18 sites |
iPTMneti | O60469 |
PhosphoSitePlusi | O60469 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000171587, Expressed in endometrium epithelium and 73 other tissues |
ExpressionAtlasi | O60469, baseline and differential |
Genevisiblei | O60469, HS |
Organism-specific databases
HPAi | ENSG00000171587, Group enriched (brain, pituitary gland, retina) |
Interactioni
Subunit structurei
Homodimer; mediates homophilic interactions to promote cell adhesion (By similarity).
Interacts with DCC; the interaction is abolished in response to NTN1 (By similarity).
Interacts (via extracellular domain) with NTN1 (PubMed:19196994). Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1 (PubMed:15169762).
Interacts (via cytoplasmic domain) with PAK1; the interaction is direct and enhanced in presence of RAC1 (PubMed:15169762).
Interacts with RAC1; the interaction requires PAK1 (PubMed:15169762).
Interacts (via extracellular domain) with UNC5C (via Ig-like C2-type domain) (PubMed:22685302).
Interacts with PTK2 (By similarity).
Interacts with FYN (By similarity).
By similarity3 PublicationsBinary interactionsi
O60469
With | #Exp. | IntAct |
---|---|---|
PIH1D2 [Q8WWB5] | 3 | EBI-19949317,EBI-10232538 |
GO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
- netrin receptor binding Source: UniProtKB
- protein tyrosine kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108160, 3 interactors |
IntActi | O60469, 1 interactor |
STRINGi | 9606.ENSP00000383303 |
Miscellaneous databases
RNActi | O60469, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 129 | Ig-like C2-type 1Add BLAST | 91 | |
Domaini | 125 – 216 | Ig-like C2-type 2Add BLAST | 92 | |
Domaini | 225 – 305 | Ig-like C2-type 3Add BLAST | 81 | |
Domaini | 313 – 401 | Ig-like C2-type 4Add BLAST | 89 | |
Domaini | 407 – 500 | Ig-like C2-type 5Add BLAST | 94 | |
Domaini | 504 – 592 | Ig-like C2-type 6Add BLAST | 89 | |
Domaini | 596 – 685 | Ig-like C2-type 7Add BLAST | 90 | |
Domaini | 690 – 783 | Ig-like C2-type 8Add BLAST | 94 | |
Domaini | 787 – 883 | Ig-like C2-type 9Add BLAST | 97 | |
Domaini | 885 – 982 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 987 – 1086 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 1091 – 1187 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 1191 – 1285 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 1285 – 1377 | Ig-like C2-type 10Add BLAST | 93 | |
Domaini | 1379 – 1473 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 1474 – 1575 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 102 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1617 – 2012 | Required for netrin-mediated axon repulsion of neuronal growth conesBy similarityAdd BLAST | 396 | |
Regioni | 1718 – 1810 | DisorderedSequence analysisAdd BLAST | 93 | |
Regioni | 1855 – 1883 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1971 – 2012 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1725 – 1767 | Polar residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 1782 – 1810 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1855 – 1869 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1982 – 1996 | Polar residuesSequence analysisAdd BLAST | 15 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3510, Eukaryota |
GeneTreei | ENSGT00940000154678 |
HOGENOMi | CLU_001038_0_1_1 |
InParanoidi | O60469 |
OMAi | TFATLNY |
OrthoDBi | 14047at2759 |
PhylomeDBi | O60469 |
TreeFami | TF316846 |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 16 hits |
InterProi | View protein in InterPro IPR043204, Basigin-like IPR033027, DSCAM_metazoan IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR10075, PTHR10075, 1 hit PTHR10075:SF51, PTHR10075:SF51, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 5 hits PF07679, I-set, 5 hits |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 9 hits SM00408, IGc2, 9 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 9 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 9 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWILALSLFQ SFANVFSEDL HSSLYFVNAS LQEVVFASTT GTLVPCPAAG
60 70 80 90 100
IPPVTLRWYL ATGEEIYDVP GIRHVHPNGT LQIFPFPPSS FSTLIHDNTY
110 120 130 140 150
YCTAENPSGK IRSQDVHIKA VLREPYTVRV EDQKTMRGNV AVFKCIIPSS
160 170 180 190 200
VEAYITVVSW EKDTVSLVSG SRFLITSTGA LYIKDVQNED GLYNYRCITR
210 220 230 240 250
HRYTGETRQS NSARLFVSDP ANSAPSILDG FDHRKAMAGQ RVELPCKALG
260 270 280 290 300
HPEPDYRWLK DNMPLELSGR FQKTVTGLLI ENIRPSDSGS YVCEVSNRYG
310 320 330 340 350
TAKVIGRLYV KQPLKATISP RKVKSSVGSQ VSLSCSVTGT EDQELSWYRN
360 370 380 390 400
GEILNPGKNV RITGINHENL IMDHMVKSDG GAYQCFVRKD KLSAQDYVQV
410 420 430 440 450
VLEDGTPKII SAFSEKVVSP AEPVSLMCNV KGTPLPTITW TLDDDPILKG
460 470 480 490 500
GSHRISQMIT SEGNVVSYLN ISSSQVRDGG VYRCTANNSA GVVLYQARIN
510 520 530 540 550
VRGPASIRPM KNITAIAGRD TYIHCRVIGY PYYSIKWYKN SNLLPFNHRQ
560 570 580 590 600
VAFENNGTLK LSDVQKEVDE GEYTCNVLVQ PQLSTSQSVH VTVKVPPFIQ
610 620 630 640 650
PFEFPRFSIG QRVFIPCVVV SGDLPITITW QKDGRPIPGS LGVTIDNIDF
660 670 680 690 700
TSSLRISNLS LMHNGNYTCI ARNEAAAVEH QSQLIVRVPP KFVVQPRDQD
710 720 730 740 750
GIYGKAVILN CSAEGYPVPT IVWKFSKGAG VPQFQPIALN GRIQVLSNGS
760 770 780 790 800
LLIKHVVEED SGYYLCKVSN DVGADVSKSM YLTVKIPAMI TSYPNTTLAT
810 820 830 840 850
QGQKKEMSCT AHGEKPIIVR WEKEDRIINP EMARYLVSTK EVGEEVISTL
860 870 880 890 900
QILPTVREDS GFFSCHAINS YGEDRGIIQL TVQEPPDPPE IEIKDVKART
910 920 930 940 950
ITLRWTMGFD GNSPITGYDI ECKNKSDSWD SAQRTKDVSP QLNSATIIDI
960 970 980 990 1000
HPSSTYSIRM YAKNRIGKSE PSNELTITAD EAAPDGPPQE VHLEPISSQS
1010 1020 1030 1040 1050
IRVTWKAPKK HLQNGIIRGY QIGYREYSTG GNFQFNIISV DTSGDSEVYT
1060 1070 1080 1090 1100
LDNLNKFTQY GLVVQACNRA GTGPSSQEII TTTLEDVPSY PPENVQAIAT
1110 1120 1130 1140 1150
SPESISISWS TLSKEALNGI LQGFRVIYWA NLMDGELGEI KNITTTQPSL
1160 1170 1180 1190 1200
ELDGLEKYTN YSIQVLAFTR AGDGVRSEQI FTRTKEDVPG PPAGVKAAAA
1210 1220 1230 1240 1250
SASMVFVSWL PPLKLNGIIR KYTVFCSHPY PTVISEFEAS PDSFSYRIPN
1260 1270 1280 1290 1300
LSRNRQYSVW VVAVTSAGRG NSSEIITVEP LAKAPARILT FSGTVTTPWM
1310 1320 1330 1340 1350
KDIVLPCKAV GDPSPAVKWM KDSNGTPSLV TIDGRRSIFS NGSFIIRTVK
1360 1370 1380 1390 1400
AEDSGYYSCI ANNNWGSDEI ILNLQVQVPP DQPRLTVSKT TSSSITLSWL
1410 1420 1430 1440 1450
PGDNGGSSIR GYILQYSEDN SEQWGSFPIS PSERSYRLEN LKCGTWYKFT
1460 1470 1480 1490 1500
LTAQNGVGPG RISEIIEAKT LGKEPQFSKE QELFASINTT RVRLNLIGWN
1510 1520 1530 1540 1550
DGGCPITSFT LEYRPFGTTV WTTAQRTSLS KSYILYDLQE ATWYELQMRV
1560 1570 1580 1590 1600
CNSAGCAEKQ ANFATLNYDG STIPPLIKSV VQNEEGLTTN EGLKMLVTIS
1610 1620 1630 1640 1650
CILVGVLLLF VLLLVVRRRR REQRLKRLRD AKSLAEMLMS KNTRTSDTLS
1660 1670 1680 1690 1700
KQQQTLRMHI DIPRAQLLIE ERDTMETIDD RSTVLLTDAD FGEAAKQKSL
1710 1720 1730 1740 1750
TVTHTVHYQS VSQATGPLVD VSDARPGTNP TTRRNAKAGP TARNRYASQW
1760 1770 1780 1790 1800
TLNRPHPTIS AHTLTTDWRL PTPRAAGSVD KESDSYSVSP SQDTDRARSS
1810 1820 1830 1840 1850
MVSTESASST YEELARAYEH AKMEEQLRHA KFTITECFIS DTSSEQLTAG
1860 1870 1880 1890 1900
TNEYTDSLTS STPSESGICR FTASPPKPQD GGRVMNMAVP KAHRPGDLIH
1910 1920 1930 1940 1950
LPPYLRMDFL LNRGGPGTSR DLSLGQACLE PQKSRTLKRP TVLEPIPMEA
1960 1970 1980 1990 2000
ASSASSTREG QSWQPGAVAT LPQREGAELG QAAKMSSSQE SLLDSRGHLK
2010
GNNPYAKSYT LV
The sequence of this isoform differs from the canonical sequence as follows:
1562-1571: NFATLNYDGS → KEAARCKEFS
1572-2012: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8WY19 | Q8WY19_HUMAN | Down syndrome cell adhesion molecul... | DSCAM | 1,746 | Annotation score: | ||
A0A087WUI7 | A0A087WUI7_HUMAN | Down syndrome cell adhesion molecul... | DSCAM | 1,847 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1893 – 2012 | HRPGD…SYTLV → IGQVTSYICLHTLEWTFC in AAC17966 (PubMed:9426258).CuratedAdd BLAST | 120 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020080 | 232 | D → E. Corresponds to variant dbSNP:rs2297270Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002502 | 1562 – 1571 | NFATLNYDGS → KEAARCKEFS in isoform Short. Curated | 10 | |
Alternative sequenceiVSP_002503 | 1572 – 2012 | Missing in isoform Short. CuratedAdd BLAST | 441 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF023450 mRNA Translation: AAC17967.1 AF023449 mRNA Translation: AAC17966.1 AF217525 mRNA Translation: AAF27525.1 AL163283 Genomic DNA Translation: CAB90464.1 AL163282 Genomic DNA Translation: CAB90436.1 AL163281 Genomic DNA Translation: CAB90444.1 |
CCDSi | CCDS42929.1 [O60469-1] |
RefSeqi | NP_001380.2, NM_001389.3 [O60469-1] |
Genome annotation databases
Ensembli | ENST00000400454; ENSP00000383303; ENSG00000171587 |
GeneIDi | 1826 |
KEGGi | hsa:1826 |
MANE-Selecti | ENST00000400454.6; ENSP00000383303.1; NM_001389.5; NP_001380.2 |
UCSCi | uc002yyq.2, human [O60469-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF023450 mRNA Translation: AAC17967.1 AF023449 mRNA Translation: AAC17966.1 AF217525 mRNA Translation: AAF27525.1 AL163283 Genomic DNA Translation: CAB90464.1 AL163282 Genomic DNA Translation: CAB90436.1 AL163281 Genomic DNA Translation: CAB90444.1 |
CCDSi | CCDS42929.1 [O60469-1] |
RefSeqi | NP_001380.2, NM_001389.3 [O60469-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6ZR7 | X-ray | 1.85 | AAA | 595-884 | [»] | |
SMRi | O60469 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108160, 3 interactors |
IntActi | O60469, 1 interactor |
STRINGi | 9606.ENSP00000383303 |
PTM databases
GlyGeni | O60469, 18 sites |
iPTMneti | O60469 |
PhosphoSitePlusi | O60469 |
Genetic variation databases
BioMutai | DSCAM |
Proteomic databases
EPDi | O60469 |
jPOSTi | O60469 |
MassIVEi | O60469 |
PaxDbi | O60469 |
PeptideAtlasi | O60469 |
PRIDEi | O60469 |
ProteomicsDBi | 49414 [O60469-1] 49415 [O60469-2] |
Protocols and materials databases
Antibodypediai | 23484, 167 antibodies from 31 providers |
DNASUi | 1826 |
Genome annotation databases
Ensembli | ENST00000400454; ENSP00000383303; ENSG00000171587 |
GeneIDi | 1826 |
KEGGi | hsa:1826 |
MANE-Selecti | ENST00000400454.6; ENSP00000383303.1; NM_001389.5; NP_001380.2 |
UCSCi | uc002yyq.2, human [O60469-1] |
Organism-specific databases
CTDi | 1826 |
DisGeNETi | 1826 |
GeneCardsi | DSCAM |
HGNCi | HGNC:3039, DSCAM |
HPAi | ENSG00000171587, Group enriched (brain, pituitary gland, retina) |
MIMi | 602523, gene |
neXtProti | NX_O60469 |
OpenTargetsi | ENSG00000171587 |
PharmGKBi | PA27491 |
VEuPathDBi | HostDB:ENSG00000171587 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3510, Eukaryota |
GeneTreei | ENSGT00940000154678 |
HOGENOMi | CLU_001038_0_1_1 |
InParanoidi | O60469 |
OMAi | TFATLNY |
OrthoDBi | 14047at2759 |
PhylomeDBi | O60469 |
TreeFami | TF316846 |
Enzyme and pathway databases
PathwayCommonsi | O60469 |
Reactomei | R-HSA-376172, DSCAM interactions |
SignaLinki | O60469 |
SIGNORi | O60469 |
Miscellaneous databases
BioGRID-ORCSi | 1826, 3 hits in 1036 CRISPR screens |
ChiTaRSi | DSCAM, human |
GenomeRNAii | 1826 |
Pharosi | O60469, Tbio |
PROi | PR:O60469 |
RNActi | O60469, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171587, Expressed in endometrium epithelium and 73 other tissues |
ExpressionAtlasi | O60469, baseline and differential |
Genevisiblei | O60469, HS |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 16 hits |
InterProi | View protein in InterPro IPR043204, Basigin-like IPR033027, DSCAM_metazoan IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR10075, PTHR10075, 1 hit PTHR10075:SF51, PTHR10075:SF51, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 5 hits PF07679, I-set, 5 hits |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 9 hits SM00408, IGc2, 9 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 9 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DSCAM_HUMAN | |
Accessioni | O60469Primary (citable) accession number: O60469 Secondary accession number(s): O60468 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references