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Entry version 180 (08 May 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Neuropilin-2

Gene

NRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi197CalciumCombined sources1 Publication1
Metal bindingi211CalciumCombined sources1 Publication1
Metal bindingi252CalciumCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Receptor
Biological processDifferentiation, Host-virus interaction, Neurogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194306 Neurophilin interactions with VEGF and VEGFR
R-HSA-447038 NrCAM interactions

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60462

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuropilin-2
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRP2
Synonyms:VEGF165R2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8005 NRP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602070 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60462

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 864ExtracellularSequence analysisAdd BLAST844
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei865 – 889HelicalSequence analysisAdd BLAST25
Topological domaini890 – 931CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8828

Open Targets

More...
OpenTargetsi
ENSG00000118257

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31784

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NRP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Or 22Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002186321 – 931Neuropilin-2Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 551 Publication
Disulfide bondi83 ↔ 1051 Publication
Disulfide bondi149 ↔ 1751 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi152N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi157N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi208 ↔ 2301 Publication
Disulfide bondi277 ↔ 4271 Publication
Disulfide bondi434 ↔ 5921 Publication
Glycosylationi629N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi839N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60462

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60462

PeptideAtlas

More...
PeptideAtlasi
O60462

PRoteomics IDEntifications database

More...
PRIDEi
O60462

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49409
49410 [O60462-2]
49411 [O60462-3]
49412 [O60462-4]
49413 [O60462-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60462

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60462

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60462

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118257 Expressed in 176 organ(s), highest expression level in lower esophagus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60462 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60462 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039980
HPA054974

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with NRP1. Binds PLXNB1.1 Publication
(Microbial infection) Interacts with human cytomegalovirus proteins gL, UL128, UL130 and UL131A.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
VegfcP97953-13EBI-12586256,EBI-16148671From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114355, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O60462

Database of interacting proteins

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DIPi
DIP-5745N

Protein interaction database and analysis system

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IntActi
O60462, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353582

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1931
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QQJX-ray1.95A275-595[»]
2QQKX-ray2.75A23-595[»]
2QQLX-ray3.10A23-595[»]
2QQOX-ray2.30A/B145-595[»]
4QDQX-ray1.95A/B276-595[»]
4QDRX-ray2.40A276-595[»]
4QDSX-ray2.40A/B275-457[»]
5DN2X-ray1.95A/B/C/D275-429[»]
5DQ0X-ray1.80A275-430[»]
6GH8X-ray2.44A/C27-146[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60462

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O60462

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 142CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 267CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini277 – 427F5/8 type C 1PROSITE-ProRule annotationAdd BLAST151
Domaini434 – 592F5/8 type C 2PROSITE-ProRule annotationAdd BLAST159
Domaini642 – 802MAMPROSITE-ProRule annotationAdd BLAST161

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi671 – 674Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neuropilin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHB5 Eukaryota
ENOG410ZPIE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155270

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60462

KEGG Orthology (KO)

More...
KOi
K06819

Identification of Orthologs from Complete Genome Data

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OMAi
NCNFDLP

Database of Orthologous Groups

More...
OrthoDBi
124611at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60462

TreeFam database of animal gene trees

More...
TreeFami
TF316506

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 2 hits
cd00057 FA58C, 2 hits
cd06263 MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR027143 Neuropilin-2
IPR022579 Neuropilin_C
IPR035914 Sperma_CUB_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46806:SF2 PTHR46806:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036960 Neuropilin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00020 MAMDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS50060 MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A22 (identifier: O60462-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP
60 70 80 90 100
SHQNCEWIVY APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL
110 120 130 140 150
LGKHCGNIAP PTIISSGSML YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS
160 170 180 190 200
KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL AKPKMEIILQ FLIFDLEHDP
210 220 230 240 250
LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS STGILSLTFH
260 270 280 290 300
TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS
310 320 330 340 350
DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR
360 370 380 390 400
ETQNGYYVKS YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA
410 420 430 440 450
PLLTRFVRIR PQTWHSGIAL RLELFGCRVT DAPCSNMLGM LSGLIADSQI
460 470 480 490 500
SASSTQEYLW SPSAARLVSS RSGWFPRIPQ AQPGEEWLQV DLGTPKTVKG
510 520 530 540 550
VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD PRTQQPKLFE
560 570 580 590 600
GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT
610 620 630 640 650
VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF
660 670 680 690 700
LEEPCGWMYD HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA
710 720 730 740 750
RLISPPVHLP RSPVCMEFQY QATGGRGVAL QVVREASQES KLLWVIREDQ
760 770 780 790 800
GGEWKHGRII LPSYDMEYQI VFEGVIGKGR SGEIAIDDIR ISTDVPLENC
810 820 830 840 850
MEPISAFAGE NFKVDIPEIH EREGYEDEID DEYEVDWSNS SSATSGSGAP
860 870 880 890 900
STDKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR
910 920 930
SCTTLENYNF ELYDGLKHKV KMNHQKCCSE A
Length:931
Mass (Da):104,831
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i270CBAE69A0A797C
GO
Isoform A0 (identifier: O60462-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-830: Missing.

Show »
Length:909
Mass (Da):102,215
Checksum:i983E34FD23E3B3FB
GO
Isoform A17 (identifier: O60462-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.

Show »
Length:926
Mass (Da):104,255
Checksum:i40000DC73D237AF6
GO
Isoform B0 (identifier: O60462-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.
     814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

Show »
Length:901
Mass (Da):101,381
Checksum:iA1310304AFD086AB
GO
Isoform B5 (identifier: O60462-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

Show »
Length:906
Mass (Da):101,957
Checksum:iEB183F265457B0B9
GO
Isoform s9 (identifier: O60462-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-555: LFEGNMHY → VGCSWRPL
     556-931: Missing.

Show »
Length:555
Mass (Da):62,430
Checksum:iB67B7C992AB0546F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JH98C9JH98_HUMAN
Neuropilin-2
NRP2
101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047754123K → R1 PublicationCorresponds to variant dbSNP:rs849541Ensembl.1
Natural variantiVAR_067537334R → C Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 PublicationCorresponds to variant dbSNP:rs114144673EnsemblClinVar.1
Natural variantiVAR_067538428R → W Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 PublicationCorresponds to variant dbSNP:rs139711818Ensembl.1
Natural variantiVAR_065167602E → K2 PublicationsCorresponds to variant dbSNP:rs1128169Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044908548 – 555LFEGNMHY → VGCSWRPL in isoform s9. 1 Publication8
Alternative sequenceiVSP_044909556 – 931Missing in isoform s9. 1 PublicationAdd BLAST376
Alternative sequenceiVSP_004342809 – 830Missing in isoform A0. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_004341809 – 813Missing in isoform A17 and isoform B0. 3 Publications5
Alternative sequenceiVSP_041160814 – 931VDIPE…CCSEA → GGTLLPGTEPTVDTVPMQPI PAYWYYVMAAGGAVLVLVSV ALALVLHYHRFRYAAKKTDH SITYKTSHYTNGAPLAVEPT LTIKLEQDRGSHC in isoform B0 and isoform B5. 2 PublicationsAdd BLAST118

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF022859 mRNA Translation: AAC51788.1
AF022860 mRNA Translation: AAC51789.1
AF016098 mRNA Translation: AAC12922.1
AF280544 mRNA Translation: AAG41403.1
AF280545 mRNA Translation: AAG41404.1
AF280546 mRNA Translation: AAG41405.1
KJ534899 mRNA Translation: AHW56539.1
AF281074 Genomic DNA Translation: AAG41897.1
AF281074 Genomic DNA Translation: AAG41898.1
AF281074 Genomic DNA Translation: AAG41899.1
AF281074 Genomic DNA Translation: AAG41900.1
AC007362 Genomic DNA Translation: AAX93216.1
AC007561 Genomic DNA Translation: AAY14875.1
KF459587 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70362.1
CH471063 Genomic DNA Translation: EAW70363.1
CH471063 Genomic DNA Translation: EAW70364.1
CH471063 Genomic DNA Translation: EAW70366.1
CH471063 Genomic DNA Translation: EAW70368.1
CH471063 Genomic DNA Translation: EAW70369.1
CH471063 Genomic DNA Translation: EAW70371.1
CH471063 Genomic DNA Translation: EAW70372.1
CH471063 Genomic DNA Translation: EAW70373.1
BC101525 mRNA Translation: AAI01526.1
BC104770 mRNA Translation: AAI04771.1
BC143238 mRNA Translation: AAI43239.1
BC117413 mRNA Translation: AAI17414.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2364.1 [O60462-1]
CCDS2365.1 [O60462-5]
CCDS46496.1 [O60462-3]
CCDS46497.1 [O60462-2]
CCDS46498.1 [O60462-4]
CCDS46499.1 [O60462-6]

NCBI Reference Sequences

More...
RefSeqi
NP_003863.2, NM_003872.2 [O60462-3]
NP_061004.3, NM_018534.3 [O60462-5]
NP_957716.1, NM_201264.1 [O60462-6]
NP_957718.1, NM_201266.1 [O60462-1]
NP_957719.1, NM_201267.1 [O60462-4]
NP_958436.1, NM_201279.1 [O60462-2]
XP_005246990.2, XM_005246933.3
XP_005246991.2, XM_005246934.3
XP_016860674.1, XM_017005185.1
XP_016860675.1, XM_017005186.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272849; ENSP00000272849; ENSG00000118257 [O60462-5]
ENST00000357118; ENSP00000349632; ENSG00000118257 [O60462-4]
ENST00000357785; ENSP00000350432; ENSG00000118257 [O60462-3]
ENST00000360409; ENSP00000353582; ENSG00000118257 [O60462-1]
ENST00000412873; ENSP00000407626; ENSG00000118257 [O60462-2]
ENST00000417189; ENSP00000387519; ENSG00000118257 [O60462-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8828

UCSC genome browser

More...
UCSCi
uc002vau.4 human [O60462-1]
uc002vav.4 human
uc002vaw.3 human
uc002vax.4 human
uc002vay.4 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022859 mRNA Translation: AAC51788.1
AF022860 mRNA Translation: AAC51789.1
AF016098 mRNA Translation: AAC12922.1
AF280544 mRNA Translation: AAG41403.1
AF280545 mRNA Translation: AAG41404.1
AF280546 mRNA Translation: AAG41405.1
KJ534899 mRNA Translation: AHW56539.1
AF281074 Genomic DNA Translation: AAG41897.1
AF281074 Genomic DNA Translation: AAG41898.1
AF281074 Genomic DNA Translation: AAG41899.1
AF281074 Genomic DNA Translation: AAG41900.1
AC007362 Genomic DNA Translation: AAX93216.1
AC007561 Genomic DNA Translation: AAY14875.1
KF459587 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70362.1
CH471063 Genomic DNA Translation: EAW70363.1
CH471063 Genomic DNA Translation: EAW70364.1
CH471063 Genomic DNA Translation: EAW70366.1
CH471063 Genomic DNA Translation: EAW70368.1
CH471063 Genomic DNA Translation: EAW70369.1
CH471063 Genomic DNA Translation: EAW70371.1
CH471063 Genomic DNA Translation: EAW70372.1
CH471063 Genomic DNA Translation: EAW70373.1
BC101525 mRNA Translation: AAI01526.1
BC104770 mRNA Translation: AAI04771.1
BC143238 mRNA Translation: AAI43239.1
BC117413 mRNA Translation: AAI17414.1
CCDSiCCDS2364.1 [O60462-1]
CCDS2365.1 [O60462-5]
CCDS46496.1 [O60462-3]
CCDS46497.1 [O60462-2]
CCDS46498.1 [O60462-4]
CCDS46499.1 [O60462-6]
RefSeqiNP_003863.2, NM_003872.2 [O60462-3]
NP_061004.3, NM_018534.3 [O60462-5]
NP_957716.1, NM_201264.1 [O60462-6]
NP_957718.1, NM_201266.1 [O60462-1]
NP_957719.1, NM_201267.1 [O60462-4]
NP_958436.1, NM_201279.1 [O60462-2]
XP_005246990.2, XM_005246933.3
XP_005246991.2, XM_005246934.3
XP_016860674.1, XM_017005185.1
XP_016860675.1, XM_017005186.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QQJX-ray1.95A275-595[»]
2QQKX-ray2.75A23-595[»]
2QQLX-ray3.10A23-595[»]
2QQOX-ray2.30A/B145-595[»]
4QDQX-ray1.95A/B276-595[»]
4QDRX-ray2.40A276-595[»]
4QDSX-ray2.40A/B275-457[»]
5DN2X-ray1.95A/B/C/D275-429[»]
5DQ0X-ray1.80A275-430[»]
6GH8X-ray2.44A/C27-146[»]
SMRiO60462
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114355, 21 interactors
CORUMiO60462
DIPiDIP-5745N
IntActiO60462, 2 interactors
STRINGi9606.ENSP00000353582

PTM databases

iPTMnetiO60462
PhosphoSitePlusiO60462
SwissPalmiO60462

Polymorphism and mutation databases

BioMutaiNRP2

Proteomic databases

jPOSTiO60462
PaxDbiO60462
PeptideAtlasiO60462
PRIDEiO60462
ProteomicsDBi49409
49410 [O60462-2]
49411 [O60462-3]
49412 [O60462-4]
49413 [O60462-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8828
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272849; ENSP00000272849; ENSG00000118257 [O60462-5]
ENST00000357118; ENSP00000349632; ENSG00000118257 [O60462-4]
ENST00000357785; ENSP00000350432; ENSG00000118257 [O60462-3]
ENST00000360409; ENSP00000353582; ENSG00000118257 [O60462-1]
ENST00000412873; ENSP00000407626; ENSG00000118257 [O60462-2]
ENST00000417189; ENSP00000387519; ENSG00000118257 [O60462-6]
GeneIDi8828
KEGGihsa:8828
UCSCiuc002vau.4 human [O60462-1]
uc002vav.4 human
uc002vaw.3 human
uc002vax.4 human
uc002vay.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8828
DisGeNETi8828

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NRP2
HGNCiHGNC:8005 NRP2
HPAiHPA039980
HPA054974
MIMi602070 gene
neXtProtiNX_O60462
OpenTargetsiENSG00000118257
PharmGKBiPA31784

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHB5 Eukaryota
ENOG410ZPIE LUCA
GeneTreeiENSGT00940000155270
InParanoidiO60462
KOiK06819
OMAiNCNFDLP
OrthoDBi124611at2759
PhylomeDBiO60462
TreeFamiTF316506

Enzyme and pathway databases

ReactomeiR-HSA-194306 Neurophilin interactions with VEGF and VEGFR
R-HSA-447038 NrCAM interactions
SIGNORiO60462

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NRP2 human
EvolutionaryTraceiO60462

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NRP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8828

Protein Ontology

More...
PROi
PR:O60462

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118257 Expressed in 176 organ(s), highest expression level in lower esophagus
ExpressionAtlasiO60462 baseline and differential
GenevisibleiO60462 HS

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00057 FA58C, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR027143 Neuropilin-2
IPR022579 Neuropilin_C
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR46806:SF2 PTHR46806:SF2, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
PRINTSiPR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS50060 MAM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60462
Secondary accession number(s): A0A024R3W6
, A0A024R412, E9PF66, O14820, O14821, Q53TQ4, Q53TS3, Q7LBX6, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4, X5D2Q8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 28, 2018
Last modified: May 8, 2019
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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