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Entry version 178 (07 Oct 2020)
Sequence version 3 (11 Jan 2011)
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Protein

Lymphocyte antigen 75

Gene

LY75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.By similarity

Miscellaneous

Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O60449

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lymphocyte antigen 75
Short name:
Ly-75
Alternative name(s):
C-type lectin domain family 13 member B
DEC-205
gp200-MR6
CD_antigen: CD205
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LY75
Synonyms:CD205, CLEC13B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000054219.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6729, LY75

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604524, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60449

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1666ExtracellularSequence analysisAdd BLAST1639
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1667 – 1691HelicalSequence analysisAdd BLAST25
Topological domaini1692 – 1722CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100526664
4065

Open Targets

More...
OpenTargetsi
ENSG00000054219
ENSG00000248672

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30493

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60449, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LY75

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 271 PublicationAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001755228 – 1722Lymphocyte antigen 75Add BLAST1695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi169 ↔ 194By similarity
Disulfide bondi183 ↔ 209By similarity
Disulfide bondi247 ↔ 340By similarity
Disulfide bondi317 ↔ 332By similarity
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi389 ↔ 485By similarity
Disulfide bondi462 ↔ 477By similarity
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi597 ↔ 614By similarity
Disulfide bondi840 ↔ 930By similarity
Glycosylationi843N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi865N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi904 ↔ 922By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei933PhosphotyrosineCombined sources1
Glycosylationi934N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1060 ↔ 1080By similarity
Glycosylationi1076N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1197 ↔ 1211By similarity
Glycosylationi1225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1392N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1488 ↔ 1502By similarity
Glycosylationi1593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1626N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1635 ↔ 1650By similarity
Modified residuei1703PhosphoserineBy similarity1
Modified residuei1719PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60449

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O60449

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60449

PeptideAtlas

More...
PeptideAtlasi
O60449

PRoteomics IDEntifications database

More...
PRIDEi
O60449

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49406 [O60449-1]
49407 [O60449-2]
49408 [O60449-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
O60449

GlyConnect protein glycosylation platform

More...
GlyConnecti
1472, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O60449, 20 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60449

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60449

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000054219, Expressed in thymus and 205 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60449, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000054219, Group enriched (intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O60449, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263636

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O60449, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60449

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 156Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST124
Domaini164 – 211Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST48
Domaini225 – 341C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini368 – 486C-type lectin 2PROSITE-ProRule annotationAdd BLAST119
Domaini493 – 625C-type lectin 3PROSITE-ProRule annotationAdd BLAST133
Domaini652 – 778C-type lectin 4PROSITE-ProRule annotationAdd BLAST127
Domaini818 – 931C-type lectin 5PROSITE-ProRule annotationAdd BLAST114
Domaini958 – 1091C-type lectin 6PROSITE-ProRule annotationAdd BLAST134
Domaini1110 – 1222C-type lectin 7PROSITE-ProRule annotationAdd BLAST113
Domaini1251 – 1374C-type lectin 8PROSITE-ProRule annotationAdd BLAST124
Domaini1401 – 1513C-type lectin 9PROSITE-ProRule annotationAdd BLAST113
Domaini1542 – 1661C-type lectin 10PROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002069_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60449

KEGG Orthology (KO)

More...
KOi
K06559

Identification of Orthologs from Complete Genome Data

More...
OMAi
TGKCIKP

Database of Orthologous Groups

More...
OrthoDBi
29241at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60449

TreeFam database of animal gene trees

More...
TreeFami
TF316663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062, FN2, 1 hit
cd00161, RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 10 hits
SM00059, FN2, 1 hit
SM00458, RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 10 hits
SSF57440, SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 10 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 4 (identifier: O60449-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTGWATPRR PAGLLMLLFW FFDLAEPSGR AANDPFTIVH GNTGKCIKPV
60 70 80 90 100
YGWIVADDCD ETEDKLWKWV SQHRLFHLHS QKCLGLDITK SVNELRMFSC
110 120 130 140 150
DSSAMLWWKC EHHSLYGAAR YRLALKDGHG TAISNASDVW KKGGSEESLC
160 170 180 190 200
DQPYHEIYTR DGNSYGRPCE FPFLIDGTWH HDCILDEDHS GPWCATTLNY
210 220 230 240 250
EYDRKWGICL KPENGCEDNW EKNEQFGSCY QFNTQTALSW KEAYVSCQNQ
260 270 280 290 300
GADLLSINSA AELTYLKEKE GIAKIFWIGL NQLYSARGWE WSDHKPLNFL
310 320 330 340 350
NWDPDRPSAP TIGGSSCARM DAESGLWQSF SCEAQLPYVC RKPLNNTVEL
360 370 380 390 400
TDVWTYSDTR CDAGWLPNNG FCYLLVNESN SWDKAHAKCK AFSSDLISIH
410 420 430 440 450
SLADVEVVVT KLHNEDIKEE VWIGLKNINI PTLFQWSDGT EVTLTYWDEN
460 470 480 490 500
EPNVPYNKTP NCVSYLGELG QWKVQSCEEK LKYVCKRKGE KLNDASSDKM
510 520 530 540 550
CPPDEGWKRH GETCYKIYED EVPFGTNCNL TITSRFEQEY LNDLMKKYDK
560 570 580 590 600
SLRKYFWTGL RDVDSCGEYN WATVGGRRRA VTFSNWNFLE PASPGGCVAM
610 620 630 640 650
STGKSVGKWE VKDCRSFKAL SICKKMSGPL GPEEASPKPD DPCPEGWQSF
660 670 680 690 700
PASLSCYKVF HAERIVRKRN WEEAERFCQA LGAHLSSFSH VDEIKEFLHF
710 720 730 740 750
LTDQFSGQHW LWIGLNKRSP DLQGSWQWSD RTPVSTIIMP NEFQQDYDIR
760 770 780 790 800
DCAAVKVFHR PWRRGWHFYD DREFIYLRPF ACDTKLEWVC QIPKGRTPKT
810 820 830 840 850
PDWYNPDRAG IHGPPLIIEG SEYWFVADLH LNYEEAVLYC ASNHSFLATI
860 870 880 890 900
TSFVGLKAIK NKIANISGDG QKWWIRISEW PIDDHFTYSR YPWHRFPVTF
910 920 930 940 950
GEECLYMSAK TWLIDLGKPT DCSTKLPFIC EKYNVSSLEK YSPDSAAKVQ
960 970 980 990 1000
CSEQWIPFQN KCFLKIKPVS LTFSQASDTC HSYGGTLPSV LSQIEQDFIT
1010 1020 1030 1040 1050
SLLPDMEATL WIGLRWTAYE KINKWTDNRE LTYSNFHPLL VSGRLRIPEN
1060 1070 1080 1090 1100
FFEEESRYHC ALILNLQKSP FTGTWNFTSC SERHFVSLCQ KYSEVKSRQT
1110 1120 1130 1140 1150
LQNASETVKY LNNLYKIIPK TLTWHSAKRE CLKSNMQLVS ITDPYQQAFL
1160 1170 1180 1190 1200
SVQALLHNSS LWIGLFSQDD ELNFGWSDGK RLHFSRWAET NGQLEDCVVL
1210 1220 1230 1240 1250
DTDGFWKTVD CNDNQPGAIC YYSGNETEKE VKPVDSVKCP SPVLNTPWIP
1260 1270 1280 1290 1300
FQNCCYNFII TKNRHMATTQ DEVHTKCQKL NPKSHILSIR DEKENNFVLE
1310 1320 1330 1340 1350
QLLYFNYMAS WVMLGITYRN KSLMWFDKTP LSYTHWRAGR PTIKNEKFLA
1360 1370 1380 1390 1400
GLSTDGFWDI QTFKVIEEAV YFHQHSILAC KIEMVDYKEE YNTTLPQFMP
1410 1420 1430 1440 1450
YEDGIYSVIQ KKVTWYEALN MCSQSGGHLA SVHNQNGQLF LEDIVKRDGF
1460 1470 1480 1490 1500
PLWVGLSSHD GSESSFEWSD GSTFDYIPWK GQTSPGNCVL LDPKGTWKHE
1510 1520 1530 1540 1550
KCNSVKDGAI CYKPTKSKKL SRLTYSSRCP AAKENGSRWI QYKGHCYKSD
1560 1570 1580 1590 1600
QALHSFSEAK KLCSKHDHSA TIVSIKDEDE NKFVSRLMRE NNNITMRVWL
1610 1620 1630 1640 1650
GLSQHSVDQS WSWLDGSEVT FVKWENKSKS GVGRCSMLIA SNETWKKVEC
1660 1670 1680 1690 1700
EHGFGRVVCK VPLGPDYTAI AIIVATLSIL VLMGGLIWFL FQRHRLHLAG
1710 1720
FSSVRYAQGV NEDEIMLPSF HD
Length:1,722
Mass (Da):198,311
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BC17EC646BF016F
GO
Isoform 2 (identifier: O60449-2) [UniParc]FASTAAdd to basket
Also known as: Fusion protein variant V34-2

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1722: GPDYTAIAII...DEIMLPSFHD → DCPSSTWIQF...EENEYPVQFD

Note: Produced by intergenic splicing of LY75 and CD302.Curated
Show »
Length:1,873
Mass (Da):215,781
Checksum:iFCB3376C05559AD1
GO
Isoform 5 (identifier: Q8IX05-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8IX05.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:174
Mass (Da):19,562
GO
Isoform 3 (identifier: O60449-3) [UniParc]FASTAAdd to basket
Also known as: Fusion protein variant V33-2

The sequence of this isoform differs from the canonical sequence as follows:
     1608-1722: DQSWSWLDGS...DEIMLPSFHD → DCPSSTWIQF...EENEYPVQFD

Note: Produced by intergenic splicing of LY75 and CD302.Curated
Show »
Length:1,817
Mass (Da):209,438
Checksum:iA9B77FE92CC444D4
GO
Isoform 1 (identifier: Q8IX05-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8IX05.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:232
Mass (Da):26,183
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05615620W → R. Corresponds to variant dbSNP:rs35284483Ensembl.1
Natural variantiVAR_027824268E → D1 PublicationCorresponds to variant dbSNP:rs2271381Ensembl.1
Natural variantiVAR_027825486K → M. Corresponds to variant dbSNP:rs2729709Ensembl.1
Natural variantiVAR_056157666V → A. Corresponds to variant dbSNP:rs34020639EnsemblClinVar.1
Natural variantiVAR_024522692D → N. Corresponds to variant dbSNP:rs1397706Ensembl.1
Natural variantiVAR_027826807D → E1 PublicationCorresponds to variant dbSNP:rs3951216Ensembl.1
Natural variantiVAR_027827884D → A. Corresponds to variant dbSNP:rs3815875Ensembl.1
Natural variantiVAR_0278281202T → S. Corresponds to variant dbSNP:rs2303549Ensembl.1
Natural variantiVAR_0278291321K → N2 PublicationsCorresponds to variant dbSNP:rs12692566Ensembl.1
Natural variantiVAR_0278301347K → R. Corresponds to variant dbSNP:rs17827158Ensembl.1
Natural variantiVAR_0278311391Y → H. Corresponds to variant dbSNP:rs2059696Ensembl.1
Natural variantiVAR_0561581393T → I. Corresponds to variant dbSNP:rs35941588Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0209081608 – 1722DQSWS…PSFHD → DCPSSTWIQFQDSCYIFLQE AIKVESIEDVRNQCTDHGAD MISIHNEEENAFILDTLKKQ WKGPDDILLGMFYDTDDASF KWFDNSNMTFDKWTDQDDDE DLVDTCAFLHIKTGEWKKGN CEVSSVEGTLCKTAIPYKRK YLSDNHILISALVIASTVIL TVLGAIIWFLYKKHSDSRFT TVFSTAPQSPYNEDCVLVVG EENEYPVQFD in isoform 3. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_0209091664 – 1722GPDYT…PSFHD → DCPSSTWIQFQDSCYIFLQE AIKVESIEDVRNQCTDHGAD MISIHNEEENAFILDTLKKQ WKGPDDILLGMFYDTDDASF KWFDNSNMTFDKWTDQDDDE DLVDTCAFLHIKTGEWKKGN CEVSSVEGTLCKTAIPYKRK YLSDNHILISALVIASTVIL TVLGAIIWFLYKKHSDSRFT TVFSTAPQSPYNEDCVLVVG EENEYPVQFD in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF064827 mRNA Translation: AAC62622.1
AF011333 mRNA Translation: AAC17636.1
AY184222 mRNA Translation: AAN85434.1
AY314006 mRNA Translation: AAP79899.1
AC009961 Genomic DNA Translation: AAY14943.1
AC093873 Genomic DNA Translation: AAY24189.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2211.1 [O60449-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001185688.1, NM_001198759.1 [O60449-2]
NP_001185689.1, NM_001198760.1 [O60449-3]
NP_002340.2, NM_002349.3 [O60449-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263636; ENSP00000263636; ENSG00000054219 [O60449-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100526664
4065

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100526664
hsa:4065

UCSC genome browser

More...
UCSCi
uc002ubc.6, human [O60449-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

DEC-205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064827 mRNA Translation: AAC62622.1
AF011333 mRNA Translation: AAC17636.1
AY184222 mRNA Translation: AAN85434.1
AY314006 mRNA Translation: AAP79899.1
AC009961 Genomic DNA Translation: AAY14943.1
AC093873 Genomic DNA Translation: AAY24189.1
CCDSiCCDS2211.1 [O60449-1]
RefSeqiNP_001185688.1, NM_001198759.1 [O60449-2]
NP_001185689.1, NM_001198760.1 [O60449-3]
NP_002340.2, NM_002349.3 [O60449-1]

3D structure databases

SMRiO60449
ModBaseiSearch...

Protein-protein interaction databases

IntActiO60449, 2 interactors
STRINGi9606.ENSP00000263636

PTM databases

CarbonylDBiO60449
GlyConnecti1472, 1 N-Linked glycan (1 site)
GlyGeniO60449, 20 sites
iPTMnetiO60449
PhosphoSitePlusiO60449

Polymorphism and mutation databases

BioMutaiLY75

Proteomic databases

jPOSTiO60449
MassIVEiO60449
PaxDbiO60449
PeptideAtlasiO60449
PRIDEiO60449
ProteomicsDBi49406 [O60449-1]
49407 [O60449-2]
49408 [O60449-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3669, 552 antibodies

The DNASU plasmid repository

More...
DNASUi
4065

Genome annotation databases

EnsembliENST00000263636; ENSP00000263636; ENSG00000054219 [O60449-1]
GeneIDi100526664
4065
KEGGihsa:100526664
hsa:4065
UCSCiuc002ubc.6, human [O60449-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100526664
4065
DisGeNETi100526664
4065
EuPathDBiHostDB:ENSG00000054219.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LY75
HGNCiHGNC:6729, LY75
HPAiENSG00000054219, Group enriched (intestine, lymphoid tissue)
MIMi604524, gene
neXtProtiNX_O60449
OpenTargetsiENSG00000054219
ENSG00000248672
PharmGKBiPA30493

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00990000203637
HOGENOMiCLU_002069_2_0_1
InParanoidiO60449
KOiK06559
OMAiTGKCIKP
OrthoDBi29241at2759
PhylomeDBiO60449
TreeFamiTF316663

Enzyme and pathway databases

PathwayCommonsiO60449

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
100526664, 27 hits in 493 CRISPR screens
4065, 5 hits in 845 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LY75
PharosiO60449, Tbio
RNActiO60449, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000054219, Expressed in thymus and 205 other tissues
GenevisibleiO60449, HS

Family and domain databases

CDDicd00062, FN2, 1 hit
cd00161, RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 10 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PfamiView protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 10 hits
SMARTiView protein in SMART
SM00034, CLECT, 10 hits
SM00059, FN2, 1 hit
SM00458, RICIN, 1 hit
SUPFAMiSSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 10 hits
SSF57440, SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 10 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLY75_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60449
Secondary accession number(s): O75913
, Q53R46, Q53TF5, Q7Z575, Q7Z577
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 11, 2011
Last modified: October 7, 2020
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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