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UniProtKB - O60437 (PEPL_HUMAN)

Entry version 184 (02 Dec 2020)
Sequence version 4 (11 Jan 2011)
Previous versions | rss
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Protein

Periplakin

Gene

PPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processKeratinization

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60437

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6809371, Formation of the cornified envelope
R-HSA-8851680, Butyrophilin (BTN) family interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Periplakin
Alternative name(s):
190 kDa paraneoplastic pemphigus antigen
195 kDa cornified envelope precursor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPL
Synonyms:KIAA0568
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000118898.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:9273, PPL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602871, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60437

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5493

Open Targets

More...OpenTargetsi		ENSG00000118898

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33602

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60437, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781491 – 1756PeriplakinAdd BLAST1756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei1584PhosphoserineCombined sources1
Modified residuei1657PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60437

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60437

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60437

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60437

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60437

PeptideAtlas

More...PeptideAtlasi		O60437

PRoteomics IDEntifications database

More...PRIDEi		O60437

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49402

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60437

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60437

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O60437

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in stratified squamous epithelia and in some other epithelia.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the epidermis, nuclei of dermal fibroblasts, cell periphery of flattened keratinocytes, and dermal and epithelial cells lining the excretory ducts of the sweat glands in neonatal foreskin.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

During differentiation of epidermal keratinocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118898, Expressed in mouth mucosa and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60437, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60437, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118898, Tissue enhanced (esophagus, lymphoid tissue, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or a heterodimer with EVPL (PubMed:9412476).

Found in a complex composed of PPL (via C-terminal linker domain), BFSP1 and BFSP2 in the retinal lens (By similarity). Within the complex interacts (via C-terminal linker domain) with BFSP2 (By similarity).

Interacts with VIM (By similarity). Binds to the PH domain of AKT1 (PubMed:12244133).

Interacts with FCGR1A (PubMed:15229321). May interact with PPHLN1 (PubMed:12853457).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O60437
With#Exp.IntAct
ACTR5 [Q9H9F9]3EBI-368321,EBI-769418
AHCYL1 [O43865]3EBI-368321,EBI-2371423
AKT1 [P31749]2EBI-368321,EBI-296087
ALAS1 [P13196]6EBI-368321,EBI-3905054
ANXA9 [O76027]6EBI-368321,EBI-720960
BTN3A1 [O00481]6EBI-368321,EBI-2809309
BTN3A1 - isoform 2 [O00481-2]5EBI-368321,EBI-14033666
C6orf141 [Q5SZD1]3EBI-368321,EBI-10697767
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-368321,EBI-10181988
DES [P17661]3EBI-368321,EBI-1055572
HECTD3 [Q5T447]3EBI-368321,EBI-2691157
IKZF1 - isoform Ik7 [Q13422-7]3EBI-368321,EBI-11522367
KCTD21 [Q4G0X4]3EBI-368321,EBI-11976683
KNSTRN [Q9Y448]3EBI-368321,EBI-373334
KRT25 [Q7Z3Z0]3EBI-368321,EBI-11980019
KRT39 [Q6A163]4EBI-368321,EBI-11958242
MRPL28 [Q13084]3EBI-368321,EBI-723426
PBX4 [Q9BYU1]3EBI-368321,EBI-10302990
PICK1 [Q9NRD5]3EBI-368321,EBI-79165
PLEKHA7 - isoform 2 [Q6IQ23-2]3EBI-368321,EBI-12069346
POF1B - isoform 1 [Q8WVV4-1]3EBI-368321,EBI-11986735
RAB3IP [Q96QF0]3EBI-368321,EBI-747844
RAB3IP - isoform 7 [Q96QF0-7]3EBI-368321,EBI-11984839
RALBP1 [Q15311]5EBI-368321,EBI-749285
TRAF2 [Q12933]6EBI-368321,EBI-355744
TRIM27 [P14373]3EBI-368321,EBI-719493
TSC22D4 [Q9Y3Q8]3EBI-368321,EBI-739485
UPRT [Q96BW1]3EBI-368321,EBI-742943
VIM [P08670]3EBI-368321,EBI-353844
ZBTB26 [Q9HCK0]3EBI-368321,EBI-3918996
ZNF165 [P49910]3EBI-368321,EBI-741694
ZNF213 [O14771]3EBI-368321,EBI-12838388
ZNF263 [O14978]3EBI-368321,EBI-744493
ZNF474 [Q6S9Z5]3EBI-368321,EBI-17269964
ZSCAN1 [Q8NBB4]3EBI-368321,EBI-5292994
ZSCAN1 - isoform 2 [Q8NBB4-2]3EBI-368321,EBI-12021938
ZSCAN16 [Q9H4T2]3EBI-368321,EBI-723596

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111488, 98 interactors

Protein interaction database and analysis system

More...IntActi		O60437, 61 interactors

Molecular INTeraction database

More...MINTi		O60437

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340510

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60437, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11756
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60437

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati216 – 317Spectrin 1Add BLAST102
Repeati323 – 485Spectrin 2Add BLAST163
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini399 – 455SH3PROSITE-ProRule annotationAdd BLAST57
Repeati505 – 612Spectrin 3Add BLAST108
Repeati733 – 861Spectrin 4Add BLAST129
Repeati1651 – 1685Plectin 1Add BLAST35
Repeati1700 – 1735Plectin 2Add BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1557 – 1756Interacts with BFSP2 and VIMBy similarityAdd BLAST200

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 125Sequence analysisAdd BLAST110
Coiled coili188 – 389Sequence analysisAdd BLAST202
Coiled coili585 – 820Sequence analysisAdd BLAST236
Coiled coili886 – 1645Sequence analysisAdd BLAST760

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0516, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153578

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60437

Identification of Orthologs from Complete Genome Data

More...OMAi		EVHKVQQ

Database of Orthologous Groups

More...OrthoDBi		35436at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60437

TreeFam database of animal gene trees

More...TreeFami		TF342779

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041615, Desmoplakin_SH3
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17902, SH3_10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00250, PLEC, 2 hits
SM00150, SPEC, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF75399, SSF75399, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O60437-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLFRKRNK GKYSPTVQTR SISNKELSEL IEQLQKNADQ VEKNIVDTEA 
        60         70         80         90        100
KMQSDLARLQ EGRQPEHRDV TLQKVLDSEK LLYVLEADAA IAKHMKHPQG 
       110        120        130        140        150
DMIAEDIRQL KERVTNLRGK HKQIYRLAVK EVDPQVNWAA LVEEKLDKLN 
       160        170        180        190        200
NQSFGTDLPL VDHQVEEHNI FHNEVKAIGP HLAKDGDKEQ NSELRAKYQK 
       210        220        230        240        250
LLAASQARQQ HLSSLQDYMQ RCTNELYWLD QQAKGRMQYD WSDRNLDYPS 
       260        270        280        290        300
RRRQYENFIN RNLEAKEERI NKLHSEGDQL LAAEHPGRNS IEAHMEAVHA 
       310        320        330        340        350
DWKEYLNLLI CEESHLKYME DYHQFHEDVK DAQELLRKVD SDLNQKYGPD 
       360        370        380        390        400
FKDRYQIELL LRELDDQEKV LDKYEDVVQG LQKRGQQVVP LKYRRETPLK 
       410        420        430        440        450
PIPVEALCDF EGEQGLISRG YSYTLQKNNG ESWELMDSAG NKLIAPAVCF 
       460        470        480        490        500
VIPPTDPEAL ALADSLGSQY RSVRQKAAGS KRTLQQRYEV LKTENPGDAS 
       510        520        530        540        550
DLQGRQLLAG LDKVASDLDR QEKAITGILR PPLEQGRAVQ DSAERAKDLK 
       560        570        580        590        600
NITNELLRIE PEKTRSTAEG EAFIQALPGS GTTPLLRTRV EDTNRKYEHL 
       610        620        630        640        650
LQLLDLAQEK VDVANRLEKS LQQSWELLAT HENHLNQDDT VPESSRVLDS 
       660        670        680        690        700
KGQELAAMAC ELQAQKSLLG EVEQNLQAAK QCSSTLASRF QEHCPDLERQ 
       710        720        730        740        750
EAEVHKLGQR FNNLRQQVER RAQSLQSAKA AYEHFHRGHD HVLQFLVSIP 
       760        770        780        790        800
SYEPQETDSL SQMETKLKNQ KNLLDEIASR EQEVQKICAN SQQYQQAVKD 
       810        820        830        840        850
YELEAEKLRS LLDLENGRRS HVSKRARLQS PATKVKEEEA ALAAKFTEVY 
       860        870        880        890        900
AINRQRLQNL EFALNLLRQQ PEVEVTHETL QRNRPDSGVE EAWKIRKELD 
       910        920        930        940        950
EETERRRQLE NEVKSTQEEI WTLRNQGPQE SVVRKEVLKK VPDPVLEESF 
       960        970        980        990       1000
QQLQRTLAEE QHKNQLLQEE LEALQLQLRA LEQETRDGGQ EYVVKEVLRI 
      1010       1020       1030       1040       1050
EPDRAQADEV LQLREELEAL RRQKGAREAE VLLLQQRVAA LAEEKSRAQE 
      1060       1070       1080       1090       1100
KVTEKEVVKL QNDPQLEAEY QQLQEDHQRQ DQLREKQEEE LSFLQDKLKR 
      1110       1120       1130       1140       1150
LEKERAMAEG KITVKEVLKV EKDAATEREV SDLTRQYEDE AAKARASQRE 
      1160       1170       1180       1190       1200
KTELLRKIWA LEEENAKVVV QEKVREIVRP DPKAESEVAN LRLELVEQER 
      1210       1220       1230       1240       1250
KYRGAEEQLR SYQSELEALR RRGPQVEVKE VTKEVIKYKT DPEMEKELQR 
      1260       1270       1280       1290       1300
LREEIVDKTR LIERCDLEIY QLKKEIQALK DTKPQVQTKE VVQEILQFQE 
      1310       1320       1330       1340       1350
DPQTKEEVAS LRAKLSEEQK KQVDLERERA SQEEQIARKE EELSRVKERV 
      1360       1370       1380       1390       1400
VQQEVVRYEE EPGLRAEASA FAESIDVELR QIDKLRAELR RLQRRRTELE 
      1410       1420       1430       1440       1450
RQLEELERER QARREAEREV QRLQQRLAAL EQEEAEAREK VTHTQKVVLQ 
      1460       1470       1480       1490       1500
QDPQQAREHA LLRLQLEEEQ HRRQLLEGEL ETLRRKLAAL EKAEVKEKVV 
      1510       1520       1530       1540       1550
LSESVQVEKG DTEQEIQRLK SSLEEESRSK RELDVEVSRL EARLSELEFH 
      1560       1570       1580       1590       1600
NSKSSKELDF LREENHKLQL ERQNLQLETR RLQSEINMAA TETRDLRNMT 
      1610       1620       1630       1640       1650
VADSGTNHDS RLWSLERELD DLKRLSKDKD LEIDELQKRL GSVAVKREQR 
      1660       1670       1680       1690       1700
ENHLRRSIVV IHPDTGRELS PEEAHRAGLI DWNMFVKLRS QECDWEEISV 
      1710       1720       1730       1740       1750
KGPNGESSVI HDRKSGKKFS IEEALQSGRL TPAQYDRYVN KDMSIQELAV 

LVSGQK
Length:1,756
Mass (Da):204,747
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA7EAF3E756D78B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKI8K7EKI8_HUMAN
Periplakin
PPL
1,754Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ71K7EQ71_HUMAN
Periplakin
PPL
1,115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti657A → P in AAC39668 (PubMed:9521878).Curated1
Sequence conflicti657A → P in AAD17459 (PubMed:10051401).Curated1
Sequence conflicti994V → F in AAC17738 (PubMed:9412476).Curated1
Sequence conflicti1663P → L in AAC17738 (PubMed:9412476).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055125520R → Q. Corresponds to variant dbSNP:rs8063727EnsemblClinVar.1
Natural variantiVAR_055126572A → S. Corresponds to variant dbSNP:rs35300633Ensembl.1
Natural variantiVAR_055127589R → Q4 PublicationsCorresponds to variant dbSNP:rs1049205Ensembl.1
Natural variantiVAR_055128631H → Y. Corresponds to variant dbSNP:rs34936263EnsemblClinVar.1
Natural variantiVAR_055129819R → S6 PublicationsCorresponds to variant dbSNP:rs2734742Ensembl.1
Natural variantiVAR_055130891E → Q. Corresponds to variant dbSNP:rs35869286Ensembl.1
Natural variantiVAR_0551311007A → V. Corresponds to variant dbSNP:rs2075639Ensembl.1
Natural variantiVAR_0551321199E → Q. Corresponds to variant dbSNP:rs12446946EnsemblClinVar.1
Natural variantiVAR_0551331573Q → E3 PublicationsCorresponds to variant dbSNP:rs2037912Ensembl.1
Natural variantiVAR_0551341754G → R. Corresponds to variant dbSNP:rs35865314Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF001691 mRNA Translation: AAC17738.1
AF013717 mRNA Translation: AAC39668.1
AF041004 AF041003 Genomic DNA Translation: AAD17459.1
AC027687 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85248.1
BC114620 mRNA Translation: AAI14621.1
AB011140 mRNA Translation: BAA25494.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10526.1

Protein sequence database of the Protein Information Resource

More...PIRi		T00337

NCBI Reference Sequences

More...RefSeqi		NP_002696.3, NM_002705.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000345988; ENSP00000340510; ENSG00000118898

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5493

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5493

UCSC genome browser

More...UCSCi		uc002cyd.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001691 mRNA Translation: AAC17738.1
AF013717 mRNA Translation: AAC39668.1
AF041004 AF041003 Genomic DNA Translation: AAD17459.1
AC027687 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85248.1
BC114620 mRNA Translation: AAI14621.1
AB011140 mRNA Translation: BAA25494.1
CCDSiCCDS10526.1
PIRiT00337
RefSeqiNP_002696.3, NM_002705.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q28X-ray2.64A/B/C/D1655-1756[»]
SMRiO60437
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111488, 98 interactors
IntActiO60437, 61 interactors
MINTiO60437
STRINGi9606.ENSP00000340510

PTM databases

iPTMnetiO60437
PhosphoSitePlusiO60437
SwissPalmiO60437

Polymorphism and mutation databases

BioMutaiPPL

Proteomic databases

EPDiO60437
jPOSTiO60437
MassIVEiO60437
MaxQBiO60437
PaxDbiO60437
PeptideAtlasiO60437
PRIDEiO60437
ProteomicsDBi49402

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24458, 185 antibodies

Genome annotation databases

EnsembliENST00000345988; ENSP00000340510; ENSG00000118898
GeneIDi5493
KEGGihsa:5493
UCSCiuc002cyd.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5493
DisGeNETi5493
EuPathDBiHostDB:ENSG00000118898.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPL
HGNCiHGNC:9273, PPL
HPAiENSG00000118898, Tissue enhanced (esophagus, lymphoid tissue, tongue)
MIMi602871, gene
neXtProtiNX_O60437
OpenTargetsiENSG00000118898
PharmGKBiPA33602

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000153578
InParanoidiO60437
OMAiEVHKVQQ
OrthoDBi35436at2759
PhylomeDBiO60437
TreeFamiTF342779

Enzyme and pathway databases

PathwayCommonsiO60437
ReactomeiR-HSA-6809371, Formation of the cornified envelope
R-HSA-8851680, Butyrophilin (BTN) family interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5493, 17 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPL, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Periplakin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5493
PharosiO60437, Tbio

Protein Ontology

More...PROi		PR:O60437
RNActiO60437, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118898, Expressed in mouth mucosa and 216 other tissues
ExpressionAtlasiO60437, baseline and differential
GenevisibleiO60437, HS

Family and domain databases

InterProiView protein in InterPro
IPR041615, Desmoplakin_SH3
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 1 hit
PfamiView protein in Pfam
PF17902, SH3_10, 1 hit
SMARTiView protein in SMART
SM00250, PLEC, 2 hits
SM00150, SPEC, 5 hits
SUPFAMiSSF75399, SSF75399, 1 hit
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEPL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60437
Secondary accession number(s): O60314, O60454, Q14C98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 11, 2011
Last modified: December 2, 2020
This is version 184 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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