UniProtKB - O60437 (PEPL_HUMAN)

BLAST

>sp|O60437|PEPL_HUMAN Periplakin OS=Homo sapiens OX=9606 GN=PPL PE=1 SV=4
MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQ
EGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK
HKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP
HLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD
WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA
DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL
LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRG
YSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS
KRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQ
DSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHL
LQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMAC
ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER
RAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR
EQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRRSHVSKRARLQSPATKVKEEEA
ALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD
EETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE
QHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEAL
RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQ
DQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDE
AAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQER
KYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR
LIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK
KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELR
QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK
VTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV
LSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDF
LREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD
DLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLI
DWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVN
KDMSIQELAVLVSGQK

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History
Entry version 168 (12 Sep 2018)
Sequence version 4 (11 Jan 2011)
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Protein

Periplakin

Gene

PPL

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.1 Publication

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
structural constituent of cytoskeleton
Source: ProtInc
Traceable author statementⁱ
- 9521878

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cornification Source: Reactome
response to mechanical stimulus
Source: BHF-UCL
Inferred from expression patternⁱ
- 19211270

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Keratinization

Biological process

Keratinization

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6809371 Formation of the cornified envelope R-HSA-8851680 Butyrophilin (BTN) family interactions

Reactomeⁱ

R-HSA-6809371 Formation of the cornified envelope
R-HSA-8851680 Butyrophilin (BTN) family interactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Periplakin Alternative name(s): 190 kDa paraneoplastic pemphigus antigen 195 kDa cornified envelope precursor protein
Gene namesⁱ	Name:PPL Synonyms:KIAA0568
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118898.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9273 PPL
MIMⁱ	602871 gene
neXtProtⁱ	NX_O60437

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5493
Open Targets More...OpenTargetsⁱ	ENSG00000118898
PharmGKBⁱ	PA33602

Polymorphism and mutation databases

BioMutaⁱ	PPL

BioMutaⁱ

PPL

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000078149	1 – 1756	PeriplakinAdd BLAST		1756

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	14	PhosphoserineCombined sources	1
Modified residueⁱ	465	PhosphoserineCombined sources	1
Modified residueⁱ	887	PhosphoserineCombined sources	1
Modified residueⁱ	949	PhosphoserineCombined sources	1
Modified residueⁱ	1584	PhosphoserineCombined sources	1
Modified residueⁱ	1657	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O60437
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60437
PaxDbⁱ	O60437
PeptideAtlas More...PeptideAtlasⁱ	O60437
PRIDEⁱ	O60437
ProteomicsDBⁱ	49402

PTM databases

iPTMnetⁱ	O60437
PhosphoSitePlusⁱ	O60437
SwissPalmⁱ	O60437

Expressionⁱ

Tissue specificityⁱ

Expressed in stratified squamous epithelia and in some other epithelia.2 Publications

Inductionⁱ

During differentiation of epidermal keratinocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000118898 Expressed in 206 organ(s), highest expression level in mouth mucosa
CleanExⁱ	HS_PPL
ExpressionAtlasⁱ	O60437 baseline and differential
Genevisibleⁱ	O60437 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042550 HPA059859

HPAⁱ

HPA042550
HPA059859

Interactionⁱ

Subunit structureⁱ

Homodimer or a heterodimer with EVPL. Interacts with PPHLN1 and VIM. Binds to the PH domain of AKT1. Interacts with FCGR1A.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AHCYL1	O43865	3	EBI-368321,EBI-2371423
AKT1	P31749	2	EBI-368321,EBI-296087
ALAS1	P13196	5	EBI-368321,EBI-3905054
ANXA9	O76027	6	EBI-368321,EBI-720960
BTN3A1	O00481	6	EBI-368321,EBI-2809309
BTN3A1	O00481-2	5	EBI-368321,EBI-14033666
CEP57L1	Q8IYX8-2	3	EBI-368321,EBI-10181988
RAB3IP	Q96QF0	3	EBI-368321,EBI-747844
RALBP1	Q15311	3	EBI-368321,EBI-749285
TRAF2	Q12933	5	EBI-368321,EBI-355744
TRIM27	P14373	3	EBI-368321,EBI-719493
TSC22D4	Q9Y3Q8	3	EBI-368321,EBI-739485
VIM	P08670	3	EBI-368321,EBI-353844
ZSCAN1	Q8NBB4	3	EBI-368321,EBI-5292994

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111488, 70 interactors
IntActⁱ	O60437, 44 interactors
Molecular INTeraction database More...MINTⁱ	O60437
STRINGⁱ	9606.ENSP00000340510

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	1655 – 1661	Combined sources	7
Turnⁱ	1663 – 1665	Combined sources	3
Helixⁱ	1671 – 1676	Combined sources	6
Helixⁱ	1682 – 1689	Combined sources	8
Beta strandⁱ	1693 – 1701	Combined sources	9
Beta strandⁱ	1706 – 1712	Combined sources	7
Turnⁱ	1713 – 1716	Combined sources	4
Beta strandⁱ	1717 – 1721	Combined sources	5
Helixⁱ	1722 – 1726	Combined sources	5
Helixⁱ	1732 – 1739	Combined sources	8
Helixⁱ	1745 – 1753	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	O60437
SMRⁱ	O60437
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	216 – 317	Spectrin 1Add BLAST	102
Repeatⁱ	323 – 485	Spectrin 2Add BLAST	163
Domainⁱ	399 – 455	SH3PROSITE-ProRule annotationAdd BLAST	57
Repeatⁱ	505 – 612	Spectrin 3Add BLAST	108
Repeatⁱ	733 – 861	Spectrin 4Add BLAST	129
Repeatⁱ	1651 – 1685	Plectin 1Add BLAST	35
Repeatⁱ	1700 – 1735	Plectin 2Add BLAST	36

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	16 – 125	Sequence analysisAdd BLAST	110
Coiled coilⁱ	188 – 389	Sequence analysisAdd BLAST	202
Coiled coilⁱ	585 – 820	Sequence analysisAdd BLAST	236
Coiled coilⁱ	886 – 1645	Sequence analysisAdd BLAST	760

Sequence similaritiesⁱ

Belongs to the plakin or cytolinker family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	ENOG410IQBN Eukaryota ENOG410YHVZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119163
HOGENOMⁱ	HOG000168302
HOVERGENⁱ	HBG053564
InParanoidⁱ	O60437
KEGG Orthology (KO) More...KOⁱ	K10386
OMAⁱ	ADWKEYL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00CT
PhylomeDBⁱ	O60437
TreeFamⁱ	TF342779

Family and domain databases

InterProⁱ	View protein in InterPro IPR035915 Plakin_repeat_sf IPR001101 Plectin_repeat IPR001452 SH3_domain IPR018159 Spectrin/alpha-actinin
SMARTⁱ	View protein in SMART SM00250 PLEC, 2 hits SM00150 SPEC, 5 hits
SUPFAMⁱ	SSF75399 SSF75399, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002 SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O60437-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNSLFRKRNK GKYSPTVQTR SISNKELSEL IEQLQKNADQ VEKNIVDTEA 
        60         70         80         90        100
KMQSDLARLQ EGRQPEHRDV TLQKVLDSEK LLYVLEADAA IAKHMKHPQG 
       110        120        130        140        150
DMIAEDIRQL KERVTNLRGK HKQIYRLAVK EVDPQVNWAA LVEEKLDKLN 
       160        170        180        190        200
NQSFGTDLPL VDHQVEEHNI FHNEVKAIGP HLAKDGDKEQ NSELRAKYQK 
       210        220        230        240        250
LLAASQARQQ HLSSLQDYMQ RCTNELYWLD QQAKGRMQYD WSDRNLDYPS 
       260        270        280        290        300
RRRQYENFIN RNLEAKEERI NKLHSEGDQL LAAEHPGRNS IEAHMEAVHA 
       310        320        330        340        350
DWKEYLNLLI CEESHLKYME DYHQFHEDVK DAQELLRKVD SDLNQKYGPD 
       360        370        380        390        400
FKDRYQIELL LRELDDQEKV LDKYEDVVQG LQKRGQQVVP LKYRRETPLK 
       410        420        430        440        450
PIPVEALCDF EGEQGLISRG YSYTLQKNNG ESWELMDSAG NKLIAPAVCF 
       460        470        480        490        500
VIPPTDPEAL ALADSLGSQY RSVRQKAAGS KRTLQQRYEV LKTENPGDAS 
       510        520        530        540        550
DLQGRQLLAG LDKVASDLDR QEKAITGILR PPLEQGRAVQ DSAERAKDLK 
       560        570        580        590        600
NITNELLRIE PEKTRSTAEG EAFIQALPGS GTTPLLRTRV EDTNRKYEHL 
       610        620        630        640        650
LQLLDLAQEK VDVANRLEKS LQQSWELLAT HENHLNQDDT VPESSRVLDS 
       660        670        680        690        700
KGQELAAMAC ELQAQKSLLG EVEQNLQAAK QCSSTLASRF QEHCPDLERQ 
       710        720        730        740        750
EAEVHKLGQR FNNLRQQVER RAQSLQSAKA AYEHFHRGHD HVLQFLVSIP 
       760        770        780        790        800
SYEPQETDSL SQMETKLKNQ KNLLDEIASR EQEVQKICAN SQQYQQAVKD 
       810        820        830        840        850
YELEAEKLRS LLDLENGRRS HVSKRARLQS PATKVKEEEA ALAAKFTEVY 
       860        870        880        890        900
AINRQRLQNL EFALNLLRQQ PEVEVTHETL QRNRPDSGVE EAWKIRKELD 
       910        920        930        940        950
EETERRRQLE NEVKSTQEEI WTLRNQGPQE SVVRKEVLKK VPDPVLEESF 
       960        970        980        990       1000
QQLQRTLAEE QHKNQLLQEE LEALQLQLRA LEQETRDGGQ EYVVKEVLRI 
      1010       1020       1030       1040       1050
EPDRAQADEV LQLREELEAL RRQKGAREAE VLLLQQRVAA LAEEKSRAQE 
      1060       1070       1080       1090       1100
KVTEKEVVKL QNDPQLEAEY QQLQEDHQRQ DQLREKQEEE LSFLQDKLKR 
      1110       1120       1130       1140       1150
LEKERAMAEG KITVKEVLKV EKDAATEREV SDLTRQYEDE AAKARASQRE 
      1160       1170       1180       1190       1200
KTELLRKIWA LEEENAKVVV QEKVREIVRP DPKAESEVAN LRLELVEQER 
      1210       1220       1230       1240       1250
KYRGAEEQLR SYQSELEALR RRGPQVEVKE VTKEVIKYKT DPEMEKELQR 
      1260       1270       1280       1290       1300
LREEIVDKTR LIERCDLEIY QLKKEIQALK DTKPQVQTKE VVQEILQFQE 
      1310       1320       1330       1340       1350
DPQTKEEVAS LRAKLSEEQK KQVDLERERA SQEEQIARKE EELSRVKERV 
      1360       1370       1380       1390       1400
VQQEVVRYEE EPGLRAEASA FAESIDVELR QIDKLRAELR RLQRRRTELE 
      1410       1420       1430       1440       1450
RQLEELERER QARREAEREV QRLQQRLAAL EQEEAEAREK VTHTQKVVLQ 
      1460       1470       1480       1490       1500
QDPQQAREHA LLRLQLEEEQ HRRQLLEGEL ETLRRKLAAL EKAEVKEKVV 
      1510       1520       1530       1540       1550
LSESVQVEKG DTEQEIQRLK SSLEEESRSK RELDVEVSRL EARLSELEFH 
      1560       1570       1580       1590       1600
NSKSSKELDF LREENHKLQL ERQNLQLETR RLQSEINMAA TETRDLRNMT 
      1610       1620       1630       1640       1650
VADSGTNHDS RLWSLERELD DLKRLSKDKD LEIDELQKRL GSVAVKREQR 
      1660       1670       1680       1690       1700
ENHLRRSIVV IHPDTGRELS PEEAHRAGLI DWNMFVKLRS QECDWEEISV 
      1710       1720       1730       1740       1750
KGPNGESSVI HDRKSGKKFS IEEALQSGRL TPAQYDRYVN KDMSIQELAV 

LVSGQK

Length:1,756

Mass (Da):204,747

Last modified:January 11, 2011 - v4

Checksum:ⁱEA7EAF3E756D78B4

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EKI8	K7EKI8_HUMAN	Periplakin Periplakin	PPL	1,754	Annotation score:
K7EQ71	K7EQ71_HUMAN	Periplakin Periplakin	PPL	1,115	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	657	A → P in AAC39668 (PubMed:9521878).Curated	1
Sequence conflictⁱ	657	A → P in AAD17459 (PubMed:10051401).Curated	1
Sequence conflictⁱ	994	V → F in AAC17738 (PubMed:9412476).Curated	1
Sequence conflictⁱ	1663	P → L in AAC17738 (PubMed:9412476).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055125	520	R → Q. Corresponds to variant dbSNP:rs8063727Ensembl.	1
Natural variantⁱVAR_055126	572	A → S. Corresponds to variant dbSNP:rs35300633Ensembl.	1
Natural variantⁱVAR_055127	589	R → Q4 PublicationsCorresponds to variant dbSNP:rs1049205Ensembl.	1
Natural variantⁱVAR_055128	631	H → Y. Corresponds to variant dbSNP:rs34936263Ensembl.	1
Natural variantⁱVAR_055129	819	R → S6 PublicationsCorresponds to variant dbSNP:rs2734742Ensembl.	1
Natural variantⁱVAR_055130	891	E → Q. Corresponds to variant dbSNP:rs35869286Ensembl.	1
Natural variantⁱVAR_055131	1007	A → V. Corresponds to variant dbSNP:rs2075639Ensembl.	1
Natural variantⁱVAR_055132	1199	E → Q. Corresponds to variant dbSNP:rs12446946Ensembl.	1
Natural variantⁱVAR_055133	1573	Q → E3 PublicationsCorresponds to variant dbSNP:rs2037912Ensembl.	1
Natural variantⁱVAR_055134	1754	G → R. Corresponds to variant dbSNP:rs35865314Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF001691 mRNA Translation: AAC17738.1 AF013717 mRNA Translation: AAC39668.1 AF041004 AF041003 Genomic DNA Translation: AAD17459.1 AC027687 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85248.1 BC114620 mRNA Translation: AAI14621.1 AB011140 mRNA Translation: BAA25494.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10526.1
PIRⁱ	T00337
NCBI Reference Sequences More...RefSeqⁱ	NP_002696.3, NM_002705.4
UniGeneⁱ	Hs.192233

Genome annotation databases

Ensemblⁱ	ENST00000345988; ENSP00000340510; ENSG00000118898
GeneIDⁱ	5493
KEGGⁱ	hsa:5493
UCSC genome browser More...UCSCⁱ	uc002cyd.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60437	Uncharacterized protein		COLAP		1837	UniRef90_O60437
Uncharacterized protein		PROCO		1756
Periplakin		CALJA		1756
PPL isoform 2		PONAB		1756
PPL isoform 2		PANTR		1756
+47

Protein	Similar proteins		Species	Score	Length	Source
O60437	Uncharacterized protein		COLAP		1837	UniRef50_O60437
Uncharacterized protein		CERAT		1756
Uncharacterized protein		PROCO		1756
Uncharacterized protein		CHLSB		1756
PPL isoform 2		PANTR		1756
+204

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF001691 mRNA Translation: AAC17738.1 AF013717 mRNA Translation: AAC39668.1 AF041004 AF041003 Genomic DNA Translation: AAD17459.1 AC027687 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85248.1 BC114620 mRNA Translation: AAI14621.1 AB011140 mRNA Translation: BAA25494.1
CCDSⁱ	CCDS10526.1
PIRⁱ	T00337
RefSeqⁱ	NP_002696.3, NM_002705.4
UniGeneⁱ	Hs.192233

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4Q28	X-ray	2.64	A/B/C/D	1655-1756	[»]
ProteinModelPortalⁱ	O60437
SMRⁱ	O60437
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111488, 70 interactors
IntActⁱ	O60437, 44 interactors
MINTⁱ	O60437
STRINGⁱ	9606.ENSP00000340510

PTM databases

iPTMnetⁱ	O60437
PhosphoSitePlusⁱ	O60437
SwissPalmⁱ	O60437

Polymorphism and mutation databases

BioMutaⁱ	PPL

BioMutaⁱ

PPL

Proteomic databases

EPDⁱ	O60437
MaxQBⁱ	O60437
PaxDbⁱ	O60437
PeptideAtlasⁱ	O60437
PRIDEⁱ	O60437
ProteomicsDBⁱ	49402

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000345988; ENSP00000340510; ENSG00000118898
GeneIDⁱ	5493
KEGGⁱ	hsa:5493
UCSCⁱ	uc002cyd.1 human

Organism-specific databases

CTDⁱ	5493
DisGeNETⁱ	5493
EuPathDBⁱ	HostDB:ENSG00000118898.15
GeneCardsⁱ	PPL
H-InvDBⁱ	HIX0012794
HGNCⁱ	HGNC:9273 PPL
HPAⁱ	HPA042550 HPA059859
MIMⁱ	602871 gene
neXtProtⁱ	NX_O60437
OpenTargetsⁱ	ENSG00000118898
PharmGKBⁱ	PA33602
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQBN Eukaryota ENOG410YHVZ LUCA
GeneTreeⁱ	ENSGT00760000119163
HOGENOMⁱ	HOG000168302
HOVERGENⁱ	HBG053564
InParanoidⁱ	O60437
KOⁱ	K10386
OMAⁱ	ADWKEYL
OrthoDBⁱ	EOG091G00CT
PhylomeDBⁱ	O60437
TreeFamⁱ	TF342779

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6809371 Formation of the cornified envelope R-HSA-8851680 Butyrophilin (BTN) family interactions

Reactomeⁱ

R-HSA-6809371 Formation of the cornified envelope
R-HSA-8851680 Butyrophilin (BTN) family interactions

Miscellaneous databases

GeneWikiⁱ	Periplakin
GenomeRNAiⁱ	5493
Protein Ontology More...PROⁱ	PR:O60437
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118898 Expressed in 206 organ(s), highest expression level in mouth mucosa
CleanExⁱ	HS_PPL
ExpressionAtlasⁱ	O60437 baseline and differential
Genevisibleⁱ	O60437 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR035915 Plakin_repeat_sf IPR001101 Plectin_repeat IPR001452 SH3_domain IPR018159 Spectrin/alpha-actinin
SMARTⁱ	View protein in SMART SM00250 PLEC, 2 hits SM00150 SPEC, 5 hits
SUPFAMⁱ	SSF75399 SSF75399, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PEPL_HUMAN
Accessionⁱ	O60437Primary (citable) accession number: O60437 Secondary accession number(s): O60314, O60454, Q14C98
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
	Last sequence update:	January 11, 2011
	Last modified:	September 12, 2018
	This is version 168 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O60437 (PEPL_HUMAN)

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Periplakin

PPL

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Cytoskeleton

Mitochondrion

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ