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Protein

Olfactory receptor 1I1

Gene

OR1I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1I1
Alternative name(s):
Olfactory receptor 19-20
Short name:
OR19-20
Gene namesi
Name:OR1I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000094661.2
HGNCiHGNC:8207 OR1I1
neXtProtiNX_O60431

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 355CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32078

Polymorphism and mutation databases

BioMutaiOR1I1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504371 – 355Olfactory receptor 1I1Add BLAST355

Proteomic databases

PaxDbiO60431
PRIDEiO60431
ProteomicsDBi49401

PTM databases

iPTMnetiO60431
PhosphoSitePlusiO60431

Expressioni

Gene expression databases

BgeeiENSG00000094661 Expressed in 2 organ(s), highest expression level in urinary bladder
CleanExiHS_OR1I1
GenevisibleiO60431 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000209540

Structurei

3D structure databases

ProteinModelPortaliO60431
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC4 Eukaryota
ENOG4111DX9 LUCA
GeneTreeiENSGT00860000133676
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiO60431
KOiK04257
OMAiALMCGVV
OrthoDBiEOG091G0B53
PhylomeDBiO60431
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O60431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPEKQTEIS EFFLQGLSEK PEHQTLLFTM FLSTYLVTII GNALIILAII
60 70 80 90 100
TDSHLHTPMY FFLFNLSLVD TLLSSTTVPK MLANIQAQSR AIPFVGCLTQ
110 120 130 140 150
MYAFHLFGTM DSFLLAVMAI DRFVAIVHPQ RYLVLMCSPV CGLLLGASWM
160 170 180 190 200
ITNLQSLIHT CLMAQLTFCA GSEISHFFCD LMPLLKLSGS DTHTNELVIF
210 220 230 240 250
AFGIVVGTSP FSCILLSYIR IFWTVFKIPS TRGKWKAFST CGLHLTVVSL
260 270 280 290 300
SYGTIFAVYL QPTSPSSSQK DKAAALMCGV FIPMLNPFIY SIRNKDMKAA
310 320 330 340 350
LGKLIGKVAV PCPRPEQLLD VYHVPGSLLA ARDTEMHPIP YPGGVQSLAG

NRDME
Length:355
Mass (Da):39,297
Last modified:August 1, 1998 - v1
Checksum:i0C210102C186E413
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06200950I → F. Corresponds to variant dbSNP:rs59166286Ensembl.1
Natural variantiVAR_034164139P → R. Corresponds to variant dbSNP:rs8104843Ensembl.1
Natural variantiVAR_080450163M → L1 PublicationCorresponds to variant dbSNP:rs76524797Ensembl.1
Natural variantiVAR_034165211F → L. Corresponds to variant dbSNP:rs8108721Ensembl.1
Natural variantiVAR_034166252Y → S. Corresponds to variant dbSNP:rs8105737Ensembl.1
Natural variantiVAR_080451282I → F1 PublicationCorresponds to variant dbSNP:rs75323205Ensembl.1
Natural variantiVAR_034167292I → T. Corresponds to variant dbSNP:rs16980312Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004794 Genomic DNA Translation: AAC18915.1
BC140930 mRNA Translation: AAI40931.1
AF399548 Genomic DNA Translation: AAK95033.1
CCDSiCCDS32937.1
RefSeqiNP_001004713.1, NM_001004713.1
UniGeneiHs.631610

Genome annotation databases

EnsembliENST00000209540; ENSP00000209540; ENSG00000094661
ENST00000641398; ENSP00000493393; ENSG00000094661
GeneIDi126370
KEGGihsa:126370
UCSCiuc010xoe.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004794 Genomic DNA Translation: AAC18915.1
BC140930 mRNA Translation: AAI40931.1
AF399548 Genomic DNA Translation: AAK95033.1
CCDSiCCDS32937.1
RefSeqiNP_001004713.1, NM_001004713.1
UniGeneiHs.631610

3D structure databases

ProteinModelPortaliO60431
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000209540

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO60431
PhosphoSitePlusiO60431

Polymorphism and mutation databases

BioMutaiOR1I1

Proteomic databases

PaxDbiO60431
PRIDEiO60431
ProteomicsDBi49401

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000209540; ENSP00000209540; ENSG00000094661
ENST00000641398; ENSP00000493393; ENSG00000094661
GeneIDi126370
KEGGihsa:126370
UCSCiuc010xoe.3 human

Organism-specific databases

CTDi126370
EuPathDBiHostDB:ENSG00000094661.2
GeneCardsiOR1I1
H-InvDBiHIX0202915
HGNCiHGNC:8207 OR1I1
neXtProtiNX_O60431
PharmGKBiPA32078
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEC4 Eukaryota
ENOG4111DX9 LUCA
GeneTreeiENSGT00860000133676
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiO60431
KOiK04257
OMAiALMCGVV
OrthoDBiEOG091G0B53
PhylomeDBiO60431
TreeFamiTF337210

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR1I1
GenomeRNAii126370
PROiPR:O60431

Gene expression databases

BgeeiENSG00000094661 Expressed in 2 organ(s), highest expression level in urinary bladder
CleanExiHS_OR1I1
GenevisibleiO60431 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR1I1_HUMAN
AccessioniPrimary (citable) accession number: O60431
Secondary accession number(s): B2RU23, Q96R92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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