FADS1

Functionⁱ

Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.By similarity2 Publications

Pathwayⁱ: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functionⁱ

C-5 sterol desaturase activity
Source: ProtInc
Traceable author statementⁱ
- 10601301
omega-6 fatty acid desaturase activity Source: Reactome
oxidoreductase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10601301

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

alpha-linolenic acid metabolic process Source: Reactome
cell-cell signaling
Source: UniProtKB
Non-traceable author statementⁱ
- 10601301
cellular response to starvation
Source: UniProtKB
Inferred from direct assayⁱ
- 10601301
icosanoid biosynthetic process
Source: UniProtKB
Traceable author statementⁱ
- 10601301
linoleic acid metabolic process Source: Reactome
phospholipid biosynthetic process
Source: UniProtKB
Traceable author statementⁱ
- 10601301
regulation of cell differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 10601301
regulation of lipid metabolic process Source: Reactome
regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 10601301
unsaturated fatty acid biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10601301

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS07617-MONOMER
Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2046105 Linoleic acid (LA) metabolism R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
UniPathwayⁱ	UPA00658

Chemistry databases

SwissLipidsⁱ	SLP:000000368

SwissLipidsⁱ

SLP:000000368

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fatty acid desaturase 1 (EC:1.14.19.-) Alternative name(s): Delta(5) fatty acid desaturase Short name: D5D Short name: Delta(5) desaturase Short name: Delta-5 desaturase
Gene namesⁱ	Name:FADS1 Synonyms:FADSD5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149485.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3574 FADS1
MIMⁱ	606148 gene
neXtProtⁱ	NX_O60427

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 121	CytoplasmicSequence analysisAdd BLAST	121
Transmembraneⁱ	122 – 142	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	143 – 145	LumenalSequence analysis	3
Transmembraneⁱ	146 – 170	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	171 – 267	CytoplasmicSequence analysisAdd BLAST	97
Transmembraneⁱ	268 – 288	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	289 – 305	LumenalSequence analysisAdd BLAST	17
Transmembraneⁱ	306 – 326	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	327 – 444	CytoplasmicSequence analysisAdd BLAST	118

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3992
Open Targets More...OpenTargetsⁱ	ENSG00000149485
PharmGKBⁱ	PA27973

Chemistry databases

ChEMBLⁱ	CHEMBL5840
Drug and drug target database More...DrugBankⁱ	DB00132 Alpha-Linolenic Acid DB00159 Icosapent

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000307096	1 – 444	Fatty acid desaturase 1Add BLAST		444

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources1 Publication		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O60427
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60427
PaxDbⁱ	O60427
PeptideAtlas More...PeptideAtlasⁱ	O60427
PRIDEⁱ	O60427
ProteomicsDBⁱ	49399

PTM databases

iPTMnetⁱ	O60427
PhosphoSitePlusⁱ	O60427

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain.3 Publications

Inductionⁱ

Strongly down-regulated upon differentiation in a neuroblastoma cell line (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000149485 Expressed in 232 organ(s), highest expression level in mammalian vulva
ExpressionAtlasⁱ	O60427 baseline and differential
Genevisibleⁱ	O60427 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042705

HPAⁱ

HPA042705

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	110180, 27 interactors
IntActⁱ	O60427, 2 interactors
Molecular INTeraction database More...MINTⁱ	O60427
STRINGⁱ	9606.ENSP00000322229

Chemistry databases

BindingDBⁱ

O60427

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60427
SMRⁱ	O60427
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 94	Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST		78

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	179 – 183	Histidine box-1	5
Motifⁱ	216 – 220	Histidine box-2	5
Motifⁱ	382 – 386	Histidine box-3	5

Domainⁱ

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesⁱ

Belongs to the fatty acid desaturase type 1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4232 Eukaryota ENOG410XVSZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046574
HOGENOMⁱ	HOG000012997
HOVERGENⁱ	HBG002839
InParanoidⁱ	O60427
KEGG Orthology (KO) More...KOⁱ	K10224
PhylomeDBⁱ	O60427
TreeFamⁱ	TF313604

Family and domain databases

Gene3Dⁱ	3.10.120.10, 1 hit
InterProⁱ	View protein in InterPro IPR001199 Cyt_B5-like_heme/steroid-bd IPR036400 Cyt_B5-like_heme/steroid_sf IPR005804 FA_desaturase_dom IPR012171 Fatty_acid_desaturase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00173 Cyt-b5, 1 hit PF00487 FA_desaturase, 1 hit
PIRSFⁱ	PIRSF015921 FA_sphinglp_des, 1 hit
PRINTSⁱ	PR00363 CYTOCHROMEB5
SMARTⁱ	View protein in SMART SM01117 Cyt-b5, 1 hit
SUPFAMⁱ	SSF55856 SSF55856, 1 hit
PROSITEⁱ	View protein in PROSITE PS50255 CYTOCHROME_B5_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O60427-1) [UniParc]FASTA Add to basket

Also known as: FADS1CS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR 
        60         70         80         90        100
RHPGGSRVIS HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF 
       110        120        130        140        150
EPTKNKELTD EFRELRATVE RMGLMKANHV FFLLYLLHIL LLDGAAWLTL 
       160        170        180        190        200
WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD FGHLSVFSTS KWNHLLHHFV 
       210        220        230        240        250
IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA LGKILSVELG 
       260        270        280        290        300
KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI 
       310        320        330        340        350
TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD 
       360        370        380        390        400
RNMDWVSTQL QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA 
       410        420        430        440 
PLVQSLCAKH GIEYQSKPLL SAFADIIHSL KESGQLWLDA YLHQ

Length:444

Mass (Da):51,964

Last modified:December 11, 2013 - v3

Checksum:ⁱCC3C28D82AA49BF2

GO

Isoform 2 (identifier: O60427-2) [UniParc]FASTA Add to basket

Also known as: FADS1AT1

The sequence of this isoform differs from the canonical sequence as follows:
1-84: Missing.

« Hide

        10         20         30         40         50
MNSLLIGELS PEQPSFEPTK NKELTDEFRE LRATVERMGL MKANHVFFLL 
        60         70         80         90        100
YLLHILLLDG AAWLTLWVFG TSFLPFLLCA VLLSAVQAQA GWLQHDFGHL 
       110        120        130        140        150
SVFSTSKWNH LLHHFVIGHL KGAPASWWNH MHFQHHAKPN CFRKDPDINM 
       160        170        180        190        200
HPFFFALGKI LSVELGKQKK KYMPYNHQHK YFFLIGPPAL LPLYFQWYIF 
       210        220        230        240        250
YFVIQRKKWV DLAWMITFYV RFFLTYVPLL GLKAFLGLFF IVRFLESNWF 
       260        270        280        290        300
VWVTQMNHIP MHIDHDRNMD WVSTQLQATC NVHKSAFNDW FSGHLNFQIE 
       310        320        330        340        350
HHLFPTMPRH NYHKVAPLVQ SLCAKHGIEY QSKPLLSAFA DIIHSLKESG 
       360
QLWLDAYLHQ

Note: No experimental confirmation available.

Show »

Length:360

Mass (Da):42,474

Checksum:ⁱCD55B8317E4BF21E

GO

Computationally mapped potential isoform sequencesⁱ

There are 16 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A0A0MR51	A0A0A0MR51_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1 hCG_40849	501	Annotation score:
	F5H3U5	F5H3U5_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	192	Annotation score:
	C9JJB3	C9JJB3_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	139	Annotation score:
	F5H3P6	F5H3P6_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	146	Annotation score:
	F5GWE3	F5GWE3_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	165	Annotation score:
	F5GYH4	F5GYH4_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	153	Annotation score:
	F5H852	F5H852_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	164	Annotation score:
	H7C2V0	H7C2V0_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	228	Annotation score:
	H0YB97	H0YB97_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	175	Annotation score:
	F5H8G5	F5H8G5_HUMAN	Fatty acid desaturase 1 Fatty acid desaturase 1	FADS1	124	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence BAC11182 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAC11229 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	V → L in AAF29378 (PubMed:16554811).Curated	1
Sequence conflictⁱ	9	E → G in BAB55103 (PubMed:10601301).Curated	1
Sequence conflictⁱ	15	P → L in AAF29378 (PubMed:16554811).Curated	1
Sequence conflictⁱ	100	F → L in BAC11182 (PubMed:10601301).Curated	1
Sequence conflictⁱ	143	D → E in BAC11182 (PubMed:10601301).Curated	1
Sequence conflictⁱ	180	D → G in BAD96626 (PubMed:17974005).Curated	1
Sequence conflictⁱ	212	W → R in BAB55173 (PubMed:10601301).Curated	1
Sequence conflictⁱ	213	N → S in BAC11182 (PubMed:10601301).Curated	1
Sequence conflictⁱ	255	K → N in AAF29378 (PubMed:16554811).Curated	1
Sequence conflictⁱ	319	F → L in BAB55103 (PubMed:10601301).Curated	1
Sequence conflictⁱ	361	Q → L in AAF70457 (PubMed:15489334).Curated	1
Sequence conflictⁱ	381	F → S in BAC11229 (PubMed:10601301).Curated	1
Sequence conflictⁱ	410	H → R in AAF70457 (PubMed:15489334).Curated	1
Sequence conflictⁱ	431	K → E in BAC11229 (PubMed:10601301).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035340	272	P → S1 PublicationCorresponds to variant dbSNP:rs17856235Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047521	1 – 84	Missing in isoform 2. 1 PublicationAdd BLAST		84

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027427 mRNA Translation: BAB55103.1 AK027522 mRNA Translation: BAB55173.1 AK074754 mRNA Translation: BAC11182.1 Different initiation. AK074819 mRNA Translation: BAC11229.1 Different initiation. AK096275 mRNA Translation: BAG53244.1 AK289552 mRNA Translation: BAF82241.1 AK314199 mRNA Translation: BAG36877.1 AC004770 Genomic DNA Translation: AAC23397.1 AP002380 Genomic DNA No translation available. AF084558 mRNA Translation: AAG23120.1 AL512760 mRNA Translation: CAC21679.1 AL834479 mRNA Translation: CAD39138.1 AK222906 mRNA Translation: BAD96626.1 BC007846 mRNA Translation: AAH07846.1 AF199596 mRNA Translation: AAF29378.1 AF226273 mRNA Translation: AAF70457.1
NCBI Reference Sequences More...RefSeqⁱ	NP_037534.3, NM_013402.4
UniGeneⁱ	Hs.503546

Genome annotation databases

Ensemblⁱ	ENST00000433932; ENSP00000405087; ENSG00000149485 [O60427-2] ENST00000542506; ENSP00000441403; ENSG00000149485 [O60427-2]
GeneIDⁱ	3992
KEGGⁱ	hsa:3992
UCSC genome browser More...UCSCⁱ	uc010rln.2 human [O60427-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60427	Fatty acid desaturase 1		HUMAN		501	UniRef100_O60427
FADS1 isoform 8 (Fragment)		PANTR		124
Fatty acid desaturase 1 (Fragment)		HUMAN		124
Fatty acid desaturase 1 (Fragment)		HUMAN		112
FADS1 isoform 15 (Fragment)		PANTR		112
+22

Protein	Similar proteins		Species	Score	Length	Source
O60427	Fatty acid desaturase 1		PAPAN		444	UniRef90_O60427
Fatty acid desaturase 1		HUMAN		501
FADS1 isoform 8 (Fragment)		PANTR		124
Fatty acid desaturase 1		CHLSB		501
Uncharacterized protein		RHIBE		501
+60

Protein	Similar proteins		Species	Score	Length	Source
O60427	Fatty acid desaturase 1		PAPAN		444	UniRef50_O60427
Fatty acid desaturase 1		HUMAN		501
FADS1 isoform 8 (Fragment)		PANTR		124
Uncharacterized protein		MACMU		501
Macaca fascicularis brain cDNA clone: QflA-22081, similar to human fatty acid desaturase 1 (FADS1), mRNA, RefSeq: NM_013402.3		MACFA		146
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027427 mRNA Translation: BAB55103.1 AK027522 mRNA Translation: BAB55173.1 AK074754 mRNA Translation: BAC11182.1 Different initiation. AK074819 mRNA Translation: BAC11229.1 Different initiation. AK096275 mRNA Translation: BAG53244.1 AK289552 mRNA Translation: BAF82241.1 AK314199 mRNA Translation: BAG36877.1 AC004770 Genomic DNA Translation: AAC23397.1 AP002380 Genomic DNA No translation available. AF084558 mRNA Translation: AAG23120.1 AL512760 mRNA Translation: CAC21679.1 AL834479 mRNA Translation: CAD39138.1 AK222906 mRNA Translation: BAD96626.1 BC007846 mRNA Translation: AAH07846.1 AF199596 mRNA Translation: AAF29378.1 AF226273 mRNA Translation: AAF70457.1
RefSeqⁱ	NP_037534.3, NM_013402.4
UniGeneⁱ	Hs.503546

3D structure databases

ProteinModelPortalⁱ	O60427
SMRⁱ	O60427
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110180, 27 interactors
IntActⁱ	O60427, 2 interactors
MINTⁱ	O60427
STRINGⁱ	9606.ENSP00000322229

Chemistry databases

BindingDBⁱ	O60427
ChEMBLⁱ	CHEMBL5840
DrugBankⁱ	DB00132 Alpha-Linolenic Acid DB00159 Icosapent
SwissLipidsⁱ	SLP:000000368

PTM databases

iPTMnetⁱ	O60427
PhosphoSitePlusⁱ	O60427

Proteomic databases

EPDⁱ	O60427
MaxQBⁱ	O60427
PaxDbⁱ	O60427
PeptideAtlasⁱ	O60427
PRIDEⁱ	O60427
ProteomicsDBⁱ	49399

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3992
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000433932; ENSP00000405087; ENSG00000149485 [O60427-2] ENST00000542506; ENSP00000441403; ENSG00000149485 [O60427-2]
GeneIDⁱ	3992
KEGGⁱ	hsa:3992
UCSCⁱ	uc010rln.2 human [O60427-1]

Organism-specific databases

CTDⁱ	3992
DisGeNETⁱ	3992
EuPathDBⁱ	HostDB:ENSG00000149485.16
GeneCardsⁱ	FADS1
HGNCⁱ	HGNC:3574 FADS1
HPAⁱ	HPA042705
MIMⁱ	606148 gene
neXtProtⁱ	NX_O60427
OpenTargetsⁱ	ENSG00000149485
PharmGKBⁱ	PA27973
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4232 Eukaryota ENOG410XVSZ LUCA
GeneTreeⁱ	ENSGT00510000046574
HOGENOMⁱ	HOG000012997
HOVERGENⁱ	HBG002839
InParanoidⁱ	O60427
KOⁱ	K10224
PhylomeDBⁱ	O60427
TreeFamⁱ	TF313604

Enzyme and pathway databases

UniPathwayⁱ	UPA00658
BioCycⁱ	MetaCyc:HS07617-MONOMER
Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2046105 Linoleic acid (LA) metabolism R-HSA-2046106 alpha-linolenic acid (ALA) metabolism

Miscellaneous databases

ChiTaRSⁱ	FADS1 human
GeneWikiⁱ	FADS1
GenomeRNAiⁱ	3992
Protein Ontology More...PROⁱ	PR:O60427
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149485 Expressed in 232 organ(s), highest expression level in mammalian vulva
ExpressionAtlasⁱ	O60427 baseline and differential
Genevisibleⁱ	O60427 HS

Family and domain databases

Gene3Dⁱ	3.10.120.10, 1 hit
InterProⁱ	View protein in InterPro IPR001199 Cyt_B5-like_heme/steroid-bd IPR036400 Cyt_B5-like_heme/steroid_sf IPR005804 FA_desaturase_dom IPR012171 Fatty_acid_desaturase
Pfamⁱ	View protein in Pfam PF00173 Cyt-b5, 1 hit PF00487 FA_desaturase, 1 hit
PIRSFⁱ	PIRSF015921 FA_sphinglp_des, 1 hit
PRINTSⁱ	PR00363 CYTOCHROMEB5
SMARTⁱ	View protein in SMART SM01117 Cyt-b5, 1 hit
SUPFAMⁱ	SSF55856 SSF55856, 1 hit
PROSITEⁱ	View protein in PROSITE PS50255 CYTOCHROME_B5_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FADS1_HUMAN
Accessionⁱ	O60427Primary (citable) accession number: O60427 Secondary accession number(s): A8K0I7 Q9NYX1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	December 11, 2013
	Last modified:	September 12, 2018
	This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - O60427 (FADS1_HUMAN)

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Fatty acid desaturase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: polyunsaturated fatty acid biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Mitochondrion

Endoplasmic reticulum

Endoplasmic reticulum

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: polyunsaturated fatty acid biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ