UniProtKB - O60427 (FADS1_HUMAN)
Acyl-CoA (8-3)-desaturase
FADS1
Functioni
Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175).
As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity).
Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).
By similarity2 PublicationsDoes not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.
By similarityCatalytic activityi
- (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O2 PublicationsEC:1.14.19.442 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O1 PublicationEC:1.14.19.441 PublicationThis reaction proceeds in the forward1 Publication direction.
- (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2OBy similarityThis reaction proceeds in the forwardBy similarity direction.
: polyunsaturated fatty acid biosynthesis Pathwayi
This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- acyl-CoA delta5-desaturase activity Source: UniProtKB
- C-5 sterol desaturase activity Source: ProtInc
- linoleoyl-CoA desaturase activity Source: MGI
- omega-6 fatty acid desaturase activity Source: Reactome
- oxidoreductase activity Source: UniProtKB
- oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Source: GO_Central
GO - Biological processi
- alpha-linolenic acid metabolic process Source: Reactome
- cell-cell signaling Source: UniProtKB
- cellular response to starvation Source: UniProtKB
- icosanoid biosynthetic process Source: UniProtKB
- linoleic acid metabolic process Source: Reactome
- lipid metabolic process Source: GO_Central
- long-chain fatty acid biosynthetic process Source: MGI
- phospholipid biosynthetic process Source: UniProtKB
- regulation of cell differentiation Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- unsaturated fatty acid biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport |
Enzyme and pathway databases
BRENDAi | 1.14.19.30, 2681 |
PathwayCommonsi | O60427 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2046105, Linoleic acid (LA) metabolism R-HSA-2046106, alpha-linolenic acid (ALA) metabolism |
SignaLinki | O60427 |
SIGNORi | O60427 |
UniPathwayi | UPA00658 |
Chemistry databases
SwissLipidsi | SLP:000000368 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-CoA (8-3)-desaturaseCurated (EC:1.14.19.442 Publications)Alternative name(s): Delta(5) fatty acid desaturase Short name: D5DBy similarity Short name: Delta(5) desaturaseBy similarity Short name: Delta-5 desaturase2 Publications Fatty acid desaturase 11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3574, FADS1 |
MIMi | 606148, gene |
neXtProti | NX_O60427 |
VEuPathDBi | HostDB:ENSG00000149485 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- integral component of membrane Source: ProtInc
- intracellular membrane-bounded organelle Source: UniProtKB
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 121 | CytoplasmicSequence analysisAdd BLAST | 121 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 143 – 145 | LumenalSequence analysis | 3 | |
Transmembranei | 146 – 170 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 171 – 267 | CytoplasmicSequence analysisAdd BLAST | 97 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 289 – 305 | LumenalSequence analysisAdd BLAST | 17 | |
Transmembranei | 306 – 326 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 327 – 444 | CytoplasmicSequence analysisAdd BLAST | 118 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 3992 |
OpenTargetsi | ENSG00000149485 |
PharmGKBi | PA27973 |
Miscellaneous databases
Pharosi | O60427, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5840 |
DrugBanki | DB00132, alpha-Linolenic acid DB11358, Evening primrose oil DB00159, Icosapent DB13168, Omega-6 fatty acids DB09328, Vayarin |
Genetic variation databases
BioMutai | FADS1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307096 | 1 – 444 | Acyl-CoA (8-3)-desaturaseAdd BLAST | 444 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O60427 |
jPOSTi | O60427 |
MassIVEi | O60427 |
MaxQBi | O60427 |
PaxDbi | O60427 |
PeptideAtlasi | O60427 |
PRIDEi | O60427 |
ProteomicsDBi | 1836 49399 [O60427-1] |
PTM databases
iPTMneti | O60427 |
PhosphoSitePlusi | O60427 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000149485, Expressed in mammalian vulva and 241 other tissues |
ExpressionAtlasi | O60427, baseline and differential |
Genevisiblei | O60427, HS |
Organism-specific databases
HPAi | ENSG00000149485, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 110180, 74 interactors |
IntActi | O60427, 19 interactors |
MINTi | O60427 |
STRINGi | 9606.ENSP00000322229 |
Chemistry databases
BindingDBi | O60427 |
Miscellaneous databases
RNActi | O60427, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 94 | Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST | 78 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 179 – 183 | Histidine box-1 | 5 | |
Motifi | 216 – 220 | Histidine box-2 | 5 | |
Motifi | 382 – 386 | Histidine box-3 | 5 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4232, Eukaryota |
GeneTreei | ENSGT00950000182990 |
HOGENOMi | CLU_016265_0_0_1 |
InParanoidi | O60427 |
OMAi | MITFYIR |
OrthoDBi | 1060606at2759 |
PhylomeDBi | O60427 |
TreeFami | TF313604 |
Family and domain databases
Gene3Di | 3.10.120.10, 1 hit |
InterProi | View protein in InterPro IPR001199, Cyt_B5-like_heme/steroid-bd IPR036400, Cyt_B5-like_heme/steroid_sf IPR005804, FA_desaturase_dom IPR012171, Fatty_acid_desaturase |
PANTHERi | PTHR19353, PTHR19353, 1 hit |
Pfami | View protein in Pfam PF00173, Cyt-b5, 1 hit PF00487, FA_desaturase, 1 hit |
PIRSFi | PIRSF015921, FA_sphinglp_des, 1 hit |
PRINTSi | PR00363, CYTOCHROMEB5 |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF55856, SSF55856, 1 hit |
PROSITEi | View protein in PROSITE PS50255, CYTOCHROME_B5_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR
60 70 80 90 100
RHPGGSRVIS HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF
110 120 130 140 150
EPTKNKELTD EFRELRATVE RMGLMKANHV FFLLYLLHIL LLDGAAWLTL
160 170 180 190 200
WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD FGHLSVFSTS KWNHLLHHFV
210 220 230 240 250
IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA LGKILSVELG
260 270 280 290 300
KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI
310 320 330 340 350
TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD
360 370 380 390 400
RNMDWVSTQL QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA
410 420 430 440
PLVQSLCAKH GIEYQSKPLL SAFADIIHSL KESGQLWLDA YLHQ
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MR51 | A0A0A0MR51_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 hCG_40849 | 501 | Annotation score: | ||
F5H3U5 | F5H3U5_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 192 | Annotation score: | ||
H7C2V0 | H7C2V0_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 228 | Annotation score: | ||
F5GWE3 | F5GWE3_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 165 | Annotation score: | ||
F5GYH4 | F5GYH4_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 153 | Annotation score: | ||
F5H3P6 | F5H3P6_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 146 | Annotation score: | ||
F5H852 | F5H852_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 164 | Annotation score: | ||
H0YB97 | H0YB97_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 175 | Annotation score: | ||
C9J425 | C9J425_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 47 | Annotation score: | ||
F5H1Q7 | F5H1Q7_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 86 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | V → L in AAF29378 (PubMed:16554811).Curated | 1 | |
Sequence conflicti | 9 | E → G in BAB55103 (PubMed:10601301).Curated | 1 | |
Sequence conflicti | 15 | P → L in AAF29378 (PubMed:16554811).Curated | 1 | |
Sequence conflicti | 100 | F → L in BAC11182 (PubMed:10601301).Curated | 1 | |
Sequence conflicti | 143 | D → E in BAC11182 (PubMed:10601301).Curated | 1 | |
Sequence conflicti | 180 | D → G in BAD96626 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 212 | W → R in BAB55173 (PubMed:10601301).Curated | 1 | |
Sequence conflicti | 213 | N → S in BAC11182 (PubMed:10601301).Curated | 1 | |
Sequence conflicti | 255 | K → N in AAF29378 (PubMed:16554811).Curated | 1 | |
Sequence conflicti | 319 | F → L in BAB55103 (PubMed:10601301).Curated | 1 | |
Sequence conflicti | 361 | Q → L in AAF70457 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 381 | F → S in BAC11229 (PubMed:10601301).Curated | 1 | |
Sequence conflicti | 410 | H → R in AAF70457 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 431 | K → E in BAC11229 (PubMed:10601301).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035340 | 272 | P → S1 PublicationCorresponds to variant dbSNP:rs17856235Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047521 | 1 – 84 | Missing in isoform 2. 1 PublicationAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027427 mRNA Translation: BAB55103.1 AK027522 mRNA Translation: BAB55173.1 AK074754 mRNA Translation: BAC11182.1 Different initiation. AK074819 mRNA Translation: BAC11229.1 Different initiation. AK096275 mRNA Translation: BAG53244.1 AK289552 mRNA Translation: BAF82241.1 AK314199 mRNA Translation: BAG36877.1 AC004770 Genomic DNA Translation: AAC23397.1 AP002380 Genomic DNA No translation available. AF084558 mRNA Translation: AAG23120.1 AL512760 mRNA Translation: CAC21679.1 AL834479 mRNA Translation: CAD39138.1 AK222906 mRNA Translation: BAD96626.1 BC007846 mRNA Translation: AAH07846.1 AF199596 mRNA Translation: AAF29378.1 AF226273 mRNA Translation: AAF70457.1 |
RefSeqi | NP_037534.3, NM_013402.4 |
Genome annotation databases
Ensembli | ENST00000433932.5; ENSP00000405087.1; ENSG00000149485.19 [O60427-2] ENST00000542506.5; ENSP00000441403.1; ENSG00000149485.19 [O60427-2] |
GeneIDi | 3992 |
KEGGi | hsa:3992 |
UCSCi | uc010rln.2, human [O60427-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027427 mRNA Translation: BAB55103.1 AK027522 mRNA Translation: BAB55173.1 AK074754 mRNA Translation: BAC11182.1 Different initiation. AK074819 mRNA Translation: BAC11229.1 Different initiation. AK096275 mRNA Translation: BAG53244.1 AK289552 mRNA Translation: BAF82241.1 AK314199 mRNA Translation: BAG36877.1 AC004770 Genomic DNA Translation: AAC23397.1 AP002380 Genomic DNA No translation available. AF084558 mRNA Translation: AAG23120.1 AL512760 mRNA Translation: CAC21679.1 AL834479 mRNA Translation: CAD39138.1 AK222906 mRNA Translation: BAD96626.1 BC007846 mRNA Translation: AAH07846.1 AF199596 mRNA Translation: AAF29378.1 AF226273 mRNA Translation: AAF70457.1 |
RefSeqi | NP_037534.3, NM_013402.4 |
3D structure databases
AlphaFoldDBi | O60427 |
SMRi | O60427 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110180, 74 interactors |
IntActi | O60427, 19 interactors |
MINTi | O60427 |
STRINGi | 9606.ENSP00000322229 |
Chemistry databases
BindingDBi | O60427 |
ChEMBLi | CHEMBL5840 |
DrugBanki | DB00132, alpha-Linolenic acid DB11358, Evening primrose oil DB00159, Icosapent DB13168, Omega-6 fatty acids DB09328, Vayarin |
SwissLipidsi | SLP:000000368 |
PTM databases
iPTMneti | O60427 |
PhosphoSitePlusi | O60427 |
Genetic variation databases
BioMutai | FADS1 |
Proteomic databases
EPDi | O60427 |
jPOSTi | O60427 |
MassIVEi | O60427 |
MaxQBi | O60427 |
PaxDbi | O60427 |
PeptideAtlasi | O60427 |
PRIDEi | O60427 |
ProteomicsDBi | 1836 49399 [O60427-1] |
Protocols and materials databases
Antibodypediai | 21596, 274 antibodies from 36 providers |
DNASUi | 3992 |
Genome annotation databases
Ensembli | ENST00000433932.5; ENSP00000405087.1; ENSG00000149485.19 [O60427-2] ENST00000542506.5; ENSP00000441403.1; ENSG00000149485.19 [O60427-2] |
GeneIDi | 3992 |
KEGGi | hsa:3992 |
UCSCi | uc010rln.2, human [O60427-1] |
Organism-specific databases
CTDi | 3992 |
DisGeNETi | 3992 |
GeneCardsi | FADS1 |
HGNCi | HGNC:3574, FADS1 |
HPAi | ENSG00000149485, Low tissue specificity |
MIMi | 606148, gene |
neXtProti | NX_O60427 |
OpenTargetsi | ENSG00000149485 |
PharmGKBi | PA27973 |
VEuPathDBi | HostDB:ENSG00000149485 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4232, Eukaryota |
GeneTreei | ENSGT00950000182990 |
HOGENOMi | CLU_016265_0_0_1 |
InParanoidi | O60427 |
OMAi | MITFYIR |
OrthoDBi | 1060606at2759 |
PhylomeDBi | O60427 |
TreeFami | TF313604 |
Enzyme and pathway databases
UniPathwayi | UPA00658 |
BRENDAi | 1.14.19.30, 2681 |
PathwayCommonsi | O60427 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2046105, Linoleic acid (LA) metabolism R-HSA-2046106, alpha-linolenic acid (ALA) metabolism |
SignaLinki | O60427 |
SIGNORi | O60427 |
Miscellaneous databases
BioGRID-ORCSi | 3992, 19 hits in 1083 CRISPR screens |
ChiTaRSi | FADS1, human |
GeneWikii | FADS1 |
GenomeRNAii | 3992 |
Pharosi | O60427, Tchem |
PROi | PR:O60427 |
RNActi | O60427, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149485, Expressed in mammalian vulva and 241 other tissues |
ExpressionAtlasi | O60427, baseline and differential |
Genevisiblei | O60427, HS |
Family and domain databases
Gene3Di | 3.10.120.10, 1 hit |
InterProi | View protein in InterPro IPR001199, Cyt_B5-like_heme/steroid-bd IPR036400, Cyt_B5-like_heme/steroid_sf IPR005804, FA_desaturase_dom IPR012171, Fatty_acid_desaturase |
PANTHERi | PTHR19353, PTHR19353, 1 hit |
Pfami | View protein in Pfam PF00173, Cyt-b5, 1 hit PF00487, FA_desaturase, 1 hit |
PIRSFi | PIRSF015921, FA_sphinglp_des, 1 hit |
PRINTSi | PR00363, CYTOCHROMEB5 |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF55856, SSF55856, 1 hit |
PROSITEi | View protein in PROSITE PS50255, CYTOCHROME_B5_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FADS1_HUMAN | |
Accessioni | O60427Primary (citable) accession number: O60427 Secondary accession number(s): A8K0I7 Q9NYX1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | December 11, 2013 | |
Last modified: | May 25, 2022 | |
This is version 177 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families