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Protein

Phospholipid-transporting ATPase IK

Gene

ATP8B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida.By similarity

Miscellaneous

Association with flippase complex beta subunits TMEM30A and TMEM30A has not been detected, neither did their coexpression change the localization in ER.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4954-aspartylphosphate intermediateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi939MagnesiumBy similarity1
Metal bindingi943MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-936837 Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid-transporting ATPase IK (EC:7.6.2.1)
Alternative name(s):
ATPase class I type 8B member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP8B3
Synonyms:ATP1K, FOS37502_2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000130270.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13535 ATP8B3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605866 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60423

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 149CytoplasmicSequence analysisAdd BLAST149
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei150 – 171HelicalSequence analysisAdd BLAST22
Topological domaini172 – 177Exoplasmic loopSequence analysis6
Transmembranei178 – 197HelicalSequence analysisAdd BLAST20
Topological domaini198 – 381CytoplasmicSequence analysisAdd BLAST184
Transmembranei382 – 403HelicalSequence analysisAdd BLAST22
Topological domaini404 – 430Exoplasmic loopSequence analysisAdd BLAST27
Transmembranei431 – 452HelicalSequence analysisAdd BLAST22
Topological domaini453 – 995CytoplasmicSequence analysisAdd BLAST543
Transmembranei996 – 1016HelicalSequence analysisAdd BLAST21
Topological domaini1017 – 1028Exoplasmic loopSequence analysisAdd BLAST12
Transmembranei1029 – 1048HelicalSequence analysisAdd BLAST20
Topological domaini1049 – 1078CytoplasmicSequence analysisAdd BLAST30
Transmembranei1079 – 1100HelicalSequence analysisAdd BLAST22
Topological domaini1101 – 1112Exoplasmic loopSequence analysisAdd BLAST12
Transmembranei1113 – 1135HelicalSequence analysisAdd BLAST23
Topological domaini1136 – 1141CytoplasmicSequence analysis6
Transmembranei1142 – 1162HelicalSequence analysisAdd BLAST21
Topological domaini1163 – 1182Exoplasmic loopSequence analysisAdd BLAST20
Transmembranei1183 – 1207HelicalSequence analysisAdd BLAST25
Topological domaini1208 – 1300CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
148229

Open Targets

More...
OpenTargetsi
ENSG00000130270

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25168

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP8B3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463671 – 1300Phospholipid-transporting ATPase IKAdd BLAST1300

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60423

PeptideAtlas

More...
PeptideAtlasi
O60423

PRoteomics IDEntifications database

More...
PRIDEi
O60423

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49396
49397 [O60423-1]
49398 [O60423-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60423

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60423

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 was only detected in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000130270 Expressed in 96 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_ATP8B3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60423 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60423 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311336

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60423

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITKD Eukaryota
ENOG410XPYK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000202528

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050601

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60423

KEGG Orthology (KO)

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KOi
K01530

Identification of Orthologs from Complete Genome Data

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OMAi
KCQAVIC

Database of Orthologous Groups

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OrthoDBi
EOG091G0139

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60423

TreeFam database of animal gene trees

More...
TreeFami
TF300654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030349 ATP8B3
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c

The PANTHER Classification System

More...
PANTHERi
PTHR24092 PTHR24092, 1 hit
PTHR24092:SF78 PTHR24092:SF78, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60423-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTGPAQTPR STRAGPEPSP APPGPGDTGD SDVTQEGSGP AGIRGGETVI
60 70 80 90 100
RAGMGDSPGR GAPERRHKAQ PGRARKYEWR PEGPTSMGSL GQREDLQDED
110 120 130 140 150
RNSAFTWKVQ ANNRAYNGQF KEKVILCWQR KKYKTNVIRT AKYNFYSFLP
160 170 180 190 200
LNLYEQFHRV SNLFFLIIII LQSIPDISTL PWFSLSTPMV CLLFIRATRD
210 220 230 240 250
LVDDMGRHKS DRAINNRPCQ ILMGKSFKQK KWQDLCVGDV VCLRKDNIVP
260 270 280 290 300
ADMLLLASTE PSSLCYVETV DIDGETNLKF RQALMVTHKE LATIKKMASF
310 320 330 340 350
QGTVTCEAPN SRMHHFVGCL EWNDKKYSLD IGNLLLRGCR IRNTDTCYGL
360 370 380 390 400
VIYAGFDTKI MKNCGKIHLK RTKLDLLMNK LVVVIFISVV LVCLVLAFGF
410 420 430 440 450
GFSVKEFKDH HYYLSGVHGS SVAAESFFVF WSFLILLSVT IPMSMFILSE
460 470 480 490 500
FIYLGNSVFI DWDVQMYYKP QDVPAKARST SLNDHLGQVE YIFSDKTGTL
510 520 530 540 550
TQNILTFNKC CISGRVYGPD SEATTRPKEN PYLWNKFADG KLLFHNAALL
560 570 580 590 600
HLVRTNGDEA VREFWRLLAI CHTVMVRESP RERPDQLLYQ AASPDEGALV
610 620 630 640 650
TAARNFGYVF LSRTQDTVTI MELGEERVYQ VLAIMDFNST RKRMSVLVRK
660 670 680 690 700
PEGAICLYTK GADTVIFERL HRRGAMEFAT EEALAAFAQE TLRTLCLAYR
710 720 730 740 750
EVAEDIYEDW QQRHQEASLL LQNRAQALQQ LLGATAIEDR LQDGVPETIK
760 770 780 790 800
CLKKSNIKIW VLTGDKQETA VNIGFACELL SENMLILEEK EISRILETYW
810 820 830 840 850
ENSNNLLTRE SLSQVKLALV INGDFLDKLL VSLRKEPRAL AQNVNMDEAW
860 870 880 890 900
QELGQSRRDF LYARRLSLLC RRFGLPLAAP PAQDSRARRS SEVLQERAFV
910 920 930 940 950
DLASKCQAVI CCRVTPKQKA LIVALVKKYH QVVTLAIGDG ANDINMIKTA
960 970 980 990 1000
DVGVGLAGQE GMQAVQNSDF VLGQFCFLQR LLLVHGRWSY VRICKFLRYF
1010 1020 1030 1040 1050
FYKSMASMMV QVWFACYNGF TGQPLYEGWF LALFNLLYST LPVLYIGLFE
1060 1070 1080 1090 1100
QDVSAEQSLE KPELYVVGQK DELFNYWVFV QAIAHGVTTS LVNFFMTLWI
1110 1120 1130 1140 1150
SRDTAGPASF SDHQSFAVVV ALSCLLSITM EVILIIKYWT ALCVATILLS
1160 1170 1180 1190 1200
LGFYAIMTTT TQSFWLFRVS PTTFPFLYAD LSVMSSPSIL LVVLLSVSIN
1210 1220 1230 1240 1250
TFPVLALRVI FPALKELRAK EEKVEEGPSE EIFTMEPLPH VHRESRARRS
1260 1270 1280 1290 1300
SYAFSHREGY ANLITQGTIL RRGPGVSSDI ASESLDPSDE EAASSPKESQ
Length:1,300
Mass (Da):146,752
Last modified:October 5, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i356B1972DD49DFF5
GO
Isoform 2 (identifier: O60423-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     730-730: Q → QVYNEMEQDLR

Note: No experimental confirmation available.
Show »
Length:1,310
Mass (Da):148,031
Checksum:iF1A1C25A8DE696FC
GO
Isoform 3 (identifier: O60423-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     354-354: A → ADGYMFV
     730-730: Q → QVYNEMEQDLR

Note: No experimental confirmation available.
Show »
Length:1,263
Mass (Da):143,705
Checksum:i246752DB1DAC2E44
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3R9F5H3R9_HUMAN
Phospholipid-transporting ATPase IK
ATP8B3
562Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ52K7EJ52_HUMAN
Phospholipid-transporting ATPase IK
ATP8B3
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZM8F5GZM8_HUMAN
Phospholipid-transporting ATPase IK
ATP8B3
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFS1H0YFS1_HUMAN
Phospholipid-transporting ATPase IK
ATP8B3
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC17601 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB71492 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05554445G → R. Corresponds to variant dbSNP:rs7250872Ensembl.1
Natural variantiVAR_055545618V → I. Corresponds to variant dbSNP:rs8100856Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0435541 – 53Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_043555354A → ADGYMFV in isoform 3. 1 Publication1
Alternative sequenceiVSP_039716730Q → QVYNEMEQDLR in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY302538 mRNA Translation: AAQ19028.1
AC004755 Genomic DNA Translation: AAC17601.1 Sequence problems.
AC012615 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69455.1
AK057452 mRNA Translation: BAB71492.1 Different initiation.
BC035162 mRNA Translation: AAH35162.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45901.1 [O60423-2]
CCDS54196.1 [O60423-3]

NCBI Reference Sequences

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RefSeqi
NP_001171473.1, NM_001178002.2 [O60423-3]
NP_620168.1, NM_138813.3 [O60423-2]
XP_006722717.1, XM_006722654.2 [O60423-1]
XP_006722718.1, XM_006722655.2 [O60423-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.306212

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000310127; ENSP00000311336; ENSG00000130270 [O60423-2]
ENST00000525591; ENSP00000437115; ENSG00000130270 [O60423-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
148229

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:148229

UCSC genome browser

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UCSCi
uc002ltv.5 human [O60423-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302538 mRNA Translation: AAQ19028.1
AC004755 Genomic DNA Translation: AAC17601.1 Sequence problems.
AC012615 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69455.1
AK057452 mRNA Translation: BAB71492.1 Different initiation.
BC035162 mRNA Translation: AAH35162.3
CCDSiCCDS45901.1 [O60423-2]
CCDS54196.1 [O60423-3]
RefSeqiNP_001171473.1, NM_001178002.2 [O60423-3]
NP_620168.1, NM_138813.3 [O60423-2]
XP_006722717.1, XM_006722654.2 [O60423-1]
XP_006722718.1, XM_006722655.2 [O60423-1]
UniGeneiHs.306212

3D structure databases

ProteinModelPortaliO60423
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311336

PTM databases

iPTMnetiO60423
PhosphoSitePlusiO60423

Polymorphism and mutation databases

BioMutaiATP8B3

Proteomic databases

PaxDbiO60423
PeptideAtlasiO60423
PRIDEiO60423
ProteomicsDBi49396
49397 [O60423-1]
49398 [O60423-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310127; ENSP00000311336; ENSG00000130270 [O60423-2]
ENST00000525591; ENSP00000437115; ENSG00000130270 [O60423-3]
GeneIDi148229
KEGGihsa:148229
UCSCiuc002ltv.5 human [O60423-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
148229
DisGeNETi148229
EuPathDBiHostDB:ENSG00000130270.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ATP8B3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0202756
HGNCiHGNC:13535 ATP8B3
MIMi605866 gene
neXtProtiNX_O60423
OpenTargetsiENSG00000130270
PharmGKBiPA25168

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00940000160463
HOGENOMiHOG000202528
HOVERGENiHBG050601
InParanoidiO60423
KOiK01530
OMAiKCQAVIC
OrthoDBiEOG091G0139
PhylomeDBiO60423
TreeFamiTF300654

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATP8B3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ATP8B3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
148229

Protein Ontology

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PROi
PR:O60423

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130270 Expressed in 96 organ(s), highest expression level in right testis
CleanExiHS_ATP8B3
ExpressionAtlasiO60423 baseline and differential
GenevisibleiO60423 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR030349 ATP8B3
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF78 PTHR24092:SF78, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT8B3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60423
Secondary accession number(s): Q7Z485
, Q8IVB8, Q8N4Y8, Q96M22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 172 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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