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Protein

Olfactory receptor 7C2

Gene

OR7C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7C2
Alternative name(s):
Olfactory receptor 19-18
Short name:
OR19-18
Olfactory receptor 7C3
Olfactory receptor OR19-22
Gene namesi
Name:OR7C2
Synonyms:OR7C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127529.7
HGNCiHGNC:8374 OR7C2
neXtProtiNX_O60412

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 236CytoplasmicSequence analysisAdd BLAST19
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 319CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32625

Polymorphism and mutation databases

BioMutaiOR7C2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506471 – 319Olfactory receptor 7C2Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60412
PRIDEiO60412
ProteomicsDBi49394

Expressioni

Gene expression databases

BgeeiENSG00000127529 Expressed in 3 organ(s), highest expression level in putamen
CleanExiHS_OR7C2
GenevisibleiO60412 HS

Organism-specific databases

HPAiHPA047295

Interactioni

Protein-protein interaction databases

IntActiO60412, 2 interactors
STRINGi9606.ENSP00000248072

Structurei

3D structure databases

ProteinModelPortaliO60412
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118801
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiO60412
KOiK04257
OMAiMITFAGC
OrthoDBiEOG091G0B53
PhylomeDBiO60412
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O60412-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERGNQTEVG NFLLLGFAED SDMQLLLHGL FLSMYLVTII GNLLIILTIS
60 70 80 90 100
SDSHLHTPMY FFLSNLSFAD ICFTSTTVPK MLVNIQTQSK MITFAGCLTQ
110 120 130 140 150
IFFFIAFGCL DNLLLTMTAY DRFVAICYPL HYTVIMNPRL CGLLVLGSWC
160 170 180 190 200
ISVMGSLLET LTILRLSFCT NMEIPHFFCD PSEVLKLACS DTFINNIVMY
210 220 230 240 250
FVTIVLGVFP LCGILFSYSQ IFSSVLRVSA RGQHKAFSTC GSHLSVVSLF
260 270 280 290 300
YGTGLGVYLS SAVTPPSRTS LAASVMYTMV TPMLNPFIYS LRNKDMKGSL
310
GRLLLRATSL KEGTIAKLS
Length:319
Mass (Da):35,323
Last modified:October 17, 2006 - v4
Checksum:i1FAF5A196B2B566C
GO

Sequence cautioni

The sequence DAA04611 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168F → S in AAC39626 (PubMed:9500546).Curated1
Sequence conflicti168F → S in AAK95030 (PubMed:12213199).Curated1
Sequence conflicti200Y → C in AAC39626 (PubMed:9500546).Curated1
Sequence conflicti200Y → C in AAK95030 (PubMed:12213199).Curated1
Sequence conflicti229S → SS in AAC39626 (PubMed:9500546).Curated1
Sequence conflicti229S → SS in AAK95030 (PubMed:12213199).Curated1
Sequence conflicti238S → T in AAC39626 (PubMed:9500546).Curated1
Sequence conflicti238S → T in AAK95030 (PubMed:12213199).Curated1
Sequence conflicti277Y → H in AAC39626 (PubMed:9500546).Curated1
Sequence conflicti277Y → H in AAK95030 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027808118T → M. Corresponds to variant dbSNP:rs8113325Ensembl.1
Natural variantiVAR_053234122R → H. Corresponds to variant dbSNP:rs11883178Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004659 Genomic DNA Translation: AAC15755.1
U86255 Genomic DNA Translation: AAC39626.1
AF399545 Genomic DNA Translation: AAK95030.1
BK004213 Genomic DNA Translation: DAA04611.1 Different initiation.
CCDSiCCDS12320.1
RefSeqiNP_036509.1, NM_012377.1
UniGeneiHs.589620

Genome annotation databases

EnsembliENST00000248072; ENSP00000248072; ENSG00000127529
GeneIDi26658
KEGGihsa:26658
UCSCiuc010xoc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004659 Genomic DNA Translation: AAC15755.1
U86255 Genomic DNA Translation: AAC39626.1
AF399545 Genomic DNA Translation: AAK95030.1
BK004213 Genomic DNA Translation: DAA04611.1 Different initiation.
CCDSiCCDS12320.1
RefSeqiNP_036509.1, NM_012377.1
UniGeneiHs.589620

3D structure databases

ProteinModelPortaliO60412
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60412, 2 interactors
STRINGi9606.ENSP00000248072

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7C2

Proteomic databases

PaxDbiO60412
PRIDEiO60412
ProteomicsDBi49394

Protocols and materials databases

DNASUi26658
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248072; ENSP00000248072; ENSG00000127529
GeneIDi26658
KEGGihsa:26658
UCSCiuc010xoc.2 human

Organism-specific databases

CTDi26658
EuPathDBiHostDB:ENSG00000127529.7
GeneCardsiOR7C2
HGNCiHGNC:8374 OR7C2
HPAiHPA047295
neXtProtiNX_O60412
PharmGKBiPA32625
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118801
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiO60412
KOiK04257
OMAiMITFAGC
OrthoDBiEOG091G0B53
PhylomeDBiO60412
TreeFamiTF337210

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR7C2
GenomeRNAii26658
PROiPR:O60412

Gene expression databases

BgeeiENSG00000127529 Expressed in 3 organ(s), highest expression level in putamen
CleanExiHS_OR7C2
GenevisibleiO60412 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR7C2_HUMAN
AccessioniPrimary (citable) accession number: O60412
Secondary accession number(s): O43881, Q6IFP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 144 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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