UniProtKB - O60404 (O10H3_HUMAN)
Protein
Olfactory receptor 10H3
Gene
OR10H3
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- G protein-coupled serotonin receptor activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
- olfactory receptor activity Source: InterPro
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 10H3Alternative name(s): Olfactory receptor OR19-24 |
Gene namesi | Name:OR10H3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8174 OR10H3 |
neXtProti | NX_O60404 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 54 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 99 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 100 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 197 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 198 – 218 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 219 – 238 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 239 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 272 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 273 – 293 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 294 – 316 | CytoplasmicSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA31979 |
Miscellaneous databases
Pharosi | O60404 |
Polymorphism and mutation databases
BioMutai | OR10H3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150704 | 1 – 316 | Olfactory receptor 10H3Add BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 98 ↔ 190 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | O60404 |
PeptideAtlasi | O60404 |
PRIDEi | O60404 |
ProteomicsDBi | 49393 |
PTM databases
iPTMneti | O60404 |
PhosphoSitePlusi | O60404 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171936 Expressed in 8 organ(s), highest expression level in muscle tissue |
ExpressionAtlasi | O60404 differential |
Genevisiblei | O60404 HS |
Interactioni
Protein-protein interaction databases
BioGridi | 117734, 8 interactors |
IntActi | O60404, 6 interactors |
STRINGi | 9606.ENSP00000307130 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410J91Z Eukaryota ENOG4111CKD LUCA |
GeneTreei | ENSGT00970000193373 |
HOGENOMi | HOG000041365 |
InParanoidi | O60404 |
KOi | K04257 |
OMAi | TVWIERR |
OrthoDBi | 970259at2759 |
PhylomeDBi | O60404 |
TreeFami | TF338279 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O60404-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV
60 70 80 90 100
WIERRLHTPM YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI
110 120 130 140 150
QMFFSFMFGF THSFLLMVMG YDHYVTICHP LHYNMLMSPR GCAHLVAWTW
160 170 180 190 200
AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC HVLSLLKLAC GSKTSSVIMG
210 220 230 240 250
VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF STCVSHLTVV
260 270 280 290 300
VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK
310
NAINKNFCRR FCPLSS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024128 | 7 | R → S. Corresponds to variant dbSNP:rs1966357Ensembl. | 1 | |
Natural variantiVAR_034288 | 14 | L → I. Corresponds to variant dbSNP:rs2240227Ensembl. | 1 | |
Natural variantiVAR_034289 | 54 | R → H. Corresponds to variant dbSNP:rs11670007Ensembl. | 1 | |
Natural variantiVAR_020381 | 224 | V → M1 PublicationCorresponds to variant dbSNP:rs2240228Ensembl. | 1 | |
Natural variantiVAR_020382 | 293 | S → N. Corresponds to variant dbSNP:rs2240229Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004597 Genomic DNA Translation: AAC14389.1 BC106707 mRNA Translation: AAI06708.1 BC113844 mRNA Translation: AAI13845.1 BK004212 Genomic DNA Translation: DAA04610.1 |
CCDSi | CCDS12334.1 |
RefSeqi | NP_039226.1, NM_013938.1 |
Genome annotation databases
Ensembli | ENST00000305892; ENSP00000307130; ENSG00000171936 ENST00000641646; ENSP00000493287; ENSG00000171936 |
GeneIDi | 26532 |
KEGGi | hsa:26532 |
UCSCi | uc010xoq.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004597 Genomic DNA Translation: AAC14389.1 BC106707 mRNA Translation: AAI06708.1 BC113844 mRNA Translation: AAI13845.1 BK004212 Genomic DNA Translation: DAA04610.1 |
CCDSi | CCDS12334.1 |
RefSeqi | NP_039226.1, NM_013938.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 117734, 8 interactors |
IntActi | O60404, 6 interactors |
STRINGi | 9606.ENSP00000307130 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | O60404 |
PhosphoSitePlusi | O60404 |
Polymorphism and mutation databases
BioMutai | OR10H3 |
Proteomic databases
PaxDbi | O60404 |
PeptideAtlasi | O60404 |
PRIDEi | O60404 |
ProteomicsDBi | 49393 |
Genome annotation databases
Ensembli | ENST00000305892; ENSP00000307130; ENSG00000171936 ENST00000641646; ENSP00000493287; ENSG00000171936 |
GeneIDi | 26532 |
KEGGi | hsa:26532 |
UCSCi | uc010xoq.2 human |
Organism-specific databases
CTDi | 26532 |
GeneCardsi | OR10H3 |
HGNCi | HGNC:8174 OR10H3 |
neXtProti | NX_O60404 |
PharmGKBi | PA31979 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410J91Z Eukaryota ENOG4111CKD LUCA |
GeneTreei | ENSGT00970000193373 |
HOGENOMi | HOG000041365 |
InParanoidi | O60404 |
KOi | K04257 |
OMAi | TVWIERR |
OrthoDBi | 970259at2759 |
PhylomeDBi | O60404 |
TreeFami | TF338279 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR10H3 |
GenomeRNAii | 26532 |
Pharosi | O60404 |
PROi | PR:O60404 |
Gene expression databases
Bgeei | ENSG00000171936 Expressed in 8 organ(s), highest expression level in muscle tissue |
ExpressionAtlasi | O60404 differential |
Genevisiblei | O60404 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O10H3_HUMAN | |
Accessioni | O60404Primary (citable) accession number: O60404 Secondary accession number(s): Q2HIZ3, Q6IFQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | November 13, 2019 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations