OR10H3

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
olfactory receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 10H3 Alternative name(s): Olfactory receptor OR19-24
Gene namesⁱ	Name:OR10H3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171936.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8174 OR10H3
neXtProtⁱ	NX_O60404

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 46	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	47 – 54	CytoplasmicSequence analysis	8
Transmembraneⁱ	55 – 75	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	76 – 99	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	100 – 120	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	121 – 139	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	140 – 160	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 197	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	198 – 218	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	219 – 238	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	239 – 259	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	260 – 272	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	273 – 293	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	294 – 316	CytoplasmicSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA31979

PharmGKBⁱ

PA31979

Polymorphism and mutation databases

BioMutaⁱ	OR10H3

BioMutaⁱ

OR10H3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150704	1 – 316	Olfactory receptor 10H3Add BLAST		316

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	98 ↔ 190	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	O60404
PeptideAtlas More...PeptideAtlasⁱ	O60404
PRIDEⁱ	O60404
ProteomicsDBⁱ	49393

PTM databases

iPTMnetⁱ	O60404
PhosphoSitePlusⁱ	O60404

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171936 Expressed in 8 organ(s), highest expression level in muscle tissue
CleanExⁱ	HS_OR10H3
ExpressionAtlasⁱ	O60404 baseline and differential
Genevisibleⁱ	O60404 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	117734, 8 interactors
STRINGⁱ	9606.ENSP00000307130

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60404
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J91Z Eukaryota ENOG4111CKD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119043
HOGENOMⁱ	HOG000041365
HOVERGENⁱ	HBG017625
InParanoidⁱ	O60404
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	TVWIERR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EWJ
PhylomeDBⁱ	O60404
TreeFamⁱ	TF338279

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O60404-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV 
        60         70         80         90        100
WIERRLHTPM YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI 
       110        120        130        140        150
QMFFSFMFGF THSFLLMVMG YDHYVTICHP LHYNMLMSPR GCAHLVAWTW 
       160        170        180        190        200
AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC HVLSLLKLAC GSKTSSVIMG 
       210        220        230        240        250
VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF STCVSHLTVV 
       260        270        280        290        300
VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK 
       310 
NAINKNFCRR FCPLSS

Length:316

Mass (Da):35,721

Last modified:August 1, 1998 - v1

Checksum:ⁱD055291FB9B49BC3

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024128	7	R → S. Corresponds to variant dbSNP:rs1966357Ensembl.	1
Natural variantⁱVAR_034288	14	L → I. Corresponds to variant dbSNP:rs2240227Ensembl.	1
Natural variantⁱVAR_034289	54	R → H. Corresponds to variant dbSNP:rs11670007Ensembl.	1
Natural variantⁱVAR_020381	224	V → M1 PublicationCorresponds to variant dbSNP:rs2240228Ensembl.	1
Natural variantⁱVAR_020382	293	S → N. Corresponds to variant dbSNP:rs2240229Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004597 Genomic DNA Translation: AAC14389.1 BC106707 mRNA Translation: AAI06708.1 BC113844 mRNA Translation: AAI13845.1 BK004212 Genomic DNA Translation: DAA04610.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12334.1
NCBI Reference Sequences More...RefSeqⁱ	NP_039226.1, NM_013938.1
UniGeneⁱ	Hs.553524

Genome annotation databases

Ensemblⁱ	ENST00000305892; ENSP00000307130; ENSG00000171936 ENST00000641646; ENSP00000493287; ENSG00000171936
GeneIDⁱ	26532
KEGGⁱ	hsa:26532
UCSC genome browser More...UCSCⁱ	uc010xoq.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60404	OR10H3		HUMAN		316	UniRef100_O60404

Protein	Similar proteins		Species	Score	Length	Source
O60404	Olfactory receptor 10H4		HUMAN		316	UniRef90_O60404
Uncharacterized protein		COLAP		322
Uncharacterized protein		MACNE		322
Uncharacterized protein		MACMU		322
Uncharacterized protein		MACFA		322
+42

Protein	Similar proteins		Species	Score	Length	Source
O60404	Olfactory receptor 10H4		HUMAN		316	UniRef50_O60404
Uncharacterized protein		MACNE		322
Uncharacterized protein		MACMU		322
Uncharacterized protein		MACFA		322
Uncharacterized protein		COLAP		322
+206

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004597 Genomic DNA Translation: AAC14389.1 BC106707 mRNA Translation: AAI06708.1 BC113844 mRNA Translation: AAI13845.1 BK004212 Genomic DNA Translation: DAA04610.1
CCDSⁱ	CCDS12334.1
RefSeqⁱ	NP_039226.1, NM_013938.1
UniGeneⁱ	Hs.553524

3D structure databases

ProteinModelPortalⁱ	O60404
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117734, 8 interactors
STRINGⁱ	9606.ENSP00000307130

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	O60404
PhosphoSitePlusⁱ	O60404

Polymorphism and mutation databases

BioMutaⁱ	OR10H3

BioMutaⁱ

OR10H3

Proteomic databases

PaxDbⁱ	O60404
PeptideAtlasⁱ	O60404
PRIDEⁱ	O60404
ProteomicsDBⁱ	49393

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000305892; ENSP00000307130; ENSG00000171936 ENST00000641646; ENSP00000493287; ENSG00000171936
GeneIDⁱ	26532
KEGGⁱ	hsa:26532
UCSCⁱ	uc010xoq.2 human

Organism-specific databases

CTDⁱ	26532
EuPathDBⁱ	HostDB:ENSG00000171936.1
GeneCardsⁱ	OR10H3
HGNCⁱ	HGNC:8174 OR10H3
neXtProtⁱ	NX_O60404
PharmGKBⁱ	PA31979
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J91Z Eukaryota ENOG4111CKD LUCA
GeneTreeⁱ	ENSGT00760000119043
HOGENOMⁱ	HOG000041365
HOVERGENⁱ	HBG017625
InParanoidⁱ	O60404
KOⁱ	K04257
OMAⁱ	TVWIERR
OrthoDBⁱ	EOG091G0EWJ
PhylomeDBⁱ	O60404
TreeFamⁱ	TF338279

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR10H3
GenomeRNAiⁱ	26532
Protein Ontology More...PROⁱ	PR:O60404

Gene expression databases

Bgeeⁱ	ENSG00000171936 Expressed in 8 organ(s), highest expression level in muscle tissue
CleanExⁱ	HS_OR10H3
ExpressionAtlasⁱ	O60404 baseline and differential
Genevisibleⁱ	O60404 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O10H3_HUMAN
Accessionⁱ	O60404Primary (citable) accession number: O60404 Secondary accession number(s): Q2HIZ3, Q6IFQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	August 1, 1998
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - O60404 (O10H3_HUMAN)

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Olfactory receptor 10H3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ