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Protein

Olfactory receptor 10H2

Gene

OR10H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H2
Alternative name(s):
Olfactory receptor OR19-23
Gene namesi
Name:OR10H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171942.4
HGNCiHGNC:8173 OR10H2
neXtProtiNX_O60403

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 315CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171942
PharmGKBiPA31978

Polymorphism and mutation databases

BioMutaiOR10H2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507031 – 315Olfactory receptor 10H2Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60403
PeptideAtlasiO60403
PRIDEiO60403
ProteomicsDBi49392

Expressioni

Gene expression databases

BgeeiENSG00000171942 Expressed in 1 organ(s), highest expression level in skin of leg
CleanExiHS_OR10H2
ExpressionAtlasiO60403 baseline and differential
GenevisibleiO60403 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306095

Structurei

3D structure databases

ProteinModelPortaliO60403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIZW Eukaryota
ENOG41119UX LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiO60403
KOiK04257
OMAiGPHSQEG
OrthoDBiEOG091G0EWJ
PhylomeDBiO60403
TreeFamiTF337675

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O60403-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLNHTSMS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW
60 70 80 90 100
SERSLHTPMY LFLCVLSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ
110 120 130 140 150
MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA
160 170 180 190 200
GGSVMGMVVT SAIFQLTFCG SHEIQHFLCH VPPLLKLACG NNVPAVALGV
210 220 230 240 250
GLVCIMALLG CFLLILLSYA FIVADILKIP SAEGRNKAFS TCASHLIVVI
260 270 280 290 300
VHYGFASVIY LKPKGPHSQE GDTLMATTYA VLTPFLSPII FSLRNKELKV
310
AMKRTFLSTL YSSGT
Length:315
Mass (Da):34,663
Last modified:August 1, 1998 - v1
Checksum:iC68387742D3B9382
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06206240L → Q. Corresponds to variant dbSNP:rs4569397Ensembl.1
Natural variantiVAR_077833131R → H Found in a child with sporadic epilepsy; unknown pathological significance. 1 Publication1
Natural variantiVAR_022049171S → F. Corresponds to variant dbSNP:rs1806931Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA Translation: AAC14388.1
BC069085 mRNA Translation: AAH69085.1
BC069457 mRNA Translation: AAH69457.1
BC112178 mRNA Translation: AAI12179.1
BC113647 mRNA Translation: AAI13648.1
AF399585 Genomic DNA Translation: AAK95070.1
BK004211 Genomic DNA Translation: DAA04609.1
CCDSiCCDS12333.1
RefSeqiNP_039227.1, NM_013939.2
UniGeneiHs.247694

Genome annotation databases

EnsembliENST00000305899; ENSP00000306095; ENSG00000171942
GeneIDi26538
KEGGihsa:26538
UCSCiuc002nbm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA Translation: AAC14388.1
BC069085 mRNA Translation: AAH69085.1
BC069457 mRNA Translation: AAH69457.1
BC112178 mRNA Translation: AAI12179.1
BC113647 mRNA Translation: AAI13648.1
AF399585 Genomic DNA Translation: AAK95070.1
BK004211 Genomic DNA Translation: DAA04609.1
CCDSiCCDS12333.1
RefSeqiNP_039227.1, NM_013939.2
UniGeneiHs.247694

3D structure databases

ProteinModelPortaliO60403
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306095

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10H2

Proteomic databases

PaxDbiO60403
PeptideAtlasiO60403
PRIDEiO60403
ProteomicsDBi49392

Protocols and materials databases

DNASUi26538
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305899; ENSP00000306095; ENSG00000171942
GeneIDi26538
KEGGihsa:26538
UCSCiuc002nbm.3 human

Organism-specific databases

CTDi26538
EuPathDBiHostDB:ENSG00000171942.4
GeneCardsiOR10H2
HGNCiHGNC:8173 OR10H2
neXtProtiNX_O60403
OpenTargetsiENSG00000171942
PharmGKBiPA31978
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZW Eukaryota
ENOG41119UX LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiO60403
KOiK04257
OMAiGPHSQEG
OrthoDBiEOG091G0EWJ
PhylomeDBiO60403
TreeFamiTF337675

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

ChiTaRSiOR10H2 human
GeneWikiiOR10H2
GenomeRNAii26538
PROiPR:O60403

Gene expression databases

BgeeiENSG00000171942 Expressed in 1 organ(s), highest expression level in skin of leg
CleanExiHS_OR10H2
ExpressionAtlasiO60403 baseline and differential
GenevisibleiO60403 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10H2_HUMAN
AccessioniPrimary (citable) accession number: O60403
Secondary accession number(s): Q6IFQ1, Q96R58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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